3D engineered cardiac tissue models of human heart disease: learning more from our mice

Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts

Zimmermann, W., Melnychenko, I., Wasmeier, G. H., Didié, M., Naito, H., Nixdorff, U., Heß, A., Budinský, L., Brune, K., Michaelis, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1394 · Cited by 996 · see citing works

Growth of engineered human myocardium with mechanical loading and vascular coculture

Tulloch, N. L., Muskheli, V., Razumova, M. V., Korte, F. S., Regnier, M., Hauch, K. D., Pabon, L., Reinecke, H., & Murry, C. E. (2011) · Circulation Research · doi:10.1161/circresaha.110.237206 · Cited by 666 · see citing works

Three‐dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system

Eschenhagen, T., Fink, C., Remmers, U., Scholz, H., Wattchow, J., Weil, J., Zimmermann, W., Dohmen, H. H., Schäfer, H., Bishopric, N., et al. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.8.9240969 · Cited by 636 · see citing works

Development of a drug screening platform based on engineered heart tissue

Hansen, A., Eder, A., Bönstrup, M., Flato, M., Mewe, M., Schaaf, S., Aksehirlioglu, B., Schwörer, A., Uebeler, J., & Eschenhagen, T. (2010) · Circulation Research · doi:10.1161/circresaha.109.211458 · Cited by 510 · see citing works

Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion

Bell, R. M., Mocanu, M. M., & Yellon, D. M. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.02.018 · Cited by 508 · see citing works

Methods in cardiomyocyte isolation, culture, and gene transfer

Louch, W. E., Sheehan, K. A., & Wolska, B. M. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.06.012 · Cited by 498 · see citing works

Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology

Schaaf, S., Shibamiya, A., Mewe, M., Eder, A., Stöhr, A., Hirt, M. N., Rau, T., Zimmermann, W.-H., Conradi, L., Eschenhagen, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026397 · Cited by 365 · see citing works

Isolation and Culture of Adult Mouse Cardiac Myocytes

O’Connell, T. D., Rodrigo, M. C., & Simpson, P. C. (2006) · Humana Press eBooks · doi:10.1385/1-59745-214-9:271 · Cited by 341 · see citing works

Tissue-Engineered Vascular Grafts for Use in the Treatment of Congenital Heart Disease: From the Bench to the Clinic and Back Again

Patterson, J. T., Gilliland, T., Maxfield, M. W., Church, S. N., Naito, Y., Shinoka, T., & Breuer, C. K. (2012) · Regenerative Medicine · doi:10.2217/rme.12.12 · Cited by 110 · see citing works

Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells

Xi, J., Khalil, M., Shishechian, N., Hannes, T., Pfannkuche, K., Liang, H., Fatima, A., Haustein, M., Suhr, F., Bloch, W., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-145177 · Cited by 94 · see citing works

Neonatal Mouse–Derived Engineered Cardiac Tissue

de Lange, W. J., Hegge, L. F., Grimes, A. C., Tong, C. W.-C., Brost, T. M., Moss, R. L., & Ralphe, J. C. (2011) · Circulation Research · doi:10.1161/circresaha.111.242354 · Cited by 70 · see citing works

Engineered early embryonic cardiac tissue retains proliferative and contractile properties of developing embryonic myocardium

Tobita, K., Liu, L., Janczewski, A. M., Tinney, J. P., Nonemaker, J. M., Augustine, S. M., Stolz, D. B., Shroff, S. G., & Keller, B. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00205.2006 · Cited by 58 · see citing works

Three-Dimensional Culture Alters Primary Cardiac Cell Phenotype

Akins, R. E., Rockwood, D. N., Robinson, K. G., Sandusky, D., Rabolt, J. F., & Pizarro, C. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0458 · Cited by 47 · see citing works

Three-dimensional co-culture facilitates the differentiation of embryonic stem cells into mature cardiomyocytes

Ou, D., He, Y., Chen, R., Teng, J., Wang, H., Zeng, D., Liu, X., Ding, L., Huang, J., & Zheng, Q. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23283 · Cited by 44 · see citing works

From mouse to man: Understanding heart failure through genetically altered mouse models

