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Cited by 97Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentAdrenal Hormones and Disorders

Outcomes of adrenal cortical carcinoma in the United States

Paton, B. Lauren, Novitsky, Yuri W., Zerey, Marc, Harrell, Andrew G., Norton, H. James, Asbun, Horatio, Kercher, Kent W., Heniford, B. Todd·2006·Surgery
DOI 10.1016/j.surg.2006.07.035
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Abstract

Background Improvements in the sensitivity of radiographic imaging have lead to an increase in the number of adrenal masses diagnosed. The purpose of this study is to determine if technologic advancements have resulted in the diagnosis of earlier-staged adrenal cortical cancer (ACC) and to determine if the survival of patients with ACC has improved over the past 15 years.Methods Patients with ACC were identified in the Surveillance, Epidemiology, and End Results database between 1988 and 2002. Changes in demographics, stage, size, and treatment were analyzed by standard statistical testing.Results We identified 602 patients with a mean age of 53 years and an average tumor size of 11.8 cm. Two hundred thirty-eight (39.5%) patients presented with localized disease (stages I and II), and 311 (52%) patients presented with advanced disease (stages III and IV). The comparison of smaller lesions and number of patients were 5 to 6 cm in 24 (4%) patients, 4 to 5 cm in 27 (4.5%) patients, and <4 cm in 19 (3.1%) patients. Patients with masses less than 5 cm were statistically more likely to have localized disease (P <. 001). Age (P = .10), tumor size (P = .85), tumor stage (P = .45), and 5-year survival (P = .5) did not change over the 15-year study.Conclusions Over the 15-year study, patients with ACC were not diagnosed at an earlier stage or with tumors smaller, and survival did not improve.

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  • Only a minority of ACC tumors are <6 cm (9%-14%), with only 3% presenting as lesions <4 cm.

    “Only a minority of tumors are <6 cm (9%–14%), with only 3% presenting as lesions <4 cm (89, 90).”

    From Adrenocortical carcinoma (2014) · cites this paper as [90]

  • In the United States, radiotherapy is used in approximately 10% of ACC cases.

    “In the United States, it is used in approximately 10% of cases, according to analyses of both the National Cancer Data Base and the SEER program (4, 11, 90).”

    From Adrenocortical carcinoma (2014) · cites this paper as [90]

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Authors
Paton, B. L., Novitsky, Y. W., Zerey, M., Harrell, A. G., Norton, H. J., Asbun, H., Kercher, K. W., & Heniford, B. T.
Affiliations
  • Carolinas Medical Center (US)
  • John Muir Health (US)
ORCID
Venue
Surgery
Publisher
Elsevier BV
Published
2006-12
Volume
140
Issue
6
Pages
914-920
ISSN
0039-6060 (ISSN-L)
DOI
10.1016/j.surg.2006.07.035
OpenAlex
W2063410286
Cited by
97
References
24
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 6
FWCI
8.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenocortical carcinoma, adrenal mass, tumor size, tumor stage, early diagnosis, survival trends, SEER database
MeSH terms
Adrenal Cortex Neoplasms, Adrenal Glands, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, United States, Survival Rate, SEER Program

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