NAD+ and sirtuins in aging and disease

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482

The hidden side of the human FAD synthase 2

Leone, P., Galluccio, M., Brizio, C., Barbiroli, A. G., Iametti, S., Indiveri, C., & Barile, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.138 · Cited by 23

Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1

Spinck, M., Bischoff, M., Lampe, P., Meyer‐Almes, F., Sievers, S., & Neumann, H. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00017 · Cited by 23

Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD+-Sirt3 pathway

Wang, T., Zhang, F., Peng, W., Wang, L., Zhang, J., Dong, W., Tian, X., Ye, C., Li, Y., & Gong, Y. (2022) · Bioscience Reports · doi:10.1042/bsr20211005 · Cited by 23

Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer’s Disease Transgenic Mouse Brains

Yoshida, N., Kato, Y., Takatsu, H., & Fukui, K. (2022) · Biomedicines · doi:10.3390/biomedicines10020281 · Cited by 23

Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1)

He, S., Zhou, M., Zheng, H., Wang, Y., Wu, S., Gao, Y., & Chen, J. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2029488 · Cited by 23

Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury

Zhu, X., Jin, C. S., Yu, J., Liu, R., Ma, H., & Zhao, Y. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.80942 · Cited by 23

Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway

Li, Y., Liu, X., Wan, L., Han, B., Ma, S., Pan, H., Wei, J., & Cui, X. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.013 · Cited by 24

NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells

Fang, J., Hou, P., Liu, S., Zuo, M., Liu, Z., Chen, W., Han, Y., Li, Y., Wang, T., Feng, C., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01073-2 · Cited by 23

AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling

Guo, S., Li, F., Liang, Y., Zheng, Y., Mo, Y., Zhao, D., Jiang, Z., Cui, M., Qi, L., Chen, J., et al. (2023) · Oncogenesis · doi:10.1038/s41389-023-00491-1 · Cited by 23

Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?

Baralle, M., & Romano, M. (2023) · Cells · doi:10.3390/cells12242819 · Cited by 25

Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging

Orlandi, I., Pellegrino-Coppola, D., Strippoli, M., Ronzulli, R., & Vai, M. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.006 · Cited by 23

Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation

Workman, J. J., Chen, H., & Laribee, R. N. (2016) · Genetics · doi:10.1534/genetics.116.188458 · Cited by 23

Anti-apoptotic quinolinate phosphoribosyltransferase ( QPRT ) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells

Ullmark, T., Montano, G., Järvstråt, L., Nilsson, H. J., Håkansson, E., Drott, K., Nilsson, B., Vidovic, K., & Gullberg, U. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.114 · Cited by 23

Mitochondrial NUDIX hydrolases: A metabolic link between NAD catabolism, GTP and mitochondrial dynamics

Long, A., Klimova, N., & Kristián, T. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.009 · Cited by 26

Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells

Hwang, D., Jo, H., Ma, S.-H., & Lim, Y. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.06.039 · Cited by 23

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connexin 43

Roh, E., Park, J.-W., Kang, G. M., Lee, C. H., Dugu, H., Gil, S. Y., Song, D. K., Kim, H. J., Son, G. H., Yu, R., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.08.005 · Cited by 23

Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons

Flores‐León, M., Pérez‐Domínguez, M., González‐Barrios, R., & Arias, C. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02810-8 · Cited by 24

Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults

Freeberg, K. A., Craighead, D. H., Martens, C. R., You, Z., Chonchol, M., & Seals, D. R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.881703 · Cited by 23

NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs

Zong, L., Tanaka-Yano, M., Park, B., Yanai, H., Turhan, F. T., Croteau, D. L., Tian, J., Fang, E. F., Bohr, V. A., & Beerman, I. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00078-3 · Cited by 22

From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications

Cannito, S., Giardino, I., D’Apolito, M., Ranaldi, A., Pettoello‐Mantovani, M., Scaltrito, F., & Piscazzi, A. (2025) · Genes · doi:10.3390/genes16121442 · Cited by 23

Distinct Roles of the NAD+-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development

Nakao, M., Anan, K., Araki, H., & Hino, S. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.010 · Cited by 22

Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth

Velázquez-Torres, G., Fuentes‐Mattei, E., Choi, H. H., Yeung, S. J., Meng, X., & Lee, M. (2020) · Gastroenterology report · doi:10.1093/gastro/goaa018 · Cited by 22

