Ketone bodies as signaling metabolites

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Ketone Body Metabolism in Diabetic Kidney Disease

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The Cardioprotective Effects of Nutritional Ketosis: Mechanisms and Clinical Implications

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Sodium Butyrate More Effectively Mitigates the Negative Effects of High-Concentrate Diet in Dairy Cows than Sodium β-Hydroxybutyrate via Reducing Free Bacterial Cell Wall Components in Rumen Fluid and Plasma

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Ketogenic diet attenuates post-cardiac arrest brain injury by upregulation of pentose phosphate pathway–mediated antioxidant defense in a mouse model of cardiac arrest

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Bioinspired micro- and nano-structured neural interfaces

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Effects of Caprylic Triglyceride on Cognitive Performance and Cerebral Glucose Metabolism in Mild Alzheimer’s Disease: A Single-Case Observation

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Ketone bodies in exercise, health and disease: Metabolic mechanisms, pathophysiology, and therapeutic implications

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Signaling roles for astrocytic lipid metabolism in brain function

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Cardio-Onco-Metabolism – Metabolic vulnerabilities in cancer and the heart

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Decreased expression of 3-hydroxybutyrate dehydrogenase 1 is a prognostic marker and promotes tumor progression in hepatocellular carcinoma

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Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase

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Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2

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Targeting ketone body metabolism to treat fatty liver disease

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Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives

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Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages

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Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart

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β-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner

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Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations

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Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization

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Metabolic Contrasts: Fatty Acid Oxidation and Ketone Bodies in Healthy Brains vs. Glioblastoma Multiforme

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Traditional Chinese medicine and plant-derived natural products in regulating triglyceride metabolism: Mechanisms and therapeutic potential

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Targeting the Gut Microbiome to Improve Immunotherapy Outcomes: A Review

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Therapeutic ketogenic diet as treatment for anorexia nervosa

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Validation and Application of a Derivatization-Free RP-HPLC-DAD Method for the Determination of Low Molecular Weight Salivary Metabolites

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Comprendre la physiopathologie de la dénutrition pour mieux la traiter

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Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats

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Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate

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HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure

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Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies

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Breaking the metabolic–inflammatory vicious cycle in polycystic ovary syndrome: a comparative review of ketogenic and high-fat diets

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Association between Impaired Ketogenesis and Metabolic-Associated Fatty Liver Disease

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The role of novel protein acylations in cancer

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ADORA3 activation promotes goblet cell differentiation via enhancing HMGCS2-mediated ketogenesis in ulcerative colitis

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Postprandial Metabolomics Analysis Reveals Disordered Serotonin Metabolism in Post-Bariatric Hypoglycemia

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Ketogenic Metabolism in Neurodegenerative Diseases: Mechanisms of Action and Therapeutic Potential

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Endothelial Heme Dynamics Drive Cancer Cell Metabolism by Shaping the Tumor Microenvironment

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Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male mice

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ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism

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Measuring ketones in the field: rapid and reliable measures of β‐hydroxybutyrate in birds

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Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma‐specific survival

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Age- and Sex-Dependent Modulation of Exogenous Ketone Supplement-Evoked Effects on Blood Glucose and Ketone Body Levels in Wistar Albino Glaxo Rijswijk Rats

Kovács, Z., Brunner, B., D’Agostino, D. P., & Ari, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.618422 · Cited by 12

Application of candle soot CNPs-TiO2-PVP composite in the detection of volatile organic compounds with aldehyde, amine and ketone functional groups by resistance and impedance responses

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Modifying microbially derived short chain fatty acids to promote health

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Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway

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Regulation of adult stem cell function by ketone bodies

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Effect of Acute and Chronic Ingestion of Exogenous Ketone Supplements on Blood Pressure: A Systematic Review and Meta-Analysis

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The interplay between glucose and ketone bodies in neural stem cell metabolism

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From starvation to time-restricted eating: a review of fasting physiology

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Manipulation of metabolism to improve liquid preservation of mammalian spermatozoa

de Hoek, M. V., Rickard, J. P., & GRAAF, S. P. D. (2024) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2024.107631 · Cited by 14

The Impact of Glucose on Corticospinal and Intracortical Excitability

Toepp, S. L., Turco, C. V., Locke, M. B., Nicolini, C., Ravi, R., & Nelson, A. J. (2019) · Brain Sciences · doi:10.3390/brainsci9120339 · Cited by 10

Should nutrition therapy be modified to account for mitochondrial dysfunction in critical illness?

