The DOI matches its Crossref record; 87 of the 89 references it cites were found in a registry or an index.
Tissue factor as a link between inflammation and coagulation
Abstract
Due to its receptor activity for factor VII, tissue factor (TF) is primary initiator of the blood coagulation cascade and ensures rapid hemostasis in case of organ damage. Inflammatory cytokines, such as tumor necrosis factor-α or interleukins, strongly induce expression of both full-length TF as well as the alternatively spliced TF in endothelial and blood cells. Beyond its role in hemostasis, TF also has signaling activity and promotes pleiotropic inflammatory responses via protease-activated receptors in concert with other coagulation factors. Alteration of TF expression and TF alternative splicing provides an effective means to change the endothelial phenotype and modulate inflammatory responses of the vessel.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Vascular TF promotes thrombosis and vascular inflammation123, particularl y in patients with type 2 diabetes who have higher levels of circulating TMAO124–126.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [123]
Citations
Cites
Rivaroxaban in Patients with a Recent Acute Coronary Syndrome
Mega, J. L., Braunwald, E., Wiviott, S. D., Bassand, J., Bhatt, D. L., Bode, C., Burton, P. B. J., Cohen, M. C., Cook‐Bruns, N., Fox, K. A. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1112277 · Cited by 1,923
Understanding alternative splicing: towards a cellular code
Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S., Drozdov, I., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,283
Blood-borne tissue factor: Another view of thrombosis
Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimón, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2311 · Cited by 990
Self-citationC-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Čermák, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 838
Guha, M., & Mackman, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203298200 · Cited by 799
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
Camerer, E., Huang, W., & Coughlin, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5255 · Cited by 674
Role of tissue factor in embryonic blood vessel development
Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressèns, P., Vlaenderen, L. V., Demunck, H., Kasper, M. E., Breier, G., Evrard, P., et al. (1996) · Nature · doi:10.1038/383073a0 · Cited by 669
Mach, F., Schönbeck, U., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Circulation · doi:10.1161/01.cir.96.2.396 · Cited by 493
Cited by
Sorted by citations
Items 201–240 of 240
Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective
Bonaroti, J. W., Zettel, K. R., Billiar, T. R., & Neal, M. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-56510-7_6 · Cited by 1
Ruan, L., Zhang, L., & Zhang, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1062 · Cited by 1
The coagulation status in women of endometriosis with stage IVPreprint
Wang, L., Ling, J., Zhu, X., Zhang, Y., Li, R., Huang, J., Huang, D., Wu, C., & Zhou, H. (2024) · Research Square · doi:10.21203/rs.3.rs-3884274/v1 · Cited by 1
DeLoughery, T. G. (2014) · Springer eBooks · doi:10.1007/978-3-319-09312-3_1
Vermeulen, J., Burt, F. J., van Heerden, E., du Preez, L. L., & Meiring, M. (2020) · Journal of Molecular Modeling · doi:10.1007/s00894-020-4350-7
ANÁLISE E CORRELAÇÃO DE CITOCINAS INFLAMATÓRIAS NO LÚPUS ERITEMATOSO SISTÊMICO
Camila Carneiro Dos, R. E. I. S., PEREIRA, S. E. D. S., & SOUZA, L. K. M. D. (2020) · doi:10.29327/515133.1.1-8
INVESTIGATING THE ROLE OF VASCULAR ACTIVATION IN ALZHEIMER’S DISEASE-RELATED NEUROINFLAMMATION
Iannucci, J. (2020) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/iannucci-jaclyn-2020
Ziętek, Z. M. (2020) · Pomeranian Journal of Life Sciences · doi:10.21164/pomjlifesci.744
CLINICAL CHARACTERISTICS AND OUTCOMES IN PATIENTS WITH INFECTIVE ENDOCARDITIS (IE)
Syed, I. (2018) · TSpace (University of Toronto)
Peng, Q., Qian, S., Alqahtani, S., Panizzi, P. R., & Shen, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.28.474395
Wang, X., Ji, J., Jiang, Y., Zhao, Y., Song, Z., He, Z., Shen, P., Wang, H., Luo, L., Guan, H., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1157925/v1
Immune System in COVID-19: Is It Temporarily Defeated While Conquering?