An update in toxicology of ageing

Račková, L., Mach, M., & Brnoliaková, Z. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103611 · Cited by 22

Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

Smith, N., Shirazi, S., Cakouros, D., & Gronthos, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076499 · Cited by 23

Decreasing Intracellular Entropy by Increasing Mitochondrial Efficiency and Reducing ROS Formation—The Effect on the Ageing Process and Age-Related Damage

Poljšak, B., & Milisav, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126321 · Cited by 22

SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

Wakeling, L. A., Ions, L. J., Escolme, S. M., Cockell, S., Su, T., Dey, M., Hampton, E. V., Jenkins, G., Wainwright, L., McKay, J. A., et al. (2015) · Human Genomics · doi:10.1186/s40246-015-0036-0 · Cited by 22

NAMPT expression in osteoblasts controls osteoclast recruitment in alveolar bone remodeling

Hassan, B., Baroukh, B., Llorens, A., Lesieur, J., Ribbes, S., Chaussain, C., Jl, S., & Gosset, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26584 · Cited by 22

The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast

Raj, C. J. T., Croft, T., Venkatakrishnan, P., Groth, B., Dhugga, G., Cater, T., & Lin, S.-J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006987 · Cited by 24

Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response

Kwon, J., Lee, S., Kim, Y.-N., & Lee, I. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0232-4 · Cited by 22

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway

Feng, D., Xu, D., Murakoshi, N., Tajiri, K., Qin, R., Yonebayashi, S., Okabe, Y., Li, S., Yuan, Z., Aonuma, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134655 · Cited by 22

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

Pinkerton, A. B., Sessions, E. H., Hershberger, P., Maloney, P., Peddibhotla, S., Hopf, M. E., Sergienko, E. A., Ma, C.-T., Smith, L. H., Jackson, M. R., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128007 · Cited by 22

Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

Fang, T., Yang, H. J., Liu, L., Xiao, H., & Wei, X. (2021) · MedComm · doi:10.1002/mco2.62 · Cited by 22

Targeting Epigenetic Mechanisms in Vascular Aging

Lin, Z., Ding, Q., Li, X., Feng, Y., He, H., Huang, C., & Zhu, Y. Z. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.806988 · Cited by 23

A multimethod computational simulation approach for investigating mitochondrial dynamics and dysfunction in degenerative aging

Hoffman, T. E., Barnett, K. J., Wallis, L. E., & Hanneman, W. H. (2017) · Aging Cell · doi:10.1111/acel.12644 · Cited by 22

Increased ROS Level in Spinal Cord of Wobbler Mice due to Nmnat2 Downregulation

Röderer, P., Klatt, L., John, F., Theis, V., Winklhofer, K. F., Theiß, C., & Matschke, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0999-7 · Cited by 22

The unexpected role of mTORC1 in intestinal stem cells during calorie restriction

Igarashi, M., & Guarente, L. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1221210 · Cited by 22

The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research

Kitada, M., Araki, S., & Koya, D. (2023) · Cells · doi:10.3390/cells12040595 · Cited by 21

Sirt5‐mediated lysine desuccinylation regulates oxidative stress adaptation in Magnaporthe oryzae during host intracellular infection

Ren, Z., Dong, X., Guan, L., Yang, L., Liu, C., Cai, X., Hu, H., Lv, Z., Liu, H., Zheng, L., et al. (2024) · New Phytologist · doi:10.1111/nph.19683 · Cited by 21

USP26 Combats Age‐Related Declines in Self‐Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis

Xu, Y., Chang, L., Chen, Y., Zhou, D., Zhou, L., Tang, J., Deng, L., Tang, G., & Li, C. (2024) · Advanced Science · doi:10.1002/advs.202406428 · Cited by 22

Decoding the mechanisms behind second primary cancers

Zeng, M., Lin, A., Jiang, A., Qiu, Z., Zhang, H., Chen, S., Xu, M., Liu, Z., Cheng, Q., Zhang, J., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06151-9 · Cited by 21

Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma–Induced Cancer Cachexia

Park, J. M., Han, Y. M., Lee, H. J., Park, Y. J., & Hahm, K. B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665493 · Cited by 21

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Schaefer, P. M., Huang, J. Y., Butic, A., Perry, C. E., Yardeni, T., Tan, W., Morrow, R. M., Baur, J. A., & Wallace, D. C. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101560 · Cited by 21

Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics

Hunt, N. J., Wahl, D., Westwood, L. J., Lockwood, G. P., Couteur, D. G. L., & Cogger, V. C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114537 · Cited by 21

SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure

Anugraha, G., Roychowdhury, S., Kibler, C. D., Cross, E., Abraham, S., Bellar, A., Nagy, L. E., Scheraga, R. G., & Vachharajani, V. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1079962 · Cited by 23

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Varela‐López, A., Romero‐Márquez, J. M., Navarro‐Hortal, M. D., Ramírez-Tortosa, C. L., Battino, M. A., Forbes-Hernández, T. Y., & Quiles, J. L. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112221 · Cited by 22

Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs)

Shen, Z., Ratia, K. M., Krider, I. S., Ackerman-Berrier, M. S., Penton, C., Musku, S. R., Gordon-Blake, J. M., Laham, M. S., Christie, N., Ma, N., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01406 · Cited by 21

Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases

Ungvari, A., Gulej, R., Patai, R., Papp, Z., Tóth, A., Szabó, A. Á., Podesser, B. K., Sótonyi, P., Benyó, Z., Yabluchanskiy, A., et al. (2025) · GeroScience · doi:10.1007/s11357-024-01489-2 · Cited by 22

Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity

Tsang, F. A., & Lin, S.-J. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1367-x · Cited by 21

Modulation of mitochondrial dysfunction for treatment of disease

Webb, M., Sideris, D. P., & Biddle, M. M. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.03.041 · Cited by 21

Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease

Shan, C., Gong, Y., Zhuang, Q.-Q., Hou, Y., Wang, S., Zhu, Q., Huang, G., Tao, B., Sun, L., Zhao, H., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109670 · Cited by 21

Acetylation of NDPK-D Regulates Its Subcellular Localization and Cell Survival

Fujita, Y., Fujiwara, K., Zenitani, S., & Yamashita, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139616 · Cited by 21

Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry

Hara, N., Osago, H., Hiyoshi, M., Kobayashi‐Miura, M., & Tsuchiya, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214000 · Cited by 21

Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Feng, S., Guo, L., Wang, H., Yang, S., & Liu, H. (2023) · Communications Biology · doi:10.1038/s42003-023-04613-8 · Cited by 20

A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Takanashi, Y., Tamannaa, Z., Kitamoto, T., Odagiri, K., & Setou, M. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.09.001 · Cited by 23

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

Zhu, Y., Xu, P., Huang, X., Wen, S., Liu, L., Zhang, S., Zhao, R., Hu, X., & Wang, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.920113 · Cited by 21

Metabolome Profiling in Aging Studies

Balashova, E. E., Maslov, D. L., Trifonova, O. P., Lokhov, P. G., & Archakov, A. I. (2022) · Biology · doi:10.3390/biology11111570 · Cited by 22

Preclinical Characterization of Pharmacologic NAD + Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis

Pérez‐Sánchez, C., Escudero‐Contreras, A., Cerdó, T., Sánchez‐Mendoza, L. M., Llamas-Urbano, A., de la Rosa, I. A., Pérez-Rodríguez, M., Muñoz-Barrera, L., Ábalos‐Aguilera, M. C., Barbarroja, N., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42528 · Cited by 20

Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Watanabe, K., Wilmanski, T. M., Baloni, P., Robinson, M., Garcia, G. G., Hoopmann, M. R., Midha, M. K., Baxter, D. H., Maes, M., Morrone, S. R., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05128-y · Cited by 20

Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro

Yang, X., Dong, W., Lei, X., Li, Q., Zhang, L.-Y., & Zhang, L. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1311310 · Cited by 20

Dunnione protects against experimental cisplatin-induced nephrotoxicity by modulating NQO1 and NAD+ levels

Ahmad, S. N. S., Rashtchizadeh, N., Argani, H., Roshangar, L., Ghorbanihaghjo, A., Sanajou, D., Panah, F., Jigheh, Z. A., Dastmalchi, S., & Abbasi, M. M. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1475732 · Cited by 20

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Zhang, J., Wang, C., Shi, H., Wu, D., & Ying, W. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00343 · Cited by 20

Vitamin D3 potentiates the renoprotective effects of vildagliptin in a rat model of fructose/salt-induced insulin resistance

