Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175 · see citing works

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,325 · see citing works

PAMP s and DAMP s: signal 0s that spur autophagy and immunity

Tang, D., Kang, R., Coyne, C. B., Zeh, H. J., & Lotze, M. T. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01146.x · Cited by 1,250 · see citing works

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Sun, M., Wu, W. H., Liu, Z., & Cong, Y. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1242-9 · Cited by 1,071 · see citing works

The interaction of hepatic lipid and glucose metabolism in liver diseases

Bechmann, L. P., Hannivoort, R. A., Gerken, G., Hotamışlıgil, G. S., Trauner, M., & Canbay, A. E. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.025 · Cited by 992 · see citing works

Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria

LeBlanc, J. G., Chain, F., Martín, R., Bermúdez‐Humarán, L. G., Courau, S., & Langella, P. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0691-z · Cited by 881 · see citing works

Lipotoxicity and the gut-liver axis in NASH pathogenesis

Marra, F., & Svegliati-Baroni, G. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.014 · Cited by 847 · see citing works

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312135 · Cited by 788 · see citing works

Primary biliary cirrhosis

Carey, E. J., Ali, A. H., & Lindor, K. D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00154-3 · Cited by 735 · see citing works

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works

Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454 · see citing works

Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment

White, R. F., Steele, L., O'Callaghan, J. P., Sullivan, K. A., Binns, J. H., Golomb, B. A., Bloom, F. E., Bunker, J. A., Crawford, F., Graves, J. C., et al. (2015) · Cortex · doi:10.1016/j.cortex.2015.08.022 · Cited by 433 · see citing works

Metabolic endotoxemia with obesity: Is it real and is it relevant?

Boutagy, N. E., McMillan, R. P., Frisard, M. I., & Hulver, M. W. (2016) · Biochimie · doi:10.1016/j.biochi.2015.06.020 · Cited by 413 · see citing works

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Mauro, C., Leow, S. C., Ansó, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., Smaele, E. D., Beg, A. A., Tergaonkar, V., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2324 · Cited by 393 · see citing works

Metabolic features of chronic fatigue syndrome

Naviaux, R. K., Naviaux, J. C., Li, K., Bright, A. T., Alaynick, W. A., Wang, L., Baxter, A., Nathan, N., Anderson, W. H., & Gordon, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607571113 · Cited by 393 · see citing works

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Oishi, Y., Spann, N. J., Link, V. M., Muse, E. D., Strid, T., Edillor, C., Kolar, M. J., Matsuzaka, T., Hayakawa, S., Tao, J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.009 · Cited by 342 · see citing works

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome

Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., & Hanson, M. R. (2016) · Microbiome · doi:10.1186/s40168-016-0171-4 · Cited by 339 · see citing works

Leptin secretion and leptin receptor in the human stomach

Sobhani, I., Bado, A., Vissuzaine, C., Buyse, M., Kermorgant, S., Laigneau, J.-P., Attoub, S., Lehy, T., Hénin, D., Mignon, M., et al. (2000) · Gut · doi:10.1136/gut.47.2.178 · Cited by 336 · see citing works

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

Sappington, P. L., Yang, R., Yang, H., Tracey, K. J., Delude, R. L., & Fink, M. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.35391 · Cited by 319 · see citing works

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation

Luettig, J., Rosenthal, R., Barmeyer, C., & Jd, S. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.977176 · Cited by 281 · see citing works

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

Chen, Y., Choi, S. S., Michelotti, G., Chan, I. S., Swiderska-Syn, M., Karaca, G., Xie, G., Moylan, C. A., Garibaldi, F., Premont, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.115 · Cited by 279 · see citing works

Mechanisms of triglyceride accumulation in activated macrophages

Feingold, K. R., Shigenaga, J. K., Kazemi, M. R., McDonald, C. M., Patzek, S. M., Cross, A. S., Moser, A. H., & Grünfeld, C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1111537 · Cited by 249 · see citing works

ChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome

Iizuka, K., & Horikawa, Y. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-110 · Cited by 222 · see citing works

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Nagy‐Szakal, D., Williams, B. L., Mishra, N., Che, X., Lee, B., Bateman, L., Klimas, N. G., Komaroff, A. L., Levine, S. M., Montoya, J. G., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0261-y · Cited by 221 · see citing works

Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

Zhang, M., Zhou, Q., Dorfman, R. G., Huang, X., Fan, T., Zhang, H., Zhang, J., & Yu, C. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0500-x · Cited by 210 · see citing works

Nonalcoholic Fatty Liver Disease/Steatohepatitis: Epidemiology, Pathogenesis, Clinical Presentation and Treatment

Milić, S., & Štimac, D. (2012) · Digestive Diseases · doi:10.1159/000336669 · Cited by 191 · see citing works

Hepatic expression and cellular distribution of the glucose transporter family

Karim, S. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6771 · Cited by 190 · see citing works

Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment

Schreuder, T. C. M. A., Verwer, B. J., van Nieuwkerk, C. M., & Mulder, C. J. J. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2474 · Cited by 189 · see citing works

Mood and Memory Deficits in a Model of Gulf War Illness Are Linked with Reduced Neurogenesis, Partial Neuron Loss, and Mild Inflammation in the Hippocampus

Parihar, V. K., Hattiangady, B., Shuai, B., & Shetty, A. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.158 · Cited by 176 · see citing works

Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis

Chiu, C.-C., Ching, Y.-H., Li, Y.-P., Liu, J.-Y., Huang, Y.-T., Huang, Y.-W., Yang, S.-S., Huang, W.-C., & Chuang, H.-L. (2017) · Nutrients · doi:10.3390/nu9111220 · Cited by 160 · see citing works

Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness

O'Callaghan, J. P., Kelly, K. A., Locker, A. R., Miller, D. B., & Lasley, S. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13088 · Cited by 154 · see citing works

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

Alhasson, F. A., Das, S., Seth, R. K., Dattaroy, D., Chandrashekaran, V., Ryan, C. N., Chan, L. S., Testerman, T. L., Burch, J. B., Hofseth, L. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172914 · Cited by 152 · see citing works

Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats

Khan, S., & Jena, G. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.08.010 · Cited by 137 · see citing works

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis

Chatterjee, S., Ganini, D., Tokar, E. J., Kumar, A., Das, S., Corbett, J. T., Kadiiska, M. B., Waalkes, M. P., Diehl, A. M., & Mason, R. P. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.035 · Cited by 134 · see citing works

Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress–Mediated Apoptosis

Anderson‐Baucum, E. K., Hill, A. A., & Hasty, A. H. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.250142 · Cited by 118 · see citing works

Duodenal Leptin Stimulates Cholecystokinin Secretion

Guilmeau, S., Buyse, M., Tsocas, A., Laigneau, J., & Bado, A. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1664 · Cited by 110 · see citing works

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

Reichardt, F., Chassaing, B., Nezami, B. G., Li, G., Tabatabavakili, S., Mwangi, S. M., Uppal, K., Liang, B., Vijay–Kumar, M., Jones, D. P., et al. (2016) · The Journal of Physiology · doi:10.1113/jp273269 · Cited by 109 · see citing works

Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate

Sekhavat, A., Sun, J., & Davie, J. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-145 · Cited by 108 · see citing works

The Role of Butyrate, A Histone Deacetylase Inhibitor in Diabetes Mellitus: Experimental Evidence for Therapeutic Intervention

Khan, S., & Jena, G. (2015) · Epigenomics · doi:10.2217/epi.15.20 · Cited by 101 · see citing works

Neuropsychological functioning in military pesticide applicators from the Gulf War: Effects on information processing speed, attention and visual memory

Sullivan, K. A., Krengel, M., Bradford, W., Stone, C., Thompson, T. A., Heeren, T., & White, R. F. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.11.002 · Cited by 100 · see citing works

Gulf War and Health

Institute of Medicine (2000) · National Academies Press eBooks · doi:10.17226/9953 · Cited by 94 · see citing works

Mitochondrial Dysfunction in Gulf War Illness Revealed by 31Phosphorus Magnetic Resonance Spectroscopy: A Case-Control Study

Koslik, H. J., Hamilton, G., & Golomb, B. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092887 · Cited by 87 · see citing works

