Cited by 240Blood Coagulation and Thrombosis MechanismsBlood properties and coagulationCoagulation, Bradykinin, Polyphosphates, and Angioedema

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Tissue factor as a link between inflammation and coagulation

Witkowski, Marco, Landmesser, Ulf, Rauch, Ursula·2016·Trends in Cardiovascular Medicine

DOI 10.1016/j.tcm.2015.12.001

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Abstract

Due to its receptor activity for factor VII, tissue factor (TF) is primary initiator of the blood coagulation cascade and ensures rapid hemostasis in case of organ damage. Inflammatory cytokines, such as tumor necrosis factor-α or interleukins, strongly induce expression of both full-length TF as well as the alternatively spliced TF in endothelial and blood cells. Beyond its role in hemostasis, TF also has signaling activity and promotes pleiotropic inflammatory responses via protease-activated receptors in concert with other coagulation factors. Alteration of TF expression and TF alternative splicing provides an effective means to change the endothelial phenotype and modulate inflammatory responses of the vessel.

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Authors: Witkowski, M., Landmesser, U., & Rauch, U.
Affiliations: Charité – Universitätsmedizin Berlin (DE)
Stiftung Charité (DE)
Corresponding author: Rauch, Ursula
ORCID: Witkowski, Marco
Landmesser, Ulf
Rauch, Ursula
Venue: Trends in Cardiovascular Medicine
Publisher: Elsevier BV
Published: 2016-05
Volume: 26
Issue: 4
Pages: 297-303
ISSN: 1050-1738 (ISSN-L)
DOI: 10.1016/j.tcm.2015.12.001
OpenAlex: W2267226449
Cited by: 240
References: 89
Citations by year: 2026: 19 · 2025: 17 · 2024: 23 · 2023: 25 · 2022: 33 · 2021: 27 · 2020: 43 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 7
FWCI: 1.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cardiovascular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords: tissue factor, inflammation, coagulation, hemostasis, factor VII, TNF-α, interleukins, alternative splicing, protease-activated receptors, endothelial cells, endothelial phenotype, inflammatory cytokines
MeSH terms: Animals, Blood Coagulation, Gene Expression Regulation, Humans, Inflammation, Protein Conformation, Thromboplastin, Signal Transduction, Alternative Splicing, Inflammation Mediators

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Tissue factor as a link between inflammation and coagulation

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