Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

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Items 201–286 of 286

1. Interrupting the FGF19-FGFR4 Axis to Therapeutically Disrupt Cancer Progression
   Liwei Lang, Austin Young Shull, Yong Teng · 2018 · Current Cancer Drug Targets
2. Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence
   Louben Dorval, Brian I. Knapp, Olufolake A. Majekodunmi, Sophia I. Eliseeva, Jean M. Bidlack · 2021 · Neuropharmacology
3. Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism
   Ashley Patton, Farooq H. Khan, Rohit Kohli · 2017 · Digestive Diseases
4. FGF21: A Sharp Weapon in the Process of Exercise to Improve NAFLD
   Zhiyuan Wang, Tingting Sun, Jingjing Yu, Siyu Li, Lijing Gong, Yimin Zhang · 2023 · Frontiers in Bioscience-Landmark
5. FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis
   Ursic-Bedoya, José, Desandré, Guillaume, Chavey, Carine, Marie, Pauline, Polizzi, Arnaud, Rivière, Benjamin, Guillou, Hervé, Assenat, Eric, Hibner, Urszula, Gregoire, Damien · 2024 · EMBO Molecular Medicine
6. The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?
   Mada Ghanem, Gabrielle Archer, Bruno Crestani, Arnaud Mailleux · 2024 · Pharmacology & Therapeutics
7. FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
   Arguiñe Ivonne Urraza Robledo, Marta Giralt, Faviel F. González-Galarza, Francesc Villarroya, Alberto Alejandro Miranda Pérez, Pablo Ruíz-Flores, María Elena Gutiérrez Pérez, Peré Domingo, Francisco Carlos López-Márquez · 2021 · PLoS ONE
8. Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice
   Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C.G. Martin, Yan Li · 2021 · International Journal of Biological Sciences
9. Endocrine FGFs and their signaling in the brain: Relevance for energy homeostasis
   Lucas Zangerolamo, Marina Uchôa Wall Barbosa De Carvalho, Licio Augusto Velloso, Helena C.L. Barbosa · 2023 · European Journal of Pharmacology
10. Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control
    Chisayo Kozuka, Vissarion Efthymiou, Vicência Sales, Liyuan Zhou, Soravis Alm Osataphan, Yixing Yuchi, JEREMY I. CHIMENE-WEISS, Christopher M. Mulla, ELVIRA M. ISGANAITIS, Jessica Desmond et al. · 2022 · Diabetes
11. Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver
    Lisanne E. Wisse, Denise Visser, Timo J. ter Braak, Abdellatif Bakkali, Eduard A. Struys, Christopher D. Morrison, Marjo S. van der Knaap, Truus E. M. Abbink · 2020 · Nutritional Neuroscience
12. Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor
    Hui Jin Jung, Eun Hye Nam, Jin Young Park, Prithwish Ghosh, In Su Kim · 2021 · Bioorganic & Medicinal Chemistry Letters
13. Foresight regarding drug candidates acting on the succinate–GPR91 signalling pathway for non-alcoholic steatohepatitis (NASH) treatment
    Chengyuan Liang, Juan Li, Bin Tian, Lei Tian, Yuzhi Liu, Jingyi Li, Liang Xin, Jun Wang, Chao Fu, Zhenfeng Shi et al. · 2021 · Biomedicine & Pharmacotherapy
14. Interaction of Klotho and sirtuins
    Farzaneh Rostamzadeh, Yasamin Moosavi-Saeed, Mahboobeh Yeganeh‐Hajahmadi · 2023 · Experimental Gerontology
15. Identification of IQ motif–containing GTPase-activating protein 1 as a regulator of long-term ketosis
    Hanna L. Erickson, Sayeepriyadarshini Anakk · 2018 · JCI Insight
16. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity
    Zhisheng Xu, Tingting Fu, Qiqi Guo, Wanping Sun, Zhenji Gan · 2018 · Pharmacological Research
