NAD+ and sirtuins in aging and disease

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482

Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model

Weng, H., Song, W., Fu, K., Guan, Y., Cai, G., Huang, E., Chen, X., Zou, H., & Ye, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1035444 · Cited by 13

Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes

Imi, Y., Amano, R., Kasahara, N., Obana, Y., & Hosooka, T. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101476 · Cited by 13

Litopenaeus vannamei sirtuin 6 homolog (LvSIRT6) is involved in immune response by modulating hemocytes ROS production and apoptosis

Nie, J., Yu, Z., Yao, D., Wang, F., Zhu, C., Sun, K., Aweya, J. J., & Zhang, Y. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.01.029 · Cited by 13

NAD(H) Regulates the Permeability Transition Pore in Mitochondria through an External Site

Kharechkina, E. S., Nikiforova, A. B., & Kruglov, A. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168560 · Cited by 13

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Balistreri, C. R., Madonna, R., & Ferdinandy, P. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100027 · Cited by 12

BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin

Ni, F.-D., Wang, F., Li, J., Liu, Y., Sun, X., Chen, J., Li, J., Zhang, Y., Jin, J., Ye, X., et al. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad168 · Cited by 12

Molecular mechanisms involved in hyperglycemia-induced cellular damage

Pardina, E., Tondo, M., Escolá‐Gil, J. C., Rossell, J., & Julve, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-88426-6.00012-9 · Cited by 12

Podocyte senescence: from molecular mechanisms to therapeutics

Zhao, Q., Huang, Y., Fu, N., Cui, C., Peng, X., Kang, H., Xiao, J., & Ke, G. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2398712 · Cited by 12

NAD + depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia

Jahan, F., Vasam, G., Cariaco, Y., Nik-Akhtar, A., Green, A. E., Menzies, K. J., & Bainbridge, S. A. (2024) · Life Science Alliance · doi:10.26508/lsa.202302505 · Cited by 12

rhCC16 Suppresses Cellular Senescence and Ameliorates COPD‐Like Symptoms by Activating the AMPK/Sirt1‐PGC‐1‐α‐TFAM Pathway to Promote Mitochondrial Function

Ren, Y., Sun, T., Yu, L., Liu, D., Gao, R., Li, T., Guo, M., Liu, Q., Wang, H.-L., & Pang, M. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70566 · Cited by 13

Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa

Gaur, U., Tu, J., Li, D., Gao, Y., Lian, T., Sun, B., Yang, D., Fan, X., & Yang, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182306 · Cited by 12

Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders

Helman, T. J., & Braidy, N. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00989-0 · Cited by 13

Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo

Wang, J., Sun, R., Xia, L., Zhu, X., Zhang, Q., & Ye, Y. (2022) · Brain Sciences · doi:10.3390/brainsci12121699 · Cited by 14

E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide

Lee, S. H., Lee, Y. J., Jung, S., & Chung, K. C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102909 · Cited by 12

Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders

Bresque, M., Esteve, D., Pehar, M., & Vargas, M. R. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0241 · Cited by 13

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Peinado, P. J., & Urbach, A. (2023) · Cells · doi:10.3390/cells12162086 · Cited by 13

Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration

Berner, A., & Kleinman, M. E. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_6 · Cited by 12

A variant in SIRT2 gene 3′-UTR is associated with susceptibility to colorectal cancer

Yang, Y., Ding, J., Gao, Z.-G., & Wang, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.17460 · Cited by 12

NMN does not protect the ovarian reserve from cancer treatments

Stringer, J. M., Groenewegen, E., Liew, S. H., & Hutt, K. J. (2019) · Reproduction · doi:10.1530/rep-19-0337 · Cited by 12

Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm

Marinescu, A. G., Chen, J., Holmes, H. E., Guarente, L., Mendes, O. R., Morris, M., & Dellinger, R. W. (2020) · International Journal of Toxicology · doi:10.1177/1091581820927406 · Cited by 12

A trifunctional split dumbbell probe coupled with ligation-triggered isothermal rolling circle amplification for label-free and sensitive detection of nicotinamide adenine dinucleotide

Meng, Y.-R., Zhang, D., Zou, X., Ma, F., Kang, Q., & Zhang, C. (2020) · Talanta · doi:10.1016/j.talanta.2020.121962 · Cited by 12