Wynn, A. A., & Mya, N. K. (2022) · Borneo Journal of Medical Sciences (BJMS) · doi:10.51200/bjms.vi.3210
A Retrospective Comparison Of Platelet Indices For Diagnosing Infected NonunionPreprint
Wang, Z., Mao, H., Qiu, X.-S., Chen, Y., & Xu, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1332517/v1
Ruan, L., Zhang, L., & Zhang, C. (2020) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1062-1
Atrial fibrillation and hypercoagulability
Scaf, B. (2022) · doi:10.26481/dis.20221020ed
Humoral immunity and thrombosis in COVID-19
Lasagni, G., Borghi, M. O., Cugno, M., & Meroni, P. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18566-3.00037-2
Sharmeen, A., Adil, M., & Kumar, R. (2023) · International Journal of Research in Dermatology · doi:10.18203/issn.2455-4529.intjresdermatol20232538
Anti-PF4 positivity and platelet activation after Ad26.COV2·S vaccination in Brazil
Bokel, J., Martins-Gonçalves, R., Grinsztejn, E., Mendes-de-Almeida, D. P., Hoagland, B., Cardoso, S. W., Geraldo, K. M., Nazer, S., Georg, I., de Oliveira, M. H. S., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126175
Mojsym, W., Kowalik, S., Chałabis‐Mazurek, A., Janczarek, I., & Kędzierski, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110429
Андреевич, К. А. (2025) · Сибирский научный медицинский журнал · doi:10.18699/ssmj20250509
Additional file 1 of The coagulation status in women of endometriosis with stage IV
Wang, L., Ling, J., Zhu, X., Zhang, Y., Li, R., Huang, J., Huang, D., Wu, C., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26170513
Shinozaki, A., Yamamoto, T., & Kurata, A. (2026) · Clinical and Experimental Nephrology · doi:10.1007/s10157-026-02825-w
Bao, Y., Erboev, A., & Huang, W. (2026) · Medicine · doi:10.1097/md.0000000000047467
Sun, L., Wang, J., Yan, Y.-D., Li, L., Cao, L.-Y., Li, R., Chong, S., Meng, H., Lin, H.-W., Yi-min, C., et al. (2026) · Thrombosis Research · doi:10.1016/j.thromres.2026.109619 · Cited by 1
Wang, W.-C., Ji, W.-D., Ma, J., Pan, Y., Chen, L., Lin, X.-J., Chen, Y., Tang, M., Liu, H.-L., Lin, M., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00471-y
Huang, G., Zhao, Z., Zhang, H., Zheng, B., Sang, Y., Geng, R., Wang, B., Hu, Y. Z., Li, L. J., & Liu, Z. (2026) · ACS Applied Polymer Materials · doi:10.1021/acsapm.6c00921
de la Peña, N. A. C., Pérez-Moreno, L. Á., Romo-Espinosa, B., del Valle‐Mondragón, L., Ramos‐Godínez, M. D. P., Cabello-Gutiérrez, C., & López‐Marure, R. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.105090
Computational Modeling of Pro-inflammatory Cytokine-Enhanced Blood Coagulation
Li, G., Zhao, C., Frydman, G. H., & Li, H. (2026) · Computational and Structural Biotechnology Journal · doi:10.34133/csbj.0180
The risk of venous thromboembolism in RA
Vojinovic, T., Askling, J., & Antovič, A. (2026) · Lara D. Veeken · doi:10.1093/rheumatology/keag388
Pan, S., Peng, Y., Hu, J., Cai, Y., Zhang, Y., & Zheng, B. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1891438
Hoxha, K., Maccaferri, I., Paparazzo, F., Sarti, A., Sciaramenti, G., Camaiti, G., Cioci, P., Rizza, C., Tezze, R., Vocale, L. R., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15176615
Xiong, W., 杨忠霞, Qian, Z., 彭雪彬, Ying, L., & Xiaorong, M. (2026) · Liver Research · doi:10.1016/j.livres.2026.08.003
Olsson, M., Tønnesen, H., Hedberg, J., Sundström, J., Nordendahl, E., Klinge, B., Fored, M., Magnusson, C., Jönsson, D., Persson, P., et al. (2026) · Journal of Internal Medicine · doi:10.1111/joim.70160
Xu, H., Huang, S., Zheng, Y., Mi, X., Chen, Y., & Wu, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1929933
Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation
Lv, W., Deng, W., Deng, F., Xu, S., & Ren, W. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70200
From Adipose Tissue Dysfunction to Venous Thromboembolism
Boccatonda, A., Brighenti, A., Caturano, A., D’Ardes, D., Acierno, C., Russo, V., Conte, C., Simioni, P., & Campello, E. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15197500
Metadata
- Authors
- Witkowski, M., Landmesser, U., & Rauch, U.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Stiftung Charité (DE)
- Corresponding author
- Rauch, Ursula
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 26
- Issue
- 4
- Pages
- 297-303
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W2267226449
- Cited by
- 240
- References
- 89
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 23 · 2023: 25 · 2022: 33 · 2021: 27 · 2020: 43 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 7
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- tissue factor, inflammation, coagulation, hemostasis, factor VII, TNF-α, interleukins, alternative splicing, protease-activated receptors, endothelial cells, endothelial phenotype, inflammatory cytokines
- MeSH terms
- Animals, Blood Coagulation, Gene Expression Regulation, Humans, Inflammation, Protein Conformation, Thromboplastin, Signal Transduction, Alternative Splicing, Inflammation Mediators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review