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Cited by 81Adrenal and Paraganglionic TumorsHormonal Regulation and HypertensionAdrenal Hormones and Disorders

Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study

Sereg, Márta, Szappanos, Ágnes, Tőke, Judit, Karlinger, Kinga, Feldman, Karolina, Kaszper, Éva, Varga, Ibolya, Gláz, Edit +2 more·2009·European Journal of Endocrinology
DOI 10.1530/eje-08-0707
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Abstract

OBJECTIVE: Despite the increased prevalences of hypertension, type 2 diabetes mellitus (T2DM), hyperlipidemy, and obesity in patients with non-functioning adrenal adenomas (NFAAs), there is a paucity of data on long-term atherosclerotic morbidity as well as the long-term cardiovascular effects of adrenalectomy in these patients. DESIGN, PATIENTS, AND METHODS: This retrospective study includes the results of baseline and follow-up investigations of 125 patients (29 males and 96 females; mean age 60.1 years) with NFAAs referred for endocrine evaluation between 1990 and 2001. Of the 125 patients, 47 underwent unilateral adrenalectomy, while 78 patients were followed conservatively. These patients were reinvestigated after a mean follow-up time of 9.1 (5-16) years in 2006, with special emphasis on laboratory and other atherosclerotic risk factors (ARF), vascular events, and interventions. RESULTS: The prevalences of hypertension, impaired glucose tolerance or T2DM, hyperlipidemy, and obesity were 82, 43, 58, and 50%, and 89, 58, 82, and 50% at baseline and follow-up, respectively. None of the investigated ARF prevalences were different between patients treated and not treated with adrenalectomy, and between patients with and without subclinical Cushing's syndrome. The prevalences of angina pectoris, acute myocardial infarction, coronary, and peripheral arterial interventions or cerebrovascular stroke did not differ significantly between patients treated and not treated with adrenalectomy. CONCLUSION: Our study confirms previous investigations reporting markedly increased prevalences of various ARF in patients with NFAAs. Adrenalectomy performed in these patients failed to decrease the prevalence of ARF and atherosclerotic morbidity.

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Crossref · 10.1530/eje-08-0707

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  • Chronic mild cortisol secretion abnormality may be associated with classic metabolic and cardiovascular complications of hypercortisolism.

    “A chronic mild cortisol secretion abnormality may be associated with classic metabolic and cardiovascular complications of hypercortisolism (, -).”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [214]

  • A recent retrospective study found no difference in hypertension, diabetes, and obesity between five and eight subclinical hypercortisolism patients treated surgically and conservatively, respectively.

    “At variance with all the above-mentioned studies, a recent retrospective study found no difference in hypertension, diabetes, and obesity between five and eight SH patients surgically and conservatively treated, respectively (97).”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [97]

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Authors
Sereg, M., Szappanos, Á., Tőke, J., Karlinger, K., Feldman, K., Kaszper, É., Varga, I., Gláz, E., Rácz, K., & Tóth, M.
Affiliations
Semmelweis University (HU)
Corresponding author
Tóth, Miklós
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-04
Volume
160
Issue
4
Pages
647-655
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-08-0707
OpenAlex
W2153168537
Cited by
81
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 9
FWCI
7.75
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Semmelweis University Repository (Semmelweis University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
non-functioning adrenal adenoma, adrenalectomy, atherosclerosis risk factors, cardiovascular morbidity, hypertension, type 2 diabetes, hyperlipidemia, obesity, subclinical Cushing's syndrome, angina pectoris, myocardial infarction, stroke, conservative treatment
MeSH terms
Adrenal Cortex Neoplasms, Adrenalectomy, Adrenocorticotropic Hormone, Cushing Syndrome, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Hydrocortisone, Male, Middle Aged, Retrospective Studies, Adrenocortical Adenoma, Atherosclerosis

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