Cited by 106Occupational and environmental lung diseasesGraphene and Nanomaterials ApplicationsNanoparticles: synthesis and applications

The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.

The asbestos-carbon nanotube analogy: An update

Open access

Kane, Agnes B., Hurt, Robert H., Gao, Huajian·2018·Toxicology and Applied Pharmacology

DOI 10.1016/j.taap.2018.06.027PMC PMC6298811

Open this paper in CoChat — free account

Abstract

Nanotechnology is an emerging industry based on commercialization of materials with one or more dimensions of 100 nm or less. Engineered nanomaterials are currently incorporated into thin films, porous materials, liquid suspensions, or filler/matrix nanocomposites with future applications predicted in energy and catalysis, microelectronics, environmental sensing and remediation, and nanomedicine. Carbon nanotubes are one-dimensional fibrous nanomaterials that physically resemble asbestos fibers. Toxicologic studies in rodents demonstrated that some types of carbon nanotubes can induce mesothelioma, and the World Health Organization evaluated long, rigid multiwall carbon nanotubes as possibly carcinogenic for humans in 2014. This review summarizes key physicochemical similarities and differences between asbestos fibers and carbon nanotubes. The "fiber pathogenicity paradigm" has been extended to include carbon nanotubes as well as other high-aspect-ratio fibrous nanomaterials including metallic nanowires. This paradigm identifies width, length, and biopersistence of high-aspect-ratio fibrous nanomaterials as critical determinants of lung disease, including mesothelioma, following inhalation. Based on recent theoretical modeling studies, a fourth factor, mechanical bending stiffness, will be considered as predictive of potential carcinogenicity. Novel three-dimensional lung tissue platforms provide an opportunity for in vitro screening of a wide range of high aspect ratio fibrous nanomaterials for potential lung toxicity prior to commercialization.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.taap.2018.06.027

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,766
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Carbon Nanotubes: Present and Future Commercial Applications
Volder, M. F. L. D., Tawfick, S., Baughman, R. H., & Hart, A. J. (2013) · Science · doi:10.1126/science.1222453 · Cited by 5,675
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
IARC monographs on the evaluation of carcinogenic risks to humans
Hopkins, J. C. A. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90054-9 · Cited by 2,867
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
The potential environmental impact of engineered nanomaterials
Colvin, V. L. (2003) · Nature Biotechnology · doi:10.1038/nbt875 · Cited by 2,161

Flagged first, then by citations

Show all 152 references

Research works printed but not linked: 5

IARC, 2002, vol. 81
IARC, 2017, vol. 111
Miller, 2008, Mounting evidence that carbon nanotubes may be the new asbestos, Friends Earth Aust., 1
Pott F, R.R., Roller M, Csicsaky M., Rosenbruch, M. & Huth, F., 1989. Tumours in the abdominal cavity of rats after intraperitoneal injection of nickel compounds. Proceedings of the International Conference on Heavy Metals in the Environment 2, Geneva, World Health Organization, 127–129.
Warheit, 2018, Nanotoxicology, Chapter 28

