Selective Arterial Calcium Stimulation With Hepatic Venous Sampling Differentiates Insulinoma From Nesidioblastosis
Open accessAbstract
CONTEXT: In adult patients with endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging, insulinoma and non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS) resulting from diffuse nesidioblastosis must be considered in the differential diagnosis. It is not known whether the biochemical results of selective arterial calcium stimulation (SACST) with hepatic venous sampling can differentiate insulinoma from diffuse nesidioblastosis. OBJECTIVE: To determine the specificity of SACST with hepatic venous sampling in differentiating insulinoma from diffuse nesidioblastosis. DESIGN: Retrospective review (January 1996 to March 2014). SETTING: Tertiary referral center. PATIENTS OR OTHER PARTICIPANTS: A total of 116 patients with biochemical evidence of endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging who were subsequently shown at surgery to have insulinoma (n = 42) or nesidioblastosis (n = 74) after undergoing SACST with hepatic venous sampling. INTERVENTION(S): SACST with hepatic venous sampling before pancreatic exploration. MAIN OUTCOME MEASURE(S): Receiver operating characteristic curves were generated from the biochemical results of SACST to determine the specificity of the maximum hepatic venous insulin concentration (mHVI) and the relative-fold increase in hepatic venous insulin concentration (rHVI) over baseline after calcium injection from the dominant artery in differentiating insulinoma from nesidioblastosis. RESULTS: The mHVI (21.5-fold; P < .001) and rHVI (3.9-fold; P < .001) were significantly higher in the insulinoma group compared to the nesidioblastosis group. The areas under the receiver operating characteristic curve for mHVI and rHVI were excellent (0.94; P < .0001) and good (0.83; P < .0001), respectively, for differentiating insulinoma from nesidioblastosis. mHVI cutoffs of > 91.5 and > 263.5 μIU/mL were 95 and 100% specific for insulinoma, respectively. A 19-fold increase in rHVI over baseline was 99% specific for insulinoma. CONCLUSIONS: These data suggest that the mHVI and rHVI at SACST may be useful in differentiating insulinoma from nesidioblastosis with high specificity in patients with hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SACS was the gold standard in the past to detect an insulin gradient in the vessels supplying the pancreas, and this invasive method might be almost completely replaced by PET imaging in the future, e.g., with 68Ga DOTA-Exendin-4 PET/CT.
“While SACS was the gold standard in the past to detect an insulin gradient in the vessels supplying the pancreas, this invasive method might be almost completely replaced by PET imaging in the future, e.g., with 68 Ga DOTA-Exendin-4 PET/CT [38-41].”
From An Uncommon Cause of Recurrent Presyncope, Dizziness, and Tachycardia: A Case Report of Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS) (2023) · cites this paper as [38]
The Discussion describes SACST as an invasive technique that measures an insulin rise after stimulation of pancreatic arterial distributions and reports high sensitivity for localizing occult insulinoma. It does not call SACST a past gold standard or predict its near-complete replacement by PET. Instead, the Discussion says emerging imaging techniques show promising early results but cannot yet distinguish occult insulinoma from diffuse nesidioblastosis. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.08.010 · Cited by 51,384 · see citing works
The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification
Klöppel, G., Perren, A. A., & Heitz, P. U. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1294.002 · Cited by 804 · see citing works
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.
Service, G. J., Thompson, G. B., Service, F. J., Andrews, J. C., Collazo-Clavell, M. L., & Lloyd, R. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043690 · Cited by 779 · see citing works
Self-citationPlaczkowski, K. A., Vella, A., Thompson, G. B., Grant, C. S., Reading, C. C., Charboneau, J. W., Andrews, J. C., Lloyd, R. V., & Service, F. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2031 · Cited by 360 · see citing works
Self-citationInsulinomas: localization with selective intraarterial injection of calcium.
