Cited by 82Heavy Metal Exposure and ToxicityDementia and Cognitive Impairment ResearchArsenic contamination and mitigation

Risk of Alzheimer's disease with metal concentrations in whole blood and urine: A case–control study using propensity score matching

Yang, Yu-Wan, Liou, Saou-Hsing, Hsueh, Yu-Mei, Lyu, Wun-Sin, Liu, Chiu-Shong, Liu, Huei-Ju, Chung, Mu-Chi, Hung, Peir-Haur +1 more·2018·Toxicology and Applied Pharmacology

Abstract

&NA; Environmental exposure to heavy metals is suspected to result in neuropathology damage and cognitive impairment. We aimed to explore the association of Alzheimer's disease (AD) risk with the internal dose of heavy metals by constructing a hospital‐based case‐control study and using propensity‐score‐matching methods. We investigated 170 patients with AD and 264 controls from the Department of Neurology and Family Medicine, China Medical University Hospital in Taiwan. All patients with AD received clinical neuropsychological examination and cognitive‐function assessments, including the mini‐mental status examination and clinical dementia rating scale. We also constructed a propensity‐score‐matched population of 82 patients with AD and 82 controls by matching age, gender, education, and AD‐related comorbidity. Blood levels with cadmium, lead, mercury, selenium, and urinary arsenic profile were measured. Logistic regression models and 95% confidence intervals (CIs) were applied to estimate AD risk. After stratification by respective quartile cutoffs of heavy metals, the AD risk of study participants with high urinary inorganic arsenic (InAs%) or low dimethylarsinic acid (DMA%) significantly increased (p < 0.05), as similarly found in the propensity‐score‐matched population. In addition, people with a low median level of selenium and high median level of InAs%, or/and a low median level of DMA% had approximately two‐ to threefold significant AD risk. Urinary arsenic profiles…

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Crossref · 10.1016/j.taap.2018.07.015

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  • Some previous studies carried out in vitro and human trials have indicated the role of non-essential heavy metals cadmium, mercury, lead, and arsenic in causing Aβ protein aggregation along with tau hyper phosphorylation.

    “Some of the previous studies carried out in vitro and human trials have indicated the role of non-essential heavy metals cadmium (Cd), mercury (Hg), lead (Pb), and arsenic (As) in causing Aβ protein aggregation along with worrisome levels of tau hyper phosphorylation [44].”
  • Individuals with high arsenic or low dimethylarsinic acid percentage have increased risks of AD.

    “Yang et al. (2018) showed increased risks of AD in individuals with high arsenic or low dimethylarsinic acid percentage with a study based on propensity-score match [44].”

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Authors
Yang, Y.-W., Liou, S.-H., Hsueh, Y.-M., Lyu, W.-S., Liu, C.-S., Liu, H.-J., Chung, M.-C., Hung, P.-H., & Chung, C.-J.
Affiliations
  • China Medical University (TW)
  • National Health Research Institutes (TW)
  • Taipei Medical University-Shuang Ho Hospital (TW)
  • China Medical University Hospital (TW)
  • Taichung Veterans General Hospital (TW)
  • Chia-Yi Christian Hospital (TW)
Corresponding author
Chung, Chi-Jung
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2018-10
Volume
356
Pages
8-14
ISSN
0041-008X (ISSN-L)
OpenAlex
W2883671654
Cited by
82
References
60
Citations by year
2026: 9 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 9
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Locations
  • Toxicology and Applied Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ditmanson Medical Foundation Chia-Yi Christian Hospital (R106-001)
  • China Medical University Hospital (DMR-105-081)
  • Kaohsiung Veterans General Hospital (TCVGH-1073601B)
  • China Medical University (CMU-106-S-20)
  • Ministry of Science and Technology, Taiwan (104-2314-B-039-015)
  • Ministerio de Ciencia y Tecnología
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
Keywords
Alzheimer's disease, heavy metal exposure, urinary arsenic, dimethylarsinic acid, inorganic arsenic, selenium, cadmium, lead, mercury, internal dose, cognitive impairment, dementia risk
MeSH terms
Mental Status and Dementia Tests, Aged, Aged, 80 and over, Alzheimer Disease, Arsenic, Cognition, Environmental Exposure, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Taiwan, Case-Control Studies, Risk Assessment, Metals, Heavy, Propensity Score

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