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Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4

Bloch, Magnus, Raj, Isha, Pape, Tillmann, Taylor, Nicholas M.I.·2023·Structure
DOI 10.1016/j.str.2023.08.014

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Figures

Fig. 1 The molecular architecture of human MRP4.
Fig. 1 The molecular architecture of human MRP4.CC-BY-NC-ND · From the PDF
Fig. 2 Basal and substrate-modulated ATPase activity of human MRP4.
Fig. 2 Basal and substrate-modulated ATPase activity of human MRP4.CC-BY-NC-ND · From the PDF
Fig. 3 Characterization of the MRP4 substrate binding pocket and its substrate coordination.
Fig. 3 Characterization of the MRP4 substrate binding pocket and its substrate coordination.CC-BY-NC-ND · From the PDF
Image 4
CC-BY-NC-ND · From the PDF
Image 5
CC-BY-NC-ND · From the PDF
Fig. 5 The MRP transport cycle.
Fig. 5 The MRP transport cycle.CC-BY-NC-ND · From the PDF

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Metadata

Authors
Bloch, M., Raj, I., Pape, T., & Taylor, N. M. I.
Venue
Structure
Publisher
Elsevier BV
Published
2023-11
Volume
31
Issue
11
Pages
1407-1418.e6
ISSN
0969-2126
DOI
10.1016/j.str.2023.08.014
Cited by
23
References
2
Language
en
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