Cited by 88Erythrocyte Function and PathophysiologyBlood properties and coagulationCellular Mechanics and Interactions

Red blood cell dynamics: from cell deformation to ATP release

Wan, Jiandi, Forsyth, Alison M., Stone, Howard A.·2011·Integrative Biology

Abstract

The mechanisms of red blood cell (RBC) deformation under both static and dynamic, i.e., flow, conditions have been studied extensively since the mid 1960s. Deformation-induced biochemical reactions and possible signaling in RBCs, however, were proposed only fifteen years ago. Therefore, the fundamental relationship between RBC deformation and cellular signaling dynamics i.e., mechanotransduction, remains incompletely understood. Quantitative understanding of the mechanotransductive pathways in RBCs requires integrative studies of physical models of RBC deformation and cellular biochemical reactions. In this article we review the physical models of RBC deformation, spanning from continuum membrane mechanics to cellular skeleton dynamics under both static and flow conditions, and elaborate the mechanistic links involved in deformation-induced ATP release.

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Registry

Crossref · 10.1039/c1ib00044f

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92 of 92 references verified0 citation errors · 0 not checkable

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  • RBC intrinsic properties, together with mechanisms regulating vascular tone and cardiac function, contribute to regulation of blood rheology, peripheral resistance, and cardiac function.

    “These RBC intrinsic properties, together with the mechanisms regulating vascular tone and cardiac function, contribute to regulation of blood rheology, peripheral resistance, and cardiac function (114, 168, 188).”

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Authors
Wan, J., Forsyth, A. M., & Stone, H. A.
Affiliations
Princeton University (US)
Corresponding author
Stone, Howard A.
Venue
Integrative Biology
Published
2011
Volume
3
Issue
10
Pages
972
ISSN
  • 1757-9694 (ISSN-L)
  • 1757-9708
OpenAlex
W2063220960
Cited by
88
References
92
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 6
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Integrative Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
red blood cell deformation, mechanotransduction, ATP release, flow-induced deformation, hemorheology
MeSH terms
Adenosine Triphosphate, Erythrocyte Deformability, Erythrocyte Membrane, Erythrocytes, Humans, Mechanotransduction, Cellular

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