Cited by 966Diet and metabolism studiesDietary Effects on HealthHistone Deacetylase Inhibitors Research

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Ketone bodies as signaling metabolites

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Newman, John C., Verdin, Eric·2014·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2013.09.002PMC PMC4176946

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Abstract

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, and gene expression via chromatin modifications. We review the regulation and functions of ketone bodies, the relationship between ketone bodies and calorie restriction, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging.

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Authors: Newman, J. C., & Verdin, E.
Affiliations: Gladstone Institutes (US)
Corresponding author: Verdin, Eric
ORCID: Verdin, Eric
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2014-01
Volume: 25
Issue: 1
Pages: 42-52
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2013.09.002
PMC: PMC4176946
OpenAlex: W2036551825
Cited by: 966
References: 143
Citations by year: 2026: 71 · 2025: 98 · 2024: 87 · 2023: 78 · 2022: 117 · 2021: 105 · 2020: 98 · 2019: 77 · 2018: 71 · 2017: 72 · 2016: 43 · 2015: 27 · 2014: 22
FWCI: 3.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: John A. Hartford Foundation
Larry L. Hillblom Foundation
Glenn Foundation for Medical Research
National Institutes of Health
National Institute on Aging (K08AG048354, T32AG000212)
National Institute of Diabetes and Digestive and Kidney Diseases
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Keywords: ketone bodies, beta-hydroxybutyrate, histone deacetylase inhibition, chromatin modification, gene expression regulation, caloric restriction, fasting, physical activity, aging, metabolism
MeSH terms: Aging, Animals, Histone Deacetylases, Humans, Ketone Bodies, Signal Transduction, 3-Hydroxybutyric Acid, Monocarboxylic Acid Transporters, Caloric Restriction, Histone Deacetylase Inhibitors

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