Hyperandrogenism accompanies increased intra-abdominal fat storage in normal weight polycystic ovary syndrome women
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CONTEXT: Normal weight polycystic ovary syndrome (PCOS) women may have altered adipose structure-function underlying metabolic dysfunction. OBJECTIVE: This study examines whether adipose structure-functional changes exist in normal weight PCOS women and correlate with hyperandrogenism and/or hyperinsulinemia. DESIGN: This is a prospective cohort study. SETTING: The setting was an academic medical center. PATIENTS: Six normal weight PCOS women and 14 age- and body mass index-matched normoandrogenic ovulatory (NL) women were included. INTERVENTION(S): All women underwent circulating hormone and metabolic measurements; frequently sampled intravenous glucose tolerance testing; total body dual-energy x-ray absorptiometry; abdominal magnetic resonance imaging; and SC abdominal fat biopsy. MAIN OUTCOME MEASURE(S): Circulating hormones and metabolites, body fat and its distribution, and adipocyte size were compared between PCOS and NL women, and were correlated with each other in all women. RESULTS: Circulating LH and androgen levels were significantly greater in PCOS than NL women, as were fasting insulin levels, pancreatic β-cell responsiveness to glucose, and total abdominal fat mass. Intra-abdominal fat mass also was significantly increased in PCOS women and was positively correlated with circulating androgen, fasting insulin, triglyceride, and non-high-density lipoprotein cholesterol levels in all women. SC abdominal fat mass was not significantly increased in PCOS women, but contained a greater proportion of small SC abdominal adipocytes that positively correlated with serum androgen levels in all women. CONCLUSION: Hyperandrogenism in normal weight PCOS women is associated with preferential intra-abdominal fat deposition and an increased population of small SC abdominal adipocytes that could constrain SC adipose storage and promote metabolic dysfunction.
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In PCOS women, COCs can improve the clinical and biochemical picture of hyperandrogenism and some metabolic aspects such as alterations in cholesterol and fat distribution.
“In PCOS women, COCs can improve the clinical and biochemical picture of hyperandrogenism and some metabolic aspects such as alterations in cholesterol and fat distribution [62], but they can also cause side effects that must be considered, especially in PCOS women with metabolic and cardiovascular risk factors [63].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [62]
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Cites
Biometry: The Principles and Practice of Statistics in Biological Research
Sokal, R. R., & Rohlf, F. J. (1969) · Cited by 20,963 · see citing works
Biometry. The Principles and Practice of Statistics in Biological Research
Fienberg, S. E., Sokal, R. R., Rohlf, F. J., Rohlf, F. J., & Sokal, R. R. (1970) · Biometrics · doi:10.2307/2529087 · Cited by 9,363 · see citing works
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967 · see citing works
Knochenhauer, E. S., Key, T. J., Kahsar-Miller, M., Waggoner, W., Boots, L. R., & Azziz, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5090 · Cited by 1,568 · see citing works
Knochenhauer, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3078 · Cited by 1,134 · see citing works
Moran, L. J., Misso, M. L., Wild, R. A., & Norman, R. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq001 · Cited by 1,108 · see citing works
Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020 · see citing works
Self-citationAdipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Virtue, S., & Vidal-Puig, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.12.006 · Cited by 1,013 · see citing works
Lim, S. S., Davies, M. J., Norman, R. J., & Moran, L. J. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms030 · Cited by 939 · see citing works
Stepto, N. K., Cassar, S., Joham, A. E., Hutchison, S. K., Harrison, C. L., Goldstein, R. F., & Teede, H. J. (2013) · Human Reproduction · doi:10.1093/humrep/des463 · Cited by 747 · see citing works
Lipid homeostasis, lipotoxicity and the metabolic syndrome
Unger, R. H., Clark, G. O., Scherer, P. E., & Orci, L. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.10.006 · Cited by 595 · see citing works
