The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Chaperone-mediated autophagy: selectivity pays off
Open accessAbstract
Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
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“Three different forms of autophagy have been described in mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (Fig. 3) (Cuervo, 2009; He and Klionsky, 2009; Mizushima et al., 2008).”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Cuervo, 2009
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Citations
Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · cited 3×
“Three different mechanisms for delivery of autophagic cargo to lysosomes co-exist in most mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA) [6,8] (Box 1).”
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“Three different mechanisms for delivery of autophagic cargo to lysosomes co-exist in most mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA) [6,8] (Box 1).”
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“Lys-HSPA8 is indispensable for CMA, acting to pull the unfolded protein through the LAMP2A channel into the lumen [138–140].”
Selective autophagy in cellular quality control
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“In addition, because the motif is based on the properties of the amino acids rather than on the exact sequence, posttranslational modifications such as phosphorylation or acetylation could generate a motif in a protein that does not contain it in the unmodified form (Cuervo 2010).”
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“The translocation to the lysosome is triggered after binding of the chaperone to a lysosomal receptor, named lysosome-associated membrane protein type 2A (LAMP2A) (Cuervo 2010).”
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Nuñez, C. E. C. (2013) · doi:10.47749/t/unicamp.2013.905630
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The role of autophagy in clearance of protein aggregates
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Kaushik, S., & Cuervo, A. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00013-0 · Cited by 1
Self-citationSchneider, J. L., & Cuervo, A. M. (2012) · Oxidative stress and disease · doi:10.1201/b12308-19
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Metadata
- Authors
- Cuervo, A. M.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 21
- Issue
- 3
- Pages
- 142-150
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC2831144
- OpenAlex
- W1964976537
- Cited by
- 260
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 20 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 16
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG021904, R37AG021904, P01AG031782, AG-021904, AG031782)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK041918, P01DK041918)
- National Institute of Neurological Disorders and Stroke (NS038370, P50NS038370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- chaperone-mediated autophagy, lysosomal degradation, substrate specificity, quality control, energy homeostasis, nutritional stress, age-related decline, aging, age-related diseases, cellular homeostasis
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Models, Biological, Molecular Chaperones
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