Angiopoietin-Like Proteins: A Comprehensive Look

Santulli, Gaetano

doi:10.3389/fendo.2014.00004

Cited by 320Lipid metabolism and disordersAngiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

Angiopoietin-Like Proteins: A Comprehensive Look

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Santulli, Gaetano·2014·Frontiers in Endocrinology

DOI 10.3389/fendo.2014.00004PMC PMC3899539

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Abstract

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.

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ANGPTL3 codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity.
“which codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity [93–95]”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [94]
The ANGPTL3 section states that ANGPTL3 inhibits LPL activity, and a reference listed in the paper reports that ANGPTL3 induces blood-vessel formation. The copy does not establish that ANGPTL3 is a glycoprotein or has roles in tissue remodeling or inflammation; its discussion of inflammation and glycoprotein status concerns other ANGPTL proteins. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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Muramoto, A., Tsushita, K., Kato, A., Ozaki, N., Tabata, M., Endo, M., Oike, Y., & Oiso, Y. (2011) · Nutrition and Diabetes · doi:10.1038/nutd.2011.16 · Cited by 40 · see citing works
Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans
van Raalte, D. H., Brands, M., Serlie, M. J. M., Mudde, K., Stienstra, R., Sauerwein, H. P., Kersten, S., & Diamant, M. (2012) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0032-1321864 · Cited by 37 · see citing works
Identification of a novel human angiopoietin-like gene expressed mainly in heart
Zeng, L., Dai, J., Ying, K., Zhao, E., Jin, W., Ye, Y., Dai, J., Xu, J., Xie, Y., & Mao, Y. (2003) · Journal of Human Genetics · doi:10.1007/s100380300025 · Cited by 36 · see citing works
Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis
Zeng, L., Gu, S., Li, Y., Zhao, E., Xu, J., Ye, X., Wu, Q., Wang, L., Xie, Y., & Mao, Y. (2003) · Journal of Human Genetics · doi:10.1007/s10038-003-0033-3 · Cited by 35 · see citing works
Dynamic roles of angiopoietin-like proteins 1, 2, 3, 4, 6 and 7 in the survival and enhancement of ex vivo expansion of bone-marrow hematopoietic stem cells
Akhter, S., Rahman, M. M., Lee, H. S., Kim, H., & Hong, S. (2013) · Protein & Cell · doi:10.1007/s13238-013-2066-5 · Cited by 35 · see citing works
The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis
Ogata, A., Endo, M., Aoi, J., Takahashi, O., Kadomatsu, T., Miyata, K., Tian, Z., Jinnin, M., Fukushima, S., Ihn, H., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.052 · Cited by 35 · see citing works
Betatrophin—inducing β-cell expansion to treat diabetes mellitus?
Kugelberg, E. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.98 · Cited by 32 · see citing works
Inactivation of lipoprotein lipase in 3T3-L1 adipocytes by angiopoietin-like protein 4 requires that both proteins have reached the cell surface
Makoveichuk, E., Vorrsjö, E., Olivecrona, T., & Olivecrona, G. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.013 · Cited by 28 · see citing works
Tumor necrosis factor-α increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes
Zheng, J., Zou, J., Wang, W., Feng, X., Shi, Y.-Y., Zhao, Y., Jin, G., & Liu, Z. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.002 · Cited by 26 · see citing works
Reduction of Insulin Signaling Upregulates Angiopoietin-like Protein 4 Through Elevated Free Fatty Acids in Diabetic Mice
Mizutani, N., Ozaki, N., Seino, Y., Fukami, A., Sakamoto, E., Fukuyama, T., Sugimura, Y., Nagasaki, H., Arima, H., & Oiso, Y. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1291258 · Cited by 25 · see citing works
Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism
Lee, H. J., Kim, J. H., Kim, J. H., Martinus, R. D., & Park, S. H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.127 · Cited by 24 · see citing works
Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques
Katano, H., & Yamada, K. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.07.046 · Cited by 23 · cited 1× · see citing works
“Indeed, a microarray analysis demonstrated that in high-calcified carotid plaques ANGPTL4 expression was significantly elevated, whereas FGFR2 expression was significantly suppressed (64).”
Background
Evidence of a role of ANGPTL6 in resting metabolic rate and its potential application in treatment of obesity.
Mirzaei, K., Hossein‐Nezhad, A., Chamari, M., & Shahbazi, S. (2011) · PubMed · Cited by 23 · see citing works
Betatrophin boosts β-cells
Crunkhorn, S. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4058 · Cited by 22 · see citing works
Angiopoietin-like protein 1 decreases blood brain barrier damage and edema following focal cerebral ischemia in mice
Lai, D., Li, H., Lee, C.-C., Tzeng, Y.-S., Hsieh, Y.-H., Hsu, W., Hsieh, F.-J., Cheng, J., & Tu, Y. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.010 · Cited by 20 · see citing works
Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study
Legry, V., Goumidi, L., Huyvaert, M., Cottel, D., Ferrières, J., Arveiler, D., Bingham, A., Wagner, A., Ruidavets, J., Ducimetière, P., et al. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.12.005 · Cited by 17 · see citing works
Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study
Tuuri, A., Jauhiainen, M., Ehnholm, C. P., Tikkanen, M. J., Nicholls, M. G., & Kaaja, R. (2013) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.784783 · Cited by 14 · see citing works
Bulking Up on Beta Cells
Seymour, P. A., & Serup, P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcibr1307038 · Cited by 13 · see citing works
Angioarrestin mRNA expression in early-stage lung cancers
Sasaki, H., Moriyama, S., Sekimura, A., Mizuno, K., Yukiue, H., Konishi, A., Yano, M., Kaji, M., Fukai, I., Yamakawa, Y., et al. (2003) · European Journal of Surgical Oncology · doi:10.1016/s0748-7983(03)00106-9 · Cited by 9 · see citing works
Exome Sequencing Links Gene Mutation in Angiopoietin-Like Protein 3 With Low-Density Lipoprotein Cholesterol
Glazer, N. L. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959510 · Cited by 9 · see citing works
Serum angiopoietin-like protein 3 concentrations in rheumatic diseases
Hayashi, Y., Jinnin, M., Makino, T., Kajihara, I., Makino, K., Honda, N., Nakayama, W., Inoue, K., Fukushima, S., & Ihn, H. (2012) · European Journal of Dermatology · doi:10.1684/ejd.2012.1774 · Cited by 4 · see citing works

