Cited by 351Angiogenesis and VEGF in CancerLymphatic System and DiseasesVascular Tumors and Angiosarcomas

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The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism

Hato, Tai, Tabata, Mitsuhisa, Oike, Yuichi·2008·Trends in Cardiovascular Medicine

DOI 10.1016/j.tcm.2007.10.003

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Abstract

Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins. However, Angptls do not bind to either the angiopoietin receptor Tie2 or the related protein Tie1 and remain orphan ligands. Nonetheless, Angptls 1, 2, 3, 4, and Angptl6/angiopoietin-related growth factor function to regulate angiogenesis. Angptls 3, 4, and Angptl6/angiopoietin-related growth factor also appear to directly regulate lipid, glucose, and energy metabolism independently of angiogenic effects. Recently, several lines of evidence reveal differential roles of Angptl structural domains in both angiogenesis and metabolism. Here, we briefly review what is currently known about Angptls function.

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Authors: Hato, T., Tabata, M., & Oike, Y.
Affiliations: Keio University (JP)
Corresponding author: Oike, Yuichi
ORCID: Hato, Tai
Oike, Yuichi
Venue: Trends in Cardiovascular Medicine
Publisher: Elsevier BV
Published: 2008-01
Volume: 18
Issue: 1
Pages: 6-14
ISSN: 1050-1738 (ISSN-L)
DOI: 10.1016/j.tcm.2007.10.003
OpenAlex: W1974975509
Cited by: 351
References: 91
Citations by year: 2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 16 · 2021: 33 · 2020: 22 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 24 · 2014: 28 · 2013: 20 · 2012: 25
FWCI: 1.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Cardiovascular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Astellas Foundation for Research on Metabolic Disorders
Japan Society for the Promotion of Science
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
Keywords: angiopoietin-like proteins, angiogenesis, energy metabolism, lipid metabolism, glucose metabolism, ANGPTL6, fibrinogen-like domain, coiled-coil domain, Tie2 receptor
MeSH terms: Animals, Energy Metabolism, Fishes, Humans, Mice, Transgenic, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Angiopoietins, Mice

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The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism

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