Sorted by citations

Transition metal impurities in carbon-based materials: Pitfalls, artifacts and deleterious effects
Kiciński, W., & Dyjak, S. (2020) · Carbon · doi:10.1016/j.carbon.2020.06.004 · Cited by 177
Biostimulation and toxicity: The magnitude of the impact of nanomaterials in microorganisms and plants
Juárez‐Maldonado, A., Tortella, G., Rubilar, O., Fincheira, P., & Benavides‐Mendoza, A. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2020.12.011 · Cited by 159
On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
Ventura, C., Pinto, F., Lourenço, A. F., Ferreira, P. J., Louro, H., & Silva, M. J. (2020) · Cellulose · doi:10.1007/s10570-020-03176-9 · Cited by 140
Bio-inspired flexible electronics for smart E-skin
Nie, B., Liu, S., Qu, Q., Zhang, Y., Zhao, M., & Liu, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.018 · Cited by 122
Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
Aoki, K., & Saito, N. (2020) · Nanomaterials · doi:10.3390/nano10020264 · Cited by 105
Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes
Dong, J., & Ma, Q. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1651920 · Cited by 100
Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
Cirillo, G., Vittorio, O., Kunhardt, D., Valli, E., Voli, F., Farfalla, A., Curcio, M., Spizzirri, U. G., & Hampel, S. (2019) · Materials · doi:10.3390/ma12182889 · Cited by 80
Carbon Nanotubes: A Summary of Beneficial and Dangerous Aspects of an Increasingly Popular Group of Nanomaterials
Zhang, C., Wu, L., de Perrot, M. E., & Zhao, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693814 · Cited by 71
An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard
Murphy, F. A., Dekkers, S., Braakhuis, H., Ma‐Hock, L., Johnston, H. J., Janer, G., Cristo, L. D., Sabella, S., Jacobsen, N. R., Oomen, A. G., et al. (2021) · NanoImpact · doi:10.1016/j.impact.2021.100314 · Cited by 68
Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities
Fraser, K., Kodali, V., Yanamala, N. V. K., Birch, M. E., Cena, L. G., Casuccio, G. S., Bunker, K. L., Lersch, T. L., Evans, D. E., Stefaniak, A. B., et al. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00392-w · Cited by 65
Recent advances in the applications of CNT-based nanomaterials in pharmaceutical nanotechnology and biomedical engineering
Barcelos, K. D. A., Garg, J., Soares, D. C. F., de Barros, A. L. B., Zhao, Y., & Alisaraie, L. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104834 · Cited by 60
The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review
Sheikhpour, M., Naghinejad, M., Kasaeian, A., Lohrasbi, A., Shahraeini, S. S., & Zomorodbakhsh, S. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s263238 · Cited by 59
Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals
Möller, P., Wils, R. S., Ianni, E. D., Gutierrez, C. A. T., Roursgaard, M., & Jacobsen, N. R. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108393 · Cited by 58
Latest Advances and Developments to Detection of Micro‐ and Nanoplastics Using Surface‐Enhanced Raman Spectroscopy
Vélez‐Escamilla, L. Y., & Contreras‐Torres, F. F. (2022) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.202100217 · Cited by 57
In vitro cytotoxicity assessment of pristine and carboxyl-functionalized MWCNTs
Kyriakidou, K., Brasinika, D., Trompeta, A.-F. A., Bergamaschi, E., Karoussis, I. K., & Charitidis, C. A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111374 · Cited by 57
A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations
Kabadi, P. K., Rodd, A. L., Simmons, A., Messier, N. J., Hurt, R. H., & Kane, A. B. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0298-0 · Cited by 54
Self-citation
The nanoGRAVUR framework to group (nano)materials for their occupational, consumer, environmental risks based on a harmonized set of material properties, applied to 34 case studies
