DNA Damage and Repair in Alzheimers Disease
Abstract
The vast majority of the studies performed so far and aimed at elucidating DNA repair mechanisms has been performed in mitotic cells, such as transformed or cancer cell lines. Therefore, our understanding of DNA repair mechanisms in post-mitotic cells, such as neurons, remains one of the most exciting areas for future investigations. Markers of DNA damage, particularly oxidative DNA damage, have been largely found in brain regions, peripheral tissues, and biological fluids of Alzheimer's disease (AD) patients. Moreover, recent studies from our and other groups in individuals affected by Mild Cognitive Impairment provided evidence that oxidative DNA damage is one of the earliest detectable events within the progression from a normal brain to dementia. Almost one decade ago a decrease in the DNA base excision repair (BER) activity was observed in post mortem brain regions of AD individuals, leading to the hypothesis that the brain in AD might be subjected to the double insult of increased DNA damage, as well as deficiencies of DNA repair pathways. Subsequent studies have provided accumulating evidence of impaired DNA repair in AD. Moreover, functional variants and polymorphisms of DNA repair genes have been the focus of several cancer association studies, but only in recent years some of them have been investigated as possible AD risk factors. The few studies performed so far suggest that some variants might play a role in AD pathogenesis and deserve further investigations. Her…
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Oxidative DNA damage and mitochondrial dysfunction are thought to contribute to neurodegeneration of AD, vascular dementia, HD, PD and epilepsy.
“Oxidative DNA damage and mitochondrial dysfunction are thought to contribute to the neurodegeneration of AD [75,76], vascular dementia [77], HD [78], PD [79] and epilepsy [80].”
From Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease? (2022) · cites this paper as [76]
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- Authors
- Coppede, F., & Migliore, L.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Migliore, Lucia
- ORCID
- Migliore, Lucia
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-02-01
- Volume
- 6
- Issue
- 1
- Pages
- 36-47
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W1558580604
- Cited by
- 148
- References
- 7
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 11
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, DNA damage, DNA repair, oxidative DNA damage, base excision repair, neurons, postmitotic cells, mild cognitive impairment, DNA repair gene polymorphisms, genetic risk factors, AD pathogenesis
- MeSH terms
- Alzheimer Disease, Animals, Cell Nucleus, DNA Damage, DNA Repair, Humans, Nerve Degeneration, Cell Death, Oxidative Stress, Genetic Predisposition to Disease
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