Doppman, J. L., Miller, D. L., Chang, R., Shawker, T. H., Gorden, P., & Norton, J. A. (1991) · Radiology · doi:10.1148/radiology.178.1.1984311 · Cited by 318 · see citing works
Grant, C. S. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.05.008 · Cited by 282 · see citing works
Self-citationLocalization of Insulinomas to Regions of the Pancreas by Intra-arterial Stimulation with Calcium
Doppman, J., Chang, R., Fraker, D., Norton, J., Alexander, H., Miller, D., Collier, E., Skarulis, M., & Gorden, P. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-4-199508150-00004 · Cited by 279 · see citing works
Meier, J. J., Butler, A. E., Galasso, R., & Butler, P. C. (2006) · Diabetes Care · doi:10.2337/dc06-0392 · Cited by 249 · see citing works
Kellogg, T., Bantle, J., Leslie, D., Redmond, J., Slusarek, B. M., Swan, T., Buchwald, H., & Ikramuddin, S. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.05.005 · Cited by 215 · see citing works
Vilarrasa, N., Goday, A., Rubio, M. A., Caixàs, A., Pellitero, S., Ciudin, A., Calañas, A., Botella, J. I., Bretón, I., Morales, M. J., et al. (2016) · Obesity Facts · doi:10.1159/000442764 · Cited by 197 · see citing works
Service, F. J., Natt, N., Thompson, G. B., Grant, C. S., van Heerden, J. A., Andrews, J. C., Lorenz, E., Terzic, A., & Lloyd, R. V. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5645 · Cited by 196 · see citing works
Self-citationChrist, E., Wild, D., Ederer, S., Béhé, M. P., Nicolas, G., Caplin, M. E., Brändle, M., Clerici, T., Fischli, S., Stettler, C., et al. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70049-4 · Cited by 185 · see citing works
Guettier, J., Kam, A. W., Chang, R., Skarulis, M. C., Cochran, C. S., Alexander, H. R., Libutti, S. K., Pingpank, J. F., & Görden, P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1986 · Cited by 176 · see citing works
Endoscopic ultrasound in the localisation of pancreatic islet cell tumours.
McLean, A. M., & Fairclough, P. D. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.11.012 · Cited by 163 · see citing works
Kauhanen, S. P., Seppänen, M., Minn, H. R. I., Gullichsen, R., Salonen, A., Alanen, K. A., Parkkola, R. K., Solin, O. H., Bergman, J. R., Sane, T., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1479 · Cited by 150 · see citing works
Endoscopic ultrasonography (EUS) in the localization of insulinoma
Sotoudehmanesh, R., Hedayat, A., Shirazian, N., Shahraeeni, S., Ainechi, S., Zeinali, F., & Kolahdoozan, S. (2007) · Endocrine · doi:10.1007/s12020-007-0045-4 · Cited by 148 · see citing works
Moreira, R. O., Moreira, R., Machado, N., Gonçalves, T. B., & Coutinho, W. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9569-9 · Cited by 136 · see citing works
Noninsulinoma pancreatogenous hypoglycemia syndrome: An update in 10 surgically treated patients
Thompson, G. B., Service, F. J., Andrews, J. C., Lloyd, R. V., Natt, N., van Heerden, J. A., & Grant, C. S. (2000) · Surgery · doi:10.1067/msy.2000.110243 · Cited by 121 · see citing works
Self-citationBlind Distal Pancreatectomy for Occult Insulinoma, an Inadvisable Procedure1
Hirshberg, B., Libutti, S. K., Alexander, R. H., Bartlett, D. L., Cochran, C. S., Livi, A., Chang, R., Shawker, T. H., Skarulis, M. C., & Görden, P. (2002) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(02)01177-8 · Cited by 115 · see citing works
Sowa-Staszczak, A., Pach, D., Mikołajczak, R., Mäcke, H., Jabrocka-Hybel, A., Stefańska, A., Tomaszuk, M., Janota, B., Gilis-Januszewska, A., Małecki, M., et al. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2299-1 · Cited by 110 · see citing works
Advances in the diagnosis and management of hyperinsulinemic hypoglycemia
Kapoor, R. R., James, C. T., & Hussain, K. (2009) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1046 · Cited by 104 · see citing works
Won, J. G., Tseng, H.-S., Yang, A.-H., Tang, K.-T., Jap, T., Lee, C.-H., Lin, H.-D., Burcus, N. I., Pittenger, G., & Vinik, A. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02629.x · Cited by 95 · see citing works
Wiesli, P., Brändle, M., Schmid, C., Krähenbühl, L., Furrer, J., Keller, U., Spinas, G. A., & Pfammatter, T. (2004) · Journal of Vascular and Interventional Radiology · doi:10.1097/01.rvi.0000140638.55375.1e · Cited by 93 · see citing works
Rabiee, A., Magruder, J., Salas-Carrillo, R., Carlson, O., Egan, J. M., Askin, F., Elahi, D., & Andersen, D. K. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.09.047 · Cited by 85 · see citing works
Rumilla, K. M., Erickson, L. A., Service, F. J., Vella, A., Thompson, G. B., Grant, C. S., & Lloyd, R. V. (2009) · Modern Pathology · doi:10.1038/modpathol.2008.169 · Cited by 85 · cited 2× · see citing works
“As such, postprandial hyperinsulinemic hypoglycemia is likely the result of diverse pathophysiologic mechanisms (20, 36).”