Wohlleben, W., Hellack, B., Nickel, C., Herrchen, M., Hund‐Rinke, K., Kettler, K., Riebeling, C., Haase, A., Funk, B., Kühnel, D., et al. (2019) · Nanoscale · doi:10.1039/c9nr03306h · Cited by 48
Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
Gupta, S. S., Singh, K. P., Gupta, S. K., Dušinská, M., & Rahman, Q. (2022) · Nanomaterials · doi:10.3390/nano12101708 · Cited by 47
Carbon Nanotube- and Asbestos-Induced DNA and RNA Methylation Changes in Bronchial Epithelial Cells
Emerce, E., Ghosh, M., Öner, D., Duca, R. C., Vanoirbeek, J., Bekaert, B., Hoet, P., & Godderis, L. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00406 · Cited by 44
Far-reaching advances in the role of carbon nanotubes in cancer therapy
Dizaji, B. F., Khoshbakht, S., Farboudi, A., Azarbaijan, M. H., & Irani, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118059 · Cited by 43
Biocompatibility studies of macroscopic fibers made from carbon nanotubes: Implications for carbon nanotube macrostructures in biomedical applications
Yan, J. S., Orecchioni, M., Vitale, F., Coco, J. A., Duret, G., Antonucci, S., Pamulapati, S. S., Taylor, L. W., Dewey, O. S., Sante, M. D., et al. (2020) · Carbon · doi:10.1016/j.carbon.2020.10.077 · Cited by 43
Nanotechnology in the diagnosis and treatment of stroke
Sarmah, D., Banerjee, M., Datta, A., Kalia, K., Dhar, S., Yavagal, D. R., & Bhattacharya, P. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.018 · Cited by 40
Magnetic graphite-ODA@CoFe2O4: attempting to produce and characterize the development of an innovative nanocomposite to investigate its antimicrobial properties
Dehghani, F., Shahmoradi, S., Naghizadeh, M., Firuzyar, T., Vaez, A., Kasaee, S. R., Amani, A. M., & Mosleh-Shirazi, S. (2022) · Applied Physics A · doi:10.1007/s00339-022-05387-2 · Cited by 38
Applications of Nanotechnology in the Diagnosis and Therapy of Stroke
Landowski, L. M., Niego, B., Sutherland, B. A., Hagemeyer, C. E., & Howells, D. W. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0039-3399568 · Cited by 38
Carbon nanotube pathogenicity conforms to a unified theory for mesothelioma causation by elongate materials and fibers
Nel, A. E. (2023) · Environmental Research · doi:10.1016/j.envres.2022.114580 · Cited by 34
Multi-criteria evaluation of CO2 utilization options for cement plants using the example of Finland
Zhaurova, M., Soukka, R., & Horttanainen, M. (2021) · International journal of greenhouse gas control · doi:10.1016/j.ijggc.2021.103481 · Cited by 33
New Developments in Carbon-Based Nanomaterials for Automotive Brake Pad Applications and Future Challenges
Selvaraj, S. K., Ramesh, R., Narendhra, T. M. V., Agarwal, I. N., Chadha, U., Paramasivam, V., & Palanisamy, P. (2021) · Journal of Nanomaterials · doi:10.1155/2021/6787435 · Cited by 33
Advances in Carbon Nanotubes for Malignant Melanoma: A Chance for Treatment
Lima, E. N. D. C., Piqueira, J. R. C., & Maria, D. A. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0363-7 · Cited by 31
Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
Rodrigues, A. F., Newman, L., Jasim, D. A., Vacchi, I. A., Ménard‐Moyon, C., Crică, L. E., Bianco, A., Kostarelos, K., & Bussy, C. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2303-z · Cited by 29
Comparing in vitro cytotoxicity of graphite, short multi-walled carbon nanotubes, and long multi-walled carbon nanotubes
Azari, M. R., & Mohammadian, Y. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08036-4 · Cited by 26
Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials
Felley-Bosco, E., & MacFarlane, M. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00146 · Cited by 23
Towards health-based nano reference values (HNRVs) for occupational exposure: Recommendations from an expert panel
Visser, M., Gosens, I., Bard, D., van Broekhuizen, P., Janer, G., Kuempel, E. D., Riediker, M., Vogel, U. B., & Dekkers, S. (2022) · NanoImpact · doi:10.1016/j.impact.2022.100396 · Cited by 29
