Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

Neel, J. V. (1962) · Europe PMC (PubMed Central) · Cited by 3,172

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

(1962) · PubMed Central · Cited by 2,182

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Cohen, J., Pertsemlidis, A., Kotowski, I. K., Graham, R., Garcia, C. K., & Hobbs, H. H. (2005) · Nature Genetics · doi:10.1038/ng1509 · Cited by 1,381

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247

Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S.

Ford, E. S. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2745 · Cited by 1,199

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053

Obesidad, tejido adiposo y cirugía bariátrica

Frigolet, M. E., Dong-Hoon, K., Canizales‐Quinteros, S., & Gutiérrez‐Aguilar, R. (2020) · Boletín Médico del Hospital Infantil de México · doi:10.24875/bmhim.19000115 · Cited by 34

Association between obesity and urinary albumin-creatinine ratio in the middle-aged and elderly population of Southern and Northern China: a cross-sectional study

Qin, S., Wang, A., Gu, S., Wang, W., Gao, Z., Tang, X., Yan, L., Wan, Q., Luo, Z., Qin, G., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-040214 · Cited by 25

Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies

Rochford, J. J. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001547 · Cited by 24

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

Escande, C., Nin, V., Pirtskhalava, T., Chini, C. C. S., Tchkonia, T., Kirkland, J. L., & Chini, E. N. (2014) · Diabetes · doi:10.2337/db14-0192 · Cited by 24

l-Cysteine supplementation increases adiponectin synthesis and secretion, and GLUT4 and glucose utilization by upregulating disulfide bond A-like protein expression mediated by MCP-1 inhibition in 3T3-L1 adipocytes exposed to high glucose

Elumalai, A., & Jain, S. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2664-7 · Cited by 25

Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities

Beckmann, P. J., & Largaespada, D. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031172 · Cited by 24

Perfil metabólico-inflamatorio en la transición obesidad, síndrome metabólico y diabetes mellitus en población mediterránea. Estudio DARIOS Inflamatorio

Fernandez-Berges, D. J., Consuegra‐Sánchez, L., Peñafiel, J., de León, A. C., Vila, J., Félix-Redondo, F. J., Segura‐Fragoso, A., Lapetra, J., Guembe, M. J., Vega, T., et al. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2013.10.021 · Cited by 23

Seven-Up Is a Novel Regulator of Insulin Signaling

Musselman, L. P., Fink, J. L., Maier, E. J., Gatto, J. A., Brent, M. R., & Baranski, T. (2018) · Genetics · doi:10.1534/genetics.118.300770 · Cited by 22

Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1

Man, T. Y., Michailidou, Z., Gökçel, A., Ramage, L. E., Chapman, K. E., Kenyon, C. J., Seckl, J. R., & Morton, N. M. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00531.2010 · Cited by 23

Fu brick tea alleviates high fat induced non-alcoholic fatty liver disease by remodeling the gut microbiota and liver metabolism

Tang, Y. J., Chen, B., Huang, X., He, X., Yi, J., Zhao, H. L., Tian, F., Liu, Y., & Liu, B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1062323 · Cited by 22

In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family

Thomas, G., Brown, A. L., & Brown, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.01.004 · Cited by 22

Mouse Models of Lipodystrophy and Their Significance in Understanding Fat Regulation

Rochford, J. J. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00005-6 · Cited by 23

In immune defense: redefining the role of the immune system in chronic disease

Rubinow, K. B., & Rubinow, D. R. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/drubinow · Cited by 22

Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth

Meln, I., Wolff, G., Gajek, T., Koddebusch, J., Lerch, S., Harbrecht, L., Hong, W., Bayindir‐Buchhalter, I., Krunic, D., Augustin, H. G., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.03.012 · Cited by 22

The prevalence of metabolic syndrome in a local population in India

Thiruvagounder, M., Khan, S. A., & Sheriff, D. S. (2010) · Biochemia Medica · doi:10.11613/bm.2010.031 · Cited by 22

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

Saito, K., Sekiya, M., Kainoh, K., Yoshino, R., Hayashi, A., Han, S., Araki, M., Ohno, H., Takeuchi, Y., Tsuyuzaki, T., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104890 · Cited by 21

Increased Subcutaneous Adipose Tissue Expression of Genes Involved in Glycerolipid-Fatty Acid Cycling in Obese Insulin-Resistant Versus -Sensitive Individuals

