MANAGEMENT APPROACHES TO ADRENAL INCIDENTALOMAS
Abstract
Two biproducts of the revolution in diagnostic imaging techniques are unintended discoveries, and uncertainty for the patient and the clinician. To address the uncertainty associated with adrenal incidentalomas, clinicians need to understand the definition, differential diagnosis, and options for assessment with respect to functional status and malignancy potential. This article presents an algorithmic approach that addresses these issues.
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Adrenal incidentalomas are thought to occur in up to 4-7% of adults.
“Because AI are thought to be present in up to 4 -7% of adults (6 -11)”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [11]
Cites
Laparoscopic Adrenalectomy in Cushing's Syndrome and Pheochromocytoma
Gagner, M., Lacroix, A., & Bolté, E. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210013271417 · Cited by 1,509 · see citing works
Incidentally Discovered Adrenal Masses*
Kloos, R. T., Gross, M. D., Francis, I. R., KOROBKIN, M. T., & Shapiro, B. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-4-460 · Cited by 869 · see citing works
Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature
Boland, G. W., Lee, M. J., Gazelle, G. S., Halpern, E. F., McNicholas, M. M., & Mueller, P. R. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.171.1.9648789 · Cited by 693 · see citing works
HIGH INCIDENCE OF PRIMARY ALDOSTERONISM IN 199 PATIENTS REFERRED WITH HYPERTENSION
Gordon, R. D., Stowasser, M., Tunny, T. J., Klemm, S. A., & Rutherford, J. C. (1994) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1994.tb02519.x · Cited by 495 · see citing works
Prevalence of clinically unsuspected pheochromocytoma. Review of a 50-year autopsy series.
Sutton, M. G. S. J., Sheps, S. G., & Lie, J. T. (1981) · PubMed · Cited by 453 · see citing works
CT time-attenuation washout curves of adrenal adenomas and nonadenomas
Korobkin, M., Brodeur, F. J., Francis, I. R., Quint, L. E., Dunnick, N. R., & Londy, F. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.170.3.9490968 · Cited by 386 · see citing works
Incidentally discovered adrenal tumors: an institutional perspective.
Mf, H., Cs, G., van Heerden, J. A., Sheedy, P. F., & Dm, I. (1991) · PubMed · Cited by 360 · see citing works
The Incidentally Discovered Adrenal Mass
Copeland, P. M. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-6-940 · Cited by 350 · see citing works
Nonfunctioning adrenal masses: incidental discovery on computed tomography
Glazer, H., Weyman, P., Sagel, S., Levitt, R., & McClennan, B. (1982) · American Journal of Roentgenology · doi:10.2214/ajr.139.1.81 · Cited by 347 · see citing works
Reincke, M., Nieke, J., Krestin, G. P., Saeger, W., Allolio, B., & Winkelmann, W. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.3.1517373 · Cited by 346 · see citing works
Hormonal Evaluation of the Patient with an Incidentally Discovered Adrenal Mass
Desforges, J. F., Ross, N. S., & Aron, D. C. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232007 · Cited by 337 · see citing works
Incidentally DiscoveredAdrenal Mass
Young, W. F., & Bancos, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-79285-1.00101-1 · Cited by 304 · see citing works
Self-citationCONGENITAL HEMIHYPERTROPHY AND MALIGNANCY
Benson, P. F., Vulliamy, D. G., & Taubman, J. O. (1963) · The Lancet · doi:10.1016/s0140-6736(63)92360-2 · Cited by 291 · see citing works
Incidentally discovered adrenal masses
Kloos, R. T. (1995) · Endocrine Reviews · doi:10.1210/er.16.4.460 · Cited by 272 · see citing works
Angeli, A., Osella, G., Ali, A., & Terzolo, M. (1997) · Hormone Research · doi:10.1159/000185477 · Cited by 259 · see citing works
Risk Factors and Long-Term Follow-Up of Adrenal Incidentalomas1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Paoletta, A., & Boscaro, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5444 · Cited by 255 · see citing works
BERTAGNA, C., & Orth, D. N. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90384-3 · Cited by 245 · see citing works
Prevalence of Clinically Unsuspected Pheochromocytoma. Review of a 50-Year Autopsy Series
Sutton, M. G. S. J., Sheps, S. G., & Lie, J. T. (1982) · The Journal of Urology · doi:10.1016/s0022-5347(17)53807-0 · Cited by 240 · see citing works
Serendipitous adrenal masses: Prevalence, significance, and management
Abecassls, M., Loughlin, M. J. M., Langer, B., & Kudlow, J. E. (1985) · The American Journal of Surgery · doi:10.1016/s0002-9610(85)80186-0 · Cited by 233 · see citing works
Potentially high prevalence of primary aldosteronism in a primary-care population
Lim, P. O., Rodgers, P., Cardale, K., Watson, A., & MacDonald, T. M. (1999) · The Lancet · doi:10.1016/s0140-6736(05)74868-6 · Cited by 228 · see citing works
Percutaneous adrenal biopsy: review of a 10-year experience.
