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Cited by 70Adrenal and Paraganglionic TumorsSarcoma Diagnosis and TreatmentNeuroendocrine Tumor Research Advances

Challenges in surgical pathology of adrenocortical tumours

Erickson, Lori A.·2018·Histopathology
DOI 10.1111/his.13255
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Abstract

Adrenocortical carcinomas are rare tumours that can be diagnostically challenging. Numerous multiparametric scoring systems and diagnostic algorithms have been proposed to differentiate adrenocortical adenoma from adrenocortical carcinoma. Adrenocortical neoplasms must also be differentiated from other primary adrenal tumours, such as phaeochromocytoma and unusual primary adrenal tumours, as well as metastases to the adrenal gland. Myxoid, oncocytic and sarcomatoid variants of adrenocortical tumours must be recognized so that they are not confused with other tumours. The diagnostic criteria for oncocytic adrenocortical carcinoma are different from those for conventional adrenocortical carcinomas. Adrenocortical neoplasms in children are particularly challenging to diagnose, as histological features of malignancy in adrenocortical neoplasms in adults may not be associated with aggressive disease in the tumours of children. Recent histological and immunohistochemical studies and more comprehensive and integrated genomic characterizations continue to advance our understanding of the tumorigenesis of these aggressive neoplasms, and may provide additional diagnostic and prognostic utility and guide the development of therapeutic targets.

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Crossref · 10.1111/his.13255

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  • Adrenocortical tumors are usually (but not always) positive for Cytokeratin CAM 5.2, α-inhibin and calretinin, and pheochromocytomas are negative for these markers.

    “Adrenocortical tumors are also usually (but not always) positive (and pheochromocytomas negative) for Cytokeratin CAM 5.2, α-inhibin and calretinin.”

    From Adrenal incidentaloma (2020) · cites this paper as [109]

  • S100 protein usually highlights sustentacular cells in pheochromocytomas and is negative in adrenocortical tumors.

    “S100 protein usually highlights sustentacular cells in pheochromocytomas and is negative in adrenocortical tumors.”

    From Adrenal incidentaloma (2020) · cites this paper as [109]

  • Both adrenocortical tumors and pheochromocytomas stain positive for synaptophysin, but adrenocortical tumors are negative for chromogranin.

    “Both adrenocortical tumors and pheochromocytomas stain positive for synaptophysin but adrenocortical tumors are negative for chromogranin (109).”

    From Adrenal incidentaloma (2020) · cites this paper as [109]

  • Steroidogenic factor 1 is increasingly recognized as a key marker of adrenocortical cell lesions.

    “Steroidogenic factor 1 is increasingly recognized as a key marker of adrenocortical cell lesions (109).”

    From Adrenal incidentaloma (2020) · cites this paper as [109]

  • Both adrenocortical cancers and melanomas stain positive for Melan A, but adrenocortical tumors are negative for S100 (a positive marker for melanoma).

    “Both adrenocortical cancers and melanomas stain positive for Melan A, but adrenocortical tumors are negative for S100 (a positive marker for melanoma).”

    From Adrenal incidentaloma (2020) · cites this paper as [109]

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Authors
Erickson, L. A.
Affiliations
Mayo Clinic (US)
Corresponding author
Erickson, Lori A.
ORCID
Erickson, Lori A.
Venue
Histopathology
Publisher
Wiley
Published
2017-12-14
Volume
72
Issue
1
Pages
82-96
ISSN
  • 0309-0167 (ISSN-L)
  • 1365-2559
DOI
10.1111/his.13255
OpenAlex
W2772562032
Cited by
70
References
132
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 19 · 2020: 13 · 2019: 7 · 2018: 4
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Histopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
adrenocortical tumors, adrenocortical carcinoma, adrenal adenoma, differential diagnosis, pheochromocytoma, adrenal metastasis, myxoid variant, oncocytic variant, sarcomatoid variant, immunohistochemistry, genomic profiling, carcinogenesis, prognostic factors
MeSH terms
Adrenal Cortex Neoplasms, Adult, Child, Diagnosis, Differential, Humans, Pathology, Surgical, Adrenocortical Adenoma, Adrenocortical Carcinoma

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