Distinct autophagy-apoptosis related pathways activated by Multi-walled (NM 400) and Single-walled carbon nanotubes (NIST-SRM2483) in human bronchial epithelial (16HBE14o-) cells
Ghosh, M., Murugadoss, S., Janssen, L., Čokić, S. M., Mathyssen, C., LANDUYT, K. L. V., Janssens, W., Carpentier, S., Godderis, L., & Hoet, P. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121691 · Cited by 22
Dose-response modeling of NLRP3 inflammasome-mediated diseases: asbestos, lung cancer, and malignant mesothelioma as examples
Cox, L. A. (2019) · Critical Reviews in Toxicology · doi:10.1080/10408444.2019.1692779 · Cited by 21
The versatility of pyrene and its derivatives on sp2 carbon nanomaterials for bioelectrochemical applications
Holzinger, M., Cosnier, S., & Buzzetti, P. H. M. (2022) · Synthetic Metals · doi:10.1016/j.synthmet.2022.117219 · Cited by 20
Measurement of Flexural Rigidity of Multi-Walled Carbon Nanotubes by Dynamic Scanning Electron Microscopy
Fortini, R., Meyer-Plath, A., Kehren, D., Gernert, U., Jácome, L. A., & Sturm, H. (2020) · Fibers · doi:10.3390/fib8050031 · Cited by 18
Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM)
Brandão, F., Costa, C., Bessa, M. J., Dumortier, E., Debacq‐Chainiaux, F., Hubaux, R., Salmon, M., Laloy, J., Stan, M. S., Hermenean, A. O., et al. (2021) · Nanomaterials · doi:10.3390/nano11061502 · Cited by 16
NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities
Buitrago, E., Novello, A. M., Petri‐Fink, A., Riediker, M., Rothen‐Rutishauser, B., & Meyer, T. (2021) · Nanomaterials · doi:10.3390/nano11102768 · Cited by 16
Release and toxicity assessment of carbon nanomaterial reinforced polymers during the use and end-of-life phases: A comparative review
Romeo, D., Clement, P., & Wick, P. (2023) · NanoImpact · doi:10.1016/j.impact.2023.100477 · Cited by 15
Meta‐Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies
Dumit, V. I., Liu, Y., Bahl, A., Kohonen, P. J., Grafström, R. C., Nymark, P. E. H., Müller‐Graf, C., Haase, A., & Pink, M. (2023) · Advanced Science · doi:10.1002/advs.202306268 · Cited by 15
Chemical degradation kinetics for two-dimensional materials in natural and biological environments – a data-driven review
Shukla, V., Stone, A., McGrath, M., Kane, A. B., & Hurt, R. H. (2022) · Environmental Science Nano · doi:10.1039/d1en01171e · Cited by 14
Self-citation
Fiber biodurability and biopersistence: historical toxicological perspective of synthetic vitreous fibers (SVFs), the long fiber paradigm, and implications for advanced materials
Madl, A. K., & O’Neill, H. C. (2022) · Critical Reviews in Toxicology · doi:10.1080/10408444.2022.2154636 · Cited by 14
Acoustic performance of epoxy-based composites incorporating fluorescent single-walled carbon nanotubes
Wulf, V., Hung, A. P.-Y., Hendler‐Neumark, A., Li, W., Shamis, O., Gozin, M., Huang, X., Lau, K.-T., & Bisker, G. (2023) · Composites Part A Applied Science and Manufacturing · doi:10.1016/j.compositesa.2023.107667 · Cited by 12
Carbon Nanotubes under Scrutiny: Their Toxicity and Utility in Mesothelioma Research
Orsi, M., Hatem, C. A., Leinardi, R., & Huaux, F. (2020) · Applied Sciences · doi:10.3390/app10134513 · Cited by 13
Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer
Tang, L. M., Yang, X. Y., He, L., Zhu, C., & Chen, Q. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02429-x · Cited by 12
A Practicable Measurement Strategy for Compliance Checking Number Concentrations of Airborne Nano- and Microscale Fibers
Meyer‐Plath, A., Bäger, D., Dziurowitz, N., Perseke, D., Simonow, B. K., Thim, C., Wenzlaff, D., & Plitzko, S. (2020) · Atmosphere · doi:10.3390/atmos11111254 · Cited by 11
Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species
Okazaki, Y. (2021) · Pathology International · doi:10.1111/pin.13196 · Cited by 11
Current causes of mesothelioma: how has the asbestos ban changed the perspective?
Janošíková, M., Nakládalová, M., & Štěpánek, L. (2023) · Biomedical Papers · doi:10.5507/bp.2023.008 · Cited by 9