BackgroundMethodSelf-citationTessonnier, L., Sebag, F. A., Ghander, C., Micco, C. D., Reynaud, R., Palazzo, F. F., Conte‐Devolx, B., Henry, J. F., MUNDLER, O., & Taïeb, D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1357 · Cited by 85 · see citing works
Successful Medical Management of Status Post-Roux-en-Y-Gastric-Bypass Hyperinsulinemic Hypoglycemia
Spanakis, E., & Gragnoli, C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9888-5 · Cited by 83 · see citing works
Postprandial hyperinsulinemic hypoglycemia after gastric bypass surgical treatment
Mala, T. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.01.010 · Cited by 75 · see citing works
Vanderveen, K. A., Grant, C. S., Thompson, G. B., Farley, D. R., Richards, M. L., Vella, A., Vollrath, B., & Service, F. J. (2010) · Surgery · doi:10.1016/j.surg.2010.09.027 · Cited by 67 · cited 3× · see citing works
“The approach to management of endogenous hyperinsulinemic hypoglycemia at our institution has been described previously (1, 7, 8, 15).”
BackgroundMethodSelf-citationReubi, J. C., Perren, A. A., Rehmann, R., Waser, B., Christ, E., Callery, M. P., Goldfine, A. B., & Patti, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1901-y · Cited by 64 · see citing works
Nesidioblastosis in adults: a challenging cause of organic hyperinsulinism.
Kaczirek, K., Soleiman, A., Schindl, M., Passler, C., Scheuba, C., Prager, G., Kaserer, K., & Niederle, B. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01158.x · Cited by 57 · see citing works
What should be done in an operating room when an insulinoma cannot be found?
Rostambeigi, N., & Thompson, G. B. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03527.x · Cited by 53 · see citing works
Self-citationEndoscopic Ultrasound Imaging of Insulinomas: Limitations and Clinical Relevance
Kann, P. H., Rothmund, Μ., & Zielke, A. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-865752 · Cited by 51 · see citing works
Dravecká, I., & Lazúrová, I. (2014) · Neoplasma · doi:10.4149/neo_2014_047 · Cited by 45 · see citing works
Clinical PET Imaging of Insulinoma and Beta-Cell Hyperplasia
Kauhanen, S. P., Seppänen, M., Minn, H. R. I., & Nuutila, P. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791164090 · Cited by 44 · see citing works
Morganstein, D. L., Lewis, D. H., Jackson, J. E., Isla, A., Lynn, J., Devendra, D., Meeran, K. M., & Todd, J. F. (2009) · European Radiology · doi:10.1007/s00330-009-1444-0 · Cited by 37 · see citing works
Approach to the Patient with Postprandial Hypoglycemia
Galati, S.-J., & Rayfield, E. J. (2013) · Endocrine Practice · doi:10.4158/ep13132.ra · Cited by 31 · see citing works
Thompson, S. M., Vella, A. V., Service, F. J., Grant, C. S., Thompson, G. B., & Andrews, J. C. (2015) · Surgery · doi:10.1016/j.surg.2015.03.004 · Cited by 27 · see citing works
Self-citationKenney, B. C., Tormey, C. A., Qin, L., Sosa, J. A., Jain, D., & Neto, A. P. (2008) · PubMed · Cited by 24 · see citing works
Response of Human Insulinoma Cells to Extracellular Calcium Is Different from Normal B Cells
Kato, M., Doi, R., Imamura, M., Okada, N., Shimada, Y., Hosotani, R., & Miyazaki, J. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1026626014100 · Cited by 18 · see citing works
Catton, J. A., Zaitoun, A. M., Aithal, G. P., Sturrock, N. D. C., & Lobo, D. N. (2008) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2008.02.071 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [5]5. Grant CS. Insulinoma. Best Pract Res Clin Gastroenterol. 2005;19(5):783–798. [DOI] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Imaging of pancreatic neuroendocrine tumors: recent advances, current status, and controversies
