HDL and cholesterol handling in the brain

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Huntington's disease

Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works

Antiinflammatory Properties of HDL

Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394 · see citing works

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Mazzulli, J. R., Xu, Y.-H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A., & Krainc, D. (2011) · Cell · doi:10.1016/j.cell.2011.06.001 · Cited by 1,341 · see citing works

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

Prevalence of Metabolic Syndrome and Metabolic Abnormalities in Schizophrenia and Related Disorders—A Systematic Review and Meta-Analysis

Mitchell, A. J., Vancampfort, D., Sweers, K., van Winkel, R., Yu, W., & Binder, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr148 · Cited by 1,087 · see citing works

Brain Cholesterol: Long Secret Life Behind a Barrier

Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044 · see citing works

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 968 · see citing works

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

Reeve, A. K., Simcox, E. M., & Turnbull, D. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.004 · Cited by 961 · see citing works

The Journal of Clinical Investigation

Witkin, E. M. (2016) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(94)92394-9 · Cited by 920 · see citing works

Apolipoprotein E in Alzheimer’s disease and other neurological disorders

Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · see citing works

Parkinson's Disease and Parkinsonism: Neuropathology

Dickson, D. W. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009258 · Cited by 847 · see citing works

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology · doi:10.1002/ana.410440324 · Cited by 686 · see citing works

Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)

Hruska, K. S., LaMarca, M. E., Scott, C. R., & Sidransky, E. (2008) · Human Mutation · doi:10.1002/humu.20676 · Cited by 678 · see citing works

Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600419 · Cited by 670 · see citing works

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works

α-Synuclein Membrane Interactions and Lipid Specificity

Jo, E., McLaurin, J., Yip, C. M., George‐Hyslop, P. S., & Fraser, P. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004345200 · Cited by 602 · see citing works

Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity

Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 576 · see citing works

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works

Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215593 · Cited by 481 · see citing works

Mechanisms of neurodegeneration in Huntington’s disease

Gil‐Mohapel, J., & Rego, A. C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06310.x · Cited by 480 · see citing works

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

Murphy, K. E., Gysbers, A. M., Abbott, S. K., Tayebi, N., Kim, W. S., Sidransky, E., Cooper, A., Garner, B., & Halliday, G. M. (2014) · Brain · doi:10.1093/brain/awt367 · Cited by 475 · see citing works

Lecithin cholesterol acyltransferase

Jonas, A. M. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00153-0 · Cited by 475 · see citing works

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works

Advances in the genetics of Parkinson disease

Trinh, J., & Farrer, M. J. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.132 · Cited by 465 · see citing works

Central nervous system: cholesterol turnover, brain development and neurodegeneration

Dietschy, J. M. (2009) · bchm · doi:10.1515/bc.2009.035 · Cited by 394 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Human Apolipoprotein E Receptor 2

Kim, D.-H., Iijima, H., Goto, K., Sakai, J., Ishii, H., Kim, H.-J., Suzuki, H., Kondo, H., Saeki, S., & Yamamoto, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8373 · Cited by 384 · see citing works

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 381 · see citing works

Clusterin/Apolipoprotein J in human aging and cancer

Trougakos, I. P., & Gonos, E. S. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00041-9 · Cited by 376 · see citing works

Review: sporadic cerebral amyloid angiopathy

Attems, J., Jellinger, K., Thal, D. R., & Van Nostrand, W. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01137.x · Cited by 371 · see citing works

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., Jain, S., Hirsch-Reinshagen, V., Wellington, C. L., Bales, K. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33622 · Cited by 370 · cited 7× · see citing works

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

Linton, M. F., Gish, R., Hubl, S. T., Bütler, E., Esquivel, C., Bry, W. I., Boyles, J. K., Wardell, M. R., & Young, S. G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115288 · Cited by 367 · see citing works

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H.-S., Wang, B., Cole, S. L., Herz, J., Muglia, L., & Bu, G. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.008 · Cited by 364 · see citing works

Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

Koldamova, R., Staufenbiel, M., & Lefterov, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504513200 · Cited by 350 · see citing works

PEPTIC ULCER

Baron, J. H. (1975) · The Lancet · doi:10.1016/s0140-6736(75)93174-8 · Cited by 343 · see citing works

Smith–Lemli–Opitz syndrome: pathogenesis, diagnosis and management

Porter, F. D. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.10 · Cited by 318 · see citing works

Oxysterols and neurodegenerative diseases

Björkhem, I., Cedazo-Mı́nguez, Á., Leoni, V., & Meaney, S. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.001 · Cited by 302 · see citing works

Widespread Alterations of α-Synuclein in Multiple System Atrophy

Dickson, D. W., Liu, W.-K., Hardy, J., Farrer, M. J., Mehta, N. D., Uitti, R. J., Mark, M. H., Zimmerman, T., Golbe, L. I., Sage, J., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65226-1 · Cited by 298 · see citing works

Characterization of four lipoprotein classes in human cerebrospinal fluid

Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298 · see citing works

Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease

Valenza, M., Rigamonti, D., Goffredo, D., Zuccato, C., Fenu, S., Jamot, L., Strand, A., Tarditi, A., Woodman, B., Racchi, M., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3355-05.2005 · Cited by 298 · see citing works

ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

Wellington, C. L., Walker, E. K.-Y., Suarez, A., Kwok, A. Y. C., Bissada, N., Singaraja, R. R., Yang, Y., Zhang, L., James, E. R., Wilson, J. E., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780421 · Cited by 296 · see citing works

Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease☆

Merched, A. J., Xia, Y., Visvikis‐Siest, S., Sérot, J., & Siest, G. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00103-7 · Cited by 273 · see citing works

Apolipoprotein D

Rassart, É., Bedirian, A., Carmo, S. D., Guinard, O., Sirois, J., Terrisse, L., & Milne, R. W. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00162-x · Cited by 272 · see citing works

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Liu, Q., Trotter, J., Zhang, J., Peters, M. M., Cheng, H., Bao, J., Han, X., Weeber, E. J., & Bu, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4067-10.2010 · Cited by 268 · see citing works

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

Reitz, C., Tang, M., Schupf, N., Manly, J. J., Mayeux, R. P., & Luchsinger, J. A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.297 · Cited by 253 · see citing works

Efflux and Atherosclerosis

Singaraja, R. R., Brunham, L. R., Visscher, H., Kastelein, J. J. P., & Hayden, M. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000078520.89539.77 · Cited by 245 · see citing works

Endothelial Protection by High-Density Lipoproteins

Calabresi, L., Gomaraschi, M., & Franceschini, G. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000094961.74697.54 · Cited by 242 · see citing works

Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

Kim, W. S., Weickert, C., & Garner, B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05099.x · Cited by 240 · see citing works

Uptake and transport of high‐density lipoprotein (HDL) and HDL‐associated α‐tocopherol by an in vitro blood–brain barrier model

Balázs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., & Sattler, W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02373.x · Cited by 239 · see citing works

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

Koldamova, R. P., Lefterov, I. M., Ikonomovic, M. D., Skoko, J., Lefterov, P. I., Isanski, B. A., DeKosky, S. T., & Lazo, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300044200 · Cited by 237 · see citing works

Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

May, P., Rohlmann, A., Bock, H. H., Zurhove, K., Marth, J. D., Schomburg, E. D., Noebels, J. L., Beffert, U., Sweatt, J. D., Weeber, E. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8872-8883.2004 · Cited by 236 · see citing works

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease

Hirsch-Reinshagen, V., Maia, L. F., Burgess, B. L., Blain, J.-F., Naus, K. E., McIsaac, S. A., Parkinson, P. F., Chan, J. Y., Tansley, G. H., Hayden, M. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508781200 · Cited by 233 · see citing works

Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis

Weinstock‐Guttman, B., Zivadinov, R., Mahfooz, N., Carl, E. M., Drake, A. S., Schneider, J., Teter, B. E., Hussein, S. M., Mehta, B. K., Weiskopf, M., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-127 · Cited by 232 · see citing works

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30001 · Cited by 222 · see citing works

Scavenger receptor Bl - a cell surface receptor for high density lipoprotein

Rigotti, A., Trigatti, B. L., Babitt, J. L., Penman, M., Xu, S., & Krieger, M. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199706000-00009 · Cited by 209 · see citing works

Lipoproteins in the Central Nervous System

LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works

The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in Development, Disease, and Therapy

Lehtinen, M. K., Bjornsson, C. S., Dymecki, S. M., Gilbertson, R. J., Holtzman, D. M., & Monuki, E. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3258-13.2013 · Cited by 204 · see citing works

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

Tong, J., Wong, H., Guttman, M., Ang, L. C., Forno, L. S., Shimadzu, M., Rajput, A. H., Muenter, M. D., Kish, S. J., Hornykiewicz, O., et al. (2009) · Brain · doi:10.1093/brain/awp282 · Cited by 204 · see citing works

High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation?

Burger, D., & Dayer, J. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(01)00018-0 · Cited by 202 · see citing works

Association between high‐density lipoprotein and cognitive impairment in the oldest old

van Exel, E. R., de Craen, A. J. M., Gussekloo, J., Houx, P. J., Wiel, A. B. D., Macfarlane, P. W., Blauw, G. J., & Westendorp, R. G. J. (2002) · Annals of Neurology · doi:10.1002/ana.10220 · Cited by 189 · see citing works

The Effects of Altered Apolipoprotein A-I Structure on Plasma HDL Concentration

Sorci‐Thomas, M. G., & Thomas, M. J. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00163-3 · Cited by 189 · see citing works

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system.

Vance, J., & Hayashi, H. (2010) · Biochimica et Biophysica Acta · doi:10.1016/j.bbalip.2010.02.007 · Cited by 185 · see citing works

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

Göker-Alpan, Ö., Stubblefield, B. K., Giasson, B. I., & Sidransky, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0741-7 · Cited by 179 · see citing works

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

Manning-Bog, A., Schüle, B., & Langston, J. W. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.06.009 · Cited by 176 · see citing works

Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

Thanopoulou, K., Fragkouli, A., Stylianopoulou, F., & Georgopoulos, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005888107 · Cited by 161 · see citing works

Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

Demeester, N., Castro, G., Desrumaux, C. M., Geitere, C. D., Fruchart, J., Santens, P., Mulleners, E., Engelborghs, S., Deyn, P. P. D., Vandekerckhove, J. S., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32039-3 · Cited by 157 · see citing works

Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-Synucleinopathies

Uryu, K., Richter‐Landsberg, C., Welch, W., Sun, E., Goldbaum, O., Norris, E. H., Pham, C.-T., Yazawa, I., Hilburger, K., Micsenyi, M. C., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050770 · Cited by 157 · see citing works

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Castellano, J. M., Deane, R., Gottesdiener, A. J., Verghese, P. B., Stewart, F. R., West, T., Paoletti, A. C., Kasper, T. R., DeMattos, R. B., Zlokovic, B. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206446109 · Cited by 154 · see citing works

Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis

Chen, J., Zhang, X., Kusumo, H., Costa, L. G., & Guizzetti, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.09.007 · Cited by 153 · see citing works

Immunohistochemical and Biochemical Studies Demonstrate a Distinct Profile of α-Synuclein Permutations in Multiple System Atrophy

Duda, J. E., Giasson, B. I., Gur, T., Montine, T. J., Robertson, D., Biaggioni, I., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Grossman, M., et al. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.9.830 · Cited by 150 · see citing works

Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL‐associated vitamin E

Goti, D., Hrzenjak, A., Levak‐Frank, S., Frank, S., van der Westhuyzen, D. R., Malle, E., & Sattler, W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00100.x · Cited by 149 · see citing works

Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age

Pawlyk, A. C., Giasson, B. I., Sampathu, D. M., Perez, F. A., Lim, K. L., Dawson, V. L., Dawson, T. M., Palmiter, R. D., Trojanowski, J. Q., & Lee, V. M. ‐. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306889200 · Cited by 149 · see citing works

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

Oitzl, M. S., Mulder, M. T., Lucassen, P. J., Havekes, L. M., Grootendorst, J., & de Kloet, E. R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01448-5 · Cited by 142 · see citing works

Structure, function and amyloidogenic propensity of apolipoprotein A-I

Obici, L. P., Franceschini, G., Calabresi, L., Giorgetti, S., Stoppini, M., Merlini, G., & Bellotti, V. (2006) · Amyloid · doi:10.1080/13506120600960288 · Cited by 142 · see citing works

Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife

Singh‐Manoux, A., Gimeno, D., Mika Kivimaki, B., Brunner, E. J., & Marmot, M. G. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.163998 · Cited by 137 · see citing works

Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues

Huang, J. T.-J., Wang, L., Prabakaran, S., Wengenroth, M., Lockstone, H. E., Koethe, D., Gerth, C. W., Gross, S., Schreiber, D., Lilley, K. S., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002108 · Cited by 133 · see citing works

Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1 Contributes to Dysmyelination in Experimental Models of Huntington's Disease

Xiang, Z., Valenza, M., Cui, L., Leoni, V., Jeong, H.-K., Brilli, E., Zhang, J., Peng, Q., Duan, W., Reeves, S. A., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1291-11.2011 · Cited by 132 · see citing works

Low-Density Lipoprotein Receptor–Related Protein-1

Strickland, D. K., Au, D. T., Cunfer, P., & Muratoglu, S. C. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301924 · Cited by 132 · see citing works

Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

Lefterov, I. M., Fitz, N. F., Cronican, A. A., Fogg, A., Lefterov, P., Kodali, R. B., Wetzel, R. B., & Koldamova, R. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.127738 · Cited by 129 · see citing works

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation

Valenza, M., Carroll, J. B., Leoni, V., Bertram, L., Björkhem, I., Singaraja, R. R., Donato, S. D., Lütjohann, D., Hayden, M. R., & Cattaneo, E. F. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm170 · Cited by 129 · see citing works

Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington’s disease

Valenza, M., Leoni, V., Tarditi, A., Mariotti, C., Björkhem, I., Donato, S. D., & Cattaneo, E. F. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.004 · Cited by 123 · see citing works

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

Anderson, R., Barnes, J. C., Bliss, T. V. P., Cain, D. P., Cambon, K., Davies, H. A., Errington, M. L., Fellows, L. A., Gray, R. A., Hoh, T., et al. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00598-8 · Cited by 119 · see citing works

Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity

Yap, T. L., Velayati, A., Sidransky, E., & Lee, J. C. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2012.11.010 · Cited by 111 · see citing works

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

Beavan, M. S., & Schapira, A. H. V. (2013) · Annals of Medicine · doi:10.3109/07853890.2013.849003 · Cited by 107 · see citing works

Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein ( CETP ) Gene With Memory Decline and Incidence of Dementia

Sanders, A. E. (2010) · JAMA · doi:10.1001/jama.2009.1988 · Cited by 107 · see citing works

Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans

Özçelık, T., Akarsu, N. A., Uz, E., Çağlayan, Ş., Gülsüner, S., Onat, O. E., Tan, M., & Tan, Ü. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710010105 · Cited by 106 · see citing works

Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

de Oliveira, J., Hort, M. A., Moreira, E. L. G., Glaser, V., Ribeiro‐do‐Valle, R. M., Prediger, R. D., Farina, M., Latini, A., & Bem, A. F. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.009 · Cited by 104 · see citing works

Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

Calabresi, L., Simonelli, S., Gomaraschi, M., & Franceschini, G. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.034 · Cited by 102 · see citing works

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

Leoni, V., Long, J. D., Mills, J. A., Donato, S. D., & Paulsen, J. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.03.013 · Cited by 102 · see citing works

Recent insights into the Smith–Lemli–Opitz syndrome

Yu, H., & Patel, S. B. (2005) · Clinical Genetics · doi:10.1111/j.1399-0004.2005.00515.x · Cited by 97 · see citing works

Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

Fan, J., Donkin, J., & Wellington, C. (2009) · BioFactors · doi:10.1002/biof.37 · Cited by 97 · see citing works

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works

Low HDL cholesterol associates with major depression in a sample with a 7-year history of depressive symptoms

Lehto, S. M., Hintikka, J. J., NISKANEN, L. K., Tolmunen, T., Koivumaa-Honkanen, H. T., Honkalampi, K. M., & Viinamäki, H. T. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.021 · Cited by 95 · see citing works

Apolipoprotein E ε4 Allele in Alzheimer's Disease and Vascular Dementia

Frisoni, G. B., Calabresi, L., Geroldi, C., Bianchetti, A., D'Acquarica, A. L., Govoni, S. M., Sirtori, C. R., Trabucchi, M., & Franceschini, G. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106730 · Cited by 92 · see citing works

Whole body cholesterol metabolism is impaired in Huntington's disease

Leoni, V., Mariotti, C., Nanetti, L., Salvatore, E., Squitieri, F., Bentivoglio, A. R., del Poggio, M. B., Piacentini, S., Monza, D., Valenza, M., et al. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.025 · Cited by 90 · see citing works

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-d-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H., & May, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444364 · Cited by 85 · see citing works

ABC1: connecting yellow tonsils, neuropathy, and very low HDL

Hobbs, H. H., & Rader, D. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8509 · Cited by 80 · see citing works

Lipid Metabolism and Glial Lipoproteins in the Central Nervous System

Hayashi, H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.453 · Cited by 80 · see citing works

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

Futter, M., Diekmann, H., Schoenmakers, E., Sadiq, O., Chatterjee, K., & Rubinsztein, D. C. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066399 · Cited by 73 · see citing works

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Hirsch‐Reinshagen, V., Donkin, J. J., Stukas, S. K., Chan, J., Wilkinson, A., Fan, J., Parks, J. S., Kuivenhoven, J. A., ̈tjohann, D. L., Pritchard, H., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800584-jlr200 · Cited by 72 · see citing works

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations

Choi, J. H., Stubblefield, B. K., Cookson, M., Goldin, E., Velayati, A., Tayebi, N., & Sidransky, E. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.06.008 · Cited by 70 · see citing works

Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients

Salemi, G., Gueli, M. C., Vitale, F. M., Battaglieri, F., Guglielmini, E., Ragonese, P., Trentacosti, A., Massenti, M. F., Savettieri, G., & Bono, A. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-19 · Cited by 69 · see citing works

Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice

Krugers, H. J., Mulder, M. T., Korf, J., Havekes, L. M., de Kloet, E. R., & Joëls, M. (1997) · Neuroreport · doi:10.1097/00001756-199707280-00018 · Cited by 68 · see citing works

HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN DIFFERENTIAL DIAGNOSIS OF SENILE DEMENTIA

Muckle, T. J., & Roy, J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92866-1 · Cited by 67 · see citing works

Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease

Vuletic, S., Jin, L., Marcovina, S. M., Peskind, E. R., ̈ller, T. M., & Albers, J. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300046-jlr200 · Cited by 66 · see citing works

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

Moreira, E. L. G., de Oliveira, J., Nunes, J. C., Santos, D. B., Nunes, F. C., Vieira, D. S. C., Ribeiro-do-Valle, R. M., Pamplona, F. A., de Bem, A. F., Farina, M., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120541 · Cited by 64 · see citing works

Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats

Iwata, A., Browne, K., Chen, X.-H., Yuguchi, T., & Smith, D. H. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20607 · Cited by 64 · see citing works

Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme−Product Correlations in Human Retina but Not Human Brain

Liao, W.-L., Heo, G.-Y., Dodder, N. G., Reem, R. E., Mast, N., Huang, S., DiPatre, P. L., Turko, I. V., & Pikuleva, I. A. (2010) · Journal of Proteome Research · doi:10.1021/pr1008898 · Cited by 57 · see citing works

Paraoxonase 1 activity in different types of multiple sclerosis

Jamróz-Wiśniewska, A., Bełtowski, J., Stelmasiak, Z., & Bartosik-Psujek, H. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508098371 · Cited by 55 · see citing works

ABCA8 stimulates sphingomyelin production in oligodendrocytes

Kim, W. S., Hsiao, J.-H. T., Bhatia, S., Glaros, E. N., Don, A. S., Tsuruoka, S., Weickert, C. S., & Halliday, G. M. (2013) · Biochemical Journal · doi:10.1042/bj20121764 · Cited by 52 · see citing works

Cholesteryl ester transfer protein in human brain

Albers, J. J., Tollefson, J. H., Wolfbauer, G., & Albright, R. E. (1992) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02591657 · Cited by 50 · see citing works

Huntingtonʼs disease and Huntingtonʼs disease-like syndromes

Gövert, F., & Schneider, S. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283632d90 · Cited by 48 · see citing works

Mendelian Disorders of High-Density Lipoprotein Metabolism

Oldoni, F., Sinke, R. J., & Kuivenhoven, J. A. (2014) · Circulation Research · doi:10.1161/circresaha.113.300634 · Cited by 48 · see citing works

Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles

Ravera, S., Bartolucci, M., Calzia, D., Aluigi, M. G., Ramoino, P., Morelli, A. M., & Panfoli, I. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.003 · Cited by 47 · see citing works

Lipid dysfunction and pathogenesis of multiple system atrophy

Bleasel, J. M., Wong, J. H., Halliday, G. M., & Kim, W. S. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-15 · Cited by 47 · see citing works

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

Martiskainen, H., Haapasalo, A., Kurkinen, K. M. A., Pihlajamäki, J., Soininen, H. S., & Hiltunen, M. O. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.789862 · Cited by 45 · see citing works

Phospholipid transfer protein (PLTP) deficiency impaired blood–brain barrier integrity by increasing cerebrovascular oxidative stress

Zhou, T., He, Q., Tong, Y., Zhan, R., Xu, F., Fan, D., Guo, X., Han, H., Qin, S., & Chui, D. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.194 · Cited by 44 · see citing works

Phospholipid Transfer Protein Is Expressed in Cerebrovascular Endothelial Cells and Involved in High Density Lipoprotein Biogenesis and Remodeling at the Blood-Brain Barrier

Manavalan, A. P. C., Kober, A. C., Metso, J., Lang, I., Becker, T. M., Hasslitzer, K., Zandl‐Lang, M., Fanaee‐Danesh, E., Pippal, J. B., Sachdev, V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.499129 · Cited by 37 · see citing works

Low plasma total cholesterol in patients with Huntington’s disease and first-degree relatives

Markianos, M., Πάνας, Μ., Kalfakis, N., & Vassilopoulos, D. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.10.002 · Cited by 33 · see citing works

Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: Morphologic evidence from reeler, apolipoprotein E receptor 2‐, and very low density lipoprotein receptor knockout mice

Gebhardt, C., Turco, D. D., Drakew, A., Tielsch, A., Herz, J., Frotscher, M., & Deller, T. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10172 · Cited by 30 · see citing works

Lifelong Expression of Apolipoprotein D in the Human Brainstem: Correlation with Reduced Age-Related Neurodegeneration

Navarro, A., Méndez, E., Díaz, C., del Valle, E., Martínez‐Pinilla, E., Ordóñez, C., & Tolivia, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077852 · Cited by 21 · see citing works

No association of CETP genotype with cognitive function or age-related cognitive change

Johnson, W., Harris, S. E., Collins, P., Starr, J. M., Whalley, L. J., & Deary, I. J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.013 · Cited by 11 · see citing works

Implicación de la apolipoproteína D en las patologías del sistema nervioso

Incio, A. M. N., & Fernández, J. T. (2004) · Revista de Neurología · doi:10.33588/rn.3812.2004046 · Cited by 8 · see citing works

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

Mahley, R. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1427-y · Cited by 837 · see citing works

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

Emamzadeh, F. N., & Surguchov, A. P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00612 · Cited by 570 · see citing works

Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism

Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516 · see citing works

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278 · see citing works

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

Yanagida, K., Liu, C. H., Faraco, G., Galvani, S., Smith, H. K., Burg, N. D., Anrather, J., Sánchez, T., Iadecola, C., & Hla, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618659114 · Cited by 213 · see citing works

Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.012 · Cited by 197 · see citing works

Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System

Campos‐Bedolla, P., Walter, F. R., Veszelka, S., & Deli, M. A. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.11.018 · Cited by 196 · see citing works

Cholesterol in myelin biogenesis and hypomyelinating disorders

Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.010 · Cited by 192 · see citing works

Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors

Diotel, N., Charlier, T. D., d’Hellencourt, C. L., Couret, D., Trudeau, V. L., Cano‐Nicolau, J., Meilhac, O., Kah, O., & Pellegrini, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00084 · Cited by 189 · see citing works

Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): From bench to bedside

Bao, X., Liang, Y., Chang, H., Cai, T., Feng, B., Gordon, K., Zhu, Y., Shi, H., He, Y., & Xie, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01690-3 · Cited by 187 · see citing works

LXR Regulation of Brain Cholesterol: From Development to Disease

Courtney, R., & Landreth, G. E. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.018 · Cited by 176 · see citing works

Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions

Vargas-Caraveo, A., Sayd, A., Maus, S. R., Caso, J. R., Madrigal, J. L. M., García‐Bueno, B., & Leza, J. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-13302-6 · Cited by 175 · see citing works

Cholesterol metabolism in the brain and its association with Parkinson’s disease.

Jin, U., Park, S. J., & Park, S. M. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.5.554 · Cited by 169 · see citing works

Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid‐life: A randomized trial

Hoscheidt, S. M., Sanderlin, A. H., Baker, L. D., Jung, Y., Lockhart, S. N., Kellar, D., Whitlow, C. T., Hanson, A. J., Friedman, S. D., Register, T. C., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12421 · Cited by 170 · see citing works

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Jacobo‐Albavera, L., Domínguez‐Pérez, M., Medina-Leyte, D. J., González-Garrido, A., & Villarreal-Molina, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041593 · Cited by 163 · see citing works

Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 173 · see citing works

Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology

Pardridge, W. M. (2017) · BioDrugs · doi:10.1007/s40259-017-0248-z · Cited by 152 · see citing works

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

Rawat, V., Wang, S., Sima, J., Bar, R., Liraz, O., Gundimeda, U., Parekh, T., Chan, J., Johansson, J. O., Tang, C., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1400-19.2019 · Cited by 165 · see citing works

Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: A systematic review and meta-analysis

Misiak, B., Stańczykiewicz, B., Łaczmański, Ł., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.031 · Cited by 151 · see citing works

SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1

Fung, K. Y., Wang, C., Nyegaard, S., Heit, B., Fairn, G. D., & Lee, W. L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00841 · Cited by 129 · see citing works

Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

Kitson, A. P., Metherel, A. H., Chen, C. T., Domenichiello, A. F., Trépanier, M., Berger, A., & Bazinet, R. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.009 · Cited by 107 · see citing works

Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier

Rhea, E. M., & Banks, W. A. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03098-6 · Cited by 97 · see citing works

Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study

Mina, T. H., Yew, Y. W., Ng, H. K., Sadhu, N., Wansaicheong, G. K. L., Dalan, R., Low, D. Y., Lam, B. C. C., Ríboli, E., Lee, E. S., et al. (2023) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2023.100710 · Cited by 97 · see citing works

Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

Gliozzi, M., Musolino, V., Bosco, F., Scicchitano, M., Scarano, F., Nucera, S., Zito, M. C., Ruga, S., Carresi, C., Macrì, R., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105215 · Cited by 92 · see citing works

Role of LCAT in Atherosclerosis

Ossoli, A., Simonelli, S., Vitali, C., Franceschini, G., & Calabresi, L. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32854 · Cited by 88 · see citing works

The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

Morris, G., Puri, B. K., Bortolasci, C. C., Carvalho, A., Berk, M., Walder, K., Moreira, E. G., & Maes, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.037 · Cited by 84 · see citing works

Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies

Kjeldsen, E. W., Thomassen, J. Q., Rasmussen, I. J., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Frikke‐Schmidt, R. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab164 · Cited by 85 · see citing works

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases

Sodero, A. O. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15228 · Cited by 84 · see citing works

The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update

Mahoney‐Sanchez, L., Belaidi, A. A., Bush, A. I., & Ayton, S. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0839-z · Cited by 81 · see citing works

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Onderwater, G. L. J., Ligthart, L., Bot, M., Demirkan, A., Fu, J., Kallen, C., Vijfhuizen, L. S., Pool, R., Liu, J., Vanmolkot, F. H. M., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007313 · Cited by 74 · see citing works

Increased PCSK9 cerebrospinal fluid concentrations in Alzheimer’s disease

Zimetti, F., Caffarra, P., Ronda, N., Favari, E., Adorni, M. P., Zanotti, I., Bernini, F., Barocco, F., Spallazzi, M., Galimberti, D., et al. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160411 · Cited by 75 · see citing works

ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease

Marchi, C., Adorni, M. P., Caffarra, P., Ronda, N., Spallazzi, M., Barocco, F., Galimberti, D., Bernini, F., & Zimetti, F. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p091033 · Cited by 74 · see citing works

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0558-0 · Cited by 74 · see citing works

DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

Yassine, H. N., Croteau, É., Rawat, V., Hibbeln, J. R., Rapoport, S. I., Cunnane, S. C., & Umhau, J. C. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0250-1 · Cited by 72 · see citing works

Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease

Pillai, J. A., Bena, J., Bekris, L. M., Kodur, N., Kasumov, T., Leverenz, J. B., Kashyap, S. R., & Initiative, O. B. O. T. A. D. N. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01203-y · Cited by 72 · see citing works

Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels—The zero-LDL hypothesis

Masana, L., Girona, J., Ibarretxe, D., Rodríguez‐Calvo, R., Rosales, R., Vallvé, J.-C., Rodríguez-Borjabad, C., Guardiola, M., Rodríguez, M. M., Guaita‐Esteruelas, S., et al. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.12.018 · Cited by 71 · see citing works

Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Fellows, K., Uher, T., Browne, R. W., Weinstock‐Guttman, B., Horáková, D., Posová, H., Vaněčková, M., Seidl, Z., Krásenský, J., Týblová, M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060970 · Cited by 68 · see citing works

Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors

Mohammadi, S., Dolatshahi, M., & Rahmani, F. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01314-5 · Cited by 67 · see citing works

Peripheral Versus Central Nervous System APOE in Alzheimer’s Disease: Interplay across the Blood-Brain Barrier

Chernick, D., Ortiz-Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 54 · see citing works

Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer’s disease and strategies for treatment

Chaves, J. C. S., Dando, S. J., White, A. R., & Oikari, L. E. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166967 · Cited by 62 · see citing works

Neuronal extracellular microRNAs miR‐124 and miR‐9 mediate cell–cell communication between neurons and microglia

Veremeyko, T., Kuznetsova, I. S., Dukhinova, M., Yung, A. W. Y., Kopeikina, E., Barteneva, N. S., & Ponomarev, E. D. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24344 · Cited by 304 · see citing works

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

Magro, R. D., Simonelli, S., Cox, A., Formicola, B., Corti, R., Cassina, V., Nardo, L., Mantegazza, F., Salerno, D., Grasso, G., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00419 · Cited by 58 · see citing works

HDL Proteome and Alzheimer’s Disease: Evidence of a Link

Marsillach, J., Adorni, M. P., Zimetti, F., Papotti, B., Zuliani, G., & Cervellati, C. (2020) · Antioxidants · doi:10.3390/antiox9121224 · Cited by 57 · see citing works

Brain Lipids and Lipid Droplet Dysregulation in Alzheimer’s Disease and Neuropsychiatric Disorders

Zhao, X., Zhang, S., Sanders, A. R., & Duan, J. (2023) · Complex Psychiatry · doi:10.1159/000535131 · Cited by 54 · see citing works

Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease

Emamzadeh, F. N. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0942-9 · Cited by 54 · see citing works

Interdependence of oxysterols with cholesterol profiles in multiple sclerosis

Mukhopadhyay, S., Fellows, K., Browne, R. W., Khare, P., Radhakrishnan, S. K., Hagemeier, J., Weinstock‐Guttman, B., Zivadinov, R., & Ramanathan, M. K. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516666187 · Cited by 53 · see citing works

Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method

Daley, M., Dekaban, G. A., Bartha, R., Brown, A. M., Stewart, T. C., Doherty, T. J., Fischer, L. K., Holmes, J., Menon, R. S., Rupar, C. A., et al. (2016) · Metabolomics · doi:10.1007/s11306-016-1131-5 · Cited by 53 · see citing works

Dual Channel Microfluidics for Mimicking the Blood–Brain Barrier

Buchroithner, B., Mayr, S., Hauser, F., Priglinger, E., Stangl, H., Santa-Maria, A. R., Deli, M. A., Dér, A., Klar, T. A., Axmann, M., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c09263 · Cited by 53 · see citing works

HDL-cholesterol and apolipoproteins in relation to dementia

Koch, M., & Jensen, M. K. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000257 · Cited by 52 · see citing works