Insights into the Hexose Liver Metabolism—Glucose versus Fructose

Geidl-Flueck, B., & Gerber, P. (2017) · Nutrients · doi:10.3390/nu9091026 · Cited by 85 · see citing works

Increasing Burden of Chronic Liver Disease Among Adolescents and Young Adults in the USA: A Silent Epidemic

Doycheva, I., Watt, K. D. S., Rifai, G., Mrad, R. A., López, R., Zein, N. N., Carey, W. D., & Alkhouri, N. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4492-3 · Cited by 83 · see citing works

Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness

Koo, B., Michalovicz, L. T., Calderazzo, S. M., Kelly, K. A., Sullivan, K. A., Killiany, R., & O'Callaghan, J. P. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.003 · Cited by 82 · see citing works

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

Chandrashekaran, V., Seth, R. K., Dattaroy, D., Alhasson, F. A., Ziolenka, J., Carson, J. A., Berger, F. G., Kalyanaraman, B., Diehl, A. M., & Chatterjee, S. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.005 · Cited by 72 · see citing works

Cholinergic Autonomic Dysfunction in Veterans With Gulf War Illness

Haley, R. W., Charuvastra, E., Shell, W. E., Buhner, D. M., Marshall, W. W., Biggs, M. M., Hopkins, S., Wolfe, G. I., & Vernino, S. A. (2012) · JAMA Neurology · doi:10.1001/jamaneurol.2013.596 · Cited by 71 · see citing works

Environmental Toxin–Linked Nonalcoholic Steatohepatitis and Hepatic Metabolic Reprogramming in Obese Mice

Seth, R. K., Kumar, A., Das, S., Kadiiska, M. B., Michelotti, G. A., Diehl, A. M., & Chatterjee, S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft104 · Cited by 67 · see citing works

Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness

Abdullah, L. I., Evans, J. E., Joshi, U., Crynen, G. C., Reed, J. M., Mouzon, B., Baumann, S., Montague, H., Zakirova, Z., Emmerich, T., et al. (2016) · Toxicology · doi:10.1016/j.tox.2016.10.012 · Cited by 65 · see citing works

Gulf War illness (GWI) as a neuroimmune disease

Georgopoulos, A. P., James, L. M., Carpenter, A. F., Engdahl, B. E., Leuthold, A. C., & Lewis, S. M. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-5050-0 · Cited by 65 · see citing works

Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter‐4 and increasing glucokinase

Tang, Y., & Chen, A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00956.x · Cited by 60 · see citing works

The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome

Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., & Maes, M. H. J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160914182822 · Cited by 56 · see citing works

Nonalcoholic Fatty Liver Disease

Sweet, P. H., Khoo, T., & Nguyen, S. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.07.003 · Cited by 56 · see citing works

Fatigue, endocrinopathies, and metabolic disorders

Kaltsas, G., Vgontzas, A., & Chrousos, G. (2010) · PM&R · doi:10.1016/j.pmrj.2010.04.011 · Cited by 54 · see citing works

A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure

Zakirova, Z., Crynen, G. C., Hassan, S., Abdullah, L. I., Horne, L., Mathura, V. S., Crawford, F., & Ait‐Ghezala, G. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00071 · Cited by 53 · see citing works

Gulf War illness: an overview of events, most prevalent health outcomes, exposures, and clues as to pathogenesis

Kerr, K. J. (2015) · Reviews on Environmental Health · doi:10.1515/reveh-2015-0032 · Cited by 49 · see citing works

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases

García‐Martinez, I., Shaker, M. E., & Mehal, W. Z. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6383 · Cited by 44 · see citing works

Physical, Psychological, and Functional Comorbidities of Multisymptom Illness in Australian Male Veterans of the 1991 Gulf War

Kelsall, H. L., McKenzie, D. P., Sim, M. R., Leder, K. S., Forbes, A. B., & Dwyer, T. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp238 · Cited by 42 · see citing works

Complications, symptoms, quality of life and pregnancy in cholestatic liver disease

Zakharia, K., Tabibian, A., Lindor, K. D., & Tabibian, J. H. (2018) · Liver International · doi:10.1111/liv.13591 · Cited by 42 · see citing works

TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity

Razolli, D. S., Moraes, J. C., Morari, J., de Moura, R. F., Vinolo, M. A. R., & Velloso, L. A. (2014) · Endocrinology · doi:10.1210/en.2014-1552 · Cited by 40 · see citing works

Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

Chandrashekaran, V., Das, S., Seth, R. K., Dattaroy, D., Alhasson, F. A., Michelotti, G. A., Nagarkatti, M., Nagarkatti, P. S., Diehl, A. M., & Chatterjee, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.009 · Cited by 40 · see citing works

A Review of Gulf War illness

Coker, W. J. (1996) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-82-141 · Cited by 32 · see citing works

Selected Health Conditions Among Overweight, Obese, and Non-Obese Veterans of the 1991 Gulf War: Results from a Survey Conducted in 2003-2005

Coughlin, S. S. (2011) · The Open Epidemiology Journal · doi:10.2174/1874297101104010140 · Cited by 31 · see citing works

Fatigue in type 1 diabetes: A systematic review of Observational studies

Jensen, Ø., Bernklev, T., & Jelsness‐Jørgensen, L. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.11.002 · Cited by 30 · see citing works

Supporting a Neuroimmune Basis of Gulf War Illness

O'Callaghan, J. P., Michalovicz, L. T., & Kelly, K. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.037 · Cited by 27 · see citing works

Gut microbiota: An underestimated and unintended recipient for pesticide-induced toxicity

Yuan, X., Pan, Z., Jin, C., Ni, Y., Fu, Z., & Jin, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.04.088 · Cited by 187 · see citing works

Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer

Alrafas, H. R., Busbee, P. B., Chitrala, K. N., Nagarkatti, M., & Nagarkatti, P. S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061796 · Cited by 90 · see citing works

Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies

Dickey, B. R., Madhu, L. N., & Shetty, A. K. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107716 · Cited by 74 · see citing works

Acetylcholinesterase inhibitor exposures as an initiating factor in the development of Gulf War Illness, a chronic neuroimmune disorder in deployed veterans

Michalovicz, L. T., Kelly, K. A., Sullivan, K. A., & O'Callaghan, J. P. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108073 · Cited by 59 · see citing works

Gut microbiome: An intermediary to neurotoxicity

Dempsey, J. L., Little, M., & Cui, J. Y. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.005 · Cited by 62 · see citing works

Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness

Seth, R. K., Maqsood, R., Mondal, A., Bose, D., Kimono, D. A., Holland, L. A., Janulewicz, P. A., Klimas, N. G., Horner, R. D., Sullivan, K. A., et al. (2019) · Viruses · doi:10.3390/v11100968 · Cited by 55 · see citing works

Crosstalk between PPARs and gut microbiota in NAFLD

Wu, L., Li, J., Feng, J., Ji, J., Yu, Q., Li, Y., Zheng, Y., Dai, W., Wu, J., & Guo, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111255 · Cited by 52 · see citing works

The Gut-Microbiome in Gulf War Veterans: A Preliminary Report

Janulewicz, P. A., Seth, R. K., Carlson, J. M., Ajama, J., Quinn, E. K., Heeren, T., Klimas, N. G., Lasley, S. M., Horner, R. D., Sullivan, K. A., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193751 · Cited by 51 · see citing works

Dysbiosis-Associated Enteric Glial Cell Immune-Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology

Kimono, D. A., Sarkar, S., Albadrani, M. S., Seth, R. K., Bose, D., Mondal, A., Li, Y., Kar, A. N., Nagarkatti, M., Nagarkatti, P. S., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01229 · Cited by 48 · see citing works

Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness

Michalovicz, L. T., Locker, A. R., Kelly, K. A., Miller, J. V., Barnes, Z. M., FLETCHER, M. A., Miller, D. B., Klimas, N. G., Morris, M., Lasley, S. M., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.10.006 · Cited by 46 · see citing works

Protein-Rich Flours from Quinoa and Buckwheat Favourably Affect the Growth Parameters, Intestinal Microbial Activity and Plasma Lipid Profile of Rats

Fotschki, B., Juśkiewicz, J., Jurgoński, A., Amarowicz, R., Opyd, P., Bez, J., Muranyi, I. S., Petersen, I. L., & Laparra, J. M. (2020) · Nutrients · doi:10.3390/nu12092781 · Cited by 45 · see citing works