Welch, T. L., Sheedy, P. F., Stephens, D. H., Johnson, C. M., & Swensen, S. J. (1994) · Radiology · doi:10.1148/radiology.193.2.7972740 · Cited by 217 · see citing works
Gicquel, C., Raffin‐Sanson, M., Gaston, V., BERTAGNA, X. Y., Plouin, P., Schlumberger, M. J., Louvel, A., LUTON, J. P., & Bouc, Y. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4170 · Cited by 213 · see citing works
Prinz, R. A. (1982) · JAMA · doi:10.1001/jama.248.6.701 · Cited by 211 · see citing works
Endocrine evaluation of incidentally discovered adrenal masses (incidentalomas)
Osella, G., Terzolo, M., Borretta, G., Magro, G., Alí, A., Piovesan, A., Paccotti, P., & Angeli, A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.6.7989452 · Cited by 206 · see citing works
Subclinical Cushing's syndrome in adrenal incidentaloma.
Terzolo, Osella, Alì, Borretta, Cesario, Paccotti, & Angeli, A. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00357.x · Cited by 198 · see citing works
Primary Aldosteronism: Diagnosis and Treatment
Young, W. F., HOGAN, M. J., Klee, G. G., Grant, C. S., & van Heerden, J. A. (1990) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62114-4 · Cited by 191 · see citing works
Self-citationGicquel, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2559 · Cited by 186 · see citing works
Incidentally Discovered Adrenal Tumors: Endocrine and Scintigraphic Correlates1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Gregianin, M., Macrì, C., & Boscaro, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4501 · Cited by 184 · see citing works
Icard, P., Chapuis, Y., Andréassian, B., Bernard, A., & Proye, C. A. G. (1992) · PubMed · Cited by 179 · see citing works
Primary adrenocortical carcinoma: CT evaluation with clinical correlation
Fishman, E. K., Deutch, B., Hartman, D. S., Goldman, S., Zerhouni, E. A., & Siegelman, S. S. (1987) · American Journal of Roentgenology · doi:10.2214/ajr.148.3.531 · Cited by 173 · see citing works
Predictive value of image-guided adrenal biopsy: analysis of results of 101 biopsies.
Silverman, S. G., Müeller, P. R., Pinkney, L. P., Koenker, R. M., & Seltzer, S. E. (1993) · Radiology · doi:10.1148/radiology.187.3.8497619 · Cited by 169 · see citing works
Adrenalectomy for metastatic disease to the adrenal glands
Lo, C. Y., van Heerden, J. A., Søreide, J. A., Grant, C. S., Thompson, G. B., Lloyd, R. V., & Harmsen, W. S. (1996) · British journal of surgery · doi:10.1002/bjs.1800830432 · Cited by 167 · see citing works
Incidentally discovered mass of the adrenal gland.
Belldegrun, A. S., Hussain, S., Seltzer, S. E., Kr, L., Gittes, R. F., & Jp, R. (1986) · PubMed · Cited by 166 · see citing works
Unsuspected pheochromocytoma: risk of blood-pressure alterations during percutaneous adrenal biopsy.
Casola, G., Nicolet, V., VANSONNENBERG, E., et al. (1986) · Radiology · doi:10.1148/radiology.159.3.3517958 · Cited by 166 · see citing works
Small adenomas of the adrenal cortex in hypertension and diabetes
RUSSI, S. (1945) · Archives of Internal Medicine · doi:10.1001/archinte.1945.00210350030005 · Cited by 161 · see citing works
Imaging Features of Uncommon Adrenal Masses with Histopathologic Correlation
Otal, P., Escourrou, G., Mazerolles, C., d’Othée, B. J., Mezghani, S., Musso, S., Colombier, D., Rousseau, H., & Joffre, F. (1999) · Radiographics · doi:10.1148/radiographics.19.3.g99ma07569 · Cited by 160 · see citing works
Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management
Bornstein, S. R., Stratakis, C. A., & Chrousos, G. P. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-9-199905040-00017 · Cited by 156 · see citing works
Adrenal cortical carcinoma--a continuing challenge.