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition

Akiu, M., Tsuji, T., Sogawa, Y., Terayama, K., Yokoyama, M., Tanaka, J., Asano, D., Sakurai, K., Sergienko, E. A., Sessions, E. H., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128048 · Cited by 12

Metabolite regulates differentiation

Trefely, S., & Wellen, K. E. (2018) · Science · doi:10.1126/science.aat6663 · Cited by 12

Bone Development and Regeneration 2.0

Yudoh, K., Sugishita, Y., & Suzuki‐Takahashi, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108761 · Cited by 14

Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy

Delrue, C., Speeckaert, R., & Speeckaert, M. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199372 · Cited by 12

The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD+ metabolism in the budding yeast Saccharomyces cerevisiae

Groth, B., Huang, C.-C., & Lin, S.-J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102410 · Cited by 11

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Xu, W. Q., & Li, X. (2023) · Molecules · doi:10.3390/molecules28114432 · Cited by 11

Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function

He, H., Wang, Y., Tang, B., Dong, Q., Wu, C., Sun, W., & Wang, J. (2024) · Nature Aging · doi:10.1038/s43587-024-00609-z · Cited by 11

Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases

Han, L., Yuan, Z., Wu, J., Lu, J., Wang, Y., & Zhang, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135210 · Cited by 11

Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

Sanchez, F. J. S., Posso, J. D. G., Santaolalla, F., Zabala, J. A., Arrizabalaga-Iriondo, A., Revuelta, M., & del Rey, A. S. (2024) · Antioxidants · doi:10.3390/antiox13091105 · Cited by 11

An Updated Review on the Mechanisms, Pre‐Clinical and Clinical Comparisons of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR)

Xu, Y., Lu, A., Guan, X., Ying, T., Pan, J., Tan, M., & Lu, J. (2024) · Food Frontiers · doi:10.1002/fft2.511 · Cited by 11

Too old for healthy aging? Exploring age limits of longevity treatments

Chaudhari, P., & Ermolaeva, M. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00040-3 · Cited by 13

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Ran, Y., Guo, Z.-L., Zhang, L., Li, H., Zhang, X.-Y., Guan, X.-M., Cui, X.-D., Chen, H., & Cheng, M. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13492 · Cited by 11

Linoleic acid, mitochondria, gut microbiome, and metabolic health: a mechanistic review

Mercola, J. M. (2025) · Advances in Redox Research · doi:10.1016/j.arres.2025.100128 · Cited by 11

Cross-kingdom mechanisms of trained immunity in plant systemic acquired resistance

Conrath, U. (2025) · Nature Plants · doi:10.1038/s41477-025-02119-1 · Cited by 11

Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart’s Vulnerability to Ischemia-Reperfusion Injury

Majka, M., Kleibert, M., & Wojciechowska, M. (2021) · Cells · doi:10.3390/cells10123331 · Cited by 12

Intermittent Fasting as Possible Treatment for Heart Failure

Garza-González, S., Nieblas, B., Solbes-Gochicoa, M. M., Altamirano, J., & Garcı́a, N. (2022) · Current Vascular Pharmacology · doi:10.2174/1570161120666220610151915 · Cited by 11

Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages

Zhang, G., Zhang, J., Wu, P., Ling, X., Wang, Q., Zhou, K., Li, P., Zhang, L., Ye, H., Zhang, Q., et al. (2022) · Animals · doi:10.3390/ani12223166 · Cited by 11

Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial

Opstad, T. B., Alexander, J., Aaseth, J., Larsson, A. O., Seljeflot, I., & Alehagen, U. (2023) · Antioxidants · doi:10.3390/antiox12030759 · Cited by 11

Sirtuins and autophagy in lipid metabolism

Sun, X., Yang, X., Gui, W., Liu, S., & Gui, Q. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3860 · Cited by 11

Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome

Cai, M., Li, S., Cai, K., Du, X., Han, J., & Hu, J. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155787 · Cited by 11

SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs

Divya, K. P., Kanwar, N., Anuranjana, P. V., Kumar, G., Beegum, F., George, K. T., Kumar, N., Nandakumar, K., & Kanwal, A. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-024-09858-1 · Cited by 11

Measurement of Pyridine Nucleotides in Biological Samples Using LC-MS/MS

Petucci, C. J., Culver, J. A., Kapoor, N., Sessions, E. H., Divlianska, D. B., & Gardell, S. J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9488-5_7 · Cited by 12

Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice

Hua, R., Wang, G., Shen, Q., Yang, Y., Wang, M., Wu, M., Shao, Y., He, M., Zang, Y., Yao, Q., et al. (2020) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2020.05.030 · Cited by 11

Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice

Takeda, K., & Okumura, K. (2021) · Biomedical Research · doi:10.2220/biomedres.42.173 · Cited by 11

Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway

Lin, Z., Xiong, Y., Hu, Y., Chen, L., Panayi, A. C., Xue, H., Zhou, W., Yan, C., Hu, L., Xie, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.730362 · Cited by 11

The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes

Bunik, V. I. (2023) · Biology · doi:10.3390/biology12070897 · Cited by 11

Molecular Mechanisms of the Aging Process and Rejuvenation

Shiomi, N. (2016) · InTech eBooks · doi:10.5772/61700 · Cited by 11

Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation

Rooker, D. R., Klyubka, Y., Gautam, R., Tomat, E., & Buccella, D. (2017) · ChemBioChem · doi:10.1002/cbic.201700582 · Cited by 11

Epigenetic Contribution to the Development and Progression of Vascular Diabetic Complications

Rodriguez, H., & El‐Osta, A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7347 · Cited by 11

Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

Zhang, K., Li, Q., Zhang, Y., Nuerlan, G., Li, Y., Mao, J., & Gong, S. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400078 · Cited by 10

Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers

Myong, S., Nguyen, A. Q., & Challa, S. (2024) · Cancers · doi:10.3390/cancers16173085 · Cited by 10

BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer

Pun, R., Kumari, N., Monieb, R. H., Wagh, S., & North, B. J. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.10.005 · Cited by 10

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

Tolman, N. G., Li, T., Balasubramanian, R., Li, G., Pfeiffer, R., Bupp-Chickering, V., Kelly, R. A., Simón, M., Peregrin, J., Montgomery, C. L., et al. (2026) · eLife · doi:10.7554/elife.107161.3 · Cited by 11

Cochlear immunology and its therapeutic revolution

Liu, T., He, R., Tian, Y., Chen, W.-B., Liu, X., Zhu, L., Cao, F., Yu, Z., Cui, X., Wang, P., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1666224 · Cited by 10

SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential

Alameen, A. A. M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., Faheem, S. A., & Batiha, G. E. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08923-y · Cited by 11

Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver

Zhu, J., Lu, J. L., Tung, H., Liu, K., Li, J., Grant, D. M., Xie, W., & Ma, X. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000139 · Cited by 10

In-silico screening of bioactive phytopeptides for novel anti-ageing therapeutics

Salekeen, R., Ahmed, A., Islam, M. E., Billah, M. M., Rahman, H., & Islam, K. M. D. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1859411 · Cited by 11

NAD+ oscillation and hypothalamic neuronal functions

Tokizane, K., & Imai, S. (2021) · Faculty Reviews · doi:10.12703/r/10-42 · Cited by 10

Synthesis, Stability, and Bioavailability of Nicotinamide Riboside Trioleate Chloride

Zarei, A., Khazdooz, L., Madarshahian, S., Enayati, M., Mosleh, I., Lin, T., Yan, B., Ufheil, G., Wooster, T. J., & Abbaspourrad, A. (2021) · Nutrients · doi:10.3390/nu14010113 · Cited by 10

Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors

Chen, W., Liu, S., Yang, Y. A., Zhang, Z., & Zhao, Y. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111657 · Cited by 10

Natural Mitochondria Targeting Substances and Their Effect on Cellular Antioxidant System as a Potential Benefit in Mitochondrial Medicine for Prevention and Remediation of Mitochondrial Dysfunctions

Schniertshauer, D., Wespel, S. L., & Bergemann, J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050250 · Cited by 11

The emerging importance of NAD+ metabolome for nutrition and food sciences: A bibliometric analysis

Alegre, G. F. S., & Pastore, G. M. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103126 · Cited by 10

WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Tian, Y., Lautrup, S., Law, P. W. N., Dinh, N., Fang, E. F., & Chan, W. (2024) · Cell & Bioscience · doi:10.1186/s13578-023-01183-4 · Cited by 10

L’ADN mitochondrial, un potentiel codant mésestimé

Angers, A., Ouimet, P., Tsyvian-Dzyabko, A., Nock, T., & Breton, S. (2019) · médecine/sciences · doi:10.1051/medsci/2018308 · Cited by 10

The potential of the novel NAD+ supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich’s ataxia