Epigenetic Mechanisms in Understanding Nanomaterial-Induced Toxicity
Ghosh, M., Godderis, L., & Hoet, P. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-88071-2_9 · Cited by 9
Biocompatibility, Toxicity, and Immunological Effects of Functionalized Carbon Nanostructures
Aktürk, Ö. (2024) · Springer eBooks · doi:10.1007/978-3-031-32150-4_73 · Cited by 9
Aqueous mechano-bactericidal action of acicular aragonite crystals
Negishi, N., Inaba, T., Miyazaki, Y., Ishii, G., Yang, Y., & Koura, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-98797-w · Cited by 8
Recent Advances in the Local Drug Delivery Systems for Improvement of Anticancer Therapy
Arora, S., Singh, D. P., Kaur, P., Attri, S., Singh, S., Sharma, P., Mohana, P., Kaur, K., Kaur, H., Singh, G., et al. (2021) · Current Drug Delivery · doi:10.2174/1567201818666211214112710 · Cited by 8
Workplace Emissions and Exposures During Semiconductor Nanowire Production, Post-production, and Maintenance Work
Isaxon, C., Lovén, K., Ludvigsson, L., Sivakumar, S., Gudmundsson, A., Messing, M. E., Pagels, J., & Hedmer, M. (2019) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxz088 · Cited by 8
Comparison of proinflammatory potential of needle-shaped materials: aragonite and potassium titanate whisker
Horie, M., Tabei, Y., Sugino, S., Eguchi, K., Chiba, R., & Tajika, M. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02556-w · Cited by 7
The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products
Huynh, M. T., Veyan, J.-F., Pham, H., Rahman, R., Yousuf, S., Brown, A., Lin, J., Balkus, K. J., Diwakara, S. D., Smaldone, R. A., et al. (2020) · Nanomaterials · doi:10.3390/nano10101930 · Cited by 7
An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis
Pantzke, J., Offer, S., Zimmermann, E. J., Kuhn, E., Streibel, T., Oeder, S., Bucchianico, S. D., & Zimmermann, R. (2022) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2022.2156008 · Cited by 7
Malignant Mesothelioma: Mechanism of Carcinogenesis
Kane, A. B., Jean, D., Knuutila, S., & Jaurand, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-30766-0_19 · Cited by 7
Self-citation
The empirical metric of mesothelial carcinogenicity for carbon nanotubes and elongate mineral particles
Korchevskiy, A. A., & Wylie, A. G. (2025) · Inhalation Toxicology · doi:10.1080/08958378.2025.2486087 · Cited by 6
On the interaction between carbon nanomaterials and lipid biomembranes
Atilhan, M., da Costa, L. T., & Aparício, S. (2019) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2019.111714 · Cited by 6
Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling
Stobernack, T., Vennemann, A., Broßell, D., Gräb, O., Pink, M., Haase, A., Wiemann, M., & Dumit, V. I. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102812 · Cited by 5
Expanded “popcorn” graphite bioelectrocatalytic electrode materials for glucose/O2 biofuel cells: A cost-efficient alternative to nanostructured carbons
Buzzetti, P. H. M., Mohanty, A., Armand, P., Gross, A. J., Nédellec, Y., & Holzinger, M. (2025) · Carbon · doi:10.1016/j.carbon.2025.120691 · Cited by 5
Towards a harmonized testing strategy for nanofibers by integrating toxicological screening and proteomic profiling
Ledwith, R., Dumit, V. I., Stobernack, T., Alcolea-Rodriguez, V., Bergert, A., Wittke, D., Haase, A., & Pink, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-15423-9 · Cited by 6
Biocompatibility, Toxicity, and Immunological Effects of Functionalized Carbon Nanostructures
Aktürk, Ö. (2023) · Springer eBooks · doi:10.1007/978-3-031-14955-9_73-1 · Cited by 5
Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test
Hojo, M., Maeno, A., Sakamoto, Y., Yamamoto, Y., Taquahashi, Y., Hirose, A., Suzuki, J., Inomata, A., & Nakae, D. (2023) · Nanomaterials · doi:10.3390/nano13142105 · Cited by 5
Catch me if you can: biodegradation of nanomaterials and advanced materials
More, P. R., Gohel, V., Kaur, J., & Fadeel, B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152529 · Cited by 4
