AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
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Significance: Inflammasomes are cellular sensors of harmful situations such as the presence of microbes or alterations in cellular homeostasis. Upon activation, inflammasomes trigger the proteolytic maturation and release of inflammatory cytokines to initiate immune and repair responses. The assembly of inflammasome relies on a diverse repertoire of sensor proteins that can detect specific stimuli. For example, the AIM2 inflammasome is activated by the presence of microbial DNA within the cytosol. In this paper, alterations of the nuclear envelope integrity are found to cause the exposure of nuclear DNA in the cytosol to promote the activation of the AIM2 inflammasome. Nuclear envelope stress can therefore directly engage innate immune sensors to elicit inflammation.
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CytoDNA species share similar signaling pathways, most prominently the cGAS-STING pathway, although mtDNA, MN, and other DNA damage-associated DNA fragments are thought to also activate the AIM2 and NLRP3 inflammasome pathway.
“Third, cytoDNA species share similar signaling pathways, most prominently the cGAS-STING pathway, although mtDNA, MN, and other DNA damage-associated DNA fragments are thought to also activate the AIM2 and NLRP3 inflammasome pathway (Di Micco et al., 2016; Motwani and Fitzgerald, 2017; Zhong et al., 2018).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Di Micco et al., 2016
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- Authors
- Di Micco, A., Frera, G., Lugrin, J., Jamilloux, Y., Hsu, E.-T., Tardivel, A., De Gassart, A., Zaffalon, L., Bujisic, B., Siegert, S., Quadroni, M., Broz, P., Henry, T., Hrycyna, C. A., & Martinon, F.
- Affiliations
- Department of Biochemistry, University of Lausanne, Epalinges 1066, Switzerland;
- University of Lausanne (CH)
- Inserm (FR)
- Purdue University West Lafayette (US)
- Focal Area Infection Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-07-26
- Volume
- 113
- Issue
- 32
- Pages
- E4671-80
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4987819
- OpenAlex
- W2477702703
- Cited by
- 143
- References
- 82
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 18 · 2023: 11 · 2022: 18 · 2021: 21 · 2020: 15 · 2019: 16 · 2018: 15 · 2017: 15
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- HAL (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- EC | European Research Council (281996)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- AIM2 inflammasome, nelfinavir, nuclear envelope integrity, cytosolic DNA sensing, IL-1β, IL-1 signaling, HIV protease inhibitors, inflammasome activation
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, DNA, Mice, Inbred C57BL, Nuclear Envelope, Receptors, Interleukin-1, Nelfinavir, Caspase 1, Mice, CARD Signaling Adaptor Proteins, Interleukin-1beta, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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