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Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)

Kameda, R., Cho, K. Y., Nomoto, H., Nakamura, A., Omori, K., Nagai, S., Sachiko, E., Kawata, S., Takeuchi, J., Kameda, H., et al. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.109069 · Cited by 11

REGLIV: Molecular regulation data of diverse living systems facilitating current multiomics research

Zhang, S., Sun, X., Mou, M., Amahong, K., Sun, H., Zhang, W., Shi, S., Li, Z., Gao, J., & Zhu, F. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105825 · Cited by 11

Research progress on the relationship between mitochondrial function and heart failure: A bibliometric study from 2002 to 2021

Qi, X., Zhu, Z., Wang, Y., Wen, Z., Jiang, Z.-X., Zhang, L., Pang, Y., & Lu, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1036364 · Cited by 11

A Novel Powder Formulation of the Ketone Ester, Bis Hexanoyl (R)-1,3-Butanediol, Rapidly Increases Circulating ß-Hydroxybutyrate Concentrations in Healthy Adults

Nieman, K. M., Anthony, J. C., & Stubbs, B. J. (2022) · Journal of the American Nutrition Association · doi:10.1080/27697061.2022.2117743 · Cited by 11

A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults

Mah, E., Blonquist, T. M., Kaden, V. N., Beckman, D., Boileau, A. C., Anthony, J. C., & Stubbs, B. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1196535 · Cited by 11

Ketogenic-Mimicking Diet as a Therapeutic Modality for Bipolar Disorder: Biomechanistic Rationale and Protocol for a Pilot Clinical Trial

Bohnen, J. L. B., Wigstrom, T. P., Griggs, A., Roytman, S., Paalanen, N., Andrews, H. A., Bohnen, N. I., Franklin, J. J. H., & McInnis, M. G. (2023) · Nutrients · doi:10.3390/nu15133068 · Cited by 11

Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan

Cooper, I. D., Kyriakidou, Y., Petagine, L., Edwards, K., & Elliott, B. (2023) · Antioxidants · doi:10.3390/antiox12091749 · Cited by 11

Serum 3-Hydroxybutyrate in Patients with Psychogenic Somatoform Symptoms May Be a Predictor of the Effectiveness of Sertraline and Venlafaxine

Saito, N., Itoga, M., Minakawa, S., & Kayaba, H. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s300517 · Cited by 12

The Crucial Roles of Intermediate Metabolites in Cancer

Huang, S., Wang, Z., & Zhao, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s321433 · Cited by 11

A Pilot Study on the 1H-NMR Serum Metabolic Profile of Takotsubo Patients Reveals Systemic Response to Oxidative Stress

Vanni, D., Viceconte, N., Petrella, G., Biccirè, F. G., Pelliccia, F., Tanzilli, G., & Cicero, D. O. (2021) · Antioxidants · doi:10.3390/antiox10121982 · Cited by 11

[β-hydroxy-β-methylbutyrate as a dietary supplement (I): metabolism and toxicity].

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Ketone Bodies Signal Opportunistic Food-Seeking Activity

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Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma

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Impact of Maternal Weight Gain on the Newborn Metabolome

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Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases

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Mitochondria Inspire a Lifestyle

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Differential Proteomic Analysis of Chinese Giant Salamander Liver in Response to Fasting

Geng, X., Guo, J., Zhang, L., Sun, J., Zang, X., Qiao, Z., & Xu, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00208 · Cited by 10

Enhancement of Ketone Supplements-Evoked Effect on Absence Epileptic Activity by Co-Administration of Uridine in Wistar Albino Glaxo Rijswijk Rats

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Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

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The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats

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Development of a Three-Dimensional HPLC System for the Simultaneous Determination of Lactate and 3-Hydroxybutyrate Enantiomers in Mammalian Urine

HSIEH, C.-L., Lin, P.-Y., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2018) · Chromatography · doi:10.15583/jpchrom.2018.021 · Cited by 10

Physiological concentrations of β-hydroxybutyrate do not promote adipocyte browning

Caminhotto, R. D. O., Andreotti, S., Komino, A. C. M., Silva, F. D. F., Sertié, R. A. L., Christoffolete, M. A., Reis, G. B., & Lima, F. B. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116683 · Cited by 10

Ketone Monoester Supplementation Does Not Expedite the Recovery of Indices of Muscle Damage After Eccentric Exercise

Martin-Arrowsmith, P. W., Lov, J., Dai, J., Morais, J. A., & Churchward‐Venne, T. A. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.607299 · Cited by 12

Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions

Speer, H., & McKune, A. J. (2021) · Antioxidants · doi:10.3390/antiox10081247 · Cited by 11

