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LXR Regulation of Brain Cholesterol: From Development to Disease

Courtney, Rebecca, Landreth, Gary E.·2016·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2016.03.018PMC PMC4986614
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  • Pathway analyses identified immune-related pathways that may be relevant for the mechanisms of microglial aging, including STAT-3 and IL-6 signaling, and LXR/RXR activation.

    “Our pathway analyses identified immune-related pathways that may be of relevance for the mechanisms of microglial aging, including STAT-3 and IL-6 signaling, as well as LXR/RXR activation, which has emerged as a key player in regulating cholesterol homeostasis and inflammation in the brain with a potential role in neurodegenerative disorders65–67.”

    From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [65]

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Authors
Courtney, R., & Landreth, G. E.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2016-06
Volume
27
Issue
6
Pages
404-414
ISSN
1043-2760
DOI
10.1016/j.tem.2016.03.018
PMC
PMC4986614
Cited by
176
References
16
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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