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p53 post-translational modification: deregulated in tumorigenesis

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Dai, Chao, Gu, Wei·2010·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2010.09.002
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Abstract

The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis although some activities are also mediated in a transcription-independent manner. Here, we review the recent advances in our understanding of the wide spectrum of post-translational modifications that act as epigenetic-like codes for modulating specific functions of p53 in vivo and how deregulation of these modifications might contribute to tumorigenesis. We also discuss future research priorities to further understand p53 post-translational modifications and the interpretation of genetic data in appreciation of the increasing evidence that p53 regulates cellular metabolism, autophagy and many unconventional tumor suppressor activities.

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Research works printed but not linked: 75

  1. Vousden, 2007, p53 in health and disease, Nat. Rev. Mol. Cell Biol., 8, 275, 10.1038/nrm2147 · DOI · Paper page
  2. Matsumoto, 2006, Posttranslational phosphorylation of mutant p53 protein in tumor development, Med. Mol. Morphol., 39, 79, 10.1007/s00795-006-0320-0 · DOI
  3. Kruse, 2008, SnapShot: p53 posttranslational modifications, Cell, 133, e931
  4. Li, 2007, A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55, EMBO J, 26, 402, 10.1038/sj.emboj.7601519 · DOI
  5. Chao, 2006, Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression, EMBO J., 25, 2615
  6. Taira, 2007, DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage, Mol. Cell, 25, 725, 10.1016/j.molcel.2007.02.007 · DOI · Paper page
  7. Olsson, 2007, How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?, Cell Death Differ., 14, 1561, 10.1038/sj.cdd.4402196 · DOI
  8. Ichwan, 2006, Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells, Oncogene, 25, 1216, 10.1038/sj.onc.1209158 · DOI
  9. Feng, 2006, Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence, Cell Cycle, 5, 2812, 10.4161/cc.5.23.3526 · DOI
  10. Johnson, 2006, Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice, Cell Death Differ., 13, 902, 10.1038/sj.cdd.4401902 · DOI
  11. Bruins, 2008, The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts, Mol. Cell Biol., 28, 1974, 10.1128/MCB.01610-07 · DOI
  12. Bruins, 2007, Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation, Carcinogenesis, 28, 1814, 10.1093/carcin/bgm041 · DOI
  13. Bar, 2009, Expression of p53 protein phosphorylated at serine 20 and serine 392 in malignant and benign ovarian neoplasms: correlation with clinicopathological parameters of tumors, Int. J. Gynecol. Cancer, 19, 1322, 10.1111/IGC.0b013e3181b70465 · DOI
  14. Matsumoto, 2004, Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors, Oncol. Rep., 12, 1039
  15. Matsumoto, 2004, Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma, Oncology, 67, 143, 10.1159/000081001 · DOI
  16. Marchenko, 2007, The role of ubiquitination in the direct mitochondrial death program of p53, Cell Cycle, 6, 1718, 10.4161/cc.6.14.4503 · DOI
  17. Itahana, 2007, Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation, Cancer Cell, 12, 355, 10.1016/j.ccr.2007.09.007 · DOI · Paper page
  18. Sherr, 2006, Divorcing ARF and p53: an unsettled case, Nat. Rev. Cancer, 6, 663, 10.1038/nrc1954 · DOI · Paper page
  19. Brooks, 2007, The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP, Oncogene, 26, 7262, 10.1038/sj.onc.1210531 · DOI
  20. Meulmeester, 2005, ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation, Cell Cycle, 4, 1166, 10.4161/cc.4.9.1981 · DOI · Paper page
  21. Lu, 2007, The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop, Cancer Cell, 12, 342, 10.1016/j.ccr.2007.08.033 · DOI · Paper page
  22. Wang, 2004, Inhibition of p53 degradation by Mdm2 acetylation, FEBS Lett., 561, 195, 10.1016/S0014-5793(04)00168-1 · DOI
