The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Emerging Mechanisms and Disease Relevance of Ferroptosis
Open accessAbstract
Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating some cancers. Understanding the mechanisms governing cell death is critical for addressing its role in disease. Similarly, metabolism is essential for normal energy and biomolecule production, and goes awry in many diseases. Metabolism and cell death are tightly linked in the phenomenon of ferroptosis, a form of regulated cell death driven by peroxidation of phospholipids. Glutathione peroxidase 4 (GPX4) uses glutathione to protect cells from ferroptosis by eliminating phospholipid peroxides. Recent data have revealed glutathione/GPX4-independent axes for suppressing ferroptosis, and insight into the regulation of iron and mitochondria in ferroptosis. Ferroptosis has recently been implicated in multiple diseases, and functions as a tumor suppression mechanism. Ferroptosis induction is a promising approach in treating a number of conditions, including neoplastic diseases. Here, we summarize these recent advances.
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Cites
Regulation of Ferroptotic Cancer Cell Death by GPX4
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Self-citationHeart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Self-citationThe CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Ferroptosis as a p53-mediated activity during tumour suppression
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Self-citationAutophagy promotes ferroptosis by degradation of ferritin
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Cited by
Signaling pathways and defense mechanisms of ferroptosis
Liu, J., Kang, R., & Tang, D. (2022) · The FEBS Journal · doi:10.1111/febs.16059 · Cited by 787
Mitochondrial regulation of ferroptosis
Gan, B. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202105043 · Cited by 601
The interaction between ferroptosis and inflammatory signaling pathways
Chen, Y., Fang, Z.-M., Yi, X., Wei, X., & Jiang, D.-S. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05716-0 · Cited by 567
ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis
Zheng, D., Liu, J., Piao, H., Zhu, Z., Wei, R., & Liu, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1039241 · Cited by 566
p53 in ferroptosis regulation: The new weapon for the old guardian
Liu, Y., & Gu, W. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00943-y · Cited by 540
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Metadata
- Authors
- Stockwell, B. R., Jiang, X., & Gu, W.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 30
- Issue
- 6
- Pages
- 478-490
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W3012782412
- Cited by
- 1,099
- References
- 35
- FWCI
- 31.83
- Type
- journal article
- Language
- en
- Open access
- green
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