DeUgarte, C. M., Bartolucci, A. A., & Azziz, R. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.070 · Cited by 589 · see citing works
Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
Dunaif, A. E., Segal, K. R., Shelley, D., Green, G., Dobrjansky, A., & Licholai, T. (1992) · Diabetes · doi:10.2337/diab.41.10.1257 · Cited by 544 · see citing works
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539 · see citing works
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
Dunaif, A. E., Segal, K. R., Futterweit, W., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.9.1165 · Cited by 518 · see citing works
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468 · see citing works
Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression
Jernås, M., Palming, J., Sjöholm, K., Jennische, E., Svensson, P.-A., Gabrielsson, B. G., Levin, M., Sjögren, A., Rudemo, M., Lystig, T. C., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5678fje · Cited by 454 · see citing works
Morales, A. J., Laughlin, G. A., Bützow, T. L., Maheshwari, H., Baumann, G., & Yen, S. S. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768842 · Cited by 453 · see citing works
Mannerås-Holm, L., Leonhardt, H., Kullberg, J., Jennische, E., Odén, A., Holm, G., Hellström, M., Lönn, L., Olivecrona, G., Stener-Victorin, E., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1290 · Cited by 369 · see citing works
McLaughlin, T., Sherman, A., Tsao, P., Gonzalez, O., Yee, G., Lamendola, C., Reaven, G. M., & Cushman, S. W. (2007) · Diabetologia · doi:10.1007/s00125-007-0708-y · Cited by 364 · see citing works
Teede, H. J., Joham, A. E., Paul, E., Moran, L. J., Loxton, D., Jolley, D., & Lombard, C. (2013) · Obesity · doi:10.1002/oby.20213 · Cited by 351 · see citing works
Carmina, E., Bucchieri, S., Esposito, A., Del Puente, A., Mansueto, P., Orio, F., Di Fede, G., & Rini, G. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2725 · Cited by 317 · see citing works
It's Not How Fat You Are, It's What You Do with It That Counts
Virtue, S., & Vidal‐Puig, A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060237 · Cited by 309 · see citing works
Pathophysiology and types of dyslipidemia in PCOS
Diamanti‐Kandarakis, E., Papavassiliou, A. G., Kandarakis, S., & Chrousos, G. P. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.07.004 · Cited by 301 · see citing works
Kirchengast, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.6.1255 · Cited by 291 · see citing works
Holte, J., Bergh, T., Berne, C., Berglund, L., & Lithell, H. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.8175959 · Cited by 290 · see citing works
Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome
Moghetti, P., Tosi, F., Bonin, C., Di Sarra, D., Fiers, T., Kaufman, J.-M., Giagulli, V. A., Signori, C., Zambotti, F., Dall'Alda, M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3908 · Cited by 262 · see citing works
Metabolic risk in PCOS: Phenotype and adiposity impact
Moran, L. J., Norman, R. J., & Teede, H. J. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.12.003 · Cited by 245 · see citing works
Moghetti, P., Tosi, F., Castello, R., Magnani, C. M., Negri, C., Brun, E., Furlani, L., Caputo, M., & Muggeo, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772557 · Cited by 242 · see citing works
ROSENBAUM, D. S., Haber, R. S., & Dunaif, A. E. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.2.e197 · Cited by 223 · see citing works
Steil, G. M., Vølund, A., Kahn, S. E., & Bergman, R. N. (1993) · Diabetes · doi:10.2337/diab.42.2.250 · Cited by 215 · see citing works
Long-Term Testosterone Administration Increases Visceral Fat in Female to Male Transsexuals1
Elbers, J. M. H., Asscheman, H., Seidell, J. C., Megens, J. A. J., & Gooren, L. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4078 · Cited by 214 · see citing works
Yıldırım, B., Sabir, N., & Kaleli̇, B. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00265-6 · Cited by 195 · see citing works
Rosenzweig, J. L., Ferrannini, E., Grundy, S. M., Haffner, S. M., Heine, R. J., Horton, E. S., & Kawamori, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0222 · Cited by 194 · see citing works
Referral Bias in Defining the Phenotype and Prevalence of Obesity in Polycystic Ovary Syndrome
Ezeh, U., Yildiz, B. O., & Azziz, R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1295 · Cited by 193 · see citing works
Insulin resistance in polycystic ovary syndrome: progress and paradoxes.