Chiang, S., Kalinowski, D. S., Dharmasivam, M., Braidy, N., Richardson, D. R., & Huang, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104680 · Cited by 11

Perturbed Brain Glucose Metabolism Caused by Absent SIRT3 Activity

Kristián, T., Karimi, A. J., Fearnow, A. D., Waddell, J., & McKenna, M. C. (2021) · Cells · doi:10.3390/cells10092348 · Cited by 10

Immunological age prediction in HIV-infected, ART-treated individuals

de Armas, L. R., Pallikkuth, S., Pan, L., Rinaldi, S., Pahwa, R., & Pahwa, S. G. (2021) · Aging · doi:10.18632/aging.203625 · Cited by 10

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis – A possible therapeutic mechanism

Kidnapillai, S., Bortolasci, C. C., Panizzutti, B., Spolding, B., Connor, T., Bonifácio, K. L., Sanigorski, A. J., Dean, O. M., Crowley, T. M., Jamain, S., et al. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1669823 · Cited by 11

Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA)

Chen, S., Yang, D., Liu, Z., Li, F., Liu, B., Chen, Y., Ye, W., & Zheng, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.921692 · Cited by 10

N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD+ biosynthetic enzymes in Saccharomyces cerevisiae

Croft, T., Venkatakrishnan, P., Raj, C. J. T., Groth, B., Cater, T., Salemi, M., Phinney, B. S., & Lin, S.-J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011667 · Cited by 10

Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization

Xing, S., Kang, X., Wang, R., Wang, C., Wang, Y., Bao, X., & Zhao, J. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00038 · Cited by 9

The multifaceted role of sirtuins in inflammatory bowel diseases

Samant, S. A., Hyoju, S. K., Alverdy, J. C., & Gupta, M. P. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00311.2024 · Cited by 9

NAMPT regulates mitochondria and oxidative stress level for mouse early embryo development

Liao, M.-H., Liu, X., Yu, X., Zhang, S., Li, Y., Hu, L., Sun, S., & Wang, J. (2025) · Biological Research · doi:10.1186/s40659-025-00608-3 · Cited by 9

Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases

Brandi, G., Delbaldo, C., Deserti, M., Relli, V., Rimedio, S., Palloni, A., Deiana, C., Saccoccio, G., Ingenito, R., & Tavolari, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102802 · Cited by 9

Mitochondrial quality control in human ageing and longevity

Picca, A., & Ferrucci, L. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01563-3 · Cited by 10

Age-associated changes in microglia activation and Sirtuin-1- chromatin binding patterns

Basova, L., Bortell, N., Conti, B., Fox, H. S., Milner, R., & Marcondes, M. C. G. (2022) · Aging · doi:10.18632/aging.204329 · Cited by 9

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Habeichi, N. J., Ghali, R., Mroueh, A., Kaplan, A., Tannous, C., Jurjus, A. R., Amin, G., Mericskay, M., Booz, G. W., EL‐Yazbi, A. F., et al. (2022) · Clinical Science · doi:10.1042/cs20220513 · Cited by 9

Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men

Nakagawa-Nagahama, Y., Igarashi, M., Miura, M., Kashiwabara, K., Yaku, K., Fukamizu, Y., Sato, T., Sakurai, T., Nakagawa, T., Kadowaki, T., et al. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03796-3 · Cited by 9

Complexity and regulation of age-dependent alternative splicing in Brachypodium distachyon

Shen, Y., Qin, Z., Ren, G., Deng, P., Ji, W., Jiao, C., & Wu, L. (2023) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiad223 · Cited by 10

A secreted sirtuin from Campylobacter jejuni contributes to neutrophil activation and intestinal inflammation during infection

Callahan, S. M., Hancock, T. J., Doster, R. S., Parker, C. B., Wakim, M. E., Gaddy, J. A., & Johnson, J. G. (2023) · Science Advances · doi:10.1126/sciadv.ade2693 · Cited by 11

Influence of Oleacein, an Olive Oil and Olive Mill Wastewater Phenolic Compound, on Caenorhabditis elegans Longevity and Stress Resistance

Carrara, M., Richaud, M., Cuq, P., Galas, S., & Margout, D. (2024) · Foods · doi:10.3390/foods13132146 · Cited by 9

When nature’s robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies

Reisz, J. A., Barrett, A. S., Nemkov, T. G., Hansen, K. C., & D’Alessandro, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1453362 · Cited by 11

Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases

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