Gauthier, M., Pérusse, J. R., Lavoie, M.-È., SLADEK, R. M., Madiraju, S. R. M., Ruderman, N. B., Coulombe, B., Prentki, M., & RABASA-LHORET, R. P. R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1662 · Cited by 22

Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice

Zhao, Q., Xu, H., Hong, S., Song, N., Xie, J., Yan, Z., Wang, R., Yang, P., & Jiang, X. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01030 · Cited by 21

Anti-obesity effect of cocoa proteins (Theobroma cacao L.) variety “Criollo” and the expression of genes related to the dysfunction of white adipose tissue in high-fat diet-induced obese rats

Coronado-Cáceres, L. J., Rabadán-Chávez, G. M., Quevedo-Corona, L., Hernández‐Ledesma, B., Miliar-García, Á., Mojica, L., & Lugo‐Cervantes, E. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103519 · Cited by 21

Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet

Bae, U., Oh, M., Jung, T.-S., Chae, S., & Park, B. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.02.008 · Cited by 21

Metabolic and Inflammatory Profiles of Biomarkers in Obesity, Metabolic Syndrome, and Diabetes in a Mediterranean Population. DARIOS Inflammatory Study

Fernandez-Berges, D. J., Consuegra‐Sánchez, L., Peñafiel, J., de León, A. C., Vila, J., Félix-Redondo, F. J., Segura‐Fragoso, A., Lapetra, J., Guembe, M. J., Vega, T., et al. (2014) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2013.10.019 · Cited by 21

The paradox of obesity cardiomyopathy and the potential for weight loss as a therapy

Rayner, J. J., Neubauer, S., & Rider, O. J. (2015) · Obesity Reviews · doi:10.1111/obr.12292 · Cited by 21

Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes

Leamy, A. K., Hasenour, C. M., Egnatchik, R. A., Trenary, I. A., Yao, C.-H., Patti, G. J., Shiota, M., & Young, J. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.05.013 · Cited by 20

Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats

Elsayed, H. R. H., El-Nablaway, M., Khattab, B. A., Sherif, R., Elkashef, W. F., Abdalla, A. M., Nashar, E. M. E., Abd-Elmonem, M. M., & El‐Gamal, R. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211041607 · Cited by 19

Large polystyrene microplastics results in hepatic lipotoxicity in mice

Chen, H., Deng, Y., Wang, Q., Chen, W., Liu, Z., Tan, H., & Chen, D. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122015 · Cited by 19

The Evolution of Mammalian Adipose Tissue

Pond, C. M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_8 · Cited by 21

Adipose Tissue, Inflammation (Meta-inflammation) and Obesity Management

Meiliana, A., Dewi, N. M., & Wijaya, A. (2015) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v7i3.185 · Cited by 19

Characterization of alendronic- and undecylenic acid coated magnetic nanoparticles for the targeted delivery of rosiglitazone to subcutaneous adipose tissue

Saatchi, K., Tod, S. E., Leung, D., Nicholson, K. E., Andreu, I., Buchwalder, C., Schmitt, V., Häfeli, U. O., & Gray, S. L. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.08.012 · Cited by 19

The Evolution of Mammalian Adipose Tissues

Pond, C. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_1 · Cited by 20

Na v 1.8 neurons are involved in limiting acute phase responses to dietary fat

Udit, S., Burton, M. D., Rutkowski, J. M., Lee, S., Bookout, A. L., Scherer, P. E., Elmquist, J. K., & Gautron, L. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.07.012 · Cited by 19

TODAY — A Stark Glimpse of Tomorrow

Allen, D. B. (2012) · New England Journal of Medicine · doi:10.1056/nejme1204710 · Cited by 18

Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: Long-term changes in weight and metabolic profiles

Kemp, D. E., Karayal, O. N., Calabrese, J. R., Sachs, G. S., Pappadopulos, E. A., Ice, K. S., SIU, C. O., & Vieta, E. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.06.005 · Cited by 17

Leptin Induces Nitric Oxide-Mediated Inhibition of Lipolysis and Glyceroneogenesis in Rat White Adipose Tissue

Niang, F., Benelli, C., Ribière, C., Collinet, M., Mehebik‐Mojaat, N., Penot, G., Forest, C. D., & Jaubert, A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125765 · Cited by 17

Crossroad between Obesity and Gastrointestinal Cancers: A Review of Molecular Mechanisms and Interventions

Moodi, M., Tavakoli, T., & Tahergorabi, Z. (2021) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_266_20 · Cited by 17