Wahba, N. S., Abdel-Ghany, R. H., Ghareib, S. A., Abdel-Aal, M., & Alsemeh, A. E. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105196 · Cited by 20

Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure

Wang, R., Wu, Z., Liu, M., Wu, Y., Li, Q., Ba, Y., Zhang, H., Cheng, X., Zhou, G., & Huang, H. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147567 · Cited by 20

Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders

Abdalla, B. A., Xiong, X., Chai, X., Xu, Q., Gong, J., & Xu, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.96885 · Cited by 20

Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+) by Synergistic Inhibition of CD38 Expression

Kang, S., Park, J.-W., Cheng, Z., Ye, S., Jun, S., & Kang, N. G. (2024) · Cells · doi:10.3390/cells13211799 · Cited by 19

NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer

Lu, X., Jin, P., Tang, Q., Zhou, M., Xu, H., Su, C., Wang, L., Xu, F., Zhao, M., Yin, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202412109 · Cited by 24

Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective

Fan, Y., Zhao, H., Lu, L., & Wu, W. (2025) · Nutrients · doi:10.3390/nu17111855 · Cited by 21

SIRT1 in Aging and Diseases

Abdulkhaliq, A. A., Alasiri, G. A., Khan, J., Ajoolabady, A., Tuomilehto, J., Henninger, N., Bahijri, S., Praticò, D., Borai, A., Alrfaei, B. M., et al. (2025) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70069 · Cited by 20

ROS-Induced DNA Damage as an Underlying Cause of Aging

Robert, G., & Wagner, J. R. (2020) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20200024 · Cited by 21

The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection

Pei, Y., & Robertson, E. S. (2020) · Viruses · doi:10.3390/v12121377 · Cited by 20

Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes

Miao, Y., Cui, Z., Zhu, X., Gao, Q., & Xiong, B. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac025 · Cited by 19

Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD+ salvage metabolic pathway

Cao, P., Chen, Q., Shi, C., Wang, L., & Gong, Z. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00503-2 · Cited by 19

SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity

Podyacheva, E., & Toropova, Y. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1035387 · Cited by 19

Both prolonged high-fat diet consumption and calorie restriction boost hepatic NAD+ metabolism in mice

Wei, X., Wei, C., Tan, Y., Dong, X., Yang, Z., Yan, J., & Luo, X. M. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109296 · Cited by 19

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer

Bassal, M. A. (2023) · Biomolecules · doi:10.3390/biom13060944 · Cited by 19

Cooperative effects of SIRT1 and SIRT2 on APP acetylation

Li, N., Bai, N., Zhao, X., Cheng, R., Wu, X., Jiang, B., Li, X., Xue, M., Xu, H., Guo, Q., et al. (2023) · Aging Cell · doi:10.1111/acel.13967 · Cited by 19

Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?

Parrotta, M. E., Colangeli, L., Scipione, V., Vitale, C., Sbraccia, P., & Guglielmi, V. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00609-z · Cited by 19

Ligation-Based qPCR-Amplification Assay for Radiolabel-Free Detection of ATP and NAD+ with High Selectivity and Sensitivity

Zhang, X., Wang, Y., & Zhou, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05663 · Cited by 19

Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells

Gurgul-Convey, E. (2020) · Cells · doi:10.3390/cells9081835 · Cited by 20

Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

Kitaoka, Y., Sase, K., Tsukahara, C., Fujita, N., Arizono, I., & Takagi, H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02063-5 · Cited by 19

The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells

Parisotto, M., Vuong, N., Kalegari, P., Meharwade, T., Joumier, L., Igelmann, S., Bourdeau, V., Rowell, M., Pollak, M., Malleshaiah, M. K., et al. (2022) · Cancers · doi:10.3390/cancers14225597 · Cited by 21

Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective

Molla, M. D., Dessie, G., Akalu, Y., & Ayelign, B. (2020) · International Journal of Hepatology · doi:10.1155/2020/2374615 · Cited by 20

Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer's disease properties

Gao, S., Zhang, H., Li, N., Zhang, L., Zhu, Z., & Xu, C. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101043 · Cited by 18

Targeting the Electron Transport System for Enhanced Longevity

Radovic, M., Gartzke, L. P., Wink, S. E., van der Kleij, J. A., Politiek, F. A., & Krenning, G. (2025) · Biomolecules · doi:10.3390/biom15050614 · Cited by 17