Venkatesan, A. M., Dunaif, A., & Corbould, A. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.295 · Cited by 175 · see citing works
Insulin Sensitivity in Women with Polycystic Ovary Syndrome
Vrbíková, J., Cibula, D., Dvor̆áková, K., Stanická, S., Šindelka, G., Hill, M., Fanta, M., Vondra, K., & Škrha, J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031378 · Cited by 145 · see citing works
Anthropometric Variables and Metabolism in Polycystic Ovarian Disease
Rebuffé-Scrive, M., Cullberg, G., Lundberg, P. A., Lindstedt, G., & Björntorp, P. A. (1989) · Hormone and Metabolic Research · doi:10.1055/s-2007-1009245 · Cited by 142 · see citing works
Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
Dunaif, A. E., Segal, K. R., Shelley, D. R., et al. (1992) · Diabetes · doi:10.2337/diabetes.41.10.1257 · Cited by 141 · see citing works
Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat
McLaughlin, T., Lamendola, C. A., Coghlan, N., Liu, T.-C., Lerner, K., Sherman, A., & Cushman, S. W. (2013) · Obesity · doi:10.1002/oby.20209 · Cited by 136 · see citing works
Normal basal and insulin-stimulated fuel metabolism in lean women with the polycystic ovary syndrome
Ovesen, P., Møller, J. K., Ingerslev, H. J., Jørgensen, J. O. L., Mengel, A., Schmitz, O., Alberti, K. G. M. M., & Møller, N. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263152 · Cited by 135 · see citing works
Faulds, G., Rydén, M., Ek, I., Wahrenberg, H., & Arner, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021573 · Cited by 125 · see citing works
Insulin sensitivity and antiandrogenic therapy in women with polycystic ovary syndrome
Diamanti‐Kandarakis, E., Mitrakou, A., Hennes, M. M. I., Platanisiotis, D., Kaklas, N., Spina, J., Georgiadou, E., Hoffmann, R. G., Kissebah, A. H., & Raptis, S. A. (1995) · Metabolism · doi:10.1016/0026-0495(95)90062-4 · Cited by 120 · see citing works
Baillargeon, J., & Carpentier, A. C. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.055 · Cited by 116 · see citing works
Ciampelli, M., Fulghesu, A. M., Cucinelli, F., Pavone, V., Caruso, A., Mancuso, S., & Lanzone, A. (1997) · Human Reproduction · doi:10.1093/humrep/12.9.1897 · Cited by 115 · see citing works
Adipose tissue expandability and the early origins of PCOS
de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.06.003 · Cited by 108 · see citing works
Bone mineral density and body composition in lean women with polycystic ovary syndrome
Good, C. R., Tülchinsky, M., Mauger, D. T., DEMERS, L. M., & Legro, R. S. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00203-4 · Cited by 102 · see citing works
Faloia, E., Canibus, P., Gatti, C., Frezza, F., Santangelo, M., Garrapa, G., & Boscaro, M. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345285 · Cited by 96 · see citing works
Long-Term Testosterone Administration Increases Visceral Fat in Female to Male Transsexuals
Elbers, J. M. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2044 · Cited by 90 · see citing works
Adipocyte biology in polycystic ovary syndrome
Barber, T. M., & Franks, S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.010 · Cited by 88 · see citing works
Sørensen, T. I. A., Virtue, S., & Vidal‐Puig, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.12.011 · Cited by 86 · see citing works
Tosi, F., Di Sarra, D., Kaufman, J.-M., Bonin, C., Moretta, R., Bonora, E., Zanolin, E., & Moghetti, P. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2786 · Cited by 70 · see citing works
Marsden, P. J., Murdoch, A. P., & Taylor, R. (1994) · Metabolism · doi:10.1016/0026-0495(94)90013-2 · Cited by 67 · see citing works
Veiga‐Lopez, A., Moeller, J., Patel, D., Ye, W., Pease, A. P., Kinns, J., & Padmanabhan, V. (2013) · Endocrinology · doi:10.1210/en.2012-2145 · Cited by 64 · see citing works
Neve-Dolfing, J. G., Stassen, C. M., van Haard, P. M. M., Wolffenbuttel, B. H. R., & Schweitzer, D. H. (2011) · Human Reproduction · doi:10.1093/humrep/der070 · Cited by 62 · see citing works
Keller, E., Chazenbalk, G. D., Aguilera, P., Madrigal, V., Grogan, T., Elashoff, D., Dumesic, D. A., & Abbott, D. H. (2014) · Endocrinology · doi:10.1210/en.2014-1050 · Cited by 60 · see citing works
Self-citationGonzález, F. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1554918 · Cited by 60 · see citing works
Steil, G. M., Vølund, A., Kahn, S. E., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.2.250 · Cited by 42 · see citing works
Dumesic, D. A., Abbott, D. H., Eisner, J. R., Herrmann, R. R., Reed, J. E., Welch, T. J., & Jensen, M. D. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00098-3 · Cited by 38 · see citing works
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- Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tol- erance, type 2 diabetes and metabolic syndrome: a systemic review and meta-analysis. Hum Reprod Updates. 2010;16:347-363.
