The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
Open accessAbstract
Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.
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Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Human epicardial adipose tissue is a source of inflammatory mediators
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“The presence of inflammatory cells in epicardial adipose tissue could also reflect the response to plaque rupture and lead to amplification of vascular inflammation and plaque instability [10].”
BackgroundInfluentialLipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265
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Epicardial adipose tissue: Anatomic, biomolecular and clinical relationships with the heart
Iacobellis, G., Corradi, D., & Sharma, A. M. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0319 · Cited by 1,015
Self-citationHuman epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 969
Iacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842
Self-citationEpicardial fat from echocardiography: A new method for visceral adipose tissue prediction
Iacobellis, G., Assael, F., Ribaudo, M. C., Zappaterreno, A., Alessi, G., Di Mario, U., & Leonetti, F. (2003) · Obesity Research · doi:10.1038/oby.2003.45 · Cited by 779
Self-citationEchocardiographic epicardial fat: a review of research and clinical applications
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Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement
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Local and systemic effects of the multifaceted epicardial adipose tissue depot
Iacobellis, G. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.58 · Cited by 605
Self-citationPiché, M.-E., Poirier, P., Lemieux, I., & Després, J.-P. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.06.004 · Cited by 558
Childhood Obesity and Cardiovascular Dysfunction
Cote, A. T., Harris, K. C., Panagiotopoulos, C., Sandor, G. G. S., & Devlin, A. M. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.042 · Cited by 454
PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation
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Metadata
- Authors
- Iacobellis, G., & Bianco, A. C.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 22
- Issue
- 11
- Pages
- 450-457
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2050044059
- Cited by
- 599
- References
- 86
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Iacobellis, G., & Bianco, A. C. (2011). Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2011.07.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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