The Multiple Hit Hypothesis for Gulf War Illness: Self-Reported Chemical/Biological Weapons Exposure and Mild Traumatic Brain Injury

Janulewicz, P. A., Krengel, M., Quinn, E. K., Heeren, T., Toomey, R., Killiany, R., Zundel, C. G., Ajama, J., O'Callaghan, J. P., Steele, L., et al. (2018) · Brain Sciences · doi:10.3390/brainsci8110198 · Cited by 44 · see citing works

Pesticides: Unintended Impact on the Hidden World of Gut Microbiota

Ali, A., & AlHussaini, K. I. (2024) · Metabolites · doi:10.3390/metabo14030155 · Cited by 43 · see citing works

Dynamics of Fecal Microbiota with and without Invasive Cervical Cancer and Its Application in Early Diagnosis

Kang, G.-U., Jung, D.-R., Lee, Y. H., Jeon, S. Y., Han, H. S., Chong, G. O., & Shin, J. (2020) · Cancers · doi:10.3390/cancers12123800 · Cited by 41 · see citing works

Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis

Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works

The Innate Immune System and Inflammatory Priming: Potential Mechanistic Factors in Mood Disorders and Gulf War Illness

Trageser, K. J., Sebastian-Valverde, M., Naughton, S. X., & Pasinetti, G. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00704 · Cited by 36 · see citing works

Host Akkermansia muciniphila Abundance Correlates With Gulf War Illness Symptom Persistence via NLRP3-Mediated Neuroinflammation and Decreased Brain-Derived Neurotrophic Factor

Kimono, D. A., Bose, D., Seth, R. K., Mondal, A., Saha, P., Janulewicz, P. A., Sullivan, K. A., Lasley, S. M., Horner, R. D., Klimas, N. G., et al. (2020) · Neuroscience Insights · doi:10.1177/2633105520942480 · Cited by 38 · see citing works

Sodium butyrate alleviates lipopolysaccharide-induced endometritis in mice through inhibiting inflammatory response

Guo, J., Wang, Y., Jiang, P., Yao, H., Zhao, C., Hu, X., Cao, Y., Zhang, N., Fu, Y., & Shen, H. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103792 · Cited by 32 · see citing works

Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness

Angoa‐Pérez, M., Zagorac, B., Francescutti, D. M., Winters, A. D., Greenberg, J. M., Ahmad, M. M., Manning, S. D., Gulbransen, B. D., Theis, K. R., & Kuhn, D. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-66833-w · Cited by 32 · see citing works

A review of pre-clinical models for Gulf War Illness

Ribeiro, A. C. R., & Deshpande, L. S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107936 · Cited by 32 · see citing works

Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model

Bose, D., Saha, P., Mondal, A., Fanelli, B. C., Seth, R. K., Janulewicz, P. A., Sullivan, K. A., Lasley, S. M., Horner, R. D., Colwell, R. R., et al. (2020) · Nutrients · doi:10.3390/nu12092764 · Cited by 30 · see citing works

Butyrate inhibits the malignant biological behaviors of breast cancer cells by facilitating cuproptosis-associated gene expression

Zhang, L., Huang, S., & Yuan, Y. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05807-1 · Cited by 29 · see citing works

Impact of occupational exposure on human microbiota

Lai, P. S., & Christiani, D. C. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000502 · Cited by 28 · see citing works

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

Attaluri, S., Upadhya, R., Kodali, M., Madhu, L. N., Upadhya, D., Shuai, B., & Shetty, A. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.853000 · Cited by 26 · see citing works

Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk

Saha, P., Skidmore, P. T., Holland, L. A., Mondal, A., Bose, D., Seth, R. K., Sullivan, K. A., Janulewicz, P. A., Horner, R. D., Klimas, N. G., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11070905 · Cited by 24 · see citing works

Chemical exposures and suspected impact on Gulf War Veterans

Elhaj, R., & Reynolds, J. M. (2023) · Military Medical Research · doi:10.1186/s40779-023-00449-9 · Cited by 20 · see citing works