Cited by
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Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment
Escobar-Morreale, H. F. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.24 · Cited by 2,083 · see citing works
Adipose-tissue plasticity in health and disease
Sakers, A. P., Siqueira, M. K. D., Seale, P., & Villanueva, C. J. (2022) · Cell · doi:10.1016/j.cell.2021.12.016 · Cited by 1,061 · see citing works
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
Tata, B., Mimouni, N. E. H., Barbotin, A.-L., Malone, S. A., Loyens, A., Pigny, P., Dewailly, D., Catteau-Jonard, S., Sundström-Poromaa, I., Piltonen, T. T., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0035-5 · Cited by 434 · see citing works
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Stener‐Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 378 · see citing works
Self-citationArmanini, D., Boscaro, M., Bordin, L., & Sabbadin, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084110 · Cited by 324 · see citing works
Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616467114 · Cited by 222 · see citing works
Insulin resistance and PCOS: chicken or egg?
Moghetti, P., & Tosi, F. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01351-0 · Cited by 209 · see citing works
New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins
Walters, K. A., Gilchrist, R. B., Ledger, W. L., Teede, H. J., Handelsman, D. J., & Campbell, R. E. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.08.005 · Cited by 186 · see citing works
Dyslipidemia involvement in the development of polycystic ovary syndrome
Liu, Q., Xie, Y., Qu, L.-H., Zhang, M., & Mo, Z. (2019) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2019.05.003 · Cited by 144 · see citing works
Adiponectin protects against development of metabolic disturbances in a PCOS mouse model
Benrick, A., Chanclón, B., Micallef, P., Wu, Y., Hadi, L., Shelton, J. M., Stener‐Victorin, E., & Asterholm, I. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708854114 · Cited by 138 · see citing works
The Mechanism of Androgen Actions in PCOS Etiology
Paris, V. R., & Bertoldo, M. J. (2019) · Medical Sciences · doi:10.3390/medsci7090089 · Cited by 134 · see citing works
Hyperandrogenic origins of polycystic ovary syndrome-Implications for Pathophysiology and Therapy
Abbott, D. H., Dumesic, D. A., & Levine, J. E. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1576522 · Cited by 131 · see citing works
Self-citationHarada, M. (2022) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12487 · Cited by 125 · see citing works
Polycystic Ovary Syndrome: Pathophysiology and Therapeutic Opportunities
Dong, J., & Rees, D. A. (2023) · BMJ Medicine · doi:10.1136/bmjmed-2023-000548 · Cited by 123 · see citing works
Adipose Tissue Dysfunction in Polycystic Ovary Syndrome
Bril, F., Ezeh, U., Amiri, M., Hatoum, S., Pace, L., Chen, Y.-H., Bertrand, F., Gower, B., & Azziz, R. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad356 · Cited by 123 · see citing works
Androgens and ovarian function: translation from basic discovery research to clinical impact
Walters, K. A., Rodriguez Paris, V, Aflatounian, A., & Handelsman, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0096 · Cited by 104 · see citing works
Sidra, S., Tariq, M. H., Farrukh, M. J., & Mohsin, M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223329 · Cited by 112 · see citing works
Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index
Condorelli, R. A., Calogero, A. E., Mauro, M. D., Mongioì, L. M., Cannarella, R., Rosta, G., & Vignera, S. L. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0762-3 · Cited by 104 · see citing works
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome
de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107 · see citing works
Gender Differences in Insulin Resistance: New Knowledge and Perspectives
Ciarambino, T., Crispino, P., Guarisco, G., & Giordano, M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100496 · Cited by 103 · see citing works