Asbestos-related Cancer: Exaggerated Risk Perception
Jargin, S. V. (2023) · Cancer Screening and Prevention · doi:10.14218/csp.2022.00028 · Cited by 4
Four Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma
Xie, D., Hu, J., Wu, T., Cao, K., & Luo, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s324365 · Cited by 4
Inhalation toxicity of cellulose nanofibrils: A review of key findings and future directions
Fujita, K., & Moriyama, A. (2025) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2025.100913 · Cited by 3
Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials
Saarimäki, L. A., Fratello, M., del Giudice, G., Lieto, E. D., Afantitis, A., Alenius, H. T., Chiavazzo, E., Gulumian, M., Karisola, P., Lynch, I., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c00841 · Cited by 3
Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis
Stobernack, T., Vennemann, A., Ribalta, C., Schendel, J., Gräb, O., Ledwith, R., Pink, M., Haase, A., Wiemann, M., & Dumit, V. I. (2026) · Small · doi:10.1002/smll.202510530 · Cited by 4
Nanobiotechnology modulates neuroinflammation, marking a paradigm shift in intracerebral hemorrhage therapy
Yang, X., Liang, N., Lou, X., Zheng, H., Zhang, W., Huang, B., & Yu, Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126085 · Cited by 3
Causes and Pathogenesis of Malignant Mesothelioma
Gogou, E., Zarogiannis, S. G., Siachpazidou, D. S., Hatzoglou, C., & Gourgoulianis, K. I. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103669 · Cited by 3
Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis
Broßell, D., Meyer-Plath, A., Gräb, O., Heunisch, E., Kämpf, K., Haase, A., & Wiemann, M. (2026) · Particle and Fibre Toxicology · doi:10.1186/s12989-026-00666-9 · Cited by 2
Carbon-Based Nanostructured Bio-Assemblies for Bioelectrochemical Applications
Holzinger, M. (2023) · Biomedical Materials & Devices · doi:10.1007/s44174-023-00109-5 · Cited by 2
Exaggerated Risk Perception of Low-Dose Exposures to Asbestos: Cui Bono?
Jargin, S. V. (2022) · Journal of Surgery · doi:10.13188/2332-4139.1000054 · Cited by 2
Treatment for potency problems with Afrodor 2000.
Baumbusch, F., Papp, G. K., & Kopa, Z. S. (1995) · PubMed · Cited by 2
Involvement of lysosomal proteins in morphology-driven toxicity of (nano)fibers
Ledwith, R., Ribalta, C., Pink, M., Haase, A., & Dumit, V. I. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04503-y · Cited by 1
Evaluation of 1‐dimensional nanomaterials release during electrospinning and thermogravimetric analysis
Daneshvar, F., Hankin, S., Fern, G. J., Chen, H., Zhang, T., Aitken, R. A., & Sue, H. (2021) · Indoor Air · doi:10.1111/ina.12896 · Cited by 1
Mechanisms of the carcinogenicity of nanomaterials
Belitsky, G. A., Игоревич, К. К., Lesovaya, E. A., & Геннадиевна, Я. М. (2022) · Advances in molecular oncology · doi:10.17650/2313-805x-2022-9-4-8-23 · Cited by 1
Toxicology of carbon nanostructures. Part 2. Nanoscale materials based on graphene sheets
Litasova, E. V., Iljin, V. V., Брусина, М. А., & Piotrovskiy, L. B. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf113017 · Cited by 1
Safety of nanomaterials for energy applications
Chetprayoon, P., & Maniratanachote, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821506-7.00014-4 · Cited by 1
Understanding the Variable Drivers of Toxicity for the Broad Class of Carbon Nanotubes and Nanofibers from U.S. Facilities
Fraser, K. (2021) · doi:10.33915/etd.8085 · Cited by 1
Asbestos-Related Diseases and Policies: an UpdatePreprint
Jargin, S. V. (2022) · Preprints.org · doi:10.20944/preprints202207.0400.v1 · Cited by 1
Editorial: Asbestos and disease genomics: is mesothelioma a genomic paradigm?
Jaurand, M., Murphy, F. A., & Felley‐Bosco, E. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1536344 · Cited by 1
Case Study: Health Risks from Asbestos Exposures
Cox, L. A. (2020) · International series in management science/operations research/International series in operations research & management science · doi:10.1007/978-3-030-57358-4_5