Flagged first, then by citations

Sorted by citations

Microbiota: a key orchestrator of cancer therapy
Roy, S., & Trinchieri, G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.13 · Cited by 883 · see citing works
Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
Francque, S., van der Graaff, D., & Kwanten, W. J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.005 · Cited by 557 · see citing works
Oral Mucosal Epithelial Cells
Groeger, S., & Meyle, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00208 · Cited by 473 · see citing works
A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer
Yang, W., Huang, Z., Wu, J., Ding, C. C., Murphy, S. K., & Chi, J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0691 · Cited by 302 · see citing works
Targeting inflammation in metabolic syndrome
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287 · see citing works
The next generation of therapeutics for chronic kidney disease
Breyer, M. D., & Suszták, K. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.67 · Cited by 274 · see citing works
Apolipoproteins in vascular biology and atherosclerotic disease
Mehta, A., & Shapiro, M. D. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00613-5 · Cited by 273 · see citing works
Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer
Carbone, C., Piro, G., Merz, V., Simionato, F., Santoro, R., Zecchetto, C., Tortora, G., & Melisi, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020431 · Cited by 217 · see citing works
Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases
Sandireddy, R., Sakthivel, S., Gupta, P., Behari, J., Tripathi, M., & Singh, B. K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1433857 · Cited by 229 · see citing works
Regulation of lipid metabolism by angiopoietin-like proteins
Dijk, W., & Kersten, S. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000290 · Cited by 194 · see citing works
Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway
Paglia, L. L., Listì, A., Caruso, S., Amodeo, V., Passiglia, F., Bazan, V., & Fanale, D. (2017) · PPAR Research · doi:10.1155/2017/8187235 · Cited by 174 · see citing works
ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis
Fernandez-Hernando, C. F., & Suárez, Y. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000580 · Cited by 162 · see citing works
Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma
Hu, K., Babapoor-Farrokhran, S., Rodrigues, M. W., Deshpande, M. M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6868 · Cited by 150 · see citing works
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2021 · Cited by 149 · see citing works
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab
Khan, M., Aziz, A. A., Shafi, N., Abbas, T., & Khanani, A. M. (2020) · Cells · doi:10.3390/cells9081869 · Cited by 132 · see citing works
Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
Chung, H. S., Lee, M. J., Hwang, S. Y., Lee, H. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0324-y · Cited by 129 · see citing works
Update on the molecular biology of dyslipidemias
Ramasamy, I. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.10.033 · Cited by 126 · see citing works
Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review
Paththinige, C. S., Sirisena, N. D., & Dissanayake, V. H. W. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0488-4 · Cited by 124 · see citing works
MicroRNAs and Endothelial (Dys) Function
Santulli, G. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25276 · Cited by 116 · see citing works
Self-citation
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
Zuliani‐Alvarez, L., Marzeda, A. M., Deligne, C., Schwenzer, A., McCann, F. E., Marsden, B. D., Piccinini, A. M., & Midwood, K. S. (2017) · Nature Communications · doi:10.1038/s41467-017-01718-7 · Cited by 115 · see citing works
Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis
Novák, J., Olejníčková, V., Tkáčová, N., & Santulli, G. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22380-3_5 · Cited by 109 · see citing works
Self-citation
ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
Zhang, Y., Guo, X., Yan, W., Chen, Y., Ke, M., Cheng, C., Zhu, X., Xue, W., Zhou, Q., Zheng, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02355-w · Cited by 109 · see citing works
Angiopoietin‐like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma
Chen, H., Kuo, T., Tseng, C., Ma, J., Yang, S., Yen, C., Yang, C., Sung, S., & Su, J. (2016) · Hepatology · doi:10.1002/hep.28773 · Cited by 104 · see citing works
Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema
Sodhi, A., Ma, T., Menon, D., Deshpande, M. M., Jee, K. J., Dinabandhu, A., Vancel, J., Lu, D., & Montaner, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120879 · Cited by 104 · see citing works
Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D