Mechanisms of intergenerational transmission of polycystic ovary syndrome
Dumesic, D. A., Hoyos, L. R., Chazenbalk, G. D., Naik, R., Padmanabhan, V., & Abbott, D. H. (2020) · Reproduction · doi:10.1530/rep-19-0197 · Cited by 101 · see citing works
Self-citationMetabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
Alves, A. C., Valcarcel, B., Mäkinen, V.-P., Morin-Papunen, L. C., Sebert, S. P., Kangas, A. J., Soininen, P., Das, S., Iorio, M. D., Coin, L., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.126 · Cited by 96 · see citing works
Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome
Dumesic, D. A., Phan, J. D., Leung, K. L., Grogan, T. R., Ding, X., Li, X., Hoyos, L. R., Abbott, D. H., & Chazenbalk, G. D. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02086 · Cited by 92 · see citing works
Self-citationEndometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“…Lim et al., 2012; Sam, 2007; Wang et al., 2018) Fat distribution Estrogen promotes fat deposition below waist; androgens increase abdominal fat (Dumesic et al., 2016; Motta- Mena & Puts, 2016) Fat distribution below the waist associated with endometriosis (Backonja et al., 2016) Abdominal fat…”
BackgroundDifferential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk
Sam, S. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0014 · Cited by 91 · see citing works
Choudhury, A. A., & Rajeswari, V. D. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121069 · Cited by 92 · see citing works
Mitochondrial dysfunction: An emerging link in the pathophysiology of polycystic ovary syndrome
Shukla, P., & Mukherjee, S. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.02.006 · Cited by 88 · see citing works
Defreyne, J., de Bruaene, L. V., Rietzschel, E. R., Schuylenbergh, J. V., & T'Sjoen, G. G. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.288241 · Cited by 82 · see citing works
Mechanisms for sex differences in energy homeostasis
Wang, C., & Xu, Y. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0165 · Cited by 80 · see citing works
Endocrine-metabolic dysfunction in polycystic ovary syndrome: An evolutionary perspective
Dumesic, D. A., Abbott, D. H., Sanchita, S., & Chazenbalk, G. D. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.02.013 · Cited by 76 · see citing works
Self-citationCentral obesity, faster maturation, and “PCOS” in girls
de Zegher, F., López-Bermejo, A., & Ibáñez, L. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.09.005 · Cited by 73 · see citing works
Sex-dependent depot differences in adipose tissue development and function; role of sex steroids
Lee, M.-J., & Fried, S. K. (2017) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2017.26.3.172 · Cited by 72 · see citing works
Polycystic Ovarian Syndrome: Long-Term Health Consequences
Zore, T., Joshi, N., Lizneva, D., & Azziz, R. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1603096 · Cited by 72 · see citing works
Zhang, H., Wang, W., Zhao, J., Jiao, P., Zeng, L., Zhang, H., Zhao, Y., Shi, L., Hu, H., Luo, L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1085656 · Cited by 71 · see citing works
Reappraising the relationship between hyperinsulinemia and insulin resistance in PCOS
Houston, E. J., & Templeman, N. M. (2025) · Journal of Endocrinology · doi:10.1530/joe-24-0269 · Cited by 87 · see citing works
Cutler, D. A., Pride, S. M., & Cheung, A. P. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.977 · Cited by 69 · see citing works
A review on critical appraisal and pathogenesis of polycystic ovarian syndrome
Hajam, Y. A., Rather, H., Neelam, Kumar, R., Basheer, M., & Reshi, M. S. (2024) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2024.100162 · Cited by 72 · see citing works
Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation
Dumesic, D. A., Padmanabhan, V., Chazenbalk, G. D., & Abbott, D. H. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00878-y · Cited by 63 · see citing works