Current role of short‐term intensive insulin strategies in newly diagnosed type 2 diabetes (短期胰岛素强化治疗策略对初诊2型糖尿病患者的作用)

Xu, W., & Weng, J. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12054 · Cited by 15

Lipidomic signature of serum from the rats exposed to alcohol for one year

Li, H., Xu, W., Jiang, L., Gu, H., Li, M., Zhang, J., Guo, W., Deng, P., Long, H., Bu, Q., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.05.011 · Cited by 17

Role of hydrogen sulfide in the regulation of lipid metabolism: Implications on cardiovascular health

Flori, L., Piragine, E., Calderone, V., & Testai, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122491 · Cited by 15

Beyond body mass index: exploring the role of visceral adipose tissue in intensive care unit outcomes

Ralston, M. R., McCreath, G., Lees, Z. J., Salt, I. P., Sim, M. A. B., Watson, M. J., & Freeman, D. J. (2025) · BJA Open · doi:10.1016/j.bjao.2025.100391 · Cited by 16

World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease

Bloomgarden, Z. T. (2011) · Diabetes Care · doi:10.2337/dc11-1306 · Cited by 15

Inverse correlation of serum inflammatory markers with metabolic parameters in healthy, Black and White prepubertal youth

Zabaleta, J., Velasco‐Gonzalez, C., Estrada, J., Ravussin, É., Pelligrino, N. E., Mohler, M. C., Larson‐Meyer, E., Boulares, A. H., Powell-Young, Y. M., Bennett, B., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.220 · Cited by 15

Magnesium Isoglycyrrhizinate Reduces Hepatic Lipotoxicity through Regulating Metabolic Abnormalities

Lu, L., Hao, K., Hong, Y., Liu, J., Zhu, J., Jiang, W., Zhu, Z., Wang, G., & Peng, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115884 · Cited by 14

Ceramide dependent lipotoxicity in metabolic diseases

Li, Y., Tippetts, T. S., & Chaurasia, B. (2017) · Nutrition and Healthy Aging · doi:10.3233/nha-170032 · Cited by 14

Metreleptin for metabolic disorders associated with generalized or partial lipodystrophy

Simha, V. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.894877 · Cited by 13

Comparative gene identification-58/α/β hydrolase domain 5

Zierler, K. A., Zechner, R., & Haemmerle, G. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000058 · Cited by 14

Central Obesity Predicts Non-Hodgkin's Lymphoma Mortality and Overall Obesity Predicts Leukemia Mortality in Adult Taiwanese

Chu, D.-M., Wahlqvist, M. L., Lee, M., & Chang, H. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10719974 · Cited by 14

Genetically-encoded sensors to detect fatty acid production and trafficking

Mottillo, E. P., Zhang, H., Yang, A., Li, Z., & Granneman, J. G. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.012 · Cited by 14

A Maternal High Fat Diet Has Long‐Lasting Effects on Skeletal Muscle Lipid and PLIN Protein Content in Rat Offspring at Young Adulthood

MacPherson, R. E. K., Castelli, L. M., Miotto, P. M., Frendo‐Cumbo, S., Milburn, A., Roy, B. D., LeBlanc, P. J., Ward, W. E., & Peters, S. J. (2014) · Lipids · doi:10.1007/s11745-014-3985-5 · Cited by 14

Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and lipotoxicity

Tuthill, B. F., Quaglia, C. J., O'Hara, E., & Musselman, L. P. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.240432 · Cited by 12

Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats

Wang, K., Zhao, Y., Xu, L., Liao, X., & Xu, Z. (2023) · Current Research in Food Science · doi:10.1016/j.crfs.2023.100454 · Cited by 14

Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge

Moore, E. S., Daugherity, E. K., Karambizi, D. I., Cummings, B. P., Behling‐Kelly, E. L., Schaefer, D. M. W., Southard, T. L., McFadden, J. W., & Weiss, R. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005729 · Cited by 13

Implications of Argentine Tango for Health Promotion, Physical Well-Being as Well as Emotional, Personal and Social Life on a Group of Women Who Dance

Witkoś, J., & Hartman‐Petrycka, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115894 · Cited by 13

PPAR-γ action: it's all in your head

Myers, M. G., & Burant, C. (2011) · Nature Medicine · doi:10.1038/nm0511-544 · Cited by 13

Repeated Sense of Hunger Leads to the Development of Visceral Obesity and Metabolic Syndrome in a Mouse Model

