Reduced prenatal weight gain and/or augmented postnatal weight gain precedes polycystic ovary syndrome in adolescent girls
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OBJECTIVE: Hepato-visceral fat excess is a feature of polycystic ovary syndrome (PCOS). Risk factors for such excess include low prenatal weight gain and high postnatal weight gain. This study examined whether adolescent PCOS was preceded by a relatively low birth weight and/or a relatively high BMI at diagnosis. METHODS: Study participants included 467 girls with PCOS (298 without obesity and 169 with obesity), diagnosed, respectively, in Spain and Germany; 87 healthy girls were controls. Z scores for weight at birth and BMI at PCOS diagnosis were derived, and their differences were calculated. RESULTS: Spanish girls with PCOS and without obesity and German girls with PCOS and obesity had mean birth weight z scores of -0.7 and 0.0, respectively, and mean BMI z scores of + 0.4 and +2.7, respectively, so that mean z score increments amounted to +1.1 and +2.6 (P < 0.001 vs. controls). CONCLUSIONS: PCOS in adolescent girls was preceded by marked z score increments between weight at birth and BMI at PCOS diagnosis, thus corroborating the notion that PCOS development is driven by a mismatch between prenatal weight gain and postnatal weight gain.
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A mismatch between prenatal weight and postnatal weight gain is associated with increased risk for PCOS, ectopic fat storage, and hepatic steatosis.
“These findings are consistent with the concept that a mismatch between prenatal weight and postnatal weight gain is associated with increased risk for PCOS, ectopic fat storage, and hepatic steatosis [92–94].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [94]
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Self-citation
- Authors
- de Zegher, F., Reinehr, T., Malpique, R., Darendeliler, F., López‐Bermejo, A., & Ibáñez, L.
- Affiliations
- Department of Development and Regeneration University of Leuven Leuven Belgium
- Witten/Herdecke University (DE)
- Hospital Sant Joan de Déu Barcelona (ES)
- Department of Pediatric Endocrinology and Diabetes Istanbul Faculty of Medicine, University of Istanbul Istanbul Turkey
- Institut d'Investigació Biomèdica de Girona (ES)
- Corresponding author
- Ibáñez, Lourdes
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2017-07-24
- Volume
- 25
- Issue
- 9
- Pages
- 1486-1489
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2738305017
- Cited by
- 49
- References
- 18
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 2
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- Innovation and Science Ministry (Health Institute Carlos III) and the European Fund for Regional Development in Madrid, Spain (PI15/01078)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- polycystic ovary syndrome, adolescent girls, gestational weight gain, postnatal weight gain, birth weight, body mass index, PCOS risk factors
- MeSH terms
- Adolescent, Birth Weight, Female, Germany, Humans, Obesity, Polycystic Ovary Syndrome, Risk Factors, Spain, Weight Gain, Body Mass Index, Fetal Development
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