The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Vitamin C in Stem Cell Reprogramming and Cancer
Open accessAbstract
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe 2+- and α-ketoglutarate-dependent dioxygenases (Fe 2+/α-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.
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“For vitamin C to have a therapeutic impact on cancer, it should be given intravenously to achieve plasma levels in mM.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [103]
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“Moreover, the intracellular concentration of vitamin C should be apparently relatively high for the optimal function of these enzymes since Km for vitamin C ranges from 140 to 300 µM [103].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [103]
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Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Predoi, G., & Șerban, A. I. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112891 · Cited by 883
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553
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Epigenetics-targeted drugs: current paradigms and future challenges
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Metabolic signatures of cancer cells and stem cells
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Metadata
- Authors
- Cimmino, L., Neel, B. G., & Aifantis, I.
- Affiliations
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
- Corresponding author
- Cimmino, Luisa
- Aifantis, Iannis
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 28
- Issue
- 9
- Pages
- 698-708
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC6102081
- OpenAlex
- W2801924666
- Cited by
- 197
- References
- 87
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 23 · 2023: 28 · 2022: 29 · 2021: 31 · 2020: 34 · 2019: 20 · 2018: 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA194923, R01CA049152, R01CA149655, R01CA133379, R01CA216421, R01CA169784, R01CA173636, P30CA016087)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- vitamin C, stem cell reprogramming, induced pluripotent stem cells, embryonic stem cells, hematopoietic stem cells, histone demethylase, Jumonji C domain, epigenetic regulation, DNA methylation, histone methylation, cancer epigenetics, fibroblast reprogramming
- MeSH terms
- Animals, Antioxidants, Ascorbic Acid, Humans, Neoplasms, Stem Cells, Epigenesis, Genetic, Cellular Reprogramming
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