Han, J., Kim, H.-G., Lee, J., Choi, M., Kim, Y., & Son, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098276 · Cited by 14

Ethnic Diversity in Beta-Cell Function Susceptibility to Pancreatic Triglyceride Levels: Pilot Investigation

Lingvay, I. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000348 · Cited by 12

At the Crossroad Between Obesity and Gastric Cancer

Garai, J., Uddo, R. B., Mohler, M. C., Pelligrino, N. E., Scribner, R. A., SOTHERN, M. S., & Zabaleta, J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1804-1_36 · Cited by 13

Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity

Torre-Villalvazo, I., Cervantes-Pérez, L. G., Noriega, L. G., Jiménez, J. V., Uribe, N., Chávez‐Canales, M., Tovar‐Palacio, C., Marfil‐Garza, B. A., Torres, N., Bobadilla, N. A., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00108.2017 · Cited by 13

Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die

Mohammad, K., Dakik, P., Medkour, Y., McAuley, M., Mitrofanova, D., & Titorenko, V. I. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3074769 · Cited by 13

Fibroblast feeder layer supports adipogenic differentiation of human adipose stromal/progenitor cells

Ejaz, A., Hatzmann, F. M., Hammerle, S., Ritthammer, H., Mattesich, M., Zwierzina, M., Waldegger, P., & Zwerschke, W. (2019) · Adipocyte · doi:10.1080/21623945.2019.1608751 · Cited by 13

Quantified Metabolomics and Lipidomics Profiles Reveal Serum Metabolic Alterations and Distinguished Metabolites of Seven Chronic Metabolic Diseases

Zhang, Y., Zhao, H., Zhao, J., Lv, W., Jia, X., Lu, X., Zhao, X., & Xu, G. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00760 · Cited by 13

Correlation between advanced glycation end-products and the expression of fatty inflammatory factors in type II diabetic cardiomyopathy

Guo, Z., Huang, D., Tang, X., Han, J., & Li, J. (2015) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2015.619 · Cited by 12

Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation

Yin, L., Yong-Bo, P., Meng-Fei, Y., Weiwei, C., Ping, Z., Lu, X., Ma, L., Cai, C., Liu, Q., & Jinhua, S. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-016-0520-6 · Cited by 12

Pharmacotherapy for hyperglycemia in pregnancy – Do oral agents have a place?

Corcoy, R., Balsells, M., García‐Patterson, A., Shmueli, A., & Hadar, E. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.04.015 · Cited by 13

Exposure to bisphenol a and risk of developing type 2 diabetes: A mini review

Siddique, S., Zhang, G., & Kubwabo, C. (2020) · Emerging contaminants · doi:10.1016/j.emcon.2020.07.005 · Cited by 15

Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice

Charrier, A., Xu, X., Guan, B., Ngo, J., Wynshaw-Boris, A. J., Hatzoglou, M., & Buchner, D. A. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111109 · Cited by 11

The effects of macronutrients metabolism on cellular and organismal aging

Nehme, J., Altulea, A., Gheorghe, T., & Demaria, M. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.02.005 · Cited by 13

Impact of Two Types of Exercise Interventions on Leptin and Omentin Concentrations and Indicators of Lipid and Carbohydrate Metabolism in Males with Metabolic Syndrome

Makiel, K., Suder, A., Targosz, A., Maciejczyk, M., Kozioł-Kozakowska, A., & Haim, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082822 · Cited by 14

Alveolar–capillary adaptation to chronic hypoxia in the fatty lung

Yılmaz, C., Ravikumar, P., Gyawali, D., Iyer, R., Unger, R. H., & Hsia, C. C. W. (2014) · Acta Physiologica · doi:10.1111/apha.12419 · Cited by 12

Genetic variants in DBC1, SIRT1, UCP2 and ADRB2 as potential biomarkers for severe obesity and metabolic complications

da Fonseca, A. C. P., Assis, I. S. D. S., Salum, K. C. R., Palhinha, L., Abreu, G. D. M., Zembrzuski, V. M., Campos, M., Nogueira-Neto, J. F., Cambraia, A., Souza, M. L. F., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1363417 · Cited by 13

Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice

Singha, A. K., Yamaguchi, J., Gonzalez, N. S., Ahmed, N. I., Toney, G. M., & Fujikawa, T. (2019) · Endocrinology · doi:10.1210/en.2018-00907 · Cited by 11

Effect of exercise on renal function in diabetic nephropathy—a systematic review and meta-analysis

Nataraj, M., Maiya, A. G., Nagaraju, S. P., Shastry, B. A., & Shivashankara, K. N. (2022) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2022.11.002 · Cited by 13

Lipid Metabolism, Metabolic Syndrome, and Cancer

Hu, F., Zhang, Y., & Song, Y. (2013) · InTech eBooks · doi:10.5772/51821 · Cited by 11

Vascular repair strategies in type 2 diabetes: novel insights.

