The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Broken nuclei – lamins, nuclear mechanics, and disease
Open accessAbstract
Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of disorders, including muscular dystrophy and dilated cardiomyopathy. Lamins provide nuclear stability, help connect the nucleus to the cytoskeleton, and can modulate chromatin organization and gene expression. Nonetheless, the diverse functions of lamins remain incompletely understood. Here, we focus on the role of lamins on nuclear mechanics and its implication in human diseases. Recent findings suggest that lamin mutations can decrease nuclear stability, increase nuclear fragility, and disturb mechanotransduction signaling, possibly explaining the muscle-specific defects in many laminopathies. At the same time, altered lamin expression has been reported in many cancers, where the resulting increased nuclear deformability could enhance the ability of cells to transit tight interstitial spaces, promoting metastasis.
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Roux, K. J., Kim, D. I., Raida, M., & Burke, B. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112098 · Cited by 2,416
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J.-W., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,991
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
Guelen, L., Pagie, L., Brasset, E., Meuleman, W., Faza, M. B., Talhout, W., Eussen, B. H., de Klein, A., Wessels, L., de Laat, W., et al. (2008) · Nature · doi:10.1038/nature06947 · Cited by 1,953
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Wang, N., Tytell, J. D., & Ingber, D. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,762
Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
Bonne, G., Barletta, M. R. D., Varnous, S., Bécane, H.-M., Hammouda, E.-H., Merlini, L., Muntoni, F., Greenberg, C. R., Gary, F., Urtizberea, J.-A., et al. (1999) · Nature Genetics · doi:10.1038/6799 · Cited by 1,358
Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
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Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19670 · Cited by 1,064
Self-citationMolecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation
Peric-Hupkes, D., Meuleman, W., Pagie, L., Bruggeman, S. W. M., Solovei, I., Brugman, W., Gräf, S., Flicek, P., Kerkhoven, R. M., van Lohuizen, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.016 · Cited by 1,050
The nuclear lamina is a meshwork of intermediate-type filaments
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The AIM 2 inflammasome: Sensor of pathogens and cellular perturbations
Lugrin, J., & Martinon, F. (2018) · Immunological Reviews · doi:10.1111/imr.12618 · Cited by 333
Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments
Davidson, P. M., Denais, C., Bakshi, M. C., & Lammerding, J. (2014) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-014-0342-y · Cited by 318
Self-citationAIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
Di Micco, A., Frera, G., Lugrin, J., Jamilloux, Y., Hsu, E.-T., Tardivel, A., De Gassart, A., Zaffalon, L., Bujisic, B., Siegert, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602419113 · Cited by 143
Tillery, M. M. L., Zheng, C., Zheng, Y., & Megraw, T. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-06-0245 · Cited by 9
Metadata
- Authors
- Davidson, P. M., & Lammerding, J.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 24
- Issue
- 4
- Pages
- 247-256
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W1999646178
- Cited by
- 268
- References
- 105
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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