The DOI matches its Crossref record; 89 of the 91 references it cites were found in a registry or an index.
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Abstract
Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins. However, Angptls do not bind to either the angiopoietin receptor Tie2 or the related protein Tie1 and remain orphan ligands. Nonetheless, Angptls 1, 2, 3, 4, and Angptl6/angiopoietin-related growth factor function to regulate angiogenesis. Angptls 3, 4, and Angptl6/angiopoietin-related growth factor also appear to directly regulate lipid, glucose, and energy metabolism independently of angiogenic effects. Recently, several lines of evidence reveal differential roles of Angptl structural domains in both angiogenesis and metabolism. Here, we briefly review what is currently known about Angptls function.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“which codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity [93–95]”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [93]
In the citing paper
“In addition to their role in regulating plasma triglyceride levels, ANGPTL3, ANGPTL4, and ANGPTL8 have been associated with numerous physiological roles including stem-cell renewal, angiogenesis, and inflammation (42–45).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [43]
Citations
Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 3,510
(1989) · PubMed · Cited by 3,139
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,650
Prox1 Function Is Required for the Development of the Murine Lymphatic System
Wigle, J. T., & Oliver, G. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81511-1 · Cited by 1,581
Coiled coils: a highly versatile protein folding motif.
Burkhard, P., Stetefeld, J., & Strelkov, S. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01898-5 · Cited by 1,055
Sorting out the roles of PPAR in energy metabolism and vascular homeostasis
Lefebvre, P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27989 · Cited by 962
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
Yach, D., Stückler, D., & Brownell, K. D. (2006) · Nature Medicine · doi:10.1038/nm0106-62 · Cited by 856
Research works printed but not linked: 1
- Kitazawa, 2007, Angiopoietin-related growth factor (AGF) suppresses gluconeogenesis through the Akt/FoxO1-dependent pathway in hepatocytes, J Pharmacol Exp Ther, 17804676
Cited by
Sorted by citations
Items 301–351 of 351
Pulido-Cejudo, A., de Oca-Durán, E. R. M., Basurto-Kuba, E. O. P., Zaldivar‐Ramírez, F. R., Mendoza-Hernández, J. E., & López, L. M. H. (2023) · Cirugía y Cirujanos · doi:10.24875/ciru.21000470 · Cited by 1
Chen, B. D., Lee, C., Tapia, A. L., Reiner, A. P., Tang, H., Kooperberg, C. L., Manson, J. E., Li, Y., & Raffield, L. M. (2024) · Genetic Epidemiology · doi:10.1002/gepi.22578 · Cited by 1
Prognostic value of serum angiopoietin-like protein 2 in patients with acute coronary syndrome
Zuo, G., Zhang, J., & Xie, H. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04391-z · Cited by 1
Agis, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-21056-8_5-1 · Cited by 1
Yoshinaga, T., Nishimata, H., Tanaka, S., Hori, E., Tomiyoshi, A., Tokudome, E., Takei, T., & Yoshida, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.9610 · Cited by 1
Tuuri, A. (2014) · Työväentutkimus Vuosikirja · Cited by 1
The Role of Angiopoietin-like 4 in Lipid Homeostasis
Gray, N. E. (2012) · eScholarship (California Digital Library) · Cited by 1
Kim, J. H. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0172 · Cited by 1
Wang, F., Chen, C., Chen, W., Li, Z.-L., & Cheng, H. (2021) · Research Square · doi:10.21203/rs.3.rs-486587/v1 · Cited by 1
Baron‐Menguy, C., Fréneau, M., Mrad, M.-A., Lebot, C., Rio, M., L’Allinec, V., Quillard, T., Desal, H., Redon, R., Bourcier, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.10.632391 · Cited by 1
Recherche de déterminants génétiques des phénotypes associés au syndrome métabolique en population
Legry, V. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Packham, I. M. (2009) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Lina, Y., Lawrence, G. S., Wijaya, A., & As’ád, S. (2010) · Medical Journal of Indonesia · doi:10.13181/mji.v19i3.399
Novel factors affecting clearance of triacylglycerol-rich lipoproteins from blood
Nilsson, S. K. (2010)
Ex vivo Expansion of Hematopoietic Stem Cells
Farahbakhshian, E. (2013) · RePub (Erasmus University Rotterdam)
The role of ANGPTL2-induced chronic inflammation in lifestyle diseases and cancer
Oike, Y., Kadomatsu, T., & Endo, M. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.193
Self-citationReview Article Hematopoietic stem cells: interplay with immunity
Zhang, C. C., & Boulevard, H. H. (2012)
Angiopoietin-like protein 4 in bovine physiology
Li, S. (2011) · K-State Research Exchange (Kansas State University)
Molecular Characterization of Glioblastoma Cancer Stem Cells
Garner, J. M. (2014) · doi:10.21007/etd.cghs.2014.0106
The roles of angiopoietin-like 4 in cancer metastasis
Teo, Z. Q. (2016) · doi:10.32657/10356/66432
Lipids as an Energy Source for the Premature and Term Neonate
Herrera, E., & Ortega, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00036-6
The role of angiopoietin-like 4 in skin wound repair.