Kuschnerus, K., Landmesser, U., & Kränkel, N. (2015) · PubMed Central · doi:10.3978/j.issn.2223-3652.2015.05.11 · Cited by 10

Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus

Hoque, M., Ali, S., & Hoda, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.091 · Cited by 9

Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids

Luse, M. A., Schug, W. J., Dunaway, L. S., Nyshadham, S., Loeb, S. A., Carvalho, A. D. A., Tessema, R., Pavelec, C. M., Keller, T. C. S., Shu, X. H., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321964 · Cited by 9

On the Intimate Relationship of Adiposity to Polycystic Ovary Syndrome

Rosenfield, R. L., & Dumesic, D. A. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf527 · Cited by 11

Lipodistrofias primarias: presentación clínica y diagnóstico

Cortés, V., & Santos, J. L. (2019) · Revista médica de Chile · doi:10.4067/s0034-98872019001101449 · Cited by 9

Effect of Crocetin on Basal Lipolysis in 3T3-L1 Adipocytes

Cimas, F. J., de la Cruz-Morcillo, M. Á., Cifuentes, C., Moratalla‐López, N., Alonso, G. L., Nava, E., & Llorens, S. (2023) · Antioxidants · doi:10.3390/antiox12061254 · Cited by 9

Lipid-induced lipotoxic damage in liver and hepatocytes of black seabream Acanthopagrus schlegelii is mediated by endoplasmic reticulum stress

Zhao, W., Shen, Y., Bao, Y., Monroig, Ó., Zhu, T., Sun, P., Tocher, D. R., Zhou, Q., & Jin, M. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741102 · Cited by 9

How the Social Gets Under the Skin: From the Social as Signal to Society as a Metabolic Milieu

Landecker, H. L. (2024) · KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie · doi:10.1007/s11577-024-00951-5 · Cited by 9

Comparing lipid remodeling of brown adipose tissue, white adipose tissue, and liver after one‐week high fat diet intervention with quantitative Raman microscopy

Paul, A., Chanclón, B., Brännmark, C., Wittung-Stafshede, P. E., Olofsson, C. S., Asterholm, I. W., & Parekh, S. H. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30372 · Cited by 8

Anti-diabetic Effects of Macronutrients via Modulation of Angiogenesis: A Comprehensive Review on Carbohydrates and Proteins

Khosravifar, M., Sajadimajd, S., & Bahrami, G. (2022) · Current Molecular Medicine · doi:10.2174/1566524022666220321125548 · Cited by 9

Carotid body denervation improves hyperglycemia in obese mice

Shin, M., Tang, W., Amorim, M. R., Sham, J. S. K., & Polotsky, V. Y. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00215.2023 · Cited by 7

De la dysfonction du tissu adipeux blanc aux phénotypes anatomocliniques de l’obésité

Ziegler, O., Böhme, P., & Valet, P. (2017) · Obésité · doi:10.1007/s11690-017-0555-z · Cited by 9

Normalized neutral lipid quantitation by flow cytometry

Wolins, N. E., DeHaan, K. N., Cifarelli, V., & Stoeckman, A. K. (2018) · Journal of Lipid Research · doi:10.1194/jlr.d084871 · Cited by 8

Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd

Cao, Y., He, S., Ding, M., Gu, W., Wang, T., Zhang, S., Feng, J., Li, Q., & Zheng, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021216 · Cited by 7

Amelioration of hippocampal dysfunction by adipose tissue‐targeted stem cell transplantation in a mouse model of type 2 diabetes

Krishnan, B., Sallam, H. S., Tumurbaatar, B., Saieva, S., Baymon, D. E., Tuvdendorj, D., Micci, M., Abate, N. I., & Taglialatela, G. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14915 · Cited by 7

Palm oil consumption and its repercussion on endogenous fatty acids distribution

Li, R., Chen, C., Zheng, Z., Yang, X., Tan, C. P., Xu, Y., & Liu, Y. (2021) · Food & Function · doi:10.1039/d0fo02511a · Cited by 6

