Cited by 214Vitamin C and Antioxidants ResearchPluripotent Stem Cells ResearchEpigenetics and DNA Methylation

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Vitamin C in Stem Cell Reprogramming and Cancer

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Cimmino, Luisa, Neel, Benjamin G., Aifantis, Iannis·2018·Trends in Cell Biology

DOI 10.1016/j.tcb.2018.04.001PMC PMC6102081

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Abstract

Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe 2+- and α-ketoglutarate-dependent dioxygenases (Fe 2+/α-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.

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Authors: Cimmino, L., Neel, B. G., & Aifantis, I.
Affiliations: NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
Corresponding author: Cimmino, Luisa
Aifantis, Iannis
ORCID: Cimmino, Luisa
Neel, Benjamin G.
Aifantis, Iannis
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2018-09
Volume: 28
Issue: 9
Pages: 698-708
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2018.04.001
PMC: PMC6102081
OpenAlex: W2801924666
Cited by: 197
References: 87
Citations by year: 2026: 13 · 2025: 13 · 2024: 23 · 2023: 28 · 2022: 29 · 2021: 31 · 2020: 34 · 2019: 20 · 2018: 5
FWCI: 2.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA194923, R01CA049152, R01CA149655, R01CA133379, R01CA216421, R01CA169784, R01CA173636, P30CA016087)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: vitamin C, stem cell reprogramming, induced pluripotent stem cells, embryonic stem cells, hematopoietic stem cells, histone demethylase, Jumonji C domain, epigenetic regulation, DNA methylation, histone methylation, cancer epigenetics, fibroblast reprogramming
MeSH terms: Animals, Antioxidants, Ascorbic Acid, Humans, Neoplasms, Stem Cells, Epigenesis, Genetic, Cellular Reprogramming

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Vitamin C in Stem Cell Reprogramming and Cancer

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