NAD+ and sirtuins in aging and disease

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482

Sir-2.1 mediated attenuation of α-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans

Maulik, M., Mitra, S., Hunter, S., Hunstiger, M., Oliver, S. R., Bult‐Ito, A., & Taylor, B. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-26905-4 · Cited by 19

Metformin Beyond Diabetes: A Precision Gerotherapeutic and Immunometabolic Adjuvant for Aging and Cancer

Rehman, A., Satyam, S. M., El‐Tanani, M., Prabhakar, S., KUMARI, R. R., Shetty, P., Mohammed, S. S. N., Nafees, Z., & Alomar, B. (2025) · Cancers · doi:10.3390/cancers17152466 · Cited by 20

CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages

Wen, S., Arakawa, H., & Tamai, I. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.10.010 · Cited by 17

Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome

Tyagi, A., Musa, M., Labeikovsky, W., & Pugazhenthi, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-23652-5 · Cited by 18

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 18

Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 Signaling

Ji, J., Wang, K., Meng, X., Zhong, H., Li, X., Zhao, H., Xie, G., Xie, Y., Wang, X., & Zhu, X. (2022) · Cancers · doi:10.3390/cancers14235812 · Cited by 17

Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling

Sun, X., Li, Q., Tang, Y., Hu, W., Chen, G., An, H., Huang, D., Tong, T., & Zhang, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06002-9 · Cited by 17

MiR ‐203 improves cardiac dysfunction by targeting PARP1‐NAD + axis in aging murine

Zhao, L., Tang, P., Lin, Y., Du, M., Li, H., Jiang, L., Xu, H., Sun, H., Han, J., Sun, Z., et al. (2023) · Aging Cell · doi:10.1111/acel.14063 · Cited by 17

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Feng, B., Dong, T., Song, X., Zheng, X., Jin, C., Cheng, Z., Liu, Y., Zhang, W., Wang, X., Tao, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202305682 · Cited by 17

Mitochondrial targets in hyperammonemia: Addressing urea cycle function to improve drug therapies

Moedas, M. F., Simões, R. J., & Silva, M. F. B. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116034 · Cited by 18

Nicotinamide Mononucleotide (NMN) Ameliorates Free Fatty Acid-Induced Pancreatic β-Cell Dysfunction via the NAD+/AMPK/SIRT1/HIF-1α Pathway

Wang, Y., Liu, S., Ying, L., Zhang, K., Li, H., Liang, N., Xiao, L., & Luo, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910534 · Cited by 18

Modelling and Analysis of the Feeding Regimen Induced Entrainment of Hepatocyte Circadian Oscillators Using Petri Nets

Tareen, S. H. K., & Ahmad, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117519 · Cited by 17

Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan

Schumpert, C. A., Anderson, C., Dudycha, J. L., & Patel, R. C. (2016) · Aging · doi:10.18632/aging.100909 · Cited by 18

The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem Cells

Zainabadi, K. (2018) · Regenerative Medicine · doi:10.2217/rme-2017-0128 · Cited by 18

Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and C. elegans

Nguyễn, M. T., Somogyvári, M., & Sőti, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113661 · Cited by 17

Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice

Qiu, P., Hou, W., Wang, H., Lei, K. K. W., Wang, S., Chen, W., Pardeshi, L. A., Prothro, K. P., Shukla, Y., Su, S. S. M., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01993-1 · Cited by 17

Integrative Role of Hyperbaric Oxygen Therapy on Healthspan, Age-Related Vascular Cognitive Impairment, and Dementia

Balasubramanian, P., DelFavero, J., Nyúl‐Tóth, Á., Tarantini, A., Gulej, R., & Tarantini, S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.678543 · Cited by 18

Antioxidant effect of nicotinamide mononucleotide in tendinopathy

Yamaura, K., Mifune, Y., Inui, A., Nishimoto, H., Kurosawa, T., Mukohara, S., Hoshino, Y. Y., Niikura, T., & Kuroda, R. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05205-z · Cited by 17

Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice

Margier, M., Kuehnemann, C., Hulo, N., Morales, J. E., Kumaar, P. V. A., Cros, C. D., Cannelle, H., Charmetant, J., Verdin, E. M., Canault, M., et al. (2022) · Cells · doi:10.3390/cells12010108 · Cited by 18

