NAD+ and sirtuins in aging and disease
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- Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?Borut Poljšak, Vito Kovač, Irina Milisav · 2020 · Oxidative Medicine and Cellular Longevity
- Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administrationRuin Moaddel, Panos Zanos, Cristan Farmer, Bashkim Kadriu, Patrick J. Morris, Jacqueline Lovett, Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Peixiong Yuan, Mani Yavi et al. · 2022 · Translational Psychiatry
- TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activityHarshad S. Ugamraj, Kevin H. Dang, Laure‐Hélène Ouisse, Benjamin Buelow, Eduardo N. Chini, Giulia Castello, James Allison, Starlynn Clarke, Laura M. Davison, Roland Buelow et al. · 2022 · mAbs
- Oxidative stress impairs the Nur77‐Sirt1 axis resulting in a decline in organism homeostasis during agingYang Yu, Xiaoyu Song, Guojing Ma, Lixia Zheng, Xiaoxun Wang, Feng Chen, Tingting Liu, Huanlian Tian, Yingxi Xu, Danni Li et al. · 2023 · Aging Cell
- Visualization of Nicotine Adenine Dinucleotide Redox Homeostasis with Genetically Encoded Fluorescent SensorsYuzheng Zhao, Zhuo Zhang, Yejun Zou, Yi An Yang · 2017 · Antioxidants and Redox Signaling
- Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?Anna Wnuk, Aleksandra Stangret, Mateusz Wątroba, Anna Edyta Platek, Marta Skoda, Krzysztof Cendrowski, Włodzimierz Sawicki, Dariusz Szukiewicz · 2020 · Obesity Reviews
- Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasisXinxin Wang, Guang-Hui Mao, Qiqi Li, Jie Tang, Hua Zhang, Kang-Lin Wang, Lei Wang, Hong Ni, Rui Sheng, Zheng‐Hong Qin · 2023 · Frontiers in Pharmacology
- The immunometabolic reprogramming of microglia in Alzheimerʼs diseaseHongli Chen, Zichen Guo, Yaxuan Sun, Xueling Dai · 2023 · Neurochemistry International
- Application of omics in the diagnosis, prognosis, and treatment of acute myeloid leukemiaZhiyu Zhang, Jiayi Huang, Zhibo Zhang, Hongjie Shen, Xiaowen Tang, Depei Wu, Xiebing Bao, Guoqiang Xu, Suning Chen · 2024 · Biomarker Research
- Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle ChangesLuca Pangrazzi, Andreas Meryk · 2024 · Biology
- Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challengesAnna Hernández‐Aguilera, Salvador Fernández‐Arroyo, Elisabet Cuyàs, Fedra Luciano‐Mateo, Noemí Cabré, Jordi Camps, José López‐Miranda, Javier Abel Menéndez, Jorge Joven · 2016 · Food and Chemical Toxicology
- Silencing forkhead box M1 promotes apoptosis and autophagy through SIRT7/mTOR/IGF2 pathway in gastric cancer cellsWei Yu, Xiaofeng Cui, Zhongyi Wan, Yanhui Yu, Xiumin Liu, Lifang Jin · 2018 · Journal of Cellular Biochemistry
- Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosisSadiya Bi Shaikh, Ashwini Prabhu, Yashodhar P. Bhandary · 2018 · Journal of Cellular Biochemistry
- Therapeutic potential of nicotinamide adenine dinucleotide (NAD)Marta Arenas‐Jal, Josep Maria Suñé-Negre, Encarna García‐Montoya · 2020 · European Journal of Pharmacology
- Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse modelAlpna Tyagi, Carol Mirita, Nadine Taher, Iman Shah, Emily Moeller, Anit Tyagi, Thomas Chong, Subbiah Pugazhenthi · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategyMukesh Gautam, Aksu Günay, Navdeep S. Chandel, P. Hande Özdinler · 2022 · Scientific Reports
- Redox Homeostasis in Cardiovascular Disease: The Role of Mitochondrial SirtuinsAlberto Zullo, Rosa Guida, Rosaria Sciarrillo, Francesco Paolo Mancini · 2022 · Frontiers in Endocrinology
- Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF‐κB activation through upregulating sirtuin 7 in dental pulp fibroblastsXiaochen Liu, Chunmeng Wang, Liping Pang, Liangliang Pan, Qi Zhang · 2022 · Cell Proliferation
- Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+Kiira M Ratia, Zhengnan Shen, Jesse M. Gordon-Blake, Hyun Lee, Megan S. Laham, Isabella S. Krider, Nicholas Christie, Martha S Ackerman-Berrier, Christopher Penton, Natalie G. Knowles et al. · 2023 · Biochemistry