17. The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review
    Agata Sadowska, Elżbieta Poniedziałek‐Czajkowska, Radzisław Mierzyński · 2023 · International Journal of Molecular Sciences
18. The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids
    Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, Jong Min Choi, Yang Yang, Hyun-Jung Jung, Zhan‐Guo Gao, Yongmei Yu, Sung Yun Jung, Mikhail G. Kolonin et al. · 2024 · Diabetes
19. An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes
    Ping Wu, Zhenyu Liu, Xiaohong Jiang, Hao Fang · 2019 · Current Drug Targets
20. State of art on the mechanisms of laparoscopic sleeve gastrectomy in treating type 2 diabetes mellitus
    Fashun Liu, Song Wang, Xianshan Guo, Zhen-Xiong Ye, Hongya Zhang, Zhen Li · 2023 · World Journal of Diabetes
21. Central FGF19 signaling enhances energy homeostasis and adipose tissue thermogenesis through sympathetic activation in obese mice
    Lucas Zangerolamo, Marina Uchôa Wall Barbosa De Carvalho, Carina Solon, Davi Sidarta-Oliveira, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, Yu‐Hua Tseng, Licio Augusto Velloso, Helena C.L. Barbosa · 2025 · American Journal of Physiology-Endocrinology and Metabolism
22. Adipokines and their role in acute pancreatitis
    Saira Rafaqat, Irena Radoman Vujacic, Dimitrios Patoulias, Huma Khurshid, Aleksandra N. Klisic · 2024 · Journal of Medical Biochemistry
23. Estradiol-dependent and independent effects of FGF21 in obese female mice
    T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, Konstantin O. Baranov, E. N. Makarova, Н. М. Бажан · 2022 · Vavilov Journal of Genetics and Breeding
24. Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress
    Weijia Cai, Canye Li, Zuanjun Su, Jinming Cao, Zhicong Chen, Yitian Chen, Zhijun Guo, Jian Cai, Feng Xu · 2023 · PeerJ
25. Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight
    Vilborg Pálsdóttir, Sara H. Windahl, Daniel A. Hägg, Hanna Keantar, Jakob Bellman, Andrew G. Buchanan, Tristan J. Vaughan, Daniel Lindén, John‐Olov Jansson, Claes Ohlsson · 2019 · Endocrinology
26. RNA Expression Profiling Reveals Differentially Regulated Growth Factor and Receptor Expression in Redirected Cancer Cells
    Hannah S. Schmucker, Jang Pyo Park, Marie‐May Coissieux, Mohamed Bentires‐Alj, Frank Alex Feltus, Brian W. Booth · 2017 · Stem Cells and Development
27. Role of exercise in the mechanisms ameliorating hepatic steatosis in non-alcoholic fatty liver disease
    Javier Russell‐Guzmán, L. Karachon, Tomás A. Gacitúa, Alejandro Freundlich, Carlos Poblete-Aro, Ramón Rodrigo · 2018 · Sport Sciences for Health
28. Soluble Expression of hFGF19 without Fusion Protein through Synonymous Codon Substitutions and DsbC Co-Expression in E. coli
    Hye‐Ji Choi, Dae‐Eun Cheong, Su‐Kyoung Yoo, Jaehong Park, Dong-Hyun Lee, Geun‐Joong Kim · 2020 · Microorganisms
29. Exploring the therapeutic potential of Chinese herbs on comorbid type 2 diabetes mellitus and Parkinson's disease: A mechanistic study
    Yan Wang, Peng-Peng Gao, Zicong Wu, Bing Jiang, Yanru Wang, Zhaxicao He, Bing Zhao, Xinyun Tian, Han Gao, Li Cai et al. · 2024 · Journal of Ethnopharmacology
30. Daily liver rhythms: Coupling morphological and molecular oscillations
    Ueli Schibler, Flore Sinturel, Félix Naef, Alan Gerber, David Gatfield · 2025 · Proceedings of the National Academy of Sciences
