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Cited by 54Adrenal Hormones and DisordersThyroid Disorders and TreatmentsMedical Case Reports and Studies

Fatigue, endocrinopathies, and metabolic disorders

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Kaltsas, Gregory, Vgontzas, Alexandros, Chrousos, George·2010·PM&R
DOI 10.1016/j.pmrj.2010.04.011
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Abstract

Fatigue is a frequent reason for seeking medical attention. Endocrine dysfunction is a common etiology of fatigue. In fact, thyroid function is usually one of the first explanations on the list of possible diagnoses. The symptoms associated with endocrinopathies are frequently "nonspecific," and psychiatric disease or psychological disorders need to be differentiated. Often, this can be accomplished using biological measures of hormone function, such as measures of thyroid, pituitary, parathyroid, and adrenal hormone levels. The field of endocrinology is highly dependent on an algorithmic approach to differential diagnosis using hormone levels as the guide. The use of self-reports helps identify at-risk patients, and raises suspicions about whether there is an abnormality, but diagnosis is dependent on laboratory values. Metabolic abnormalities, such as hyper- or hypoglycemia, dyslipidemia, and gonadal dysfunction can also contribute to fatigue. A better understanding of the interactions among hormones, their releasing factors, and regulation of inflammation will help identify abnormalities early and help distinguish endocrinopathies from other causes of fatigue. Early identification of these abnormalities may reduce end-organ damage and improve treatment strategies.

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Crossref · 10.1016/j.pmrj.2010.04.011

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  • This includes endocrine and metabolic disorders which enhance (rather than decrease) the metabolic availability of energy and the activation/excitability levels of numerous tissues, e.g., hyperthyroidism, Cushing's syndrome, or hypercalcemia.

    “and may explain the counterintuitive observation that this includes endocrine and metabolic disorders which enhance (rather than decrease) the metabolic availability of energy und the activation/excitability levels of numerous tissues, e.g., hyperthyrodism, Cushing's syndrome, or hypercalcemia (Kaltsas et al., 2010).”

    From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Kaltsas et al., 2010

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Authors
Kaltsas, G., Vgontzas, A., & Chrousos, G.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • Pennsylvania State University (US)
Corresponding author
Chrousos, George
ORCID
Venue
PM&R
Publisher
Wiley
Published
2010-05
Volume
2
Issue
5
Pages
393-398
ISSN
  • 1934-1482 (ISSN-L)
  • 1934-1563
DOI
10.1016/j.pmrj.2010.04.011
OpenAlex
W1973859343
Cited by
54
References
22
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
Locations
  • PM&R (publishedVersion)
  • PubMed (publishedVersion)
  • DSpace - NTUA (National Technical University of Athens) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
Keywords
fatigue, endocrine disorders, metabolic disorders, thyroid dysfunction, pituitary dysfunction, parathyroid dysfunction, adrenal dysfunction, differential diagnosis, hormone levels, hyperglycemia, hypoglycemia, dyslipidemia, gonadal dysfunction, inflammation, self-report screening
MeSH terms
Adrenal Gland Diseases, Calcium, Diabetes Mellitus, Type 2, Endocrine System Diseases, Fatigue, Humans, Hyperthyroidism, Hypothyroidism, Metabolic Diseases, Metabolic Syndrome

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