Red blood cell dynamics: from cell deformation to ATP release
Abstract
The mechanisms of red blood cell (RBC) deformation under both static and dynamic, i.e., flow, conditions have been studied extensively since the mid 1960s. Deformation-induced biochemical reactions and possible signaling in RBCs, however, were proposed only fifteen years ago. Therefore, the fundamental relationship between RBC deformation and cellular signaling dynamics i.e., mechanotransduction, remains incompletely understood. Quantitative understanding of the mechanotransductive pathways in RBCs requires integrative studies of physical models of RBC deformation and cellular biochemical reactions. In this article we review the physical models of RBC deformation, spanning from continuum membrane mechanics to cellular skeleton dynamics under both static and flow conditions, and elaborate the mechanistic links involved in deformation-induced ATP release.
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RBC intrinsic properties, together with mechanisms regulating vascular tone and cardiac function, contribute to regulation of blood rheology, peripheral resistance, and cardiac function.
“These RBC intrinsic properties, together with the mechanisms regulating vascular tone and cardiac function, contribute to regulation of blood rheology, peripheral resistance, and cardiac function (114, 168, 188).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [188]
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- Authors
- Wan, J., Forsyth, A. M., & Stone, H. A.
- Affiliations
- Princeton University (US)
- Corresponding author
- Stone, Howard A.
- Venue
- Integrative Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011
- Volume
- 3
- Issue
- 10
- Pages
- 972
- ISSN
- 1757-9694 (ISSN-L)
- 1757-9708
- OpenAlex
- W2063220960
- Cited by
- 88
- References
- 92
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Integrative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- red blood cell deformation, mechanotransduction, ATP release, flow-induced deformation, hemorheology
- MeSH terms
- Adenosine Triphosphate, Erythrocyte Deformability, Erythrocyte Membrane, Erythrocytes, Humans, Mechanotransduction, Cellular
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