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Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Open accessAbstract
Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.
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“However, not all AT expansion is necessarily associated with pathological changes.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [3]
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“Excessive RSF and PRF may also cause lipotoxicity owing to the accumulation of intracellular triglycerides and toxic metabolites such as ceramides57,58.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [58]
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Metadata
- Authors
- Unger, R. H., & Scherer, P. E.
- Affiliations
- Veterans Health Administration (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Unger, Roger H.
- ORCID
- Scherer, Philipp E.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 21
- Issue
- 6
- Pages
- 345-352
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC2880185
- OpenAlex
- W1994949025
- Cited by
- 436
- References
- 53
- Citations by year
- 2026: 20 · 2025: 17 · 2024: 30 · 2023: 18 · 2022: 17 · 2021: 15 · 2020: 21 · 2019: 28 · 2018: 18 · 2017: 24 · 2016: 28 · 2015: 31 · 2014: 50 · 2013: 30 · 2012: 40
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK002700)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metabolic syndrome, lipotoxicity, obesity, leptin resistance, hyperleptinemia, gluttony, sloths
- MeSH terms
- Adipose Tissue, Energy Intake, Humans, Hyperphagia, Lipids, Obesity, Leptin, Metabolic Syndrome
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