  23. Ohkubo, 2006, Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription, J. Biol. Chem., 281, 16943, 10.1074/jbc.M601388200 · DOI
  24. Tang, 2008, Acetylation is indispensable for p53 activation, Cell, 133, 612, 10.1016/j.cell.2008.03.025 · DOI · Paper page
  25. Yang, 2007, CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation, J. Biol. Chem., 282, 3273, 10.1074/jbc.M610793200 · DOI
  26. Yamasaki, 2007, Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’, EMBO J., 26, 113, 10.1038/sj.emboj.7601490 · DOI · Paper page
  27. Chen, 2005, ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor, Cell, 121, 1071, 10.1016/j.cell.2005.03.037 · DOI · Paper page
  28. Laine, 2007, Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1, Oncogene, 26, 1477, 10.1038/sj.onc.1209924 · DOI
  29. Kruse, 2009, MSL2 promotes Mdm2-independent cytoplasmic localization of p53, J. Biol. Chem., 284, 3250, 10.1074/jbc.M805658200 · DOI
  30. Shi, 2009, CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53, Proc. Natl. Acad. Sci. U. S. A., 106, 16275, 10.1073/pnas.0904305106 · DOI · Paper page
  31. Duan, 2004, Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer, J. Natl. Cancer Inst., 96, 1718, 10.1093/jnci/djh292 · DOI
  32. Dornan, 2004, COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas, Cancer Res., 64, 7226, 10.1158/0008-5472.CAN-04-2601 · DOI
  33. Chen, 2007, Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer, Oncogene, 26, 2386, 10.1038/sj.onc.1210021 · DOI
  34. Chen, 2007, The amplified WWP1 gene is a potential molecular target in breast cancer, Int. J. Cancer, 121, 80, 10.1002/ijc.22653 · DOI
  35. Nijman, 2005, A genomic and functional inventory of deubiquitinating enzymes, Cell, 123, 773, 10.1016/j.cell.2005.11.007 · DOI · Paper page
  36. Li, 2004, A dynamic role of HAUSP in the p53-Mdm2 pathway, Mol. Cell, 13, 879, 10.1016/S1097-2765(04)00157-1 · DOI · Paper page
  37. Colland, 2009, Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells, Mol. Cancer Ther., 8, 2286, 10.1158/1535-7163.MCT-09-0097 · DOI · Paper page
  38. Rabut, 2008, Function and regulation of protein neddylation. ‘Protein modifications: beyond the usual suspects’ review series, EMBO Rep, 9, 969, 10.1038/embor.2008.183 · DOI · Paper page
  39. Geiss-Friedlander, 2007, Concepts in sumoylation: a decade on, Nat. Rev. Mol. Cell Biol., 8, 947, 10.1038/nrm2293 · DOI · Paper page
  40. Carter, 2008, p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53, Cell Cycle, 7, 2519, 10.4161/cc.7.16.6422 · DOI
  41. Bischof, 2006, The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis, Mol. Cell, 22, 783, 10.1016/j.molcel.2006.05.016 · DOI · Paper page
  42. Stehmeier, 2009, Regulation of p53 family members by the ubiquitin-like SUMO system, DNA Repair (Amst.), 8, 491, 10.1016/j.dnarep.2009.01.002 · DOI · Paper page
  43. Xirodimas, 2004, Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity, Cell, 118, 83, 10.1016/j.cell.2004.06.016 · DOI · Paper page
  44. Abida, 2007, FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity, J. Biol. Chem., 282, 1797, 10.1074/jbc.M609001200 · DOI · Paper page
  45. Melchior, 2002, SUMO-1 and p53, Cell Cycle, 1, 245, 10.4161/cc.1.4.131 · DOI
  46. Li, 2006, Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways, J. Biol. Chem., 281, 36221, 10.1074/jbc.M608236200 · DOI
  47. Allis, 2007, New nomenclature for chromatin-modifying enzymes, Cell, 131, 633, 10.1016/j.cell.2007.10.039 · DOI · Paper page
  48. Krummel, 2005, The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation, Proc. Natl. Acad. Sci. U. S. A., 102, 10188, 10.1073/pnas.0503068102 · DOI · Paper page
  49. Knights, 2006, Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate, J. Cell Biol., 173, 533, 10.1083/jcb.200512059 · DOI · Paper page
  50. Chao, 2006, Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage, Mol. Cell Biol., 26, 6859, 10.1128/MCB.00062-06 · DOI
  51. Tang, 2006, Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis, Mol. Cell, 24, 827, 10.1016/j.molcel.2006.11.021 · DOI · Paper page