Chu, G., Haghighi, K., & Kranias, E. G. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129284 · Cited by 42 · see citing works

Engineered Fetal Cardiac Graft Preserves Its Cardiomyocyte Proliferation Within Postinfarcted Myocardium and Sustains Cardiac Function

Fujimoto, K. L., Clause, K. C., Liu, L., Tinney, J. P., Verma, S., Wagner, W. R., Keller, B. B., & Tobita, K. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0259 · Cited by 40 · see citing works

Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration

Nistri, S., Pini, A., Sassoli, C., Squecco, R., Francini, F., Formigli, L., & Bani, D. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01328.x · Cited by 32 · see citing works

Effect of long-term cyclic mechanical load on protein synthesis and morphological changes in cultured Myocardial cells from neonatal rat

Kira, Y., Nakaoka, T., Hashimoto, E., Okabe, F., Asano, S., & SEKINE, I. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877334 · Cited by 26 · see citing works

Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes

Zimmermann, W. H., Fink, C., Kralisch, D., Remmers, U., Weil, J., & Eschenhagen, T. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000405)68:1

Engineered In Vitro Disease Models

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554 · see citing works

In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

Noshadi, I., Hong, S., Sullivan, K. E., Sani, E. S., Lara, R. P., Tamayol, A., Shin, S. R., Gao, A. E., Stoppel, W. L., Black, L. D., et al. (2017) · Biomaterials Science · doi:10.1039/c7bm00110j · Cited by 309 · see citing works

Life in 3D is never flat: 3D models to optimise drug delivery

Fitzgerald, K. A., Malhotra, M., Curtin, C. M., O’Brien, F. J., & O’Driscoll, C. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.020 · Cited by 226 · see citing works

Cardiovascular disease models: A game changing paradigm in drug discovery and screening

Savoji, H., Mohammadi, M. H., Rafatian, N., Toroghi, M. K., Wang, E. Y., Zhao, Y., Korolj, A., Ahadian, S., & Radisic, M. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.036 · Cited by 223 · see citing works

Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties

Noshadi, I., Walker, B. W., Lara, R. P., Sani, E. S., Gomes, N., Aziziyan, M. R., & Annabi, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-04280-w · Cited by 161 · see citing works

Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback

Pfeiffer, E. R., Tangney, J. R., Omens, J. H., & McCulloch, A. D. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4026221 · Cited by 131 · see citing works

Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue

Serpooshan, V., Chen, P., Wu, H., Lee, S., Sharma, A., Hu, D. A., Venkatraman, S., Ganesan, A., Usta, O. B., Yarmush, M. L., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.037 · Cited by 124 · see citing works

Heart-on-a-chip based on stem cell biology

Jastrzębska, E., Tomecka, E., & Jesion, I. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.08.012 · Cited by 91 · see citing works

An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes

Cai, W., Zhang, J., de Lange, W. J., Gregorich, Z. R., Karp, H., Farrell, E. T., Mitchell, S. D., Tucholski, T., Lin, Z., Biermann, M., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315305 · Cited by 78 · see citing works

Bioprinting technologies for disease modeling

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M., & Nikkhah, M. (2017) · Biotechnology Letters · doi:10.1007/s10529-017-2360-z · Cited by 73 · see citing works

Vascularized cardiac tissue construction with orientation by layer-by-layer method and 3D printer

Tsukamoto, Y., Akagi, T., & Akashi, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-59371-y · Cited by 69 · see citing works

Human induced pluripotent stem cell-derived fiber-shaped cardiac tissue on a chip

Morimoto, Y., Mori, S., Sakai‐Takemura, F., & Takeuchi, S. (2016) · Lab on a Chip · doi:10.1039/c6lc00422a · Cited by 67 · see citing works

Modeling the Human Scarred Heart In Vitro: Toward New Tissue Engineered Models

Deddens, J. C., Sadeghi, A. H., Hjortnaes, J., Laake, L. W. V., Buijsrogge, M. P., Doevendans, P. A., Khademhosseini, A., & Sluijter, J. P. G. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600571 · Cited by 31 · see citing works

Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications

Wu, H., Shi, S., Liu, Y., Zhang, Q., Lam, R. H. W., Lim, C. T., & Hu, J. (2023) · Biofabrication · doi:10.1088/1758-5090/acdaf9 · Cited by 23 · see citing works

Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues

Melby, J. A., de Lange, W. J., Zhang, J., Roberts, D. S., Mitchell, S. D., Tucholski, T., Kim, G., Kyrvasilis, A., McIlwain, S. J., Kamp, T. J., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00830 · Cited by 20 · see citing works

Proteomic-based approaches to cardiac development and disease

Dorr, K. M., & Conlon, F. L. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.01.001 · Cited by 17 · see citing works

Overview of Tissue Engineering Concepts and Applications

Belleghem, S. M. V., Mahadik, B. P., Snodderly, K. L., & Fisher, J. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816137-1.00081-7 · Cited by 17 · see citing works

Neonatal Murine Engineered Cardiac Tissue Toxicology Model: Impact of Metallothionein Overexpression on Cadmium-Induced Injury

Yu, H., Ye, F., Yuan, F., Cai, L., Ji, H., & Keller, B. B. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy177 · Cited by 11 · see citing works

Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice

Mayer, A., Bittihn, P., & Luther, S. (2017) · Physiological Reports · doi:10.14814/phy2.13449 · Cited by 9 · see citing works

Heart-on-a-chip

Gaudriault, P., Fassini, D., & Homs-Corbera, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817202-5.00008-5 · Cited by 7 · see citing works

Heart-on-a-chip Systems

Bułka, M., & Jastrzębska, E. (2017) · Springer eBooks · doi:10.1007/978-3-319-70685-6_8 · Cited by 5 · see citing works

Biohybrid Robot Powered by Muscle Tissues

Morimoto, Y., & Takeuchi, S. (2019) · Wiley eBooks · doi:10.1002/9783527822201.ch16 · Cited by 3 · see citing works

Bioengineering 3D Cardiac Microtissues Using Bioassembly

Gu, L., Feng, J., Zhang, D., & Chen, P. (2019) · Springer eBooks · doi:10.1007/978-3-030-20047-3_6 · Cited by 2 · see citing works

Hydrogel-based sealed microchamber arrays for rapid medium exchange and drug testing of cell spheroids

Yoshida, S., Sumomozawa, K., Nagamine, K., & Nishizawa, M. (2020) · Biomedical Microdevices · doi:10.1007/s10544-020-00505-4 · Cited by 2 · see citing works

Heart-on-a-Chip

Pradeep, A., Pillai, I. C. L., Nair, B. G., & Babu, T. G. S. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_18 · Cited by 2 · see citing works

Two-Dimensional Culture Systems to Investigate Mechanical Interactions of the Cell

Napiwocki, B. N., Stempien, A., Notbohm, J., Ashton, R. S., & Crone, W. C. (2017) · Conference proceedings of the Society for Experimental Mechanics · doi:10.1007/978-3-319-63552-1_6 · Cited by 1 · see citing works

Neonatal Mouse–Derived Engineered Cardiac Tissue

de Lange, W. J., Hegge, L. F., Grimes, A. C., Tong, C. W.-C., Brost, T. M., Moss, R. L., & Ralphe, J. C. (2011) · Circulation Research · doi:10.1161/circresaha.111.242354 · Cited by 70 · see citing works

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-228007 · Cited by 184 · see citing works

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

Goldfracht, I., Efraim, Y., Shinnawi, R., Kovalev, E., Huber, I., Gepstein, A., Arbel, G., Shaheen, N., Tiburcy, M., Zimmermann, W. H., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.016 · Cited by 222 · see citing works

Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment

Wang, K., Schriver, B. J., Aschar‐Sobbi, R., Yi, A. Y., Feric, N. T., & Graziano, M. P. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1227184 · Cited by 19 · see citing works

Expression of cardiac specific genes and functional testing of engineered cardiac tissues

Turnbull, I. C., Serrao, G. W., Cashman, T. J., Sharma, R. M., Backeris, P. C., Karakikes, I., Hadri, L., Hajjar, R. J., & Costa, K. D. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.1127.3