Risk of Alzheimer's disease with metal concentrations in whole blood and urine: A case–control study using propensity score matching
Abstract
&NA; Environmental exposure to heavy metals is suspected to result in neuropathology damage and cognitive impairment. We aimed to explore the association of Alzheimer's disease (AD) risk with the internal dose of heavy metals by constructing a hospital‐based case‐control study and using propensity‐score‐matching methods. We investigated 170 patients with AD and 264 controls from the Department of Neurology and Family Medicine, China Medical University Hospital in Taiwan. All patients with AD received clinical neuropsychological examination and cognitive‐function assessments, including the mini‐mental status examination and clinical dementia rating scale. We also constructed a propensity‐score‐matched population of 82 patients with AD and 82 controls by matching age, gender, education, and AD‐related comorbidity. Blood levels with cadmium, lead, mercury, selenium, and urinary arsenic profile were measured. Logistic regression models and 95% confidence intervals (CIs) were applied to estimate AD risk. After stratification by respective quartile cutoffs of heavy metals, the AD risk of study participants with high urinary inorganic arsenic (InAs%) or low dimethylarsinic acid (DMA%) significantly increased (p < 0.05), as similarly found in the propensity‐score‐matched population. In addition, people with a low median level of selenium and high median level of InAs%, or/and a low median level of DMA% had approximately two‐ to threefold significant AD risk. Urinary arsenic profiles…
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Some previous studies carried out in vitro and human trials have indicated the role of non-essential heavy metals cadmium, mercury, lead, and arsenic in causing Aβ protein aggregation along with tau hyper phosphorylation.
“Some of the previous studies carried out in vitro and human trials have indicated the role of non-essential heavy metals cadmium (Cd), mercury (Hg), lead (Pb), and arsenic (As) in causing Aβ protein aggregation along with worrisome levels of tau hyper phosphorylation [44].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [44]
Individuals with high arsenic or low dimethylarsinic acid percentage have increased risks of AD.
“Yang et al. (2018) showed increased risks of AD in individuals with high arsenic or low dimethylarsinic acid percentage with a study based on propensity-score match [44].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [44]
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- Authors
- Yang, Y.-W., Liou, S.-H., Hsueh, Y.-M., Lyu, W.-S., Liu, C.-S., Liu, H.-J., Chung, M.-C., Hung, P.-H., & Chung, C.-J.
- Affiliations
- China Medical University (TW)
- National Health Research Institutes (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- China Medical University Hospital (TW)
- Taichung Veterans General Hospital (TW)
- Chia-Yi Christian Hospital (TW)
- Corresponding author
- Chung, Chi-Jung
- ORCID
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 356
- Pages
- 8-14
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2883671654
- Cited by
- 82
- References
- 60
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 9
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ditmanson Medical Foundation Chia-Yi Christian Hospital (R106-001)
- China Medical University Hospital (DMR-105-081)
- Kaohsiung Veterans General Hospital (TCVGH-1073601B)
- China Medical University (CMU-106-S-20)
- Ministry of Science and Technology, Taiwan (104-2314-B-039-015)
- Ministerio de Ciencia y TecnologÃa
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Keywords
- Alzheimer's disease, heavy metal exposure, urinary arsenic, dimethylarsinic acid, inorganic arsenic, selenium, cadmium, lead, mercury, internal dose, cognitive impairment, dementia risk
- MeSH terms
- Mental Status and Dementia Tests, Aged, Aged, 80 and over, Alzheimer Disease, Arsenic, Cognition, Environmental Exposure, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Taiwan, Case-Control Studies, Risk Assessment, Metals, Heavy, Propensity Score
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