Brain‐derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons

Spagnuolo, M. S., Donizetti, A., Iannotta, L., Aliperti, V., Cupidi, C., Bruni, A. C., & Cigliano, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26480 · Cited by 52 · see citing works

Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review

Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6695796 · Cited by 49 · see citing works

Advances in high-density lipoprotein physiology: surprises, overturns, and promises

Constantinou, C., Karavia, E. A., Xepapadaki, E., Πετροπούλου, Π.-Ι., Παπακώστα, Ε., Karavyraki, M., Zvintzou, E., Theodoropoulos, V., Filou, S., Hatziri, A., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00429.2015 · Cited by 48 · see citing works

Influence of metabolic syndrome on cerebral perfusion and cognition

Livingston, J. M., McDonald, M. W., Gagnon, T., Jeffers, M. S., Gomez-Smith, M., Antonescu, S., Cron, G. O., Boisvert, C., Lacoste, B., & Corbett, D. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104756 · Cited by 45 · see citing works

Phytosterols: Targeting Neuroinflammation in Neurodegeneration

Dash, R., Mitra, S., Ali, M. C., Oktaviani, D. F., Hannan, M. A., Choi, S. M., & Moon, I. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200628022812 · Cited by 46 · see citing works

Anti-Aging and Tissue Regeneration Ability of Policosanol Along with Lipid-Lowering Effect in Hyperlipidemic Zebrafish via Enhancement of High-Density Lipoprotein Functionality

Lee, E., Yoo, J., Lim, S.-M., & Cho, K. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1745 · Cited by 44 · see citing works

miRNA and cholesterol homeostasis

Jeon, T.-I., & Osborne, T. F. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.005 · Cited by 42 · see citing works

α-Synuclein Interacts with Lipoproteins in Plasma

Emamzadeh, F. N., & Allsop, D. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0967-0 · Cited by 43 · see citing works

Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders

Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54 · see citing works

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis

Borràs, C., Mercer, A., Sirisi, S., Alcolea, D. A., Escolá‐Gil, J. C., Blanco‐Vaca, F., & Tondo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169356 · Cited by 41 · see citing works

PCSK9 affects astrocyte cholesterol metabolism and reduces neuron cholesterol supplying in vitro: potential implications in Alzheimer’s disease

Papotti, B., Adorni, M. P., Marchi, C., Zimetti, F., Ronda, N., Panighel, G., Lupo, M. G., Vilella, A., Giuliani, D., Ferri, N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012192 · Cited by 41 · see citing works

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages

Zhang, R.-Y., Dong, Y., Liu, Y., Moezzi, D., Ghorbani, S., Mirzaei, R., Lozinski, B., Dunn, J., Yong, W. V., & Xue, M. (2023) · Stroke and vascular neurology · doi:10.1136/svn-2023-002331 · Cited by 38 · see citing works

The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women

Aljondi, R., Szoeke, C. E. I., Steward, C., Gorelik, A., & Desmond, P. M. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9970-5 · Cited by 42 · see citing works

Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition

Ooi, K.-L. M., Vacy, K., & Boon, W. C. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105143 · Cited by 41 · see citing works

Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development

Cervellati, C., Valacchi, G., Tisato, V., Zuliani, G., & Marsillach, J. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05875-5 · Cited by 40 · see citing works

High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics

Jin, Y., Chifodya, K., Han, G., Jiang, W., Chen, Y., Shi, Y., Xu, Q., Xi, Y., Wang, J., Zhou, J., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.018 · Cited by 39 · see citing works

Inflammation as a Possible Link Between Dyslipidemia and Alzheimer’s Disease

Oliveira, B. C. D. L., Bellozi, P. M. Q., Reis, H. J., & de Oliveira, A. C. P. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.012 · Cited by 38 · see citing works

Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse–Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse

Boado, R. J., Lu, J. Z., Hui, E. K., & Pardridge, W. M. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00958 · Cited by 38 · see citing works

Lipid efflux mechanisms, relation to disease and potential therapeutic aspects

Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37 · see citing works

Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β

Chai, A. B., Lam, H. H. J., Kockx, M., & Gelissen, I. C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158980 · Cited by 39 · see citing works

Association of High-Density Lipoprotein Cholesterol Variability and the Risk of Developing Parkinson Disease

Park, J., Lee, C.-W., Nam, M. J., Kim, H., Kwon, D.-Y., Yoo, J. W., Lee, K. N., Han, K., Jung, J., Park, Y. G., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000011553 · Cited by 35 · see citing works

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system

Bell, A. S., Wagner, J., Rosoff, D. B., & Lohoff, F. W. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105155 · Cited by 36 · see citing works

Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases

Valkenburgh, J. S. V., Meuret, C. J., Martinez, A. E., Kodancha, V., Solomon, V. A., Chen, K., & Yassine, H. N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.700847 · Cited by 36 · see citing works

Relation between plasma and brain lipids

Wellington, C. L., & Frikke-Schmidt, R. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000291 · Cited by 33 · see citing works

Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides

Sergi, D., Zauli, E., Tisato, V., Secchiero, P., Zauli, G., & Cervellati, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054403 · Cited by 32 · see citing works

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo

Kuwahara, H., Song, J., Shimoura, T., Yoshida‐Tanaka, K., Mizuno, T., Mochizuki, T., Zeniya, S., Li, F., Nishina, K., Nagata, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22577-2 · Cited by 31 · see citing works

Cholesterol Metabolism in Neurodegenerative Diseases

He, K., Zhao, Z., Zhang, J., Li, D.-F., Wang, S., & Liu, Q. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0674 · Cited by 24 · see citing works

Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins

Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166195 · Cited by 29 · see citing works

Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys

Noveir, S. D., Kerman, B. E., Xian, H., Meuret, C. J., Smadi, S., Martinez, A. E., Johansson, J., Zetterberg, H., Parks, B. A., Kuklenyik, Z., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01028-1 · Cited by 28 · see citing works

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

Gotsbacher, M. P., Telfer, T. J., Witting, P. K., Double, K. L., Finkelstein, D. I., & Codd, R. (2017) · Metallomics · doi:10.1039/c7mt00039a · Cited by 28 · see citing works

General intelligence is associated with subclinical inflammation in Nepalese children: A population-based plasma proteomics study

Lee, S. E., West, K. P., Cole, R. N., Schulze, K. J., Wu, L. S., Yager, J. D., Groopman, J. D., & Christian, P. S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.023 · Cited by 28 · see citing works

Elevated OPRD1 promoter methylation in Alzheimer’s disease patients

Ji, H., Wang, Y., Liu, G., Chang, L. Y., Chen, Z., Zhou, D., Xu, X., Cui, W., Hong, Q., Jiang, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172335 · Cited by 27 · see citing works

A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation

Hajny, S., & Christoffersen, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081636 · Cited by 28 · see citing works

Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health

Merrill, N. J., Davidson, W. S., He, Y., Díaz Ludovico, I., Sarkar, S., Berger, M. R., McDermott, J. E., Van Eldik, L. J., Wilcock, D. M., Monroe, M. E., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi5571 · Cited by 27 · see citing works

Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

Nordestgaard, L. T., Tybjærg‐Hansen, A., Rasmussen, K. L., Nordestgaard, B. G., & Frikke‐Schmidt, R. (2018) · BMC Medicine · doi:10.1186/s12916-018-1029-3 · Cited by 27 · see citing works

Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson’s disease: A systematic review of proteomics studies

Chelliah, S. S., Bhuvanendran, S., Magalingam, K. B., Kamarudin, M. N. A., & Radhakrishnan, A. K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101514 · Cited by 27 · see citing works

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

Patel, D., Ahmad, F., Kambach, D. M., Sun, Q., Halim, A. S., Kramp, T. R., Camphausen, K. A., & Stommel, J. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-51865-8 · Cited by 27 · see citing works

Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits

Tierney, E., Remaley, A. T., Thurm, A., Jager, L. R., Wassif, C. A., Kratz, L. E., Bailey-Wilson, J. E., Bukelis, I., Sarphare, G., Jung, E. S., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01580-8 · Cited by 26 · see citing works

Association of Circulating Apolipoprotein AI Levels in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis

Tong, J., Gong, S., Zhang, Y.-S., Dong, J.-R., Zhong, X., Wei, M., & Liu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.899175 · Cited by 28 · see citing works

Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease

Turri, M., Conti, E., Pavanello, C., Gastoldi, F., Palumbo, M., Bernini, F., Aprea, V., Re, F., Barbiroli, A. G., Emide, D., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01241-6 · Cited by 26 · see citing works

Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses

Lam, S. M., Huang, X., & Shui, G. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.04.011 · Cited by 25 · see citing works

Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis

Lopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24 · see citing works

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J., Neighbors, J. D., & Hohl, R. J. (2018) · Lipids · doi:10.1002/lipd.12088 · Cited by 24 · see citing works

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

Chuang, S. T., Shon, Y., & Narayanaswami, V. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s145326 · Cited by 24 · see citing works

An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice

Finno, C. J., Bordbari, M. H., Gianino, G., Ming-Whitfield, B., Burns, E., Merkel, J., Britton, M., Durbin-Johnson, B. P., Sloma, E. A., McMackin, M. Z., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.037 · Cited by 22 · see citing works

Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

Lee, C., Murrell, C. E., Chu, A., & Pan, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417415 · Cited by 20 · see citing works

Emerging Lipid Targets in Glioblastoma

Darwish, A., Pammer, M., Gallyas, F., Vı́gh, L., Balogi, Z., & Juhász, K. (2024) · Cancers · doi:10.3390/cancers16020397 · Cited by 22 · see citing works

Spotlight on HDL biology: new insights in metabolism, function, and translation

Rader, D. J. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu164 · Cited by 21 · see citing works

Intra- and intercellular trafficking in sphingolipid metabolism in myelination

Wattenberg, B. W. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.002 · Cited by 21 · see citing works

A Human-Based Integrated Framework forAlzheimer’s Disease Research

Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 20 · see citing works

Cognitive impairments in HCV infection: From pathogenesis to neuroimaging

Amirsardari, Z., Rahmani, F., & Rezaei, N. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2019.1652728 · Cited by 20 · see citing works

SPOTLIGHT REVIEW HDL and cholesterol handling in the brain

Vitali, C., Wellington, C. L., & Calabresi, L. (2014)

Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders

Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54 · see citing works

HDLs and LDLs in the Brain: Characterizing the Lipid Secretome of Astrocytes

Nguyen, A. Q. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.948.3

Emerging roles for high‐density lipoproteins in neurodegenerative disorders

Bahrami, A., Barreto, G. E., Lombardi, G., Pirro, M., & Sahebkar, A. (2019) · BioFactors · doi:10.1002/biof.1541 · Cited by 48 · see citing works

Utilization of Enzyme Inhibitors in Study of Mechanism Underlying apoA-I-mediated HDL Generation in Rat Brain Astrocytes

Ito, J., & Michikawa, M. (2015) · Current Enzyme Inhibition · doi:10.2174/1573408011666150302220800