Cited by 436Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityDiabetes, Cardiovascular Risks, and Lipoproteins

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Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

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Unger, Roger H., Scherer, Philipp E.·2010·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2010.01.009PMC PMC2880185

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Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

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Authors: Unger, R. H., & Scherer, P. E.
Affiliations: Veterans Health Administration (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Unger, Roger H.
ORCID: Scherer, Philipp E.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-06
Volume: 21
Issue: 6
Pages: 345-352
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2010.01.009
PMC: PMC2880185
OpenAlex: W1994949025
Cited by: 436
References: 53
Citations by year: 2026: 20 · 2025: 17 · 2024: 30 · 2023: 18 · 2022: 17 · 2021: 15 · 2020: 21 · 2019: 28 · 2018: 18 · 2017: 24 · 2016: 28 · 2015: 31 · 2014: 50 · 2013: 30 · 2012: 40
FWCI: 4.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK002700)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: metabolic syndrome, lipotoxicity, obesity, leptin resistance, hyperleptinemia, gluttony, sloths
MeSH terms: Adipose Tissue, Energy Intake, Humans, Hyperphagia, Lipids, Obesity, Leptin, Metabolic Syndrome

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Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

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