A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway

Darwesh, A. M., Bassiouni, W., Adebesin, A. M., Mohammad, A. S., Falck, J. R., & Seubert, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155261 · Cited by 17

Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs

Pecher, S. J., Potthast, A. B., von Versen‐Höynck, F., & Das, A. M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082604 · Cited by 17

Cellular Models of Aging and Senescence

Kim, B., Lee, D. I., Basisty, N., & Dai, D.-F. (2025) · Cells · doi:10.3390/cells14161278 · Cited by 16

Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation

Ju, W., Zhao, S., Li, D., Zhang, J., Xiang, S., & Lian, F. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1546041 · Cited by 16

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Hakamata, A., Onoda, Y., Sato, S., Yamazaki, F., Horikawa, M., Takahashi, Y., Kitamoto, T., Suzuki, M., et al. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.04.002 · Cited by 16

Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis

Foster, P. S., Tay, H. L., & Oliver, B. G. G. (2022) · Journal of Clinical Investigation · doi:10.1172/jci160595 · Cited by 16

Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho

Borský, P., Holmannová, D., Andrýs, C., Kremláček, J., Fiala, Z., Kovaříková, H., Řeháček, V., Švadláková, T., Býma, S., Kučera, O., et al. (2023) · Biogerontology · doi:10.1007/s10522-023-10054-x · Cited by 17

Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling

Lin, L., Deng, K., Gong, Z., Fan, H., Zhang, D., & Lu, G. (2023) · ACS Omega · doi:10.1021/acsomega.3c03319 · Cited by 16

Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy

Li, Y., Liu, Y., Zhang, Y., Wu, Y., Xing, Z., Wang, J., & Fan, G.-H. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00391 · Cited by 16

Microgravity Effects and Aging Physiology: Similar Changes or Common Mechanisms?

Ratushnyy, A. Y., & Buravkova, L. B. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923110081 · Cited by 16

Sirtuin 1 and Hormonal Regulations in Aging

Keremidarska‐Markova, M., Sazdova, I., Mladenov, M. I., Pilicheva, B., Zagorchev, P. I., & Gagov, H. (2024) · Applied Sciences · doi:10.3390/app142412051 · Cited by 18

Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives

Li, J., He, W., Wu, Q., Qin, Y., Luo, C., Dai, Z., Long, Y., Yan, P., Huang, W. G., & Cao, L. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04019-0 · Cited by 16

Untargeted Metabolomics Analysis Reveals a Link between ETHE1-Mediated Disruptive Redox State and Altered Metabolic Regulation

Sahebekhtiari, N., Nielsen, C. B., Johannsen, M., & Palmfeldt, J. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00100 · Cited by 16

The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss

Liu, Y., Ao, L., Li, Y., Zhao, Y., Wen, Y., & Ding, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.084 · Cited by 16

The Relationship between Annual Airborne Pollen Levels and Occurrence of All Cancers, and Lung, Stomach, Colorectal, Pancreatic and Breast Cancers: A Retrospective Study from the National Registry Database of Cancer Incidence in Japan, 1975–2015

Awaya, A., & Kuroiwa, Y. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113950 · Cited by 16

Biomimetic Molecular Clamp Nanopores for Simultaneous Quantifications of NAD + and NADH

Liu, X., Feng, W., Yao, F., Zhang, J., Rauf, A., Chen, T., Shi, X., Qiao, X., Ma, L., Yu, S., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00986 · Cited by 16

Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases

Tian, Q., Gao, S., Zhou, X., Zheng, L., & Zhou, Y. (2021) · Stem Cells International · doi:10.1155/2021/8043346 · Cited by 16

Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation‐Induced Heart Damage

Zeng, Z., Xu, P., He, Y., Yi, Y., Liu, Z., Cai, J., Huang, L., & Liu, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4155565 · Cited by 16

Transcriptomic analysis of epigenetic modification genes in the termite Reticulitermes speratus

Mitaka, Y., Tasaki, E., Nozaki, T., Fuchikawa, T., Kobayashi, K., & Matsuura, K. (2018) · Insect Science · doi:10.1111/1744-7917.12640 · Cited by 16