- Alterations of SIRT1 / SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusionJingwen Zhang, Hao Wang, Lily A. Slotabec, Feng Cheng, Yi Tan, Ji Li · 2023 · Aging Cell
- The circadian clock in adult neural stem cell maintenanceSwip Draijer, Inês Chaves, Marco F.M. Hoekman · 2018 · Progress in Neurobiology
- Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese MiceEun Roh, Gil Myoung Kang, So Young Gil, Chan Hee Lee, Seongjun Kim, Hong Dugu, Gi Hoon Son, Min‐Seon Kim · 2018 · Obesity
- Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and DiseaseTinka Vidović, Collin Y. Ewald · 2022 · Frontiers in Aging
- Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algaeCarlos Terriente-Palacios, Susana Rubiño, María Hortos, César Peteiro, Massimo Castellari · 2022 · Scientific Reports
- The impact of aging on liver health and the development of liver diseasesSha Neisha Williams, Wen‐Xing Ding · 2025 · Hepatology Communications
- The NAD + precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiationKathrin Weidele, Sascha Beneke, Alexander Bürkle · 2017 · DNA repair
- Mitochondrial Metabolism and Aging in YeastGiacomo Baccolo, Giulia Stamerra, Damiano Pellegrino-Coppola, Ivan Orlandi, Marina Vai · 2018 · International review of cytology
- Aging Kidney and Aging-Related DiseaseZhongchi Li, Zhao Wang · 2018 · Advances in experimental medicine and biology
- Acute sources of mitochondrial NAD+ during respiratory chain dysfunctionChristos Chinopoulos · 2020 · Experimental Neurology
- Hypothalamic NAD+-Sirtuin Axis: Function and RegulationEun Roh, Min‐Seon Kim · 2020 · Biomolecules
- Aging and leukemic evolution of hematopoietic stem cells under various stress conditionsShuhei Kurosawa, Atsushi Iwama · 2020 · Inflammation and Regeneration
- Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of SirtuinsXin Zhen, Shao-Wu Zhang, Feifei Xie, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Jing Nie · 2021 · Kidney Diseases
- Mitochondrial sirtuins in stem cells and cancerAmit Jaiswal, Zhu Xudong, Zhenyu Ju, Gabriele Christine Saretzki · 2021 · FEBS Journal
- NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in miceHyun-Woo Kim, Ga-Hee Ryoo, Hyun‐Young Jang, So‐Young Rah, Dong Hyun Lee, Do‐Kyun Kim, Eun Ju Bae, Byung‐Hyun Park · 2022 · Theranostics
- Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and FibrosisHaoxiang Xiao, Yuqiao Xie, Kaiwen Xi, Jinyi Xie, Mingyue Liu, Yangming Zhang, Zishuo Cheng, Wenting Wang, Baolin Guo, Shengxi Wu · 2023 · Aging and Disease
- Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicityCristiana O’Brien, Tianyi Ling, Jacob M. Berman, Rachel Culp‐Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan R. St‐Germain, Vinitha Macwan, Audrey Astori et al. · 2023 · Haematologica
- A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic ApproachesMina Iskandar, Miguel Xiao Barbero, Mohammed Tariq Jaber, Roy Chen, Romulo Gomez-Guevara, Edwin Cruz, Sandy D. Westerheide · 2025 · Cancers
- NAD depletion in skeletal muscle does not compromise muscle function or accelerate agingSabina Chubanava, Iuliia E. Karavaeva, Amy M. Ehrlich, Roger M. Justicia, Astrid Linde Basse, Ivan Kulik, Emilie Dalbram, Danial Ahwazi, Samuel R. Heaselgrave, Kajetan Trôst et al. · 2025 · Cell Metabolism
- Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insightsLi Zhang, Yang Yang, Yanchu Li, Chenyu Wang, Chenbin Bian, Hongbin Wang, Feng Wang · 2025 · Biomarker Research
- Associations among Metabolism, Circadian Rhythm and Age-Associated DiseasesYiwei Cao, Rui-Hong Wang · 2017 · Aging and Disease
- Nicotinamide N -Methyltransferase in Health and CancerDavid Boyer Ramsden, Rosemary H. Waring, David J. Barlow, Richard B. Parsons · 2017 · International Journal of Tryptophan Research