Self-citationLuque-Ramírez, M., Nattero-Chávez, L., Ortiz Flores, A. E., & Escobar-Morreale, H. F. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmx039 · Cited by 62 · see citing works
Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model
Aflatounian, A., Edwards, M. C., Paris, V. R., Bertoldo, M. J., Desai, R., Gilchrist, R. B., Ledger, W. J., Handelsman, D. J., & Walters, K. A. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0530 · Cited by 61 · see citing works
Cox, M. J., Edwards, M. C., Paris, V. R., Aflatounian, A., Ledger, W. J., Gilchrist, R. B., Padmanabhan, V., Handelsman, D. J., & Walters, K. A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa061 · Cited by 59 · see citing works
Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome
Krentowska, A., & Kowalska, I. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3464 · Cited by 56 · see citing works
The prevalence and metabolic characteristics of polycystic ovary syndrome in the Qatari population
Dargham, S. R., Ahmed, L., Kilpatrick, E. S., & Atkin, S. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181467 · Cited by 53 · see citing works
Polycystic ovary syndrome: A metabolic disorder with therapeutic opportunities
Zhang, Y., Chen, Z., & Zhao, H. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.08.002 · Cited by 60 · see citing works
Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., Dey, A., Babu, A., Renu, K., Vellingiri, B., et al. (2023) · Metabolites · doi:10.3390/metabo13010129 · Cited by 52 · see citing works
Yao, K., Bian, C., & Zhao, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4642 · Cited by 48 · see citing works
Zhang, Y., Qu, Z., Lu, T., Shao, X., Cai, M., Dilimulati, D., Gao, X., Mao, W., Hu, F., Su, L., et al. (2023) · Nutrients · doi:10.3390/nu15030556 · Cited by 47 · see citing works
Kałużna, M., Człapka-Matyasik, M., Wachowiak-Ochmańska, K., Moczko, J., Kaczmarek, J., Janicki, A., Piątek, K., Ruchała, M., & Ziemnicka, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9093024 · Cited by 47 · see citing works
Pruett, J. E., Everman, S. J., Hoang, N., Salau, F., Taylor, L. C., Edwards, K. S., Hosler, J. P., Huffman, A. M., Romero, D. G., & Cardozo, L. L. Y. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00455-x · Cited by 46 · see citing works
Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review
Carvalho, L. M. L., dos Reis, F. M., Cândido, A. L., Nunes, F. F. C., Ferreira, C. N., & Gomes, K. B. (2018) · Endocrine Regulations · doi:10.2478/enr-2018-0026 · Cited by 46 · see citing works
Vanky, E., Hanem, L. G. E., & Abbott, D. H. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.03.015 · Cited by 44 · see citing works
Self-citationPolycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health
Brennan, K. M., Kroener, L. L., Chazenbalk, G. D., & Dumesic, D. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000661 · Cited by 44 · see citing works
Self-citationEzeh, U. I., Chen, I. Y.-D., Chen, Y., & Azziz, R. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa235 · Cited by 44 · see citing works
Why does Polycystic Ovary Syndrome (PCOS) Need Long-term Management?
Ruan, X., Li, M., & Mueck, A. O. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130104922 · Cited by 43 · see citing works
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J., & Dumesic, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00021-4 · Cited by 41 · see citing works
Self-citationAbbott, D. H., Rogers, J., Dumesic, D. A., & Levine, J. E. (2019) · Medical Sciences · doi:10.3390/medsci7120107 · Cited by 42 · see citing works
Self-citationZhu, S., Li, Z., Hu, C., Sun, F., Wang, C., Yuan, H., & Li, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.697223 · Cited by 41 · see citing works
Han, Y., Wu, H., Sun, S., Zhao, R., Deng, Y., Zeng, S., & Chen, J. (2023) · Nutrients · doi:10.3390/nu15092230 · Cited by 41 · see citing works
Hyperandrogenism and Cardiometabolic Risk in Pre- and Postmenopausal Women—What Is the Evidence?