Hazards in Filler Use
Wypych, G. (2021) · Elsevier eBooks · doi:10.1016/b978-1-927885-79-6.50023-9
Asbestos-related Lung Diseases: A Brief Update
Jargin, S. V. (2022) · Journal of Inflammatory Diseases · doi:10.32598/jid.26.2.2
Environmental impact and safety of functionalized nanofibers
Gaweł, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99461-3.00012-1
Exaggerated risk perception of asbestos-related diseases: commentary
Jargin, S. V. (2023) · Сибирский научный медицинский журнал · doi:10.18699/ssmj20230201
Nano-objets et environnements naturels et professionnels : nanoparticules, généralités, modèles expérimentaux
Faou, A. L., & Reis, J. (2020) · HAL · doi:10.1016/s1877-7856(20)55007-1
Mineralogical Characteristics and Risk Assessment of Elongate Mineral Particles (EMPs)
Wylie, A. G. (2024) · Wiley eBooks · doi:10.1002/9781119438397.ch1
Nanomaterials and Child Health
Sripada, K. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197662526.003.0038
Role of Nanotechnology in Combating Ischemic Stroke
Medhi, B., & Sidana, P. (2024) · International Journal of Pharmaceutical Sciences and Nanotechnology · doi:10.37285/ijpsn.2024.17.5.1
Nanoparticles and Pulmonary Exposures
Elder, A. C. P., & Stapleton, P. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00184-4
Long-term survival of nonoccupational pleural mesothelioma: a case report and review of the literature
Tobia, L., Tolli, E., Sedile, A. I., Cofini, V., Necozione, S., & Fabiani, L. (2025) · Journal of Medical Case Reports · doi:10.1186/s13256-025-05608-1
Evaluation of Biological Effects of Nanoneedle Calcium Carbonate Crystals Used for Water Treatment
Horie, M., & Negishi, N. (2025) · Environmental Toxicology · doi:10.1002/tox.24578
Acute and subchronic effects of cellulose nanofibers on histological, antioxidant, and acetylcholine responses in the Mediterranean mussel (Mytilus galloprovincialis)
Gürkan, M., Gürkan, S. E., Güneş, B., & Sarıtunç, V. (2025) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2025.118987
Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses
Pulido‐Artola, N., Repullés, J., Rodriguez‐Muñoz, M., Anglada, T., & Genescà, A. (2025) · Small Structures · doi:10.1002/sstr.202500660
Additional file 1 of Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities
Fraser, K., Kodali, V., Yanamala, N. V. K., Birch, M. E., Cena, L. G., Casuccio, G. S., Bunker, K. L., Lersch, T. L., Evans, D. E., Stefaniak, A., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13346932
Асбест и антиасбестовая кампания: медицинские и экономические аспектыPreprint
Яргин, С. (2025) · doi:10.24108/preprints-3113807

Authors: Kane, A. B., Hurt, R. H., & Gao, H.
Affiliations: Brown University (US)
Corresponding author: Kane, Agnes B.
ORCID: Kane, Agnes B.
Hurt, Robert H.
Gao, Huajian
Venue: Toxicology and Applied Pharmacology
Publisher: Elsevier BV
Published: 2018-12
Volume: 361
Pages: 68-80
ISSN: 0041-008X (ISSN-L)
DOI: 10.1016/j.taap.2018.06.027
PMC: PMC6298811
OpenAlex: W2811240367
Cited by: 106
References: 152
Citations by year: 2026: 8 · 2025: 15 · 2024: 5 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 3
FWCI: 9.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 378 d)
Locations: Toxicology and Applied Pharmacology (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (P42 ES013660)
National Science Foundation (CBET-1344097)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords: carbon nanotubes, asbestos fibers, mesothelioma, biopersistence, pulmonary toxicity, metallic nanowires, inhalation exposure
MeSH terms: Animals, Asbestos, Carcinogens, Disease Models, Animal, Humans, Lung Diseases, Occupational Exposure, Nanotechnology, Nanotubes, Carbon, Nanostructures

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The asbestos-carbon nanotube analogy: An update

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks