The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Chaperone-mediated autophagy: selectivity pays off
Open accessAbstract
Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
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“Three different forms of autophagy have been described in mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (Fig. 3) (Cuervo, 2009; He and Klionsky, 2009; Mizushima et al., 2008).”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Cuervo, 2009
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Citations
Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · cited 3×
“Three different mechanisms for delivery of autophagic cargo to lysosomes co-exist in most mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA) [6,8] (Box 1).”
BackgroundSelf-citationde Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 3×
“I bet you just pictured a garbage container, didn’t you? This organelle has been associated with cellular cleaning almost since its description more than 50 years ago by Christian de Duve [1].”
BackgroundInfluentialImpaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024
Self-citationAutophagy: molecular machinery for self-eating
Yorimitsu, T., & Klionsky, D. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401765 · Cited by 1,566 · cited 3×
“Three different mechanisms for delivery of autophagic cargo to lysosomes co-exist in most mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA) [6,8] (Box 1).”
BackgroundA Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins
Chiang, H.-L., Terlecky, S. R., Plant, C. P., & Dice, J. F. (1989) · Science · doi:10.1126/science.2799391 · Cited by 982
A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes
Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979 · cited 2×
“The use of blocking antibodies revealed that substrate proteins bind to the lysosomal membrane through the cytosolic tail of LAMP-2A [18].”
BackgroundSelf-citationPrimary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)
Nishino, I., Fu, J., Tanji, K., Yamada, T., Shimojo, S., Koori, T., Mora, M., Riggs, J. E., Oh, S. J., Koga, Y., et al. (2000) · Nature · doi:10.1038/35022604 · Cited by 959 · cited 1×
“Lastly, CMA is also likely to be altered in Danon’s disease, a type of vacuolar myopathy resulting from mutations in the LAMP2 gene [52].”
BackgroundAccumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E.-L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., & Saftig, P. (2000) · Nature · doi:10.1038/35022595 · Cited by 925 · cited 3×
“For example, the alterations in macroautophagy and in lysosomal biogenesis observed in Lamp2 null mice [33] and after knocking-out or knocking-down all LAMP-2 isoforms in cultured cells [34,35], cannot be reproduced by blocking only LAMP-2A in cultured cells [25].”
BackgroundPeptide sequences that target cytosolic proteins for lysosomal proteolysis
Dice, J. F. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90019-8 · Cited by 755
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“Alphasynuclein can be degraded by the ubiquitin proteasome system, CMA and macroautophagy [43,44].”
Background
Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Microautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902
“To date, three autophagy-related pathways have been described in higher eukaryotes: macroautophagy (MA), chaperone-mediated autophagy (CMA), andmicroautophagy (Cuervo, 2010; Mizushima et al., 2008).”
Self-citationAutophagy gone awry in neurodegenerative diseases
Wong, E., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 815
“In the third common type of autophagy, CMA, cargo is not sequestered but is instead selectively recognized by a complex of cytosolic chaperones that mediates its delivery to a receptor at the lysosomal membran”
Self-citation
Metadata
- Authors
- Cuervo, A. M.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 21
- Issue
- 3
- Pages
- 142-150
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC2831144
- OpenAlex
- W1964976537
- Cited by
- 260
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 20 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 16
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG021904, R37AG021904, P01AG031782, AG-021904, AG031782)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK041918, P01DK041918)
- National Institute of Neurological Disorders and Stroke (NS038370, P50NS038370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- chaperone-mediated autophagy, lysosomal degradation, substrate specificity, quality control, energy homeostasis, nutritional stress, age-related decline, aging, age-related diseases, cellular homeostasis
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Models, Biological, Molecular Chaperones
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