- Two Different Methods of Quantification of Oxidized Nicotinamide Adenine Dinucleotide (NAD+) and Reduced Nicotinamide Adenine Dinucleotide (NADH) Intracellular Levels: Enzymatic Coupled Cycling Assay and Ultra-performance Liquid Chromatography (UPLC)-Mass SpectrometryKarina S. Kanamori, Guilherme C. de Oliveira, Maria Auxiliadora‐Martins, Renee A. Schoon, Joel M. Reid, Eduardo N. Chini · 2018 · BIO-PROTOCOL
- Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsisXianfeng Wang, Nancy L. Buechler, David L. Long, Cristina M. Furdui, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani · 2018 · Inflammation
- Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other MalignanciesSarwat Chowdhury, Smitha P. Sripathy, Alyssa A. Webster, Angela Park, Uyen Lao, Joanne H. Hsu, Taylor K. Loe, Antonio Bedalov, Julian A. Simon · 2020 · Molecules
- The mitohormetic response as part of the cytoprotection mechanism of berberineXiaofei Zhu, Yihui Wei, Beibei Yang, Xiaoxiao Yin, Xiaofang Guo · 2020 · Molecular Medicine
- Sirtuin activation targets IDH-mutant tumorsJulie J. Miller, Alexandria L. Fink, Jack A Banagis, Hiroaki Nagashima, Megha P. Subramanian, Christine Kyuyoung Lee, Lisa Melamed, Shilpa S. Tummala, Kensuke Tateishi, Hiroaki Wakimoto et al. · 2020 · Neuro-Oncology
- Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical RelevanceMichał Ciebiera, Mohamed K. Ali, Magdalena Zgliczyńska, Maciej Skrzypczak, Ayman A. Al-Hendy · 2020 · International Journal of Molecular Sciences
- Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medicationsBarış Afşar, Mads Hornum, Rengin Elsürer Afşar, Lale A. Ertuğlu, Alberto Ortíz, Adrian Constantin Covic, Daniël H. van Raalte, David Z.I. Cherney, Mehmet Kanbay · 2021 · Mitochondrion
- The Interplay Between Autophagy and Senescence in Anthracycline CardiotoxicityMichele Russo, Enrico Bono, Alessandra Ghigo · 2021 · Current Heart Failure Reports
- HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsisJan Andersson, Huan Yang · 2022 · Journal of Intensive Medicine
- Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial DiseasesJuan Miguel Suarez-Rivero, Carmen J. Pastor‐Maldonado, Ana Romero-González, David Gómez-Fernández, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza et al. · 2022 · Frontiers in Pharmacology
- Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide TreatmentJ. Ok, Seon Beom Song, Eun Seong Hwang · 2018 · International Journal of Stem Cells
- CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia ConditionsXingyue Zhang, Lingfei Li, Qiong Zhang, Qinglin Wei, Jiezhi Lin, Jiezhi Jia, Junhui Zhang, Tiantian Yan, Yanling Lv, Xupin Jiang et al. · 2020 · Frontiers in Cell and Developmental Biology
- Insights into the Conserved Regulatory Mechanisms of Human and Yeast AgingRashmi Dahiya, Taj Mohammad, Mohamed Fahad Alajmi, Md Tabish Rehman, Gulam Mustafa Hasan, Afzal Hussain, Md. Imtaiyaz Hassan · 2020 · Biomolecules
- Senescence‐Targeted and NAD + ‐Dependent SIRT1‐Activated Nanoplatform to Counteract Stem Cell Senescence for Promoting Aged Bone RegenerationYing Wang, Fangru Xie, Zirui He, Lingbin Che, Xi Chen, Yuan Yuan, Changsheng Liu · 2023 · Small
- Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and DeathVelma Ganga Reddy, Isabella S. Krider, Erick T. M. Alves, Jenna M. Courey, Megan S. Laham, Gregory R. J. Thatcher · 2024 · Journal of Medicinal Chemistry
- Advancements in NMN biotherapy and research updates in the field of digestive system diseasesGuanyi Liao, Yuchen Xie, Hong Peng, Tianke Li, Xinsen Zou, Faguo Yue, Jinjun Guo, Li Rong · 2024 · Journal of Translational Medicine
- Physiologic Mechanical Stress Directly Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt-Related Transcription Factor 2 (Runx2)Shu Somemura, Takanori Kumai, Kanaka Yatabe, Chizuko Sasaki, Hiroto Fujiya, Hisateru Niki, Kazuo Yudoh · 2021 · International Journal of Molecular Sciences
- NAD+ Metabolism and Diseases with Motor DysfunctionSamuel Lundt, Shinghua Ding · 2021 · Genes
- Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stressMeijie Song, Yu Li, Yihang Zhou, Jiner Yan, Xiaohua Zhou, Qian Gao, Yilong Miao, Bo Xiong · 2022 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosisMin Zhang, Xiang Xue, Zhenshuai Lou, Yanhong Lin, Qian Li, Changbao Huang · 2024 · Journal of Translational Medicine
- Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent MannerReiko Sanokawa‐Akakura, Shin Akakura, SIAMAK S. TABIBZADEH · 2016 · PLoS ONE
- Aging: A cell source limiting factor in tissue engineeringMohammadhossein Khorraminejad‐Shirazi, Mohammadreza Dorvash, AliReza Estedlal, Amir Human Hoveidaei, Mohsen Mazloomrezaei, Pouria Mosaddeghi · 2019 · World Journal of Stem Cells
- Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1Nobuaki Miyaji, Kyohei K. Nishida, Toshikazu Tanaka, Daisuke Araki, Noriyuki Kanzaki, Yuichi Y. Hoshino, Ryosuke Kuroda, Takehiko Matsushita · 2020 · Cartilage
- Mitochondrial quality control: the real dawn of intervertebral disc degeneration?Ba Qiu, Xiaoxing Xie, Yanhai Xi · 2024 · Journal of Translational Medicine
- Roles of SIRT3 in aging and aging-related diseasesYuzi You, Zhong Wang · 2025 · International Journal of Biological Sciences
- Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT 1 activity and antioxidant gene expression in mouse cellsFiqri Dizar Khaidizar, Yasukazu Nakahata, Akira Kume, Kyosuke Sumizawa, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho · 2017 · Genes to Cells
- Resveratrol attenuates excessive ethanol exposure-induced β-cell senescence in rats: A critical role for the NAD+/SIRT1-p38MAPK/p16 pathwayGang Luo, Lin Xiao, Dongxia Wang, Ning Wang, Can Luo, Xuefeng Yang, Liping Hao · 2020 · The Journal of Nutritional Biochemistry
- Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian OscillationAtsushige Ashimori, Yasukazu Nakahata, Toshiya Sato, Yuichiro Fukamizu, Takaaki Matsui, Hikari Yoshitane, Yoshitaka Fukada, Kazuyuki Shinohara, Yasumasa Bessho · 2021 · Frontiers in Neuroscience
- Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogrammingElisabetta Mormone, Eugenio Luigi Iorio, Lucrezia Abate, Carlo Rodolfo · 2023 · Frontiers in Neuroscience
- Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegansWenqing Wang, Melanie R. McReynolds, Jimmy F. Goncalves, Muya Shu, Ineke Dhondt, Bart P. Braeckman, Stephanie E. Lange, Kelvin Kho, Ariana C. Detwiler, Marisa J. Pacella et al. · 2015 · Journal of Biological Chemistry
- Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASHKimberley D. Bruce, Dawid Szczepankiewicz, Kiran K. Sihota, Manoj Ravindraanandan, Hugh Thomas, Karen A. Lillycrop, Graham C. Burdge, Mark A. Hanson, Christopher D. Byrne, Felino Ramon A. Cagampang · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotypeAiden Eblimit, Smriti Agrawal Zaneveld, Wei Liu, Kandace Thomas, Keqing Wang, Yumei Li, Graeme Mardon, Rui Chen · 2018 · Experimental Eye Research
- The evolutionary tug-of-war of macrophage metabolism during bacterial infectionLuís Almeida, Ayesha Dhillon-LaBrooy, Tim D. Sparwasser · 2023 · Trends in Endocrinology and Metabolism
- Targeting NAD+ Metabolism to Modulate Autoimmunity and InflammationJing Wu, Kim Han, Michael N. Sack · 2024 · The Journal of Immunology
- 15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxiaFujun Li, Yanqiu You, Hui Fang Zhu · 2018 · Biomedicine & Pharmacotherapy
- Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in MammalsVeronika Kulikova, Andrey A. Nikiforov · 2020 · Biochemistry (Moscow)
- Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cellsJun Wang, Xi Liu, Yuanfeng Huang, Pan Li, Minqiang Yang, Shanshan Zeng, Danyang Chen, Qian Wang, Hao Liu, Kai Luo et al. · 2022 · Cell Death Discovery
- Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary diseaseMyungkyung Noh, Jeong Yeon Sim, Jisung Kim, Jee Hwan Ahn, Hye‐Young Min, Jong-Uk Lee, Jong-Sook Park, Ji Yun Jeong, Jae Young Lee, Shin Yup Lee et al. · 2023 · Journal of Hazardous Materials