Assays for Determination of Cellular and Mitochondrial NAD+ and NADH Content

Yang, Y. J., & Sauve, A. A. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1433-4_15 · Cited by 18

Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

Meyer‐Ficca, M. L., Zwerdling, A. E., Swanson, C. A., Tucker, A. G., Lopez, S. A., Wandersee, M. K., Warner, G. M., Thompson, K. L., Chini, C. C. S., Chen, H., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.896356 · Cited by 18

Efficient Assay and Marker Significance of NAD+ in Human Blood

Balashova, N. V., Zavileyskiy, L. G., Artiukhov, A. V., Shaposhnikov, L. A., Op, S., Tishkov, V. I., Tramonti, A., POMETUN, A. A., & Bunik, V. I. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.886485 · Cited by 19

Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

McGinnis, C. D., Jennings, E. Q., Harris, P. S., Galligan, J. J., & Fritz, K. S. (2022) · Cells · doi:10.3390/cells11132045 · Cited by 18

Sirtuins as novel pharmacological targets in podocyte injury and related glomerular diseases

Liu, T., Yang, L., Mao, H., Ma, F., Wang, Y., Shen, L., Li, P., & Zhan, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113620 · Cited by 18

Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus

Johnson, S., Yoshioka, K., Brace, C. S., & Imai, S. (2023) · npj Aging · doi:10.1038/s41514-023-00098-1 · Cited by 18

Sirtuins in osteoarthritis: current understanding

Liu, Y., Zhang, Z., Liu, C., & Zhang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1140653 · Cited by 18

The Role of Histone Deacetylases in Acute Lung Injury—Friend or Foe

Luo, G., Liu, B., Fu, T., Liu, Y., Li, B., Li, N., & Geng, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097876 · Cited by 18

The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice

Warren, A. D., Porter, R. M., Reyes‐Castro, O., Ali, M. M., Marques-Carvalho, A., Kim, H., Gatrell, L. B., Schipani, E., Nookaew, I., O’Brien, C. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39392-7 · Cited by 20

Promotion of NAD+ recycling by the hypoxia-induced shift in the lactate dehydrogenase isozyme profile reduces the senescence of human bone marrow-derived endothelial progenitor cells

Yan, K., He, Q., Lin, D., Liang, J., Chen, J., Xie, Z., & Chen, Z. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.07.035 · Cited by 18

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

Ondracek, C. R., Frappier, V., Ringel, A. E., Wolberger, C., & Guarente, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.031 · Cited by 18

Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

Barili, V., Vecchi, A. L., Rossi, M., Montali, I., Tiezzi, C., Penna, A., Laccabue, D., Missale, G., Fisicaro, P., & Boni, C. (2021) · Cells · doi:10.3390/cells10102563 · Cited by 18

Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes

Jiang, Z., Li, H., Schroer, S. A., Voisin, V., Ju, Y., Pacal, M., Erdmann, N., Shi, W., Chung, P. E. D., Deng, T., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2020106825 · Cited by 18

Nosustrophine: An Epinutraceutical Bioproduct with Effects on DNA Methylation, Histone Acetylation and Sirtuin Expression in Alzheimer’s Disease

Martínez-Iglesias, O. A., Naidoo, V., Carrera, I., Corzo, L., & Cacabelos, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112447 · Cited by 18

Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming

Nickerson, J. A., Wu, Q., & Imbalzano, A. N. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00049 · Cited by 18

Dietary resveratrol increases mid-life fecundity of female Nothobranchius guentheri

Lee, Y., Drake, A. C., Thomas, N. O., Ferguson, L. G., Chappell, P. E., & Shay, K. P. (2017) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2017.10.006 · Cited by 19

Sur l'oxydation de l'adrénochrome

Gautheron, D. C., & Chaix, P. (1954) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(54)90322-4

NAD+: a crucial regulator of sirtuin activity in aging

Braidy, N., & Villalva, M. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00008-2 · Cited by 4

The pathophysiological importance and therapeutic potential of NAD' biosynthesis and mitochondrial sirtuin SIRT3 in age-associated diseases.

Yamaguchi, S., & Yoshino, J. (2016) · PubMed · Cited by 5

NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.789479 · Cited by 193

NAD + in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319