31. The role of fibroblast growth factor 19 in the pathogenesis of nonalcoholic fatty liver disease
    Lampros Chrysavgis, Ilias Giannakodimos, Antonios Chatzigeorgiou, Κωνσταντίνος Τζιόμαλος, George Papatheodoridis, Εvangelos Cholongitas · 2022 · Expert Review of Gastroenterology & Hepatology
32. Linking the brain and bone through fat
    Elisabeta Andreea Malinici, Anca Mirela Sîrbu, Miruna Popa, Simona Vasilica Fica · 2021 · Journal of Mind and Medical Sciences
33. Relationship of fibroblast growth factor 21 with the prevalence and progression of vascular and valvular calcification: Multi-ethnic study of atherosclerosis
    Shoban Sayanthan, Matthew Allison, Matthew Jay Budoff, Kerry‐Anne Rye, Kwok Leung Ong · 2022 · International Journal of Cardiology
34. Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
    Takao Hirai, Wei Wang, Naoko Murono, Kazuo Iwasa, Makoto Inoue · 2023 · Journal of Natural Medicines
35. FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2α/GLI2 Signaling Axis
    Yeyi Zheng, Wenjie Gong, Zhaohang Wu, Siyi Zhang, Nan Wang, Zhenyu Hu, Yanni Shou, Tianpeng Xu, Yingjie Shen, Xiaokun Li et al. · 2024 · Journal of Investigative Dermatology
36. Saponins from Panax japonicus Enhance Lipolysis via Acting on FGF21-β-Klotho/FGFR1 in Obese Mice
    Tongyao Wang, Yan Huang, Mingxin Hu, Xiaofei Huang, Dianmei Yu, Liangliang Jia, Wenru Zhi, Yifei Mu, Zhiyong Zhou, Jin’e Wang · 2025 · Journal of Agricultural and Food Chemistry
37. Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins
    Hirokazu Taniguchi, Nao Akiyama, Kengo Ishihara · 2019 · Journal of Nutritional Science and Vitaminology
38. Fibroblast growth factor and kidney disease: Updates for emerging novel therapeutics
    Neerja Trivedi, Devendra Kumar · 2021 · Journal of Cellular Physiology
39. Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth
    Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo‐ichi Nabeshima · 2023 · Life Science Alliance
40. Clinical observation of basic fibroblast growth factor (bFGF) combined with minoxidil in the treatment of male androgenetic alopecia
    Chi Liu, Hongwei Zhao, Ying Zhang, Wei Wu · 2022 · Journal of Cosmetic Dermatology
41. FGF21 acting on the noradrenergic nervous system protects against influenza virus infection
    Wei Fan, Yuan Zhang, Laurent Gautron, David G. Thomas, Heather W. Stout-Delgado, Edward J. Schenck, Tadiwanashe Gwatiringa, Kartik N. Rajagopalan, David J. Mangelsdorf, Steven A. Kliewer · 2025 · Proceedings of the National Academy of Sciences
42. The role of β-Klotho in FGF signaling: from molecular insights to therapeutic innovations
    Fang Yan, Chen Yang, Shiyuan Huang, Li Yuan, Yi Qiu, Tao Liu, Xi Peng, Yang Yang · 2026 · American Journal of Physiology-Endocrinology and Metabolism
43. Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis
    David J. Matye, Xuan Qin, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li · 2022 · Liver Research
44. New Medical Treatment Strategies for Nonalcoholic Steatohepatitis
    Michael A. Fuchs · 2015 · Current Treatment Options in Gastroenterology
45. Fibroblast growth factor 19 meets mammalian target of rapamycin: A mitogenic Tête‐à‐Tête under consideration
    Elisabeth Krones, Martin Wagner · 2016 · Hepatology
46. Fibroblast growth factor 15 overexpression and combined peroxisome proliferator–activated receptor α activation attenuates metabolic dysfunction–associated steatohepatitis progression in mice