- Reduced Ssy1-Ptr3-Ssy5 (SPS) Signaling Extends Replicative Life Span by Enhancing NAD+ Homeostasis in Saccharomyces cerevisiaeFelicia A. Tsang, Christol James, Michiko Kato, Victoria Myers, Irtqa Ilyas, Matthew Tsang, Su-Ju Lin · 2015 · Journal of Biological Chemistry
- The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic targetLydia Brandl, Nina Kirstein, Jens H. L. Neumann, Andrea Sendelhofert, Michael W. Vieth, Thomas Kirchner, Antje Menssen · 2018 · Medical Oncology
- miRNA expression profiling uncovers a role of miR‐302b‐3p in regulating skin fibroblasts senescenceJingyong Tan, Longyuan Hu, Xin Yang, Xin Zhang, Canshen Wei, Qing Lü, Zhilin Chen, Jing Li · 2019 · Journal of Cellular Biochemistry
- Metabolic Intermediates in Tumorigenesis and ProgressionYuchen He, Menghui Gao, Haosheng Tang, Yiqu Cao, Shuang Liu, Yongguang Tao · 2019 · International Journal of Biological Sciences
- Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 PathwayHui Gong, Chenyi Zheng, Xing Lyu, Lini Dong, Shengyu Tan, Xiangyu Zhang · 2021 · Frontiers in Pharmacology
- SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-β/smad signaling pathwayYu Xia, Qihui Luo, Qi Gao, Chao Huang, Ping Chen, Yao Zou, Xiwen Chen, Wentao Liu, Zhengli Chen · 2024 · Chemico-Biological Interactions
- Targeting immunosenescence for improved tumor immunotherapyZaoqu Liu, Lulu Zuo, Zhaokai Zhou, Shutong Liu, Yuhao Ba, Anning Zuo, Yuqing Ren, Chuhan Zhang, Yukang Chen, Hongxuan Ma et al. · 2024 · MedComm
- Mesenchymal Stem Cell Senescence and OsteogenesisArtaria Tjempakasari, Heri Suroto, Djoko Santoso · 2021 · Medicina
- Mitochondrial respiratory quiescence: A new model for examining the role of mitochondrial metabolism in developmentHelin Hocaoglu, Matthew Sieber · 2022 · Seminars in Cell and Developmental Biology
- Fatty acids derived from apoptotic chondrocytes fuel macrophages FAO through MSR1 for facilitating BMSCs osteogenic differentiationZiyang Zheng, Tao Jiang, Zhenfei Huang, Bo Chu, Jun Gu, Xuan Zhao, Hao Liu, Jin Fan, Lipeng Yu, Shu‐Heng Jiang et al. · 2022 · Redox Biology
- Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related DiseasesCátia Sousa, Alexandrina Ferreira Mendes · 2022 · Biomolecules
- NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7Xiaotong Zhao, Manman Zhang, Jinhan Wang, Kaihua Ji, Yan Wang, Xiaohui Sun, Chang Xu, Qin Wang, Ningning He, Huijuan Song et al. · 2022 · Free Radical Biology and Medicine
- Nicotinamide mononucleotide restores oxidative stress‐related apoptosis of oocyte exposed to benzyl butyl phthalate in miceYi Jiang, Di Wang, Cheng Zhang, Yangyang Jiao, Yanan Pu, Rong Cheng, Chunyu Li, Yan Chen · 2023 · Cell Proliferation
- The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging PathomechanismsAdrianna Dzidek, Olga Czerwińska‐Ledwig, Małgorzata Żychowska, Wanda Pilch, Anna Piotrowska · 2023 · International Journal of Molecular Sciences
- Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese menShintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui et al. · 2024 · Endocrine Journal
- Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging MoleculesSurinder Kumar, David B. Lombard · 2016 · F1000Research
- NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own WayBorut Poljšak · 2017 · Rejuvenation Research
- A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiaeTrevor Croft, Christol James Theoga Raj, Michelle Salemi, Brett S. Phinney, Su-Ju Lin · 2018 · Journal of Biological Chemistry
- Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased BrainHansruedi Büeler · 2021 · International Journal of Molecular Sciences
- Early loss of endogenous NAD + following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibitionAnkita Sarkar, Sourav Dutta, Malinki Sur, Semanti Chakraborty, Puja Dey, Piyali Mukherjee · 2022 · FEBS Journal
- Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathwayYan Chang, Biyan He, Chenjun Wang, Wanzhen Li, Siming Tao, Jingqing Chen, Yuquan Wang, Ling Yang, Yingjie Wu, Zhenlong Wu et al. · 2025 · Critical Reviews in Food Science and Nutrition