Neurotoxicant exposures and rates of Chronic Multisymptom Illness and Kansas Gulf War Illness criteria in Gulf War deployed women veterans

Krengel, M., Sullivan, K. A., Heboyan, V., Zundel, C. G., Wilson, C., Klimas, N. G., & Coughlin, S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119623 · Cited by 18 · see citing works

TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model

Bose, D., Mondal, A., Saha, P., Kimono, D. A., Sarkar, S., Seth, R. K., Janulewicz, P. A., Sullivan, K. A., Horner, R. D., Klimas, N. G., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10080532 · Cited by 18 · see citing works

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Slevin, E., 小山, 幸., Harrison, K., Wan, Y., Klaunig, J. E., Wu, C., Shetty, A. K., & Meng, F. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17631 · Cited by 16 · see citing works

Distinct respiratory microbiota associates with lung cancer clinicopathological characteristics

Zheng, X., Lu, X., & Hu, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.847182 · Cited by 17 · see citing works

The Health of Gulf War and Gulf Era Veterans Over Time

Dursa, E. K., Cao, G., Porter, B., Culpepper, W. J., & Schneiderman, A. (2021) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000002331 · Cited by 17 · see citing works

Niacin for Parkinson's disease

Seamon, M., Purohit, S. B., Giri, B., Baban, B., Morgan, J. C., Chong, R. K. Y., & Wakade, C. G. (2019) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12553 · Cited by 16 · see citing works

THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming

Zhu, Z., Zuo, S., Zhu, Z., Wang, C., Du, Y., & Chen, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114091 · Cited by 15 · see citing works

The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness

Michalovicz, L. T., Kelly, K. A., Miller, D. B., Sullivan, K. A., & O'Callaghan, J. P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119962 · Cited by 15 · see citing works

Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study

Keating, J. A., Shaughnessy, C., Baubie, K., Kates, A., Putman-Buehler, N., Watson, L., Dominguez, N., Watson, K. E., Cook, D. B., Rabago, D., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031114 · Cited by 14 · see citing works

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Bose, D., Chatterjee, S., Older, E. A., Seth, R. K., Janulewicz, P. A., Saha, P., Mondal, A., Carlson, J. M., Decho, A. W., Sullivan, K. A., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03494-7 · Cited by 14 · see citing works

Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment

Kozlova, E. V., Carabelli, B., Bishay, A. E., Liu, R., Denys, M. E., Macbeth, J. C., Piamthai, V., Crawford, M. S., McCole, D. F., Nieden, N. I. Z., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120153 · Cited by 14 · see citing works

Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community

Keating, D., Zundel, C. G., Abreu, M., Krengel, M., Aenlle, K. K., Nichols, M. D., Toomey, R., Chao, L. L., Golier, J. A., Abdullah, L. I., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119903 · Cited by 12 · see citing works

Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review

Kimono, D. A. (2021) · Military Medical Research · doi:10.1186/s40779-021-00341-4 · Cited by 12 · see citing works

Assessing the Beneficial Effects of the Immunomodulatory Glycan LNFPIII on Gut Microbiota and Health in a Mouse Model of Gulf War Illness

Mote, R. S., Carpenter, J. M., Dockman, R. L., Steinberger, A. J., Suen, G., Norberg, T., Harn, D. A., Wagner, J. J., & Filipov, N. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197081 · Cited by 11 · see citing works

Effects of gut microbiota remodeling on the dysbiosis induced by high fat diet in a mouse model of Gulf war illness

Angoa‐Pérez, M., Zagorac, B., Francescutti, D. M., Theis, K. R., & Kuhn, D. M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119675 · Cited by 11 · see citing works

Fatigue and Pain Severity in Gulf War Illness Is Associated With Changes in Inflammatory Cytokines and Positive Acute Phase Proteins

Hodgin, K. S., Jones, C. L., & Younger, J. (2022) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000002625 · Cited by 11 · see citing works

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure

François, S., Mondot, S., Gerard, Q., Bel, R., Knoertzer, J., Berriche, A., Cavallero, S., Baati, R., Orset, C., Bo, G. D., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051167 · Cited by 10 · see citing works

Host gut microbiome and potential therapeutics in Gulf War Illness: A short review