Goh, Y. Y. (2011) · doi:10.32657/10356/46276
The role of angiopoietin-like 4 in inflammation
Phua, T. (2017) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/72319
Identification and Characterization of the Receptor for the Soluble Fibrinogen Like Protein 2 (FGL2)
Liu, H. (2010) · TSpace (University of Toronto)
Rôle des hépatokines dans le dialogue inter-organes en physiologie et physiopathologie
Pacheco, A., & Postic, C. (2020) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2020.04.008
Identification and regulation of (novel) human adipokines : a proteomic approach
Rosenow, A. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140207ar
Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans AlkaloidsPreprint
Wu, Y., Wang, L., Hu, X.-P., Song, S., Zhao, N., Feng, Y., Guo, J., Liu, Z., Sun, Z.-L., & Liu, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-910502/v1
(2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833592e7
Agis, H. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-319-54586-8_5
Kazlauskas, A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736655920.793567842
Introduction: Cancer a Global Challenge and Role of Angiogenesis in Cancer
Mukherjee, S., & Madamsetty, V. S. (2022) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-11284-3_1
Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2023) · doi:10.1158/0008-5472.22384311
Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2023) · doi:10.1158/0008-5472.22384311.v1
Bone Marrow–Resident Stem Cells
Senegaglia, A. C., & de Azambuja, A. P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15289-4.00010-x
Research Progress on the Correlation between ANGPTL7 and Obstructive Sleep Apnea Hypopnea Syndrome
瞿, 道. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13102320
Zhou, H., & Chen, G. (2024) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2024.3750
Pulido-Cejudo, A., de Oca-Durán, E. R. M., Basurto-Kuba, E. O. P., Zaldívar-Ramírez, F. R., Mendoza-Hernández, J. E., & López, L. M. H. (2024) · Cirugía y Cirujanos (English Edition) · doi:10.24875/cirue.m23000430
Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafishPreprint
Mo, J., Zhuo, D., Huang, Y., Cheng, T., Dong, Y., Xing, Y.-Y., Li, Y.-F., Jin, Z., Liu, X., Zhao, G.-Q., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.18.670818
Additional file 3 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Chen, L., Yu, Z., Xie, L., He, X., Mu, X., Chen, C., Yang, W., Tong, X., Liu, J., Gao, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22606052
Cao, Y., Xu, Y., Chen, C., Xie, H., Lu, H., & Hu, J. (2021) · Figshare · doi:10.6084/m9.figshare.13544243
Additional file 2 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Chen, L., Yu, Z., Xie, L., He, X., Mu, X., Chen, C., Yang, W., Tong, X., Liu, J., Gao, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22606049
Additional file 1 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Chen, L., Yu, Z., Xie, L., He, X., Mu, X., Chen, C., Yang, W., Tong, X., Liu, J., Gao, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22606046
Étude du rôle de la production hépatique de glucose dans le développement du diabète et de l’obésité
Abdul-Wahed, A. (2012) · theses.fr (ABES) · doi:10.70675/61924053za287z4f04zb650zc51c1916ee64
Tie1 et la transition endothélio-mésenchymateuse
Garcia, J. (2013) · theses.fr (ABES) · doi:10.70675/063d32edz5c5cz44e7zb912z0fa2bc96180b
Angptl5 restricts primitive hematopoiesis by promoting retinoic acid signaling in zebrafish
Mo, J., Zhuo, D., Huang, Y., Cheng, T., Dong, Y., Dong, Y., Li, Y.-F., Jin, Z.-X., Liu, X., Zhao, G.-Q., et al. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003858
Rong, W., Xu, J., Li, B., Zhang, X., Li, Y., Song, B., & Xu, Y. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02447-3
Bovine Angptl6 gene effects on growth traits in three Chinese native cattle breeds
Li, A., Lan, X., Ma, Y., Liu, D., Cai, H., LE, C., & Chen, H. (2012) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v82i11.25154
Novel mechanisms involved with lipid metabolism in adipose tissue of dairy cows
Koltes, D. A. (2013) · Iowa State University Digital Repository (Iowa State University)
Metadata
- Authors
- Hato, T., Tabata, M., & Oike, Y.
- Affiliations
- Keio University (JP)
- Corresponding author
- Oike, Yuichi
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 18
- Issue
- 1
- Pages
- 6-14
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W1974975509
- Cited by
- 351
- References
- 91
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 16 · 2021: 33 · 2020: 22 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 24 · 2014: 28 · 2013: 20 · 2012: 25
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Astellas Foundation for Research on Metabolic Disorders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-like proteins, angiogenesis, energy metabolism, lipid metabolism, glucose metabolism, ANGPTL6, fibrinogen-like domain, coiled-coil domain, Tie2 receptor
- MeSH terms
- Animals, Energy Metabolism, Fishes, Humans, Mice, Transgenic, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Angiopoietins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