Lee, L., Ito, T., & Jensen, R. T. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1496822 · Cited by 102 · see citing works
Innovative imaging of insulinoma: the end of sampling? A review
Christ, E., Antwi, K., Fani, M., & Wild, D. (2020) · Endocrine-Related Cancer · doi:10.1530/erc-19-0476 · Cited by 78 · see citing works
Molecular imaging in the investigation of hypoglycaemic syndromes and their management
Pattison, D. A., & Hicks, R. J. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0005 · Cited by 50 · see citing works
Spontaneous hypoglycemia: diagnostic evaluation and management
Kandaswamy, L., Raghavan, R., & Pappachan, J. M. (2016) · Endocrine · doi:10.1007/s12020-016-0902-0 · Cited by 38 · see citing works
Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)
Effraimidis, G., Knigge, U., Rossing, M., Oturai, P., Rasmussen, Å. K., & Feldt‐Rasmussen, U. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.011 · Cited by 37 · see citing works
Approach to the Patient with Postprandial Hypoglycemia
Galati, S.-J., & Rayfield, E. J. (2013) · Endocrine Practice · doi:10.4158/ep13132.ra · Cited by 31 · see citing works
Clinical Presentation and Diagnostic Approach to Hypoglycemia in Adults Without Diabetes Mellitus
Palani, G., Stortz, E., & Moheet, A. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2022.11.010 · Cited by 29 · see citing works
BENIGN TUMORS AND TUMOR-LIKE LESIONS OF THE PANCREAS
Basturk, O., & Askan, G. (2016) · Surgical Pathology Clinics · doi:10.1016/j.path.2016.05.007 · Cited by 21 · see citing works
Capodanno, Y., Altieri, B., Elders, R., Colao, A., Faggiano, A., & Schrader, J. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101269 · Cited by 26 · see citing works
Successful Medical Treatment of Adult Nesidioblastosis With Pasireotide over 3 Years: A Case Report
Schwetz, V., Horvath, K., Kump, P., Lackner, C., Perren, A., Forrer, F., Pieber, T. R., Treiber, G., Sourij, H., & Mader, J. K. (2016) · Medicine · doi:10.1097/md.0000000000003272 · Cited by 25 · see citing works
Zhao, K., Patel, N., Kulkarni, K., Gross, J., & Taslakian, B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103091 · Cited by 22 · see citing works
Laparoscopic surgery for pancreatic insulinomas: an update
Aggeli, C., Nixon, A. M., Karoumpalis, I., Kaltsas, G., & Zografos, G. N. (2016) · HORMONES · doi:10.14310/horm.2002.1670 · Cited by 22 · see citing works
Hypoglycemia after gastric bypass: An emerging complication
Millstein, R., & Lawler, H. M. (2017) · Cleveland Clinic journal of medicine · doi:10.3949/ccjm.84a.16064 · Cited by 19 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061732 · Cited by 19 · see citing works
Fottner, C., Sollfrank, S., Ghiasi, M., Adenaeuer, A., Musholt, T., Schad, A., Miederer, M., Schadmand-Fischer, S., Weber, M. M., Lackner, K., et al. (2022) · Cancers · doi:10.3390/cancers14071798 · Cited by 15 · see citing works
Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
Wang, H., Ba, Y., Xing, Q., & Cai, R.-C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224928 · Cited by 18 · see citing works
Case 23-2018: a 36-year-old man with episodes of confusion and hypoglycemia
Wexler, D. J., Macias-Konstantopoulos, W., Forcione, D. G., Xiong, L., Cauley, C. E., & Pierce, K. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmcpc1802828 · Cited by 16 · see citing works
Schovanek, J., Cibickova, L., Ctvrtlik, F., Tudos, Z., Karasek, D., Iacobone, M., & Frysak, Z. (2019) · Journal of Cancer · doi:10.7150/jca.30472 · Cited by 16 · see citing works
Nesidioblastosis and Insulinoma: A Rare Coexistence and a Therapeutic Challenge
Dardano, A., Daniele, G., Lupi, R., Napoli, N., Campani, D., Boggi, U., Del Prato, S., & Miccoli, R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00010 · Cited by 14 · see citing works
Pediatric Pancreatic Tumors: A Review of Current Concepts
Hsieh, L. B., & Burjonrappa, S. C. (2016) · JOP, journal of the pancreas · Cited by 11 · see citing works
Insulinoma or non-insulinoma pancreatogenous hypoglycemia? A diagnostic dilemma
Anderson, B. L., Nostedt, J. J., Girgis, S., Dixon, T., Agrawal, V., Wiebe, E., Senior, P. A., & Shapiro, A. M. J. (2016) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjw188 · Cited by 11 · see citing works
Lopes, A. A., Miranda, A. C. G., Maior, M. D. R. M. S., de Mello, R. V., & Bandeira, F. A. F. (2020) · American Journal of Case Reports · doi:10.12659/ajcr.922778 · Cited by 11 · see citing works
Kato, R., Nishimura, A., Matsumura, K., Kikuno, S., Nagasawa, K., & Mori, Y. (2020) · Clinical Case Reports · doi:10.1002/ccr3.3514 · Cited by 9 · see citing works
Demartin, S., Goffette, P., Christ, E., Freitag, M. T., Maiter, D., & Maria Furnica, R. (2022) · Endocrinology, Diabetes & Metabolism Case Reports · doi:10.1530/edm-22-0325 · Cited by 9 · see citing works
Hyperinsulinaemic, hypoglycaemic syndrome due to acquired nesidioblastosis in a cat
Hambrook, L. E., Ciavarella, A., Nimmo, J. S., & Wayne, J. (2016) · Journal of Feline Medicine and Surgery Open Reports · doi:10.1177/2055116916657846 · Cited by 9 · see citing works
Diagnostics and Imaging for Pancreatic Neuroendocrine Tumors
Tobias, J. D., & Keutgen, X. M. (2024) · Surgical Clinics of North America · doi:10.1016/j.suc.2024.02.015 · Cited by 6 · see citing works
Murakami, T., Yoshida, H., Sakaki, K., Otani, D., Miyake, K. K., Shimizu, Y., Fujimoto, H., Yabe, D., Nakamoto, Y., & Inagaki, N. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf253 · Cited by 6 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061741 · Cited by 5 · see citing works
Chen, X., Kamel, D., Barnett, B., Yung, E., Quinn, A., & Nguyen, C. (2018) · Endocrinology, Diabetes & Metabolism Case Reports · doi:10.1530/edm-18-0089 · Cited by 6 · see citing works
Adult Nesidioblastosis in Chronic Kidney Disease
Lozano-Melendez, E., Aguilar-Soto, M., Graniel-Palafox, L.-E., Ceceña-Martínez, L. E., Valdez-Ortiz, R., & Solis‐Jiménez, F. (2019) · Case Reports in Endocrinology · doi:10.1155/2019/7640384 · Cited by 5 · see citing works
Case report: Insulinomatosis: description of four sporadic cases and review of the literature
Lourenço, D., Côrrea-Giannella, M. L., Siqueira, S. A. C., Nery, M., Ribeiro, F. G., Quedas, E. P. D. S., Rocha, M. D. S., Nascimento, R. M. D., & Pereira, M. A. A. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1308662 · Cited by 4 · see citing works
Halmi, S., Berta, E., Diószegi, Á., Sira, L., Fülöp, P., Nagy, E. V., Győry, F., Kanyári, Z., Tóth, J., Bhattoa, H. P., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1305958 · Cited by 4 · see citing works
Review of Hematology-Oncology Emergencies for Internal Medicine Residents
Baralo, B., Ramesh, N. P., Deshpande, S., Buragamadagu, B. C., Khanam, A., Paravathaneni, M., Mulla, S., Bedi, V., Thota, V., Baralo, R., et al. (2023) · Cureus · doi:10.7759/cureus.33563 · Cited by 3 · see citing works
Selective Arterial Calcium Stimulation With Hepatic Venous Sampling in Immune-Mediated Hypoglycemia
Thompson, S. M., Vella, A. V., Service, F. J., & Andrews, J. C. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00146 · Cited by 3 · see citing works
Self-citationSzczepanski, J. M., Hissong, E. M., & Manthei, D. M. (2021) · Laboratory Medicine · doi:10.1093/labmed/lmab071 · Cited by 3 · see citing works
Functional Localization of Adult-Onset Idiopathic Nesidioblastosis
Hercus, J. C., Pasha, P., Lawati, S. A., Kim, P., Mattman, A., Webber, D. L., & Thompson, D. M. (2022) · Case Reports in Endocrinology · doi:10.1155/2022/2802975 · Cited by 3 · see citing works
A case report on a protracted course of a hidden insulinoma
Shah, F. Z. M., Mohamad, A. F., Zainordin, N. A., Warman, N. ‘. E., Hatta, S. F. W. M., & Ghani, R. A. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102240 · Cited by 2 · see citing works
Hypoglycemic disorders in adults
Dhanasekaran, M., & Vella, A. V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91707-0.00004-8 · Cited by 2 · see citing works
Self-citationNesidioblastosis in Patients With Severe Postbariatric Hypoglycemia: A Monocentric Case Series
Dawes, D., Trivedi, P., & Lawler, H. M. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf125 · Cited by 1 · see citing works
Thompson, S. M., Vella, A. V., Service, F. J., Thompson, G. B., & Andrews, J. C. (2017) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2017.06.039 · Cited by 2 · see citing works
Self-citationNesidioblastosis focal y difusa que simula un insulinoma
Ramos, B. G., Hernández, M. V. Á., & González-Murillo, E. A. (2024) · Medicina Clínica · doi:10.1016/j.medcli.2023.11.034 · Cited by 1 · see citing works
Successful Superficial Blood Sampling to Localize a Fibroblast Growth Factor-23-Producing Tumor
Rikitake, J., Ashida, K., Nagayama, A., Inoguchi, Y., Hasuzawa, N., Koganemaru, M., Hamada, T., Moritaka, K., Demiya, M., Sako, T., et al. (2024) · American Journal of Case Reports · doi:10.12659/ajcr.943152 · Cited by 1 · see citing works
Medically Refractory Nesidioblastosis as a Late Adverse Effect of Roux-en-Y Gastric Bypass
Ladna, M. (2025) · Cureus · doi:10.7759/cureus.84429 · Cited by 1 · see citing works
Henquin, J., Pattou, F. N., & Nenquin, M. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2017.07.008 · Cited by 1 · see citing works
Endocrine and Metabolic Complications After Bariatric Surgery
González-Campoy, J. M., Proebstle, C. B., Pierson, A., Knaebe, B., & Richardson, B. W. (2021) · Springer eBooks · doi:10.1007/978-981-33-4702-1_11 · Cited by 1 · see citing works
Schäffler, A., Bollheimer, C., Büttner, R., Girlich, C., Aslanidis, C., Dietmaier, W., Bala, M., Guralnik, V., Karrasch, T., & Schneider, S. (2018) · Springer eBooks · doi:10.1007/978-3-662-55914-7_7 · Cited by 1 · see citing works
Gomes, V., & Ferreira, F. (2019) · Journal of Endocrinology and Metabolism · doi:10.14740/jem617 · Cited by 1 · see citing works
Gupta, S., Goyal, A., Kandasamy, D., Agarwal, S., Damle, N., Pal, S., Tandon, N., & Jyotsna, V. (2024) · Indian journal of endocrinology and metabolism · doi:10.4103/ijem.ijem_87_24 · Cited by 1 · see citing works
Endurtekin krampaköst hjá ungri konu – sjúkratilfelli
Gunnarsdóttir, G., Guðmundsdóttir, A., Hellman, P., & Stålberg, P. (2016) · Læknablaðið · doi:10.17992/lbl.2016.0708.92
Long-term Outcomes of Surgical Management of Insulinoma: Single Center Experience
Ülkü, A., Yalav, O., Sarıtaş, A. G., Rencüzoğulları, A., Dalcı, K., Eray, İ. C., Yağmur, Ö., & Akçam, A. T. (2018) · Dicle Medical Journal / Dicle Tip Dergisi · doi:10.5798/dicletip.424975 · Cited by 1 · see citing works
Insulinoma Case Admitted with Reactive Hypoglycemia Symptoms.
Koca, N., Cander, S., Gul, O. O., & Uğraş, N. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666190712200716 · Cited by 1 · see citing works
Hypoglycemia in the Non-diabetic Patient
Hurtado, M. D., & Vella, A. V. (2022) · Springer eBooks · doi:10.1007/978-3-030-90684-9_34 · Cited by 1 · see citing works
Self-citationPOST–GASTRIC BYPASS HYPOGLYCEMIA IN A PATIENT WITH END-STAGE RENAL DISEASE
Gutman, D. S., & Eisenberg, Y. (2017) · AACE Clinical Case Reports · doi:10.4158/ep161467.cr
Tumor Detection in Syndromic NET: Hypoglycemic Hyperinsulinemic Syndrome
Cosaro, E., & Davì, M. V. (2017) · Springer eBooks · doi:10.1007/978-3-319-59024-0_12
Adult Nesidioblastosis With Hypoglycemia Mimicking an Insulinoma: A Challenging Case
Yürekli, B. Ş., Kutbay, N. Ö., Altun, İ., Çetinkalp, Ş., Nart, D., Çöker, A., & Özgen, G. (2017) · International Surgery · doi:10.9738/intsurg-d-17-00020.1
Case Report on Diagnostic and Treatment of Insulinoma
Моругова, Т. В., Ibragimova, O. Y., Artamonova, I. V., & Avzaletdinova, D. S. (2018) · Medicina · doi:10.29234/2308-9113-2018-6-4-28-38
UN INSOLITO CASO DI IPOGLICEMIA IPERINSULINEMICA DA NESIDIOBLASTOSI E INSULINOMA
Dardano, A., Barone, S., Daniele, G., Kurumthodathu, J. J., Prato, S. D., & Miccoli, R. (2018) · il Diabete · doi:10.30682/ildia1804h
Nesidioblastosis en una escolar, a propósito de un caso
Almánzar, R., Rosario, A., Díaz, Z., Figueroa, J., & Segura, M. (2018) · Ciencia y Salud · doi:10.22206/cysa.2018.v2i3.pp63-68
Congenital Hyperinsulinism of Infancy
Pierro, A., Zani, A., & Spitz, L. (2019) · Springer surgery atlas series · doi:10.1007/978-3-662-56282-6_44
(2020) · International Journal of Case Reports · doi:10.28933/ijcr-2020-10-0506
Arterial Stimulation Venous Sampling for Pancreatic Endocrine Tumors
Burke, C. T. (2022) · Springer eBooks · doi:10.1007/978-3-030-87189-5_10
Mak, I. Y. F., & Grossman, A. B. (2022) · doi:10.1093/med/9780198870197.003.0112
Surgical Management of Pancreatic Neuroendocrine Tumors (PNET)
Gonzalez, C. E., DeSantis, A. J., Read, M. D., & Karachristos, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-37482-2_40-1
81-Year-Old Man With Episodic Spells of Weakness, Fatigue, and “Shakes”
Berman, H. S., Bali, A. S., & Dumitrascu, A. G. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.05.023
Yi, Z., Gu, J., Li, T., Yao, J., Wang, J., Chen, H., Mei, Z., Wu, H., Li, H., Ma, Z., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2263254/v1
Surgical Management of Pancreatic Neuroendocrine Tumors (PNET)
Gonzalez, C. E., DeSantis, A. J., Read, M. D., & Karachristos, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-41683-6_40
Gottsponer, J. A., Baker, D. L., Osborn, T., Estrada, M., Giorgakis, E., Burdine, L., & Patel, R. B. (2023) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjad050
Endocrinology Evaluation Protocol: Diabetes and Thyroid
Jayant, S. S., Pal, R., & Bhadada, S. K. (2023) · Springer eBooks · doi:10.1007/978-981-19-6653-8_2
Focal and diffuse nesidioblastosis simulating insulinoma