Hirschberg, A. L. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad590 · Cited by 40 · see citing works
Fisch, S. C., Nikou, A. F., Wright, E. A., Phan, J. D., Leung, K. L., Grogan, T., Abbott, D. H., Chazenbalk, G. D., & Dumesic, D. A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.08.042 · Cited by 40 · see citing works
Self-citationSex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer
Heo, J.-W., Kim, S., & Sung, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031253 · Cited by 40 · see citing works
Role of microRNA in the Pathogenesis of Polycystic Ovary Syndrome
Chen, Z., Ou, H.-X., Wu, H., Wu, P., & Mo, Z. (2019) · DNA and Cell Biology · doi:10.1089/dna.2019.4622 · Cited by 37 · see citing works
Zhao, J., Huang, J., Geng, X., Chu, W., Li, S., Chen, Z., & Du, Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00772 · Cited by 37 · see citing works
Pharmacological Approaches to Controlling Cardiometabolic Risk in Women with PCOS
Cignarella, A., Mioni, R., Sabbadin, C., Dassie, F., Parolin, M., Vettor, R., Barbot, M., & Scaroni, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249554 · Cited by 36 · see citing works
Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome
Boumosleh, J. M., Grundy, S. M., Phan, J., Neeland, I. J., Chang, A. Y., & Vega, G. L. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00323 · Cited by 35 · see citing works
Varlamov, O., Bishop, C. V., Handu, M., Takahashi, D., Srinivasan, S., White, A., & Roberts, C. T. (2017) · Human Reproduction · doi:10.1093/humrep/dex244 · Cited by 34 · see citing works
Hormonal Regulation of Adipogenesis
Lee, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160047 · Cited by 42 · see citing works
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00970-x · Cited by 33 · see citing works
Self-citationBishop, C. V., Stouffer, R. L., Takahashi, D. L., Mishler, E., Wilcox, M. C., Slayden, O. D., & True, C. A. (2018) · Human Reproduction · doi:10.1093/humrep/dey013 · Cited by 33 · see citing works
Brand, T., van den Munckhof, I., van der Graaf, M., Schraa, K., Dekker, H. M., Joosten, L. A. B., Netea, M. G., Riksen, N. P., Graaf, J. D., & Rutten, J. H. W. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab426 · Cited by 33 · see citing works
True, C. A., Takahashi, D. L., Burns, S. E., Mishler, E., Bond, K., Wilcox, M. C., Calhoun, A. R., Bader, L., Dean, T. A., Ryan, N. D., et al. (2017) · Human Reproduction · doi:10.1093/humrep/dex246 · Cited by 32 · see citing works
Scott, D. S., Harrison, C. L., Hutchison, S. K., de Courten, B. V., & Stepto, N. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182412 · Cited by 31 · see citing works
Potential causes of male and female infertility in Qatar
Zauner, G., & Girardi, G. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103173 · Cited by 28 · see citing works
Dumesic, D. A., Tulberg, A., Leung, K. L., Fisch, S. C., Grogan, T., Abbott, D. H., Naik, R., & Chazenbalk, G. D. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.10.003 · Cited by 28 · see citing works
Self-citationPathogenesis of Reproductive and Metabolic PCOS Traits in a Mouse Model
Paris, V. R., Edwards, M. C., Aflatounian, A., Bertoldo, M. J., Ledger, W. J., Handelsman, D. J., Gilchrist, R. B., & Walters, K. A. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab060 · Cited by 28 · see citing works
Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones
Tramontana, F., Battisti, S., Napoli, N., & Strollo, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.726696 · Cited by 27 · see citing works
Guedikian, A. A., Lee, A., Grogan, T., Abbott, D. H., Largaespada, K., Chazenbalk, G. D., & Dumesic, D. A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.11.017 · Cited by 28 · see citing works
Self-citationAdipose Tissue Plasticity: A Comprehensive Definition and Multidimensional Insight
Mo, Y.-Y., Han, Y., Xu, S., Jiang, H., Wu, H., Cai, J., Li, L., Bu, Y., Xiao, F., Liang, H., et al. (2024) · Biomolecules · doi:10.3390/biom14101223 · Cited by 28 