Reprogramming the epigenome with vitamin C

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766 · see citing works

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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Epigenetic memory in induced pluripotent stem cells

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Histone demethylation by a family of JmjC domain-containing proteins

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.

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Mutation in <i>TET2</i> in Myeloid Cancers

Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,536 · see citing works

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1608368 · Cited by 1,518 · see citing works

Ink4a/Arf expression is a biomarker of aging

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Epigenetic plasticity and the hallmarks of cancer

Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

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JmjC-domain-containing proteins and histone demethylation

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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

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Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179 · see citing works

Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

Gao, X., Wu, G., Gu, X., Fu, L., & Mei, C. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355743 · Cited by 1,036 · see citing works

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature · doi:10.1038/nature08287 · Cited by 1,028 · cited 1× · see citing works

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works

Vitamin C pharmacokinetics: Implications for oral and intravenous use

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.

Esteban, M., Wang, T., Qin, B.-M., Yang, J.-Y., Qin, D.-J., Cai, J.-L., Li, W., Weng, Z., Chen, J.-K., Ni, S., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.12.001 · Cited by 989 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Blaschke, K., Ebata, K. T., Karimi, M. M., Zepeda-Martínez, J. A., Goyal, P., Mahapatra, S., Tam, A., Laird, D. J., Hirst, M., Rao, A., et al. (2013) · Nature · doi:10.1038/nature12362 · Cited by 865 · see citing works

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

Figueroa, M. E., Lugthart, S., Li, Y., Erpelinck-Verschueren, C. A. J., Deng, X., Christos, P. J., Schifano, E. D., Booth, J. G., van Putten, W., Skrabanek, L. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.020 · Cited by 833 · see citing works

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807 · see citing works

iPS cells produce viable mice through tetraploid complementation

Zhao, X., Li, W., Lv, Z., Liu, L., Tong, M., Hai, T., Hao, J., Guo, C., Ma, Q., Wang, L., et al. (2009) · Nature · doi:10.1038/nature08267 · Cited by 778 · see citing works

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

Stadtfeld, M., Apostolou, E., Akutsu, H., Fukuda, A., Follett, P., Natesan, S., Kono, T., Shioda, T., & Hochedlinger, K. (2010) · Nature · doi:10.1038/nature09017 · Cited by 763 · see citing works

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., & Yamanaka, S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.001 · Cited by 757 · see citing works

Acquired mutations in TET2 are common in myelodysplastic syndromes

Langemeijer, S. M. C., Kuiper, R. P., Berends, M., Knops, R., Aslanyan, M. G., Massop, M., Stevens-Linders, E., van Hoogen, P., van Kessel, A. G., Raymakers, R. A. P., et al. (2009) · Nature Genetics · doi:10.1038/ng.391 · Cited by 755 · see citing works

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Abdel-Wahab, O., Mullally, A., Hedvat, C., Garcia-Manero, G., Patel, J., Wadleigh, M., Malinge, S., Yao, J., Kilpivaara, O., Bhat, R., et al. (2009) · Blood · doi:10.1182/blood-2009-03-210039 · Cited by 727 · see citing works

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.032 · Cited by 707 · see citing works

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science · doi:10.1126/science.1231677 · Cited by 703 · see citing works

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and diseasePreprint

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Diagnosis and treatment of Parkinson disease: molecules to medicine

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Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance

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Senescence impairs successful reprogramming to pluripotent stem cells

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Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., Barbera, A. J., Zheng, L., Zhang, H., Huang, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.005 · Cited by 634 · see citing works

Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

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Lysine post-translational modifications of collagen

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HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition

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m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

Chen, T., Hao, Y., Zhang, Y., Li, M., Wang, M., Han, W., Yong-sheng, W., Lv, Y., Hao, J., Wang, L., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.016 · Cited by 552 · see citing works

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545 · see citing works

TET2 promotes histone O-GlcNAcylation during gene transcription

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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

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H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

