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Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2
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LRRK2 phosphorylated Rab10 interacts with JIP3 and JIP4 (JNK interacting proteins), scaffold proteins for JNK signaling.
“Moreover, LRRK2 phosphorylated Rab10 interacts with JIP3 and JIP4 (JNK interacting proteins), scaffold proteins for JNK signaling [89].”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [89]
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Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N.-Y., Chuang, L.-S., Carmi, S., Villaverde, N., Li, X., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aai7795 · Cited by 384 · cited 1×
“The ROC-COR tandem domains regulate LRRK2 activity, and numerous missense mutations have been localized to these regulatory and kinase domains (Hui et al., 2018; Paisan-Ruiz et al., 2004; Zimprich et al., 2004).”
BackgroundInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281 · cited 18×
“Sequence numbers correspond to JIP3, the interacting partners are shown above the cartoon, and p150G refers to p150Glued.”
BackgroundInfluentialDhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R., & Pfeffer, S. R. (2018) · eLife · doi:10.7554/elife.40202 · Cited by 240
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Kalogeropulou, A. F., Purlyte, E., Tonelli, F., Lange, S. M., Wightman, M., Prescott, A. R., Padmanabhan, S., Sammler, E., & Alessi, D. R. (2022) · Biochemical Journal · doi:10.1042/bcj20220161 · Cited by 129
Self-citationKhan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R., & Pfeffer, S. R. (2021) · eLife · doi:10.7554/elife.67900 · Cited by 93
Self-citationCellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Singh, V., Menard, M. A., Serrano, G. E., Beach, T. G., Zhao, H. T., Riley-DiPaolo, A., Subrahmanian, N., LaVoie, M. J., & Volpicelli-Daley, L. A. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01704-9 · Cited by 9
Metadata
- Authors
- Waschbüsch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D. R., & Khan, A. R.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 28
- Issue
- 4
- Pages
- 406-417.e6
- ISSN
- 0969-2126
- PMC
- PMC7139218
- Cited by
- 87
- References
- 3
- Language
- en
- Licence
- Funders
- Office of Research Infrastructure Programs, National Institutes of Health (S10 RR029205)
- National Institutes of Health (S10 RR029205)
- Science Foundation Ireland (12/IA/1239, 6986)
- Argonne National Laboratory (DE-AC02-06CH11357)
- Medical Research Council (MC_UU_12016/2)
- National Institute of General Medical Sciences (P41 GM103403)
- GlaxoSmithKline
- Office of Science
- Michael J. Fox Foundation for Parkinson's Research
- Merck KGaA
- U.S. Department of Energy
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