Lung cancer stem cells—Origin, characteristics and therapy
Open accessAbstract
Cancer stem cells (CSCs) have gained an increasing attention recently in cancer research. CSCs have ability to generate new tumor through their stem cell properties, essentially self-renewal potential and differentiation into multiple cell lineages. Extensive evidences report that CSCs are resistant to many conventional therapies and mediate tumor recurrence. CSCs of lung cancer are well recognized by their specific markers such as CD133, CD44, ABCG2 and ALDH1A1 together with the CSC characteristics including spheroid and colony formation. Targeting these surface proteins with blocking antibodies and inhibition of ABC transporters and aldehyde dehydrogenase (ALDH) enzymes with small molecules may prove useful in inhibiting tumor progression. The Hh, Notch and Wnt pathways are key signaling cascades that govern cell fate during development and have been shown to be involved in CSCs in various solid tumors. Therapeutic approaches also target these signaling pathways in repressing the tumor progression. This review will focus on stem cell origins, role of signaling pathways, stem cell markers and therapeutic approaches specific to lung cancer.
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Presence of CSCs is always associated with an increased incidence of metastasis, resistance to therapy, and tumor recurrence.
“Their presence is always associated with an increased incidence of metastasis, resistance to therapy, and tumor recurrence [52].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [52]
20E treatment at doses of 0.1-100 μM significantly inhibited the expression of all CSC markers studied (ALDH, CD44, Oct4, c-Kit, Nestin).
“Figure 10 demonstrates that 20E treatment at doses of 0.1–100 µM significantly inhibited the expression of all of the CSC markers studied.”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [52]
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Cancer stem cells—Origins and biomarkers: Perspectives for targeted personalized therapies
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- Authors
- Prabavathy, D., Swarnalatha, Y., & Ramadoss, N.
- Affiliations
- Sathyabama Institute of Science and Technology (IN)
- California State University, Northridge (US)
- Corresponding author
- Prabavathy, D
- Venue
- Stem Cell Investigation
- Publisher
- AME Publishing Company
- Published
- 2018-03
- Volume
- 5
- Pages
- 6-6
- ISSN
- 2306-9759 (ISSN-L)
- 2313-0792
- PMC
- PMC5897668
- OpenAlex
- W2792495697
- Cited by
- 125
- References
- 78
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 16 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 9 · 2018: 3 · 2017: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Stem Cell Investigation (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- lung cancer, cancer stem cells, stem cell markers, CD133, CD44, ABCG2, ALDH1A1, spheroid formation, drug resistance, tumor recurrence, Hedgehog signaling, Notch signaling, Wnt signaling, ABC transporter inhibitors, aldehyde dehydrogenase inhibitors, stem cell origin, targeted therapy
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