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The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M. A., Pan, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.005 · Cited by 458 · see citing works

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

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Vitamin C: Update on physiology and pharmacology

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Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

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Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins

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O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.018 · Cited by 443 · see citing works

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

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NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Costa, Y., Ding, J., Theunissen, T. W., Faiola, F., Hore, T. A., Shliaha, P. V., Fidalgo, M., Saunders, A., Lawrence, M., Dietmann, S., et al. (2013) · Nature · doi:10.1038/nature11925 · Cited by 433 · see citing works

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

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Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine

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Histone demethylases in development and disease

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Progeria syndromes and ageing: what is the connection?

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Perspectives on Oxygen Sensing

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Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

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Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming

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The Genetics of Vitamin C Loss in Vertebrates

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Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation

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Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

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The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

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Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.

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Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells

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Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State

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From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements with Vitamin C and Retinoic Acid in Diabetes Research

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Targeting the Aryl Hydrocarbon Receptor in Stem Cells to Improve the Use of Food as Medicine

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Regulation of Human Stem Cells by Functional Food Components: How Vitamins, Minerals and Phytochemicals Influence Mesenchymal Stem Cells’ Fate and Function

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Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming

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Untargeted Metabolomics Showed Accumulation of One-Carbon Metabolites to Facilitate DNA Methylation during Extracellular Matrix Detachment of Cancer Cells

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Next-generation direct reprogramming

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Vitamin C‐Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise

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Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications

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Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?

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Deciphering the neuroprotective effect of ascorbic acid mediated synthesis of iron oxide nanoparticles against Parkinson’s disease: an in vitro and in vivo approach

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Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective

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Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer

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Cardiomyocyte precursors generated by direct reprogramming and molecular beacon selection attenuate ventricular remodeling after experimental myocardial infarction

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Ascorbic Acid Ameliorates Molecular and Developmental Defects in Human-Induced Pluripotent Stem Cell and Cerebral Organoid Models of Fragile X Syndrome

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Hypo-osmolarity promotes naive pluripotency by reshaping cytoskeleton and increasing chromatin accessibility

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Pluripotent stem cell lines on the farm: naïve-state pluripotency, germline chimerism, and nuclear transfer cloning

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Therapeutic Potential of High Dose Vitamin C in Cancer: Mechanisms, Clinical Evidence and Future Directions

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Vitamin C and cancer risk and treatment

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Lifestyle and preventive medical epigenetics

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Epigenetic Inheritance in Aquatic Organisms

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High-dose vitamin C blocks HOCl production by Myeloperoxidase: A potential therapeutic strategy

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Overall and Progression-Free Survival of Patients With Malignant Neoplasm Following Intravenous Vitamin C: A Systematic Review and Meta-Analysis

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Vitamins in Health and Diseases

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Nutriepigenomics: Paving the way for personalized nutrition

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Use of vitamin C in anticancer therapy? – preclinical and clinical data overview

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Nanog in iPS cells and during reprogramming

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Bioactive Dietary Compounds and Epigenetics in Women’s Reproductive Cancers

Li, Z., & Li, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00061-x · Cited by 2 · see citing works

Vitamin C in stem cell reprogramming and cancer

Cimmino, L., Neel, B. G., & Aifantis, I. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.001 · Cited by 197 · see citing works

Vitamin C and Somatic Cell Reprogramming

Wang, J., & Cimmino, L. (2020) · CRC Press eBooks · doi:10.1201/9781003017493-6

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M. A., Pan, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.005 · Cited by 458 · see citing works

Vitamin C : An Epigenetic Regulator

Eryƒ±lmaz Pehlivan, F. (2018) · BiblioBoard Library Catalog (Open Research Library)

Vitamin C – A new player in regulation of the cancer epigenome

Gillberg, L., Ørskov, A. D., Liu, M., Harsløf, L. B. S., Jones, P. A., & Grønbæk, K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.001 · Cited by 100 · see citing works