The DOI matches its Crossref record; 89 of the 91 references it cites were found in a registry or an index.
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Abstract
Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins. However, Angptls do not bind to either the angiopoietin receptor Tie2 or the related protein Tie1 and remain orphan ligands. Nonetheless, Angptls 1, 2, 3, 4, and Angptl6/angiopoietin-related growth factor function to regulate angiogenesis. Angptls 3, 4, and Angptl6/angiopoietin-related growth factor also appear to directly regulate lipid, glucose, and energy metabolism independently of angiogenic effects. Recently, several lines of evidence reveal differential roles of Angptl structural domains in both angiogenesis and metabolism. Here, we briefly review what is currently known about Angptls function.
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“which codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity [93–95]”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [93]
In the citing paper
“In addition to their role in regulating plasma triglyceride levels, ANGPTL3, ANGPTL4, and ANGPTL8 have been associated with numerous physiological roles including stem-cell renewal, angiogenesis, and inflammation (42–45).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [43]
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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
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Metadata
- Authors
- Hato, T., Tabata, M., & Oike, Y.
- Affiliations
- Keio University (JP)
- Corresponding author
- Oike, Yuichi
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 18
- Issue
- 1
- Pages
- 6-14
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W1974975509
- Cited by
- 351
- References
- 91
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 16 · 2021: 33 · 2020: 22 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 24 · 2014: 28 · 2013: 20 · 2012: 25
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Astellas Foundation for Research on Metabolic Disorders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-like proteins, angiogenesis, energy metabolism, lipid metabolism, glucose metabolism, ANGPTL6, fibrinogen-like domain, coiled-coil domain, Tie2 receptor
- MeSH terms
- Animals, Energy Metabolism, Fishes, Humans, Mice, Transgenic, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Angiopoietins, Mice
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