White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation

Hoevenaars, F. P. M., Keijer, J., van der Stelt, I., Duivenvoorde, L. P. M., Herreman, L., van Nes, R., Friedecký, D., Hegeman, M. A., & van Schothorst, E. M. (2019) · Genes · doi:10.3390/genes10050359 · Cited by 7

Evaluation of miR-141-3p over-expression in ovarian cancer

Shi, L., Sun, H.-J., Zeng, J., Liang, Z.-Q., Lin, Y., Huang, S., Zeng, J., Li, Y., Chen, H., Luo, J., et al. (2022) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2022.04.006 · Cited by 6

The molecular mechanism of obesity: The science behind natural exercise yoga and healthy diets in the treatment of obesity

Yadav, R., Swetanshu, & Singh, P. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102345 · Cited by 6

Tapping the nutraceutical potential of industrial hemp against arthritis and diabetes - A comprehensive review

Rakha, A., Rasheed, H., Altemimi, A. B., Tul‐Muntaha, S., Fatima, I., Butt, M. S., Hussain, S., Bhat, Z. F., Khaneghah, A. M., & Aadil, R. M. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104195 · Cited by 6

Relationship of Non-Alcoholic Fatty Liver Disease to Colorectal Neoplasia

Lee, J. Y., & Kim, J. W. (2013) · Korean Journal of Medicine · doi:10.3904/kjm.2013.84.3.363 · Cited by 6

Flavonoids: A Promising Therapy for Obesity Due to the High-Fat Diet

Meneses, M. M., & Jaramillo‐Flores, M. E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84665 · Cited by 6

Application of lipidomics in nutrition research

Han, X., & Zhou, Y. (2014) · Elsevier eBooks · doi:10.1016/b978-1-78242-084-2.00004-6 · Cited by 7

Comment on: Rowan et al. Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body Composition at 2 Years of Age. Diabetes Care 2011;34:2279–2284

Barbour, L. A., Pelt, R. E. V., Brumbaugh, D. E., Hernandez, T. L., & Friedman, J. E. (2012) · Diabetes Care · doi:10.2337/dc11-2107 · Cited by 6

Vitamin D and Its Regulatory Role in Pancreatic β-Cell Function: Implications for Diabetes

Meng, X., Yang, X. H., Lu, H., Yang, X., Hu, D., & Wu, H. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s551390 · Cited by 5

Comprehensive evaluation of the triglyceride glucose index (TyG) and body roundness index (BRI) on cardiovascular disease risk prediction: a 9-year prospective cohort study in Chinese middle-aged and older adults

Gu, M., Hu, H., & Gu, D. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03092-5 · Cited by 5

Daily Lipolysis Gene Expression in Male Rat Mesenteric Adipose Tissue: Obesity and Melatonin Effects

Cano, P., Jiménez‐Ortega, V., Fernández‐Mateos, P., Virto, L., Maldonado, E., Pérez‐Miguelsanz, J., & Esquifino, A. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020577 · Cited by 5

MACRONUTRIENT INTAKE IS CORRELATED WITH DYSLIPIDEMIA AND LOW-GRADE INFLAMMATION IN CHILDHOOD OBESITY BUT MOSTLY IN MALE OBESE.

Antunes, B. M., Monteiro, P. A., Silveira, L. S., Brunholi, C. D. C., Lira, F. S., & Júnior, I. F. F. (2015) · PubMed · doi:10.3305/nh.2015.32.3.9289 · Cited by 6

Contrasting short-term temperature effects on the profiling of metabolic and stress hormones in non-obese healthy adults: A randomized cross-over trial

Makris, K. C., Konstantinou, C., Perikkou, A., Zdravic, A. B., & Christophi, C. A. (2019) · Environmental Research · doi:10.1016/j.envres.2019.109065 · Cited by 5

Lipid overload and overflow: metabolic trauma and the metabolic syndrome

UNGER, R. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.09.008 · Cited by 399

Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome

Unger, R. H. (2003) · Endocrinology · doi:10.1210/en.2003-0870 · Cited by 678

Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0870 Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome

Unger, R. H. (2013)

Lipid homeostasis, lipotoxicity and the metabolic syndrome

Unger, R. H., Clark, G. O., Scherer, P. E., & Orci, L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.10.006 · Cited by 511

Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine

Unger, R. H. (2005) · Biochimie · doi:10.1016/j.biochi.2004.11.014 · Cited by 184