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Cited by 115Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentSarcoma Diagnosis and Treatment

Adjuvant and definitive radiotherapy for adrenocortical carcinoma

Sabolch, Aaron, Feng, Mary, Griffith, Kent, Hammer, Gary, Doherty, Gerard, Ben-Josef, Edgar·2011·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2010.04.030
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Abstract

Purpose To evaluate the impact of both adjuvant and definitive radiotherapy on local control of adrenocortical carcinoma.Methods and materials Outcomes were analyzed from 58 patients with 64 instances of treatment for adrenocortical carcinoma at the University of Michigan's Multidisciplinary Adrenal Cancer Clinic. Thirty-seven of these instances were for primary disease, whereas the remaining 27 were for recurrent disease. Thirty-eight of the treatment regimens involved surgery alone, 10 surgery plus adjuvant radiotherapy, and 16 definitive radiotherapy for unresectable disease. The effects of patient, tumor, and treatment factors were modeled simultaneously using multiple variable Cox proportional hazards regression for associations with local recurrence, distant recurrence, and overall survival.Results Local failure occurred in 16 of the 38 instances that involved surgery alone, in 2 of the 10 that consisted of surgery plus adjuvant radiotherapy, and in 1 instance of definitive radiotherapy. Lack of radiotherapy use was associated with 4.7 times the risk of local failure compared with treatment regimens that involved radiotherapy (95% confidence interval, 1.2-19.0; p = 0.030).Conclusions Radiotherapy seems to significantly lower the risk of local recurrence/progression in patients with adrenocortical carcinoma. Adjuvant radiotherapy should be strongly considered after surgical resection.

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Crossref · 10.1016/j.ijrobp.2010.04.030

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  • Radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both adjuvant and palliative settings, although such improvement has not been universally demonstrated.

    “Although traditionally considered ineffective for ACC (327–331), radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both the adjuvant and palliative settings (247, 332–337), although such an improvement has not been universally demonstrated (338).”

    From Adrenocortical carcinoma (2014) · cites this paper as [247]

  • In Sabolch et al, local failure occurred in 33% of those treated with surgery alone but only 12% of those whose regimen involved radiation.

    “Local failure occurred in 33% of those treated with surgery alone but only in 12% of those whose regimen involved radiation.”

    From Adrenocortical carcinoma (2014) · cites this paper as [247]

  • In Sabolch et al, patients treated with adjuvant radiotherapy after surgery had a 20% local recurrence rate.

    “Patients treated with adjuvant radiotherapy after surgery had a 20% local recurrence rate.”

    From Adrenocortical carcinoma (2014) · cites this paper as [247]

  • In Habra et al, local recurrence rate for patients receiving adjuvant radiotherapy after surgery was 44%, compared with 14% in Fassnacht et al and 20% in Sabolch et al.

    “More specifically, although Habra et al (338) found a local recurrence rate of 44% for such patients, Fassnacht et al (332) showed a 14% local failure rate and Sabolch et al (247) found a 20% rate.”

    From Adrenocortical carcinoma (2014) · cites this paper as [247]

  • In Sabolch et al, radiotherapy was not associated with a survival benefit but significantly improved local control.

    “Results from this study showed that whereas radiotherapy was not associated with a survival benefit, it did significantly improve local control.”

    From Adrenocortical carcinoma (2014) · cites this paper as [247]

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Authors
Sabolch, A., Feng, M., Griffith, K., Hammer, G., Doherty, G., & Ben-Josef, E.
Affiliations
University of Michigan (US)
ORCID
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2011-08
Volume
80
Issue
5
Pages
1477-1484
ISSN
0360-3016 (ISSN-L)
DOI
10.1016/j.ijrobp.2010.04.030
OpenAlex
W2012899953
Cited by
115
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 12 · 2017: 10 · 2016: 9 · 2015: 13 · 2014: 8 · 2013: 11 · 2012: 11
FWCI
9.80
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
Keywords
adrenocortical carcinoma, adjuvant radiotherapy, definitive radiotherapy, local recurrence, adrenalectomy, overall survival, distant recurrence
MeSH terms
Adrenal Cortex Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Cancer Care Facilities, Combined Modality Therapy, Female, Humans, Male, Michigan, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy Dosage, Retrospective Studies, Proportional Hazards Models, Treatment Outcome, Adrenocortical Carcinoma, Radiotherapy, Adjuvant

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