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Chaperone-mediated autophagy: selectivity pays off
Open accessAbstract
Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
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“Three different forms of autophagy have been described in mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (Fig. 3) (Cuervo, 2009; He and Klionsky, 2009; Mizushima et al., 2008).”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Cuervo, 2009
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“The substrate proteins of CMA are recognized in the cytosol by the chaperone protein heat shock-cognate protein of 70KDa (Hsc70) via a pentapeptide motif similar to KFERQ in sequence [43, 44].”
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“Chaperone-mediated autophagy (CMA) is a selective form of autophagy that has only been described in mammalian cells to date [52,53].”
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Maladaptive autophagy in diabetic heart disease
Katare, R., & Munasinghe, P. E. (2016) · International Journal of Clinical and Experimental Physiology · doi:10.4103/2348-8832.196893 · Cited by 11
Nanochaperone‐Based Strategies to Control Protein Aggregation Linked to Conformational Diseases
Caballero, A. B., & Gámez, P. (2020) · Angewandte Chemie · doi:10.1002/ange.202007924 · Cited by 11
Mechanistic Insights and Potential Therapeutic Approaches in PolyQ Diseases via Autophagy
Jain, M., Patil, N., Abdi, G., Tarighat, M. A., Mohammed, A., Zain, M. R. A. M., & Goh, K. W. (2023) · Biomedicines · doi:10.3390/biomedicines11010162 · Cited by 10
Fu, C., Yang, N., Chuang, J.-Z., Nakajima, N., Iraha, S., Roy, N. S., Wu, Z., Jiang, Z., Otsu, W., Radu, R. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50189-0 · Cited by 9
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00001-9 · Cited by 10
Bopape, M., Tiloke, C., & Ntsapi, C. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2270215 · Cited by 11
“Most prominent is the role of the autophagy intracellular pathways, which have been implicated in various human diseases, including age-associated neurodegenerative diseases, cardiovascular diseases, liver disorders, as well as in the pathogenesis of HCC (23–27).”
BackgroundQiao, J., Zhang, D., Wang, Y., Li, X., Wang, S., & Liu, Q. (2018) · PeerJ · doi:10.7717/peerj.5988 · Cited by 8
Hayat, M. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801043-3.00001-7 · Cited by 8
Eating Locally: Microautophagy and Protein Turnover at the Synapse
McPherson, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.008 · Cited by 7
“…by the lysosomal membrane; and (3) chaperone-mediated autophagy, where cytosolic proteins with a specific tag are recognized by the heat shock cognate protein 70 (Hsc70), which targets them to the surface of lysosomes for translocation through a protein pore to the lysosomal lumen (Cuervo, 2010).”
BackgroundMechanisms of DNA Damage Response in Mammalian Oocytes
Sun, F., Šutovský, P., Patterson, A. L., & Balboula, A. Z. (2024) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-031-55163-5_3 · Cited by 6
The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions
Wang, H., Lv, C., Feng, L., Guo, J., Zhao, S., & Jiang, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38959 · Cited by 7
“Moreover, CMA is known to bind to substrates consisting of proteins that include a pentapeptide (KFERQ-like motif) [22].”
BackgroundXiao, S., Xu, G., Wang, Z., & Chong, T. (2021) · Oncology Reports · doi:10.3892/or.2021.8165 · Cited by 6
“There are three forms of autophagy, including chaperone‐medi‐ ated autophagy (CMA), which is a process of recognizing proteins with the KFERQ sequence through HSC70 and sending them to the surface of lysosome membrane to be combined with lysosome‐associated membrane protein 2A (LAMP‐2A), a specific CMA protein recepto…”
BackgroundAutofagia – proces o dwóch obliczach
Dereń-Wagemann, I., Kiełbiński, M., & Kuliczkowski, K. (2013) · Acta Haematologica Polonica · doi:10.1016/j.achaem.2013.05.003 · Cited by 6
Zheng, N., Wang, Z., Cao, J., Li, K., Xu, H., Wang, J., Zhang, L., Meng, J., Tang, Z., Luo, H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70369 · Cited by 5
Effects of caloric restriction on retinal aging and neurodegeneration
Adornetto, A., Morrone, L. A., Satriano, A., Laganà, M. L., Licastro, E., Nucci, C., Corasaniti, M. T., Tonin, P., Bagetta, G., & Russo, R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.07.005 · Cited by 6
Hayat, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802936-7.00001-5 · Cited by 5
Autophagic Flux Failure in Neurodegeneration: Identifying the Defect and Compensating Flux Offset
Ntsapi, C., Swart, C., Lumkwana, D., & Loos, B. (2016) · InTech eBooks · doi:10.5772/64197 · Cited by 4
“All three autophagic pathways usually coexist in the same cell, but only macroautophagy (henceforth referred to as autophagy) and CMA have been implicated in the central nervous system and associated with specific neurodegenerative diseases [8].”
BackgroundHayat, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00001-6 · Cited by 4
The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview
Nazio, F., Maiani, E., & Cecconi, F. (2018) · InTech eBooks · doi:10.5772/intechopen.71404 · Cited by 3
“Park and colleagues found that CMA is upregulated by DNA damage after both irradiation and chemotherapy, thus inducing degradation of p-Chk1 [86].”
BackgroundInfluentialAre Lysosomes Potential Therapeutic Targets for Parkinson’s Disease?
Petese, A., Cesaroni, V., Cerri, S., & Blandini, F. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210809123630 · Cited by 3
Autophagy, the “Master” Regulator of Cellular Quality Control: What Happens when Autophagy Fails?
Raquel, A., Catarina, R. A., & Morais, S. (2013) · InTech eBooks · doi:10.5772/55196 · Cited by 4
“CMA is constitutively active in many cell types and similar to macroautophagy, CMA is maximally activated under stress conditions like nutritional stress or starvation and cellular stresses leading to protein damage [3].”
BackgroundTime Flies: Autophagy During Ageing in Drosophila
Schultz, S. W., Brech, A., & Ioannis, P. (2013) · InTech eBooks · doi:10.5772/55396 · Cited by 3
Role of Autophagy in Brain Sculpture: Physiological and Pathological Implications
Nobili, A., Cavallucci, V., & D’Amelio, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-30079-5_11 · Cited by 3
Protein clearance mechanisms and their demise in age-related neurodegenerative diseases
Sáez, I., & Vı́lchez, D. (2015) · AIMS molecular science · doi:10.3934/molsci.2015.1.1 · Cited by 2
“In mammalian cells, the best-characterized types of autophagy are macroautophagy (Figure 1), microautophagy and chaperone-mediated autophagy (CMA) [37,39,40].”
BackgroundInfluentialThe Roles of ESCRT Proteins in Healthy Cells and in Disease
Ilievska, J., Naomi, E., Sarah, J. M., & Paul, R. (2012) · InTech eBooks · doi:10.5772/33537 · Cited by 2
“To date, three autophagy pathways have been described in higher eukaryotes: microautophagy (MA), chaperone-mediated autophagy (CMA) and macroautophagy (Mizushima et al., 2008; Cuervo, 2010).”
BackgroundThe Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
Aktas, B. H., Upcin, B., Henke, E., Padmasekar, M., Qin, X., & Ergün, S. (2019) · Stem Cells International · doi:10.1155/2019/1608787 · Cited by 2
“In another form of autophagy called chaperone-mediated autophagy (CMA), cytoplasmic proteins are recognized by chaperones such as HSP70 through a consensus sequence and transferred to the lysosome for proteolysis (Figure 2) [110].”
BackgroundHayat, M. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801032-7.00001-0 · Cited by 2
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805420-8.00001-9 · Cited by 3
Hayat, M. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801033-4.00001-1 · Cited by 2
Amyloid fibrils are nanoparticles that target lysosomes.
Jakhria, T. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 2
Askanas, V., Engel, W. K., & Nogalska, A. (2011) · Wiley eBooks · doi:10.1002/9781444398311.ch7 · Cited by 2
Metadata
- Authors
- Cuervo, A. M.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 21
- Issue
- 3
- Pages
- 142-150
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC2831144
- OpenAlex
- W1964976537
- Cited by
- 260
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 20 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 16
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG021904, R37AG021904, P01AG031782, AG-021904, AG031782)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK041918, P01DK041918)
- National Institute of Neurological Disorders and Stroke (NS038370, P50NS038370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- chaperone-mediated autophagy, lysosomal degradation, substrate specificity, quality control, energy homeostasis, nutritional stress, age-related decline, aging, age-related diseases, cellular homeostasis
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Models, Biological, Molecular Chaperones
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