  52. Sykes, 2009, Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53, J. Biol. Chem., 284, 20197, 10.1074/jbc.M109.026096 · DOI
  53. Luo, 2000, Deacetylation of p53 modulates its effect on cell growth and apoptosis, Nature, 408, 377, 10.1038/35042612 · DOI · Paper page
  54. Luo, 2001, Negative control of p53 by Sir2alpha promotes cell survival under stress, Cell, 107, 137, 10.1016/S0092-8674(01)00524-4 · DOI · Paper page
  55. Cheng, 2003, Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice, Proc. Natl. Acad. Sci. U. S. A., 100, 10794, 10.1073/pnas.1934713100 · DOI · Paper page
  56. Chen, 2005, Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses, Cell, 123, 437, 10.1016/j.cell.2005.08.011 · DOI · Paper page
  57. Yamakuchi, 2008, miR-34a repression of SIRT1 regulates apoptosis, Proc. Natl. Acad. Sci. U. S. A., 105, 13421, 10.1073/pnas.0801613105 · DOI · Paper page
  58. Bradbury, 2005, Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors, Leukemia, 19, 1751, 10.1038/sj.leu.2403910 · DOI · Paper page
  59. Huffman, 2007, SIRT1 is significantly elevated in mouse and human prostate cancer, Cancer Res., 67, 6612, 10.1158/0008-5472.CAN-07-0085 · DOI · Paper page
  60. Hida, 2007, Strong expression of a longevity-related protein, SIRT1, in Bowen's disease, Arch. Dermatol. Res, 299, 103, 10.1007/s00403-006-0725-6 · DOI
  61. Kim, 2008, DBC1 is a negative regulator of SIRT1, Nature, 451, 583, 10.1038/nature06500 · DOI · Paper page
  62. Zhao, 2008, Negative regulation of the deacetylase SIRT1 by DBC1, Nature, 451, 587, 10.1038/nature06515 · DOI · Paper page
  63. Deng, 2009, SIRT1, is it a tumor promoter or tumor suppressor?, Int. J. Biol. Sci., 5, 147, 10.7150/ijbs.5.147 · DOI · Paper page
  64. Lain, 2008, Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator, Cancer Cell, 13, 454, 10.1016/j.ccr.2008.03.004 · DOI · Paper page
  65. Scoumanne, 2008, Protein methylation: a new mechanism of p53 tumor suppressor regulation, Histol. Histopathol., 23, 1143
  66. Jansson, 2008, Arginine methylation regulates the p53 response, Nat. Cell Biol., 10, 1431, 10.1038/ncb1802 · DOI · Paper page
  67. Chuikov, 2004, Regulation of p53 activity through lysine methylation, Nature, 432, 353, 10.1038/nature03117 · DOI · Paper page
  68. Huang, 2006, Repression of p53 activity by Smyd2-mediated methylation, Nature, 444, 629, 10.1038/nature05287 · DOI · Paper page
  69. Shi, 2007, Modulation of p53 function by SET8-mediated methylation at lysine 382, Mol. Cell, 27, 636, 10.1016/j.molcel.2007.07.012 · DOI · Paper page
  70. Huang, 2010, G9a and Glp methylate lysine 373 in the tumor suppressor p53, J. Biol. Chem., 285, 9636, 10.1074/jbc.M109.062588 · DOI · Paper page
  71. Huang, 2007, p53 is regulated by the lysine demethylase LSD1, Nature, 449, 105, 10.1038/nature06092 · DOI · Paper page
  72. Ide, 2009, GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress, Mol. Cell, 36, 379, 10.1016/j.molcel.2009.09.031 · DOI
  73. Bensaad, 2006, TIGAR, a p53-inducible regulator of glycolysis and apoptosis, Cell, 126, 107, 10.1016/j.cell.2006.05.036 · DOI · Paper page
  74. Feng, 2005, The coordinate regulation of the p53 and mTOR pathways in cells, Proc. Natl. Acad. Sci. U. S. A., 102, 8204, 10.1073/pnas.0502857102 · DOI · Paper page
  75. Tasdemir, 2008, A dual role of p53 in the control of autophagy, Autophagy, 4, 810, 10.4161/auto.6486 · DOI · Paper page

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Metadata

Authors
Dai, C., & Gu, W.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2010-11
Volume
16
Issue
11
Pages
528-536
ISSN
1471-4914 (ISSN-L)
DOI
10.1016/j.molmed.2010.09.002
OpenAlex
W2010706742
Cited by
523
References
20
FWCI
3.24
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Dai, C., & Gu, W. (2010). p53 post-translational modification: deregulated in tumorigenesis. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2010.09.002

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