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Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus
Open accessAbstract
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve β cell survival. Understanding the molecular mechanisms of the antidiabetic effects of oleic acid may contribute to understanding the benefits of this FA in the prevention or delay of T2DM.
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Cites
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Cited by
Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 527
Judge, A., & Dodd, M. S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190041 · Cited by 365
Distinct metabolic patterns during microglial remodeling by oleate and palmitate
Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S., & Kowaltowski, A. J. (2019) · Bioscience Reports · doi:10.1042/bsr20190072 · Cited by 59
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Gao, X., Sun, H., Hao, S., Sun, H., & Ge, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115846 · Cited by 15
Metadata
- Authors
- Palomer, X., Pizarro-Delgado, J., Barroso, E., & Vázquez-Carrera, M.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 29
- Issue
- 3
- Pages
- 178-190
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2781259227
- Cited by
- 548
- References
- 18
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Palomer, X., Pizarro-Delgado, J., Barroso, E., & Vázquez-Carrera, M. (2018). Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2017.11.009
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