Chatterjee, S., Bose, D., & Seth, R. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119717 · Cited by 9 · see citing works

Examining the association between the gastrointestinal microbiota and Gulf War illness: A prospective cohort study

Kates, A., Keating, J. A., Baubie, K., Putman-Buehler, N., Watson, L., Godfrey, J. J., Deblois, C. L., Suen, G., Cook, D. B., Rabago, D., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268479 · Cited by 10 · see citing works

Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans

Reddy, D. S., Wu, X. Y., Singh, T., & Neff, M. (2023) · Current Protocols · doi:10.1002/cpz1.707 · Cited by 7 · see citing works

Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering

Collier, C. A., Salikhova, A., Sabir, S., Foncerrada, S., & Raghavan, S. A. (2024) · Military Medical Research · doi:10.1186/s40779-024-00547-2 · Cited by 8 · see citing works

The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease

Peer, A., & Samuelson, D. R. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01156-8 · Cited by 5 · see citing works

Role of microbiota in pain: From bench to bedside

Ren, H., Cao, B., Xu, Q., Zhao, R., Li, H., & Wei, B. (2025) · iMetaOmics. · doi:10.1002/imo2.58 · Cited by 6 · see citing works

Environmental Pollutants That Can Be Metabolized by the Host (Gut Microbiota)

El-Dalatony, M. M., & Li, X. (2020) · Springer eBooks · doi:10.1007/978-981-15-4759-1_5 · Cited by 4 · see citing works

Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort

Trivedi, A., Bose, D., Moffat, K. S., Pearson, E., Walsh, D. M., Cohen, D. E., Skupsky, J., Chao, L. L., Golier, J. A., Janulewicz, P. A., et al. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081102 · Cited by 3 · see citing works

Unravelling the Gut‐Skin Axis in Chronic Urticaria: Dysbiosis, Metabolites and Immunological Mechanisms

Wu, Y. H., Liu, J. L., Ren, Y., & Zou, C. (2026) · Experimental Dermatology · doi:10.1111/exd.70261 · Cited by 2 · see citing works

Contributions of the gut microbiota to Gulf War Illness susceptibility: Findings from a mouse model

Chaudhari, D. S., Francescutti, D. M., Winters, A. D., Koka, O., Kracht, D. J., Greenberg, J. M., Theis, K. R., & Angoa‐Pérez, M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123244 · Cited by 2 · see citing works

Auricular Transcutaneous Vagus Nerve Stimulation may Increase the Risk of Mild-COVID-19 Infection or of Herpetic Flare: Is there a Role of Microbiota?

Donatini, B. (2021) · JOURNAL OF CASE REPORTS AND STUDIES · doi:10.15744/2348-9820.9.205

Gut-Brain Axis and Colorectal Cancer: Neuroimmune Interactions

Prasad, A., Acharya, S., Singh, A., Raj, U., & Sharma, A. (2025) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-031-86065-2_12

Microbiome Targeted Therapies in Gulf War Illness

Kimono, D. A. (2020) · Scholar Commons (University of South Carolina)

Assessing the Beneficial Effects of the Immunomodulatory Glycan LNFPIII on Gut Microbiota and Health in a Mouse Model of Gulf War Illness

Mote, R. S., Carpenter, J. M., Dockman, R. L., Steinberger, A. J., Suen, G., Norberg, T., Harn, D. A., Wagner, J. J., & Filipov, N. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197081 · Cited by 11 · see citing works

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

Alhasson, F. A., Das, S., Seth, R. K., Dattaroy, D., Chandrashekaran, V., Ryan, C. N., Chan, L. S., Testerman, T. L., Burch, J. B., Hofseth, L. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172914 · Cited by 152 · see citing works

Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model

Bose, D., Saha, P., Mondal, A., Fanelli, B. C., Seth, R. K., Janulewicz, P. A., Sullivan, K. A., Lasley, S. M., Horner, R. D., Colwell, R. R., et al. (2020) · Nutrients · doi:10.3390/nu12092764 · Cited by 30 · see citing works

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Slevin, E., 小山, 幸., Harrison, K., Wan, Y., Klaunig, J. E., Wu, C., Shetty, A. K., & Meng, F. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17631 · Cited by 16 · see citing works