Abu‐Farha, M., Al‐Khairi, I., Cherian, P., Chandy, B., Devarajan, S., Alhubail, A., Al-Refaei, F. H., Alterki, A., & Abubaker, J. A. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0337-x · Cited by 99 · see citing works
microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis
Santulli, G. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22380-3_4 · Cited by 96 · see citing works
Self-citation
Overview of the Assessment of Endothelial Function in Humans
Chia, P. Y., Teo, A., & Yeo, T. W. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.542567 · Cited by 96 · see citing works
The Importance of Lipoprotein Lipase Regulation in Atherosclerosis
Kumari, A., Kristensen, K. K., Ploug, M., & Winther, A.-M. L. (2021) · Biomedicines · doi:10.3390/biomedicines9070782 · Cited by 95 · see citing works
Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis
Cao, Y. B., Xu, Y., Chen, C., Xie, H., Lü, H., & Hu, J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02078-8 · Cited by 84 · see citing works
Beyond the Matrix: The Many Non-ECM Ligands for Integrins
LaFoya, B., Munroe, J. A., Miyamoto, A., Detweiler, M., Crow, J. J., Gazdik, T. R., & Albig, A. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020449 · Cited by 84 · see citing works
Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
An, Y., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M., & Scherer, P. E. (2017) · eLife · doi:10.7554/elife.24071 · Cited by 77 · see citing works
Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome
Abu‐Farha, M., Abubaker, J. A., Al‐Khairi, I., Cherian, P., Noronha, F., Kavalakatt, S., Khadir, A., Behbehani, K., Alarouj, M., Bennakhi, A., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0346-0 · Cited by 77 · see citing works
An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure
Deviatiiarov, R. M., Gams, A., Kulakovskiy, I. V., Buyan, A., Meshcheryakov, G., Syunyaev, R. A., Singh, R., Shah, P. M., Tatarinova, T. V., Gusev, O., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00182-x · Cited by 74 · see citing works
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling
Yan, Q., Jiang, L., Liu, M., Yu, D., Zhang, Y., Li, Y., Fang, S., Li, Y., Zhu, Y., Yuan, Y., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0579 · Cited by 74 · see citing works
Retracted
Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer
Parri, M., Pietrovito, L., Grandi, A., Campagnoli, S., Camilli, E. D., Bianchini, F., Marchiò, S., Bussolino, F., Jin, B., Sarmientos, P., et al. (2014) · Angiogenesis · doi:10.1007/s10456-014-9435-4 · Cited by 72 · see citing works
Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover
Kirsch, N., Chang, L.-S., Koch, S., Glinka, A., Dolde, C. E., Colozza, G., Benitez, M. D. J., Robertis, E. M. D., & Niehrs, C. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.011 · Cited by 69 · see citing works
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
Tian, Z., Miyata, K., Kadomatsu, T., Horiguchi, H., Fukushima, H., Tohyama, S., Ujihara, Y., Okumura, T., Yamaguchi, S., Zhao, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13016 · Cited by 70 · see citing works
Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
Yamamoto, A., Huang, Y., Krajina, B. A., McBirney, M., Doak, A. E., Qu, S., Wang, C. L., Haffner, M. C., & Cheung, K. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214888120 · Cited by 69 · see citing works
Hypertriglyceridemia—causes, significance, and approaches to therapy
Santos-Baez, L. S., & Ginsberg, H. N. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00616 · Cited by 66 · see citing works
Factors mediating exercise‐induced organ crosstalk
Sabaratnam, R., Wojtaszewski, J. F. P., & Højlund, K. (2022) · Acta Physiologica · doi:10.1111/apha.13766 · Cited by 70 · see citing works
Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders
Morelli, M. B., Chavez, C., & Santulli, G. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1707806 · Cited by 64 · see citing works
Self-citation
Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension
Abu‐Farha, M., Cherian, P., Qaddoumi, M. G., Al‐Khairi, I., Devarajan, S., Alanbaei, M., & Abubaker, J. A. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0681-0 · Cited by 63 · see citing works
The Transcriptome of Pig Spermatozoa, and Its Role in Fertility
Álvarez‐Rodríguez, M., Martinez-Serrano, C. A., Wright, D., Barranco, I., Roca, J., & Rodríguez‐Martínez, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051572 · Cited by 62 · see citing works
Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
Qaddoumi, M. G., Alanbaei, M., Hammad, M. M., Khairi, I. A., Cherian, P., Channanath, A. M., Thanaraj, T. A., Al‐Mulla, F., Abu‐Farha, M., & Abubaker, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-63149-7 · Cited by 59 · see citing works
The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure
McQueen, A. E., Kanamaluru, D., Yan, K. L., Gray, N. E., Wu, L. C., Li, M.-L., Chang, A., Hasan, A., Stifler, D. R., Koliwad, S. K., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.803973 · Cited by 57 · see citing works
Angiopoietin-like-2: a multifaceted protein with physiological and pathophysiological properties
Thorin‐Trescases, N., & Thorin, É. (2014) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2014.19 · Cited by 56 · see citing works
ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Cho, D. I., Ahn, M. J., Cho, H. H., Cho, M., Jun, J. H., Kang, B. G., Lim, S. Y., Yoo, S. J., Kim, M. R., Kim, H.-S., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00937-x · Cited by 55 · see citing works
An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif
Balasubramaniam, D., Schroeder, O., Russell, A. M., Fitchett, J. R., Austin, A. K., Beyer, T. P., Chen, Y., Day, J. W., Ehsani, M. E., Heng, A. R., et al. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100198 · Cited by 52 · see citing works
Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm
Bourcier, R., Scouarnec, S. L., Bonnaud, S., Karakachoff, M., Bourcereau, E., Heurtebise-Chrétien, S., Baron‐Menguy, C., Christian Dina, C., Simonet, F., Moles, A., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.12.006 · Cited by 52 · see citing works
Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
Tanigawa, Y., Wainberg, M., Karjalainen, J. M., Kiiskinen, T., Venkataraman, G. R., Lemmelä, S. M., Turunen, J. A., Graham, R., Havulinna, A. S., Perola, M., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008682 · Cited by 48 · see citing works
Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism
Kim, T. H., Hong, D.-G., & Yang, Y. M. (2021) · Biomedicines · doi:10.3390/biomedicines9121903 · Cited by 52 · see citing works
In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation
Bozhilov, Y. K., Hsu, I., Brown, E. J., & Wilkinson, A. C. (2023) · Cells · doi:10.3390/cells12060896 · Cited by 47 · see citing works
Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease
Liu, D., Song, J., Ji, X., Liu, Z., Cong, M., & Hu, B. (2016) · Medicine · doi:10.1097/md.0000000000003413 · Cited by 44 · see citing works
Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia
Tarugi, P., Bertolini, S., & Calandra, S. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.32.20170114 · Cited by 44 · see citing works
The current state of the osteoarthritis drug development pipeline: a comprehensive narrative review of the present challenges and future opportunities
Kim, H., Seo, J., Lee, Y.-H., Park, K., Perry, T. A., Arden, N., Mobasheri, A., & Choi, H. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221085952 · Cited by 38 · see citing works
Perspectives on the Activities of ANGPTL8/Betatrophin
Peng, Y., Park, J.-S., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.028 · Cited by 42 · see citing works
TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4
Makoveichuk, E., Vorrsjö, E., Olivecrona, T., & Olivecrona, G. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.02.005 · Cited by 40 · see citing works
High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation
Thorin‐Trescases, N., & Thorin, É. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1096385 · Cited by 41 · see citing works
Novel Therapeutic Targets for Managing Dyslipidemia
Sathiyakumar, V., Kapoor, K., Jones, S. R., Banach, M., Martin, S. S., & Toth, P. P. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.06.001 · Cited by 42 · see citing works
Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis
Philpott, H. T., Birmingham, T. B., Blackler, G., Klapak, J. D., Knights, A. J., Farrell, E. C., Fiset, B., Walsh, L. A., Giffin, J. R., Vasarhelyi, E. M., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.43089 · Cited by 40 · see citing works
Tissue-Specific Epigenetics of Atherosclerosis-Related ANGPT and ANGPTL Genes
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Adrenergic Receptors
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Authors: Santulli, G.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Santulli, Gaetano
ORCID: Santulli, Gaetano
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2014
Volume: 5
Pages: 4-4
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2014.00004
PMC: PMC3899539
OpenAlex: W2133904925
Cited by: 320
References: 92
Citations by year: 2026: 15 · 2025: 25 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 40 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 37 · 2016: 21 · 2015: 15 · 2014: 7
FWCI: 4.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: angiopoietin-like proteins, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, ANGPTL7, ANGPTL8, angiopoietins, lipid metabolism, glucose metabolism, inflammation, hematopoiesis, cancer

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Angiopoietin-Like Proteins: A Comprehensive Look

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