    Hong Qi Shi, Mary Stofan, Bo Kong, Rulaiha E. Taylor, Zakiyah R Henry, Syeda Maliha, Daniel Rizzolo, Grace Liejun Guo · 2025 · Drug Metabolism and Disposition
47. Relationship between the levels of serum fibroblast growth factor 19 and metabolic factors in obese and normal weight subjects with and without type 2 diabetes mellitus: a case-control study
    Hamidreza Razmi, Ali Tarighat‐Esfanjani, Laleh Payahoo, Majid Mobasseri, Mahdi Amirpour, Elham Mirzaei, Zohreh Ghoreishi · 2021 · Hormone Molecular Biology and Clinical Investigation
48. Quantification of serum fibroblast growth factor-19 concentration in healthy dogs before and after feeding
    Jillian Myers, Luke Granger, Sarah Keeton, Chin‐Chi Liu, Andrea N. Johnston · 2021 · American Journal of Veterinary Research
49. Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
    Shengnan Zhou, Weijie Chen, Xuesong Bai, Jiemin Chen, Qiang Xu, Liangbo Dong, Wei Chen, Qiang Qu, Xiaodong He · 2022 · Frontiers in Endocrinology
50. Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction
    Guixiang Zeng, Jingjing Lian, Jiajia Shen, Yuan Shi · 2025 · Frontiers in Pediatrics
51. Precision Nutrition and Obesity
    Jimmy David Bell, David Heber · 2023 · Elsevier eBooks
52. Mechanistic Target of Rapamycin
    Olivia C. McKee-Muir, Ryan Charles Russell · 2017 · Elsevier eBooks
53. The Metabolic Effects of FGF21: From Physiology to Pharmacology
    Parkyong Song · 2020 · JoLS Journal of Life Sciences
54. A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes.
    Qian Lin · 2018
55. Roles of ABCG5 ABCG8 cholesterol transporter in lipid homeostasis
    Yuhuan Wang · 2015 · UKnowledge (University of Kentucky)
56. Molecular Nutrition Study of the Transcriptional Regulation of Anti-obesity Hormones
    Makoto Shimizu · 2016 · Nippon Eiyo Shokuryo Gakkaishi
57. FGF-23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity
    L. Darryl Quarles · 2017 · Elsevier eBooks
58. Fibroblast Growth Factor Receptor Inhibitors: Enhancing Therapeutic Strategies for Solid Tumors
    Cinta Hierro, Josep M. Tabernero · 2018 · Elsevier eBooks
59. Expression of the hormonal FGF co‐receptor Klotho beta in the Xenopus laevis model
    Geng Chen, Qinghua Tao · 2018 · Cell Biology International
60. PENGARUH MEDIA TERKONDISI SEL PUNCA MESENSIMAL TERHADAP EKSPRESI GEN TRANSCRIPTION FACTOR 7-LIKE 2 (TCF7L2) TIKUS MODEL DIABETES MELITUS TIPE 2
    Stefani Santi Widhiastuti, Bernadia Branitamahisi, Nor Sri Inayati, Ida Ayu Preharsini, Demas Bayu Handika, Ahmad Hamim Sadewa, Abdurahman Laqif, Sofia Mubarika Haryana · 2020 · BERITA BIOLOGI
61. Klotho-independent actions of FGF23—targets, signal transduction, and cellular effects
    John Musgrove, Alexander Grabner · 2021 · Elsevier eBooks
62. Klotho—the discovery of the FGF23 coreceptor
    Seiji Fukumoto · 2021 · Elsevier eBooks
63. Détection cérébrale du glucose et homéostasie du glucose
    Bernard Thorens, Gwenaël Labouèbe · 2021 · Médecine des Maladies Métaboliques
64. El gran papel de Klotho
    Fabiana Verónica Delgado Troche · 2021 · Revista Med
65. Evaluation of sitagliptin therapy on the levels of fibroblast growth factor-19 (FGF19) in patients with Type 2 diabetes
    Özen Öz Gül, Soner Cander · 2022 · Turkish Journal of Internal Medicine
66. Efeitos do treinamento físico intervalado de alta intensidade (HIIT) nas características morfológicas e funcionais do tecido adiposo branco e marrom