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Shoji, M., Kato, H., Koshizaka, M., Kaneko, H., Baba, Y., Ishikawa, T., Teramoto, N., Kinoshita, D., Yamaguchi, A., Maeda, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.70093 · Cited by 16

Circadian system and aging: where both times interact

Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15

Gut Microbiota: An Ally in the Mechanisms and Interventions of Healthy Aging

Chatterjee, S. S., Hebbani, A. V., & Syed, K. (2025) · Gastrointestinal Disorders · doi:10.3390/gidisord7040068 · Cited by 16

Epigenetic and post-translational regulatory networks of ferroptosis in the tumor immune microenvironment

Du, L., Zhang, Y., Luo, J., He, C., Lang, J., & Cao, X. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00737-1 · Cited by 15

Energy Metabolism Focused Analysis of Sexual Dimorphism in Biological Aging and Hypothesized Sex-specificity in Sirtuin Dependency

Salekeen, R., Diaconeasa, A. G., Billah, M. M., & Islam, K. M. D. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.07.007 · Cited by 16

Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury

Cheng, Y., Zhao, J., Zong, W., Wei, X.-J., Xu, Z., Yuan, Y., Jiang, Y.-F., Luo, X., Wang, W., & Qu, W. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03610-3 · Cited by 15

Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1

Wang, W., Wang, Z., Yang, X., Song, W., Chen, P., Gao, Z., Wu, J., & Huang, F. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121115 · Cited by 15

Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

McKay-Corkum, G. B., Collins, V. J., Yeung, C. L., Ito, T., Issaq, S. H., Holland, D. O., Vulikh, K., Zhang, Y., Lee, U., Lei, H., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0200 · Cited by 15

Fingerstick blood assay maps real‐world NAD + disparity across gender and age

Wang, P., Chen, M., Hou, Y., Luan, J., Liu, R., Chen, L., Hu, M., & Yu, Q. (2023) · Aging Cell · doi:10.1111/acel.13965 · Cited by 16

A Simple, Fast, Sensitive LC-MS/MS Method to Quantify NAD(H) in Biological Samples: Plasma NAD(H) Measurement to Monitor Brain Pathophysiology

Ishima, T., Kimura, N., Kobayashi, M., Nagai, R., Osaka, H., & Aizawa, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042325 · Cited by 15

Leukotriene D4 induces cellular senescence in osteoblasts

Wei, J., Chen, S., Guo, W., Feng, B., Yang, S., Huang, C., & Chu, J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2017.12.027 · Cited by 15

Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training

Brouwers, B., Stephens, N. A., Costford, S. R., Hopf, M. E., Ayala, J. E., Yi, F., Xie, H., Li, J., Gardell, S. J., Sparks, L. M., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00704 · Cited by 15

The E3 ligase Highwire promotes synaptic transmission by targeting the NAD‐synthesizing enzyme dNmnat

Russo, A., Goel, P., Brace, E. J., Buser, C., Dickman, D. K., & DiAntonio, A. (2019) · EMBO Reports · doi:10.15252/embr.201846975 · Cited by 16

Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Kreiner, G., Soenmez, A., Liss, B., & Parlato, R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00106 · Cited by 15

Senescence of Timing Reverted: NAD+ Rejuvenates the Circadian Clock

Schibler, U. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.010 · Cited by 15

Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons

Matsuno, H., Tsuchimine, S., Fukuzato, N., O'Hashi, K., Kunugi, H., & Sohya, K. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104959 · Cited by 15

Rodent diet aids and the fallacy of caloric restriction

Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111584 · Cited by 15

Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: A comprehensive review

Rang, Y., Liu, H., & Liu, C. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.065 · Cited by 15

The role of NAD metabolism in neuronal differentiation

Neves, D., Goodfellow, B. J., Vieira, S. I., & Silva, R. M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105402 · Cited by 15

Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency

Jonsson, B. H. (2018) · Nutrients · doi:10.3390/nu10020134 · Cited by 15

In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging

Zhu, X.-H., & Chen, W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00394 · Cited by 15

Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism

Orlandi, I., Stamerra, G., & Vai, M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00676 · Cited by 16

Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects

Podyacheva, E., & Toropova, Y. G. (2021) · Nutrients · doi:10.3390/nu13103435 · Cited by 15

Metabolomic Changes Are Predictive of Aging in Laying Hens

Bendikov-Bar, I., Malitsky, S., Itkin, M., Rusal, M., & Sagi, D. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab135 · Cited by 14

Metabolic enzymes function as epigenetic modulators: A Trojan Horse for chromatin regulation and gene expression

Liao, X., Guo, Y., He, Y., Xiao, Y., Li, J., & Liu, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105834 · Cited by 14

Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats

Song, F., Song, M., Ma, W., Gao, Z., Ti, Y., Zhang, X., Hu, B., Zhong, M., Zhang, W., & Yu, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.09.026 · Cited by 14

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway

Wang, Y., Yue, J., Xiao, M., Lu, X., & Chin, Y. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.872444 · Cited by 14

A Tale of Two: When Neural Stem Cells Encounter Hypoxia

Fan, Y., Li, J., & Fang, B. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01293-6 · Cited by 14

Effects of lifespan-extending interventions on cognitive healthspan

Čulig, L., Sahbaz, B. D., & Bohr, V. A. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.36 · Cited by 14

Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism

Nagahisa, T., Kosugi, S., & Yamaguchi, S. (2023) · Nutrients · doi:10.3390/nu15061494 · Cited by 14

Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4+ T Cells—Implications for the Pathogenesis of Systemic Lupus Erythematosus

Park, J. S., & Perl, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310749 · Cited by 14

Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives

Kal, S., Mahata, S., Jati, S., & Mahata, S. K. (2023) · Peptides · doi:10.1016/j.peptides.2023.171147 · Cited by 15

Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model

Shi, Y., Ye, D., Cui, K., Bai, X., Fan, M., Feng, Y., Hu, C., Xu, Y., & Huang, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167053 · Cited by 14

A Molecular Perspective and Role of NAD+ in Ovarian Aging

Ahmed, M., Riaz, U., Lv, H., & Yang, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094680 · Cited by 15

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren, C., Shuang, Z., Chen, Y., Deng, K., Kuang, M., Gong, Z., Zhang, K., Wang, P., Huang, P., Zhou, Z., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400453r · Cited by 14

Role of Vitamin B in Healthy Ageing and Disease

Mikkelsen, K., Trapali, M., & Apostolopoulos, V. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_12 · Cited by 15

A new facet of ADP-ribosylation reactions SIRTs and PARPs interplay

Mennella, M. R. F. (2015) · Frontiers in bioscience · doi:10.2741/4319 · Cited by 14

Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer

Wang, Y., Deng, G. G., & Davies, K. P. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00134.2016 · Cited by 14

Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion

Lee, J. M., Park, J., Lee, J. H., Song, M. K., & Kim, Y. (2021) · International Neurourology Journal · doi:10.5213/inj.2142340.170 · Cited by 14

Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease?

Xue, X., Miao, Y., & Wei, Z. (2022) · FEBS Letters · doi:10.1002/1873-3468.14528 · Cited by 14

The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma

Silva, S. G. N. E., Occhiutto, M. L., & Costa, V. P. (2023) · European Journal of Ophthalmology · doi:10.1177/11206721231161101 · Cited by 14

LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression

Guan, J., Zhang, Z., Sun, J., Wang, X.-P., Zhou, Z., & Qin, L. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10213-x · Cited by 14

Involvement of Sirtuin 1 in the Growth Hormone/Insulin-like Growth Factor 1 Signal Transduction and Its Impact on Growth Processes in Children

Fedorczak, A., Lewiñski, A., & Stawerska, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015406 · Cited by 16

Salidroside protects PC12 cells from Aβ1–40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway

Huang, X., Xing, S., Chen, C., Yu, Z., & Chen, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6931 · Cited by 14

Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool

Brunetta, H. S., Holwerda, A. M., van Loon, L. J. C., & Holloway, G. P. (2019) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-019-00037-1 · Cited by 14

Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer’s Disease

Ryu, W., Cohen, B. M., & Sonntag, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.697578 · Cited by 14

NAD metabolism and the SLC34 family: evidence for a liver-kidney axis regulating inorganic phosphate

Tatsumi, S., Katai, K., Kaneko, I., Segawa, H., & Miyamoto, K. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2204-2 · Cited by 14

Deciphering Mitochondria: Unveiling Their Roles in Mechanosensing and Mechanotransduction

Yu, J., Huang, Y., Qin, Y., Zhu, J., Zhao, T., Wu, H., Ye, X., Qin, X., Li, S., Chen, Y., et al. (2025) · Research · doi:10.34133/research.0816 · Cited by 13

Testicular immunosenescence: a key player in age-related spermatogenic decline

Zhan, M.-W., Zhou, M.-H., Zhao, B.-B., Bao, X.-J., Chen, Y., & Zhu, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1669826 · Cited by 13

Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer

Easwaran, H., & Weeraratna, A. T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00868-x · Cited by 15

Cellular senescence in cancer: Friend or fraud?

Chen, Q., Liu, J., Wu, J., Xiang, X., Zhou, X., Mi, J., Wei, J., Zou, X., & Wu, A. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101363 · Cited by 15

Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice

Zhao, X.-Y., Dong, Y. J., Shi, X., Hou, S., & Teng, D. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001805 · Cited by 13

Xiaoyaosan ameliorates CUMS-induced depressive-like and anorexia behaviors in mice via necroptosis related cellular senescence in hypothalamus

Jiao, H., Fan, Y., Gong, A., Li, T., Fu, X., & Yan, Z. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116938 · Cited by 13

Exploring the metabolomics profile of frailty- a systematic review

Shekarchian, A., Bandarian, F., Hadizadeh, A., Amirsardari, Z., Sharifi, Y., Ayati, A., Varmaghani, M., Shandiz, A. F., Sharifi, F., Ghadery, A. H., et al. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01379-y · Cited by 13

The enzymes of serine synthesis pathway in cancer metastasis

Li, L., Qin, Y., & Chen, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119697 · Cited by 13

Why is NMNAT Protective against Neuronal Cell Death and Axon Degeneration, but Inhibitory of Axon Regeneration?

Tang, B. L. (2019) · Cells · doi:10.3390/cells8030267 · Cited by 14

Cross-talk in NAD+ metabolism: insights from Saccharomyces cerevisiae

Raj, C. J. T., & Lin, S.-J. (2019) · Current Genetics · doi:10.1007/s00294-019-00972-0 · Cited by 13

In silico insights into potential gut microbial modulation of NAD+ metabolism and longevity

Salekeen, R., Siam, M. H. B., Sharif, D. I., Lustgarten, M. S., Billah, M. M., & Islam, K. M. D. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22925 · Cited by 14

Keeping the beat against time: Mitochondrial fitness in the aging heart

Mendoza, A., & Karch, J. M. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.951417 · Cited by 13

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside

Birkisdóttir, M. B., van Galen, I., Brandt, R. M. C., Barnhoorn, S., van Vliet, N., van Dijk, C., Nagarajah, B., Imholz, S., van Oostrom, C. T., Reiling, E., et al. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1005322 · Cited by 13

Role of SIRT3 in neurological diseases and rehabilitation training

Li, Y.-L., Li, J., Wu, G., Yang, H. Q., Yang, X., Wang, D., & He, Y. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01111-4 · Cited by 13

Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3

Zhang, W., Fan, Z., Wang, F., Yin, L., Wu, J., Li, D., Song, S., Wang, X., Tang, Y., & Huang, C. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/9966355 · Cited by 13

Sur l'oxydation de l'adrénochrome

Gautheron, D. C., & Chaix, P. (1954) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(54)90322-4

NAD+: a crucial regulator of sirtuin activity in aging

Braidy, N., & Villalva, M. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00008-2 · Cited by 4

The pathophysiological importance and therapeutic potential of NAD' biosynthesis and mitochondrial sirtuin SIRT3 in age-associated diseases.

Yamaguchi, S., & Yoshino, J. (2016) · PubMed · Cited by 5

NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.789479 · Cited by 193

NAD + in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319