β-Hydroxybutyric Inhibits Vascular Calcification via Autophagy Enhancement in Models Induced by High Phosphate

Liang, J., Huang, J., He, W., Shi, G., Chen, J., & Huang, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.685748 · Cited by 10

Psychology and Pathophysiological Outcomes of Eating

Takada, A., & Himmerich, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.92917 · Cited by 10

Intermittent Fasting as Possible Treatment for Heart Failure

Garza-González, S., Nieblas, B., Solbes-Gochicoa, M. M., Altamirano, J., & Garcı́a, N. (2022) · Current Vascular Pharmacology · doi:10.2174/1570161120666220610151915 · Cited by 11

Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise

Herring, R. A., Parsons, I., Shojaee‐Moradie, F., Stevenage, M., Jackson, N., MANDERS, R. J. F., Umpleby, A. M., Fielding, B. A., Davies, M. J., & Russell-Jones, D. L. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac617 · Cited by 10

Detecting creatine excreted in the urine of swimming athletes by means of Raman spectroscopy

Moreira, L. P., Rocco, D. D. F. M., da Silva, A. G., Pacheco, M. T. T., & Silveira, L. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02843-z · Cited by 10

Effects of exercise before breakfast on plasma free fatty acid profile and 24-h fat oxidation

Iwayama, K., Ogawa, A., Tanaka, Y., Yajima, K., Park, I., Ando, A., Ogata, H., Kayaba, M., Zhang, S., Tanji, F., et al. (2020) · Metabolism Open · doi:10.1016/j.metop.2020.100067 · Cited by 12

3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways.

Qiu, X., Wu, W., Zhang, S., Huang, C., & Lin, D.-H. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c01150 · Cited by 10

Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer

Liang, X., Tian, R.-F., Li, T., Wang, H., Qin, Y., Qian, M., Fan, J., Wang, D., Cui, H., & Jiang, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02421-z · Cited by 9

Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges

Nikanfar, M., Avci, Ç. B., Khalilnezhad, A., Shahriyari, E., & Nourazarian, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05247-z · Cited by 10

Metabolic reprogramming in the spinal cord drives the transition to pain chronicity

Tagne, A. M., Fotio, Y., Lee, H.-L., Jung, K., Katz, J., Ahmed, F., Le, J., Bazinet, R. P., Jang, C., & Piomelli, D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116261 · Cited by 10

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance

Wakita, M., Ito, K., Fujii, K., Sakamoto, D., Mikawa, T., Sugawara, S., Zhou, X., Park, J. H., Miyagawa, H., Motooka, D., et al. (2026) · Nature Aging · doi:10.1038/s43587-025-01057-z · Cited by 9

PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

Chhabra, N. F., Amarie, O. V., Wu, M., Amend, A., Rubey, M., Gradinger, D., Irmler, M., Beckers, J., Rathkolb, B., Wolf, E., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01337-x · Cited by 10

Short-Term Influence of Caffeine and Medium-Chain Triglycerides on Ketogenesis: A Controlled Double-Blind Intervention Study

Baumeister, A., Gardemann, J., Fobker, M., Spiegler, V., & Fischer, T. W. (2021) · Journal of Nutrition and Metabolism · doi:10.1155/2021/1861567 · Cited by 9

Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase

Schlicker, L., Zhao, G., Dudek, C.-A., Boers, H. M., Meyer‐Hermann, M., Jacobs, D. M., & Hiller, K. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.785999 · Cited by 12

Natural Antioxidant By-Product Mixture Counteracts the Effects of Aflatoxin B1 and Ochratoxin A Exposure of Piglets after Weaning: A Proteomic Survey on Liver Microsomal Fraction

Popescu, R. G., Marinescu, G. C., Rădulescu, A. L., Marin, D. E., Țăranu, I., & Dinischiotu, A. (2023) · Toxins · doi:10.3390/toxins15040299 · Cited by 11

β-hydroxybutyrate: Much more than a metabolite

Newman, J. C., & Verdin, E. M. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.08.009 · Cited by 347

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777

[Cellular metabolite controls oxidative stress resistance.]

Shimazu, T. (2018) · PubMed

Stress Protector

Ray, L. B. (2013) · Science Signaling · doi:10.1126/scisignal.2003956

β-hydroxybutyrate serves as a regulator in ketone body metabolism through lysine β-hydroxybutyrylation

Fang, J., Hu, Z., Luo, T., Chen, S., Li, J., Yang, H., Sheng, X., Zhang, X., Zhang, Z., & Xie, C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108475 · Cited by 14