    Luiz Felipe Martucci · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
67. FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons
    Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Yuan Zhang, Jeffrey M. Friedman, David J. Mangelsdorf, Steven A. Kliewer · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
68. The developing link of metabolic growth factors in insulin resistance
    Rongyin Gao, Waseem Hassan, Andleeb Shahzadi, Fiaz ud din, Hafiz Muhammad Farhan Rasheed · 2017 · Journal of Contemporary Pharmacy
69. Molecular and Cellular Basics of Intermittent Fasting: Traditional Review
    Melike Özder, Yüce ERÇETİN, Hasan Akbaba · 2023 · Journal of Literature Pharmacy Sciences
70. The endocrine functions of bone
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71. The Correlation between NAFLD and T2DM
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72. Fibroblast growth factor 21 responds to taurocholic acid sodium-induced acute pancreatic injury
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73. The effect of Klotho protein on biological behavior of JEG-3 cells
    Guixiang Zeng, Jingjing Lian, Jiajia Shen, Yuan Shi · 2025 · Tissue and Cell
74. Effects of Stress of the Endoplasmic Reticulum on Genome-Wide Gene Expression in the Bovine Liver Cell Model BFH12
    Eron Bajrami, Gaiping Wen, Sarah M. Grundmann, Robert Ringseis, Denise K. Geßner, Klaus Eder · 2025 · Dairy
75. Additional file 1 of Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota
    Zhong, Yue, Xiao, Yang, Gao, Jing, Zheng, Zhaozheng, Zhang, Ziheng, Yao, Lu, Li, Dongmin · 2022 · Figshare
76. Additional file 1 of FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
    Wang, Runfeng, Wang, Jin, Zhang, Zhiguo, Ma, Bo, Sun, Shukai, Gao, Li, Gao, Guodong · 2024 · Figshare
77. Additional file 2 of FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
    Wang, Runfeng, Wang, Jin, Zhang, Zhiguo, Ma, Bo, Sun, Shukai, Gao, Li, Guodong Gao · 2024 · Figshare
78. Additional file 3 of FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
    Wang, Runfeng, Wang, Jin, Zhang, Zhiguo, Ma, Bo, Sun, Shukai, Gao, Li, Gao, Guodong · 2024 · Figshare
79. Plasma proteome mendelian randomization and network pharmacology reveal therapeutic targets for thyroid disorders
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80. Infections virales respiratoires et tissus adipeux blancs : Exemple de la grippe et de la COVID-19
    Johanna Barthelemy · 2022 · theses.fr (ABES)
81. Rôle des FGFs endocrines et leurs récepteurs au cours de la fibrose pulmonaire idiopathique
    Mada Ghanem · 2023 · theses.fr (ABES)
82. Positive actions of fibroblast growth factor 21 on female zebrafish reproductive axis
    Chinelo Nnenna Uju, Suraj Unniappan · 2026 · Theriogenology
83. Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
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84. Canonical and Non-Canonical Regulators of Lipid Metabolism in the Liver and the “Liver–Other Organs” Axes
    Stanislav Nikolaevich Kotlyarov, Анна Анатольевна Котлярова, Roberto Catanzaro, Francesco Marotta · 2026 · International Journal of Molecular Sciences
85. Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance
    Rocío A. Martín‐Chamorro, Catalina Amadora Pomar, Andreu Palou, Catalina Picó, Ana María Rodríguez · 2026 · The FASEB Journal
86. BindingDB Entry 50012408: Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor.
    BindingDB · 2022 · UC San Diego