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An Acetyl-Methyl Switch Drives a Conformational Change in p53
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“This domain is intrinsically disordered, but can fold upon binding to partner proteins to form localized structural elements, including α-helices (seen in binding to the S100B protein16), β-turns (seen with the bromodomain of CBP/p30017), or stable conformations lacking defined secondary structure (seen with 53BP1 18).”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [18]
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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature · doi:10.1038/nature03114 · Cited by 884 · cited 2×
“The dimethylated p53K382 species is recognized by the TTD of 53BP1, a DNA damage response protein and a p53 co-factor that also binds to H4K20me2 (histone 4 dimethylated at K20) (Botuyan et al., 2006; Huang et al., 2007; Huyen et al., 2004; Kachirskaia et al., 2008).”
BackgroundAcetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
Tang, J., Cho, N. W., Cui, G., Manion, E. M., Shanbhag, N. M., Botuyan, M. V., Mer, G., & Greenberg, R. A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2499 · Cited by 521
Self-citationExtensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53
DeHart, C. J., Chahal, J. S., Flint, S. J., & Perlman, D. H. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.030254 · Cited by 70
Research works printed but not linked: 34
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Cited by
Krois, A. S., Park, S., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00528 · Cited by 14
Metadata
- Authors
- Tong, Q., Mazur, S. J., Rincon-Arano, H., Rothbart, S. B., Kuznetsov, D. M., Cui, G., Liu, W. H., Gete, Y., Klein, B. J., Jenkins, L., Mer, G., Kutateladze, A. G., Strahl, B. D., Groudine, M., Appella, E., & Kutateladze, T. G.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 23
- Issue
- 2
- Pages
- 322-331
- ISSN
- 0969-2126
- Cited by
- 28
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
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- Tong, Q., Mazur, S. J., Rincon-Arano, H., Rothbart, S. B., Kuznetsov, D. M., Cui, G., Liu, W. H., Gete, Y., Klein, B. J., Jenkins, L., Mer, G., Kutateladze, A. G., Strahl, B. D., Groudine, M., Appella, E., & Kutateladze, T. G. (2015). An Acetyl-Methyl Switch Drives a Conformational Change in p53. Structure. https://doi.org/10.1016/j.str.2014.12.010
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