Dj, H., van Heerden, J. A., Cs, G., Carney, J. A., & Carpenter, P. C. (1983) · PubMed · Cited by 156 · see citing works
Kasperlik‐Załuska, A. A., Rosłonowska, E., Słowińska‐Srzednicka, J., Migdalska, B., Jeske, W., Makowska, A., & Snochowska, H. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.d01-1751.x · Cited by 155 · see citing works
Szolar, D. H., & Kammerhuber, F. (1997) · Radiology · doi:10.1148/radiology.202.2.9015083 · Cited by 151 · see citing works
Adrenocortical nodular hyperplasia: The ageing adrenal
Dobbie, J. W. (1969) · The Journal of Pathology · doi:10.1002/path.1710990102 · Cited by 150 · see citing works
CT-guided adrenal biopsy: accuracy, safety, and indications
Bernardino, M., Mm, W., Vm, P., et al. (1985) · American Journal of Roentgenology · doi:10.2214/ajr.144.1.67 · Cited by 145 · see citing works
Prevalence of Adrenal Carcinoma Among Incidentally Discovered Adrenal Masses
Terzolo, M. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430320116020 · Cited by 143 · see citing works
Incidentally Discovered Adrenal Tumors: Endocrine and Scintigraphic Correlates
Barzon, L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.55 · Cited by 140 · see citing works
Percutaneous CT-Guided Biopsy of Adrenal Masses
Mody, M. K., Kazerooni, E. A., & KOROBKIN, M. T. (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199505000-00017 · Cited by 139 · see citing works
Adrenal Incidentaloma: An Overview of Hormonal Data from the National Italian Study Group
Mantero, F., Masini, A. M., Opocher, G., Giovagnetti, M., & Arnaldi, G. (1997) · Hormone Research · doi:10.1159/000185478 · Cited by 139 · see citing works
Subclinical hormone secretion by incidentally discovered adrenal masses
Caplan, R. H. (1994) · Archives of Surgery · doi:10.1001/archsurg.1994.01420270067016 · Cited by 133 · see citing works
A CASE REPORT OF LAPAROSCOPIC ADRENALECTOMY
Higashihara, E., Tanaka, Y., Horie, S., et al. (1992) · The Japanese Journal of Urology · doi:10.5980/jpnjurol1989.83.1130 · Cited by 130 · see citing works
Lee, J. E., Evans, D. B., Hickey, R. C., et al. (1998) · Surgery · doi:10.1067/msy.1998.92009 · Cited by 128 · see citing works
Fine-needle aspiration of catecholamine-producing adrenal masses: a possibly fatal mistake
McCorkell, S., & Niles, N. (1985) · American Journal of Roentgenology · doi:10.2214/ajr.145.1.113 · Cited by 127 · see citing works
Fine needle aspiration cytology of the adrenal gland.
Katz, R. L., Patel, S. N., Mackay, B., & Zornoza, J. (1984) · PubMed · Cited by 122 · see citing works
Scintigraphic evaluation of clinically silent adrenal masses.
Gross, M. D., Shapiro, B., Francis, I. R., Glazer, G. M., Bree, R. L., Arcomano, M. A., SCHTEINGART, D. E., McLeod, M. K., Sanfield, J. A., & Thompson, N. W. (1994) · PubMed · Cited by 121 · see citing works
Primary aldosteronism: A common and curable form of hypertension.
Young, W. F. (1999) · PubMed · Cited by 121 · see citing works
Self-citationAdenomas of the adrenal cortex
COMMONS, R. R. (1948) · Archives of Internal Medicine · doi:10.1001/archinte.1948.00220190045004 · Cited by 121 · see citing works
Risk Factors and Long-Term Follow-Up of Adrenal Incidentalomas
Barzon, L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.520 · Cited by 120 · see citing works
Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue
Kojima, M., Morisaki, T., Tsukahara, Y., Uchiyama, A., Matsunari, Y., Mibu, R., & Tanaka, M. (1999) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(199904)70:4 · Cited by 117 · see citing works
McLeod, M. K., Thompson, N. W., Gross, M. D., Bondeson, A. G., & Bondeson, L. (1990) · PubMed · Cited by 111 · see citing works
Does the corticoadrenal adenoma with "pre-Cushing's syndrome" exist?
Charbonnel, B. H., Chatal, J. F., & Ozanne, P. (1981) · PubMed · Cited by 109 · see citing works
Clinical review 50: Clinically silent adrenal masses
Gross, M., & Shapiro, B. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.4.8408461 · Cited by 106 · see citing works
Incidentally Discovered Mass of the Adrenal Gland
Belldegrun, A. S., Hussain, S., Seltzer, S. E., Loughlin, K. R., Gittes, R. F., & Richie, J. P. (1987) · The Journal of Urology · doi:10.1016/s0022-5347(17)44402-8 · Cited by 106 · see citing works
Young, W. F. (1999) · Cardiology in Review · doi:10.1097/00045415-199907000-00012 · Cited by 105 · see citing works
Self-citationAdrenal masses in oncologic patients: functional and morphologic evaluation.
Francis, I. R., Smid, A., Gross, M. D., et al. (1988) · Radiology · doi:10.1148/radiology.166.2.3336710 · Cited by 101 · see citing works
Adrenal adenoma and hypertension
Kokko, J. P., Brown, T., & Berman, M. (1967) · The Lancet · doi:10.1016/s0140-6736(67)91092-6 · Cited by 101 · see citing works
Gajraj, H., & Young, A. E. (1993) · British journal of surgery · doi:10.1002/bjs.1800800405 · Cited by 100 · see citing works
Torlontano, M., Chiodini, I., Pileri, M., Guglielmi, G., Cammisa, M., Modoni, S., Carnevale, V., Trischitta, V., & Scillitani, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5856 · Cited by 91 · see citing works
KOROBKIN, M. T., Francis, I. R., Kloos, R. T., et al. (1996) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(22)00684-4 · Cited by 88 · see citing works
Osella, G., Terzolo, M., Reimondo, G., Piovesan, A., Pia, A., Termine, A., Paccotti, P., & Angeli, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4282 · Cited by 87 · see citing works
Can Adrenal Incidentalomas Be Safely Observed?
Barry, M. K., van Heerden, J. A., Farley, D. R., Grant, C. S., Thompson, G. B., & Ilstrup, D. M. (1998) · World Journal of Surgery · doi:10.1007/s002689900441 · Cited by 87 · see citing works
Ravichandran, R., Lafferty, F. W., McGinniss, M. J., & Taylor, H. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626833 · Cited by 83 · see citing works
Narrow gauge needle aspiration of solid adrenal masses
Heaston, D., Handel, D., Pr, A., et al. (1982) · American Journal of Roentgenology · doi:10.2214/ajr.138.6.1143 · Cited by 83 · see citing works
Selection of Patients with Adrenal Incidentalomas for Operation
Staren, E. D., & Prinz, R. A. (1995) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)46636-3 · Cited by 81 · see citing works
State-of-the-art MR imaging of the adrenal gland.
Lee, M. J., Mayo-Smith, W. W., Hahn, P. F., et al. (1994) · Radiographics · doi:10.1148/radiographics.14.5.7991811 · Cited by 78 · see citing works
Incidentalomas of the adrenal gland: 36 Operated patients and review of literature
Sirén, J. E., Haapiainen, R. K., Huikuri, K., & Sivula, A. H. (1993) · World Journal of Surgery · doi:10.1007/bf01659129 · Cited by 76 · see citing works
Tsagarakis, S., Roboti, C., Kokkoris, P., Vasiliou, V., Alevizaki, C., & Thalassinos, N. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00509.x · Cited by 75 · see citing works
Flecchla, D., Mazza, E., Carllni, M., Blatto, A., Ollvlerl, F., Serra:, G., Camannl, F., & Messlna, M. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01852.x · Cited by 75 · see citing works
Russell, R. P., Masi, A. T., & Richter, E. D. (1972) · PubMed · Cited by 73 · see citing works
Adrenaloma: A Call for More Aggressive Management
Linos, D. A., Stylopoulos, N., & Raptis, S. (1996) · World Journal of Surgery · doi:10.1007/s002689900120 · Cited by 72 · see citing works
Kudva, Y. C., Young, W. F., Thompson, G. B., Grant, C. S., & van Heerden, J. A. (1999) · The Endocrinologist · doi:10.1097/00019616-199903000-00002 · Cited by 70 · see citing works
Self-citationCook, D. M., & Loriaux, D. L. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00082-4 · Cited by 69 · see citing works
RUSSELL, R. P., MASI, A. T., & RICHTER, E. D. (1972) · Medicine · doi:10.1097/00005792-197205000-00007 · Cited by 67 · see citing works
A-I-D-S: the new endocrine epidemic.
Griffing, G. T. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.6.7989451 · Cited by 65 · see citing works
Tsagarakis, S., Kokkoris, P., Roboti, C., Malagari, C., Kaskarelis, J., Vlassopoulou, V., Alevizaki, C. C., & Thalassinos, N. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00464.x · Cited by 63 · see citing works
Evaluation of hormonal function in a series of incidentally discovered adrenal masses.
Bondanelli, M., Campo, M., Trasforini, G., Ambrosio, M. R., Zatelli, M. C., Franceschetti, P., Valentini, A., Pansini, R., & Uberti, E. C. D. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90176-1 · Cited by 61 · see citing works
Virkkala, A., Välimäki, M. J., Pelkonen, R., Huikuri, K., Kahri, A. I., Kivisaari, L., Korhonen, T., Salmi, J., & Seppälä, P. (1989) · European Journal of Endocrinology · doi:10.1530/acta.0.1210067 · Cited by 58 · see citing works
Fine-needle aspiration biopsy of adrenal masses in patients with extraadrenal malignancy.
Candel, A. G., Gattuso, P., Reyes, C. V., Prinz, R. A., & Castelli, M. J. (1993) · PubMed · Cited by 57 · see citing works
Höfle, G., Gasser, R. W., Lhotta, K., Janetschek, G., Kreczy, A., & FINKENSTEDT, G. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023282 · Cited by 56 · see citing works
Adrenal "incidentalomas". Need for surgery.
Seddon, J. M., Baranetsky, N., & Boxel, P. V. (1985) · Urology · doi:10.1016/0090-4295(85)90552-7 · Cited by 52 · see citing works
Incidentalomas of the adrenal gland: diagnostic and therapeutic implications.
Bastounis, E., Karayiannakis, A. J., Anapliotou, M. L. G., Nakopoulou, L., Makri, G. G., & Papalambros, E. L. (1997) · PubMed · Cited by 52 · see citing works
Fine Needle Aspiration Cytology of Benign Adrenal Cortical Nodules
Wu, H. H., Cramer, H. M., Kho, J., et al. (1998) · Acta Cytologica · doi:10.1159/000332167 · Cited by 51 · see citing works
Bencsik, Z., Szabolcs, I., Kovács, Z., Ferencz, A., Vörös, A., Kaszás, I., Bor, K., Gönczi, J., Góth, M., Kovács, L., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626824 · Cited by 49 · see citing works
Percutaneous biopsy of left adrenal masses: prevalence of pancreatitis after anterior approach.
Kane, N. M., KOROBKIN, M. T., Francis, I. R., Quint, L. E., & Cascade, P. N. (1991) · American Journal of Roentgenology · doi:10.2214/ajr.157.4.1892034 · Cited by 48 · see citing works
Diagnostic evaluation of the adrenal incidentaloma: decision and cost-effectiveness analyses.
Dwamena, B. A., Kloos, R. T., Fendrick, A. M., et al. (1998) · PubMed · Cited by 43 · see citing works
Asymptomatic Adrenal Tumor; 386 Cases in Japan Including Our 7 Cases.
Yamakita, N., Saitoh, M., MERCADO-ASIS, L. B., Kitada, M., Morita, H., Yasuda, K., & Miura, K. (1990) · Endocrinologia Japonica · doi:10.1507/endocrj1954.37.671 · Cited by 42 · see citing works
DISEASES OF THE ADRENAL GLANDS
Kepler, E. J. (1941) · Archives of Internal Medicine · doi:10.1001/archinte.1941.00200110162009 · Cited by 42 · see citing works
Incidentally discovered adrenal masses
Kloos, R. T., KOROBKIN, M. T., Thompson, N. W., Francis, I. R., Shapiro, B., & Gross, M. D. (1997) · Cancer treatment and research · doi:10.1007/978-1-4615-6355-6_13 · Cited by 41 · see citing works
Common problems in endocrine surgery
Heerden, V., & Jonathan, A. (1989) · Year Book Medical Publishers · Cited by 40 · see citing works
Delayed Complications from Fine-Needle Biopsies of Solid Masses of the Abdomen
Yankaskas, B. C., Staab, E. V., CRAVEN, M. B., et al. (1986) · Investigative Radiology · doi:10.1097/00004424-198604000-00006 · Cited by 40 · see citing works
Iodocholesterol Adrenal Tissue Uptake and Imaging in Adrenal Neoplasms*
SCHTEINGART, D. E., Seabold, J. E., Gross, M. D., & Swanson, D. P. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-6-1156 · Cited by 39 · see citing works
Incidentally discovered adrenal masses
Bitter, D. A., & Ross, D. S. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90367-x · Cited by 37 · see citing works
Percutaneous biopsy of adrenal tumors
Zornoza, J., Ordóǹez, N. G., Bernardino, M. E., et al. (1981) · Urology · doi:10.1016/0090-4295(81)90407-6 · Cited by 36 · see citing works
In vitro adrenal cortex lesions characterization by NMR spectroscopy
Leroy‐Willig, A., Roucayrol, J. C., LUTON, J. P., et al. (1987) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(87)90123-8 · Cited by 35 · see citing works
Management of incidentally discovered adrenal masses
Murai, M., Baba, S., Nakashima, J., & Tachibana, M. (1999) · World Journal of Urology · doi:10.1007/s003450050098 · Cited by 34 · see citing works
Phaeochromocytoma: how to catch a moonbeam in your hand
Young, W. F. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360028 · Cited by 34 · see citing works
Self-citationA-I-D-S: the new endocrine epidemic
Griffing, G. T. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.6.1530 · Cited by 34 · see citing works
BENCSIK, Z., Szabolcs, I., Góth, M., VÖRÖS, A., Kaszás, I., Gönczi, J., Kovács, L., Dohán, O., & Szilägyi, G. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00889.x · Cited by 33 · see citing works
Experience gained from operation of 103 adrenal incidentalomas
Proye, C. A. G., Manjili, M. J., Combemale, F., Pattou, F. N., Ernst, O., Carnaille, B. M. L., & Wémeau, J.-L. (1998) · Langenbeck s Archives of Surgery · doi:10.1007/s004230050142 · Cited by 32 · see citing works
Investigation protocol: adrenal enlargement
Mantero, F., & Arnaldi, G. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00642.x · Cited by 30 · see citing works
The incidental nonhyperfunctioning adrenal mass: an imaging algorithm for characterization
Pender, S. M., Boland, G. W., & Lee, M. J. (1998) · Clinical Radiology · doi:10.1016/s0009-9260(98)80189-x · Cited by 30 · see citing works
Fallo, F. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00506-7 · Cited by 30 · see citing works
Lightner, E. S. (1993) · American journal of diseases of children · doi:10.1001/archpedi.1993.02160360016002 · Cited by 29 · see citing works
Cook, D. M. (1997) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70284-x · Cited by 28 · see citing works
Adrenal Insufficiency as a Manifestation of Disseminated Non-Hodgkin's Lymphoma
Levy, N. T., Young, W. F., Habermann, T. M., et al. (1997) · Mayo Clinic Proceedings · doi:10.4065/72.9.818 · Cited by 27 · see citing works
Self-citationNo overrepresentation of congenital adrenal hyperplasia in patients with adrenocortical tumours
Kjellman, M., Holst, M., Bäckdahl, M., Larsson, C., Farnebo, L., & Wedell, A. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00655.x · Cited by 26 · see citing works
Diagnostic puzzle of the adrenal "incidentaloma"
Oelkers, W. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1320419 · Cited by 25 · see citing works
Dévényi, I. (1967) · Journal of Clinical Pathology · doi:10.1136/jcp.20.1.49 · Cited by 25 · see citing works
Clinical experience with incidentally discovered pheochromocytoma.
Miyajima, A., Nakashima, J., Baba, S., et al. (1997) · PubMed · Cited by 23 · see citing works
Clinical Experience With Incidentally Discovered Pheochromocytoma
Miyajima, A., Nakashima, J., Baba, S., et al. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64794-3 · Cited by 22 · see citing works
Classification of silent adrenal masses: time to get practical.
Falke, T. H. M., & Sandler, M. P. (1994) · PubMed · Cited by 21 · see citing works
Adrenal incidentalomas and glucocorticoid autonomy
Aron, D. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00522.x · Cited by 20 · see citing works
SURGERY FOR ADRENAL TUMOURS: IS OPERATION FOR THE SMALL INCIDENTAL TUMOUR APPROPRIATE?
Wood, D. E., Delbridge, L., & Reeve, T. S. (1987) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1987.tb01253.x · Cited by 19 · see citing works
Adrenal incidentaloma: subclinical Cushing’s syndrome
Newell-Price, J. D. C., & Grossman, A. B. (1996) · Postgraduate Medical Journal · doi:10.1136/pgmj.72.846.207 · Cited by 18 · see citing works
From needles to numbers: can noninvasive imaging distinguish benign and malignant adrenal lesions?
Choyke, P. L. (1998) · World Journal of Urology · doi:10.1007/s003450050022 · Cited by 16 · see citing works
Satoh, F., Murakami, O., Takahashi, K., et al. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.1130930.x · Cited by 15 · see citing works
SOLITARY ADRENAL CORTICAL ADENOMA IN ELDERLY FEMALE; FREQUENCY.
Dm, S., & Weinsaft, P. P. (1964) · PubMed · Cited by 15 · see citing works
Utility of plasma dehydroepiandrosterone sulphate determination in adrenal incidentalomas
Bernini, G. P., Argenio, G. F., Vivaldi, M. S., Moretti, A., Miccoli, P., Iacconi, P., Magagna, A., & Salvetti, A. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350772 · Cited by 14 · see citing works
Adrenal abscess as a complication of adrenal fine-needle biopsy
Masmiquel, L., Hernández-Pascual, C., Simó, R., & Mesa, J. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90269-u · Cited by 13 · see citing works
Current concepts in imaging of adrenal masses
Teeger, S., Papanicolaou, N., & Vaughan, E. D. (1999) · World Journal of Urology · doi:10.1007/s003450050097 · Cited by 12 · see citing works
Evaluation and Management of the Incidentally Discovered Adrenal Mass
Nadler, J. L., & Radin, R. (1991) · The Endocrinologist · doi:10.1097/00019616-199102000-00003 · Cited by 9 · see citing works
Preclinical Cushing's syndrome in patients with an adrenal incidentaloma
Tjan‐Heijnen, V. C. G. (1998) · The Netherlands Journal of Medicine · doi:10.1016/s0300-2977(97)00091-0 · Cited by 9 · see citing works
Steroid secretions in patients with adrenal incidentalomas.
Reincke, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855843 · Cited by 7 · see citing works
Laparoscopic adrenalectomy: an endocrinologist’s perspective
Young, W. F. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199906000-00005 · Cited by 7 · see citing works
Self-citation[Therapeutic procedure in "incidentaloma" of the adrenal glands].
Waldner, H., Wilker, D. K., & Eibl-Eibesfeldt, B. (1986) · PubMed · Cited by 6 · see citing works
[Incidental discovery of adrenal neoplasms: our experience].
Bellantone, R. D. A., Ferrante, A. M. R., Raffaelli, M., et al. (1996) · PubMed · Cited by 5 · see citing works
Escherichia coli Abscess as an Adrenal Mass
Echániz, A., PRIETO, J. D. M., ARNAL, F., et al. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-3-481_2 · Cited by 5 · see citing works
[When should incidentalomas of the adrenal gland be surgically treated?].
Göhring, U.-J., Ziegler, R., & Buhr, H. J. (1990) · PubMed · Cited by 5 · see citing works
[Incidentalomas of the adrenal gland].
Licata, A., Puleo, S., Cataldo, A. D., et al. (1997) · PubMed · Cited by 5 · see citing works
Management of the incidentally discovered adrenal mass or "incidentaloma".
Bd, L., & Douglass, H. O. (1997) · PubMed · Cited by 4 · see citing works
Surgery of the incidentally discovered mass of the adrenal gland (incidentaloma).
Cm, F., Gentilli, S., Quiriconi, F., Ferrero, A., & Masenti, E. (1995) · PubMed · Cited by 2 · see citing works
Miyajima, A., Nakashima, J., Baba, S., et al. (1997) · The Journal of Urology · doi:10.1097/00005392-199705000-00007 · Cited by 1 · see citing works
Steroid secretions in patients with adrenal incidentalomas
Reincke, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.10.3811 · Cited by 1 · see citing works
Wooten (1993) · doi:10.1002/1097-0142(19931201)72:11
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Fassnacht, M., Arlt, W., Bancos, I., Dralle, H., Newell-Price, J., Sahdev, A., Tabarin, A., Terzolo, M., Tsagarakis, S., & Dekkers, O. M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0467 · Cited by 1,566 · see citing works
The clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781 · see citing works
Prevalence of adrenal incidentaloma in a contemporary computerized tomography series
Bovio, S., Cataldi, A., Reimondo, G., Sperone, P., Novello, S., Berruti, A., Borasio, P., Fava, C., Dogliotti, L., Scagliotti, G. V., et al. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344099 · Cited by 712 · see citing works
Sawka, A. M., Jaeschke, R., Singh, R. J., & Young, W. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021251 · Cited by 503 · see citing works
Self-citationZeiger, M. A., Thompson, G. B., Duh, Q.-Y., Hamrahian, A. H., Angelos, P., Elaraj, D., Fishman, E., Kharlip, J., Zeiger, M. A., Thompson, G. B., et al. (2009) · Endocrine Practice · doi:10.4158/ep.15.s1.1 · Cited by 499 · see citing works
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“Interestingly, in patients with bilateral disease, it is possible for 1 mass to be a nonfunctioning cortical adenoma while the other mass may be hormone secreting (316).”
BackgroundAdrenal incidentaloma: a new cause of the metabolic syndrome?
Terzolo, M., Pia, A., Alì, A., Osella, G., Reimondo, G., Bovio, S., Daffara, F., Procopio, M., Paccotti, P., Borretta, G., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8277 · Cited by 322 · see citing works
Cawood, T. J., Hunt, P. J., O'Shea, D., Cole, D., & Soule, S. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0234 · Cited by 300 · see citing works
Approach to the patient with an adrenal incidentaloma
Nieman, L. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0457 · Cited by 290 · see citing works
Diagnosis and Treatment of Subclinical Hypercortisolism
Chiodini, I. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2722 · Cited by 279 · see citing works
Long-term follow-up study of patients with adrenal incidentalomas.
Libe, R., Dall'Asta, C., Barbetta, L., Baccarelli, A., Beck-Peccoz, P., & Ambrosi, B. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470489 · Cited by 215 · see citing works
Sturgeon, C., Shen, W. T., Clark, O. H., Duh, Q.-Y., & Kebebew, E. (2006) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.11.005 · Cited by 194 · see citing works
Subclinical Cushing’s syndrome in adrenal incidentalomas
Terzolo, M., Bovio, S., Reimondo, G., Pia, A., Osella, G., Borretta, G., & Angeli, A. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.008 · Cited by 179 · see citing works
Update on CT and MRI of adrenal nodules
Schieda, N., & Siegelman, E. S. (2017) · American Journal of Roentgenology · doi:10.2214/ajr.16.17758 · Cited by 173 · see citing works
EMRAL, R., UYSAL, A. R., ASIK, M., GULLU, S., CORAPCIOGLU, D., TONYUKUK, V., & ERDOGAN, G. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.399 · Cited by 104 · see citing works
Bourdeau, I., El Ghorayeb, N., Gagnon, N., & Lacroix, A. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0296 · Cited by 98 · see citing works
Outcomes of adrenal cortical carcinoma in the United States
Paton, B. L., Novitsky, Y. W., Zerey, M., Harrell, A. G., Norton, H. J., Asbun, H., Kercher, K. W., & Heniford, B. T. (2006) · Surgery · doi:10.1016/j.surg.2006.07.035 · Cited by 97 · see citing works
[123I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes
Hahner, S., Stuermer, A., Kreissl, M., Reiners, C., Fassnacht, M., Haenscheid, H., Beuschlein, F., Zink, M., Lang, K., Allolio, B., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0050 · Cited by 95 · see citing works
Terzolo, M., Bovio, S., Pia, A., Conton, P. A., Reimondo, G., Dall’Asta, C., Bemporad, D., Angeli, A., Opocher, G., Mannelli, M., et al. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01959 · Cited by 89 · see citing works
Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas.
Valli, N., Catargi, B., Ronci, N., Vergnot, V, Leccia, F., Ferriere, J., Chene, G., Grenier, N., Laurent, F., & Tabarin, A. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440401 · Cited by 83 · see citing works
Subclinical Cushing's syndrome.
Terzolo, M., Reimondo, G., Bovio, S., & Angeli, A. (2004) · Pituitary · doi:10.1007/s11102-005-4024-6 · Cited by 80 · see citing works
Clinical characteristics for 348 patients with adrenal incidentaloma
Kim, J., Bae, K. H., Choi, Y. K., Jeong, J. Y., Park, K. G., Kim, J. G., & Lee, I. K. (2013) · Endocrinology and Metabolism · doi:10.3803/enm.2013.28.1.20 · Cited by 72 · see citing works
Ahn, S. H., Kim, J. H., Baek, S. H., Kim, H., Cho, Y. Y., Suh, S., Kim, B.-J., Hong, S., Koh, J.-M., Lee, S. H., et al. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.4.501 · Cited by 43 · see citing works
Adrenal incidentalomas: management in British district general hospitals
Davenport, E., Lang Ping Nam, P., Wilson, M., Reid, A., & Aspinall, S. (2014) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2013-132386 · Cited by 26 · see citing works
- Authors
- Young, W. F.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Young, William F.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 29
- Issue
- 1
- Pages
- 159-185
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W1983996547
- Cited by
- 415
- References
- 142
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 16 · 2017: 11 · 2016: 20 · 2015: 27 · 2014: 15 · 2013: 17 · 2012: 29
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenal incidentaloma, adrenal tumors, differential diagnosis, functional status assessment, malignant potential, diagnostic imaging, patient uncertainty, management methods
- MeSH terms
- Adenoma, Adrenal Cortex Neoplasms, Adrenalectomy, Biopsy, Needle, Diagnostic Imaging, Humans, Hyperaldosteronism, Iodine Radioisotopes, Pheochromocytoma
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