Ramos, B. G., Hernández, M. V. Á., & González-Murillo, E. A. (2024) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2023.11.025
Schäffler, A., & Karrasch, T. (2024) · Springer eBooks · doi:10.1007/978-3-662-68563-1_7
Evaluation and Diagnosis of Pancreatic and Gastrointestinal Neuroendocrine Tumors
Hubbs, D., & Fahey, T. (2024) · Contemporary surgical clerkships · doi:10.1007/978-3-031-62091-1_25
Schäffler, A., & Karrasch, T. (2024) · Springer eBooks · doi:10.1007/978-3-662-70260-4_7
28-Year-Old Woman With Undifferentiated Spells
Moazzami, M., Mohan, S., & Egan, A. M. (2025) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2024.04.019
Gastrointestinal neuroendocrine tumor syndromes (GI-NETS)
Ito, T., & Jensen, R. T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00239-9
Unmasking an insulinoma: From biochemical to pathological diagnosis
Mach, T., Walfish, L., & Pancer, J. (2025) · Canadian Journal of General Internal Medicine · doi:10.3138/cjgim.2024.0015
Surgical Management of Hypoglycemia in Non-Diabetic Patients
Ramos, B. G., Montoya, E. G. V., Martínez, D. J. A., Ramos, V. G., Ruiz, A. A. S., Magallanes, J. L. G., & Aguirre, P. A. V. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1013550
Iwamoto, H., Anno, T., Iwamoto, Y., Kawasaki, F., Kaku, K., & Kaneto, H. (2026) · Diabetology International · doi:10.1007/s13340-026-00879-5
Bavaria, S., Chana, A., Nurani, K., & Kimang’a, J. (2026) · World Journal of Diabetes · doi:10.4239/wjd.v17.i3.116660
Yu, M., Ji, X., & Zheng, P. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1802157
Beyond Postprandial Symptoms: Fasting Hypoglycemia in Post-Bariatric Hypoglycemia
Lin, J., Shams, A., & Lawler, H. M. (2026) · Endocrine Practice · doi:10.1016/j.eprac.2026.09.119
- Authors
- Thompson, S. M., Vella, A., Thompson, G. B., Rumilla, K. M., Service, F. J., Grant, C. S., & Andrews, J. C.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Thompson, Scott M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-11
- Volume
- 100
- Issue
- 11
- Pages
- 4189-4197
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC4702445
- OpenAlex
- W2109360431
- Cited by
- 80
- References
- 41
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 8 · 2013: 1
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (TL1TR000137)
- Guangdong Academy of Sciences
- Norwegian Institute of Public Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078646)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- insulinoma, nesidioblastosis, hepatic venous sampling, hyperinsulinemic hypoglycemia, differential diagnosis, diagnostic specificity, hepatic insulin secretion, receiver operating characteristic
- MeSH terms
- Adult, Aged, Calcium, Diagnosis, Differential, Female, Hepatic Veins, Humans, Hyperinsulinism, Hypoglycemia, Insulinoma, Male, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, ROC Curve, Body Mass Index, Nesidioblastosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
