Central obesity, faster maturation, and “PCOS” in girls

de Zegher, Francis; López-Bermejo, Abel; Ibáñez, Lourdes

doi:10.1016/j.tem.2018.09.005

Cited by 73Ovarian function and disordersHypothalamic control of reproductive hormonesReproductive Biology and Fertility

Central obesity, faster maturation, and “PCOS” in girls

de Zegher, Francis, López-Bermejo, Abel, Ibáñez, Lourdes·2018·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2018.09.005

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Abstract

Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturation. This homeostatic mechanism is lost upon reaching adult height, and PCOS may ensue. Prevention and/or treatment of PCOS should aim at reducing central fat excess.

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A mismatch between prenatal weight and postnatal weight gain is associated with increased risk for PCOS, ectopic fat storage, and hepatic steatosis.
“These findings are consistent with the concept that a mismatch between prenatal weight and postnatal weight gain is associated with increased risk for PCOS, ectopic fat storage, and hepatic steatosis [92–94].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [93]

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Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
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Twells, L., Gregory, D. M., Lester, K. K., et al. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.01.085
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Salmon, P. A. (1993) · Obesity Surgery · doi:10.1381/096089293765559098 · Cited by 8 · see citing works
Early weight loss in adolescents following bariatric surgery predicts weight loss at 12 and 24 months
Chu, L., Howell, B., Steinberg, A., Bar-Dayan, A., Toulany, A., Langer, J. C., & Hamilton, J. K. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12519 · Cited by 27 · see citing works
Revisional bariatric surgery: who, what, where, and when?
Radtka, J. F., Puleo, F. J., Wang, L., & Cooney, R. N. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.04.005 · Cited by 97 · see citing works
Re-sleeve Gastrectomy for Failed Laparoscopic Sleeve Gastrectomy: A Feasibility Study
Iannelli, A., Schneck, A. S., Noe͏̈l, P., et al. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0290-0 · Cited by 109 · see citing works

Authors: de Zegher, F., López-Bermejo, A., & Ibáñez, L.
Affiliations: Instituto de Salud Carlos III (ES)
Corresponding author: Ibáñez, Lourdes
ORCID: Ibáñez, Lourdes
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2018-12
Volume: 29
Issue: 12
Pages: 815-818
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2018.09.005
OpenAlex: W2894791893
Cited by: 73
References: 15
Citations by year: 2025: 4 · 2024: 4 · 2023: 19 · 2022: 14 · 2021: 12 · 2020: 9 · 2019: 11
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: polycystic ovary syndrome, abdominal obesity, adolescent girls, growth acceleration, pubertal development, adult height, PCOS prevention, PCOS treatment
MeSH terms: Adolescent, Adult, Female, Humans, Polycystic Ovary Syndrome, Obesity, Abdominal

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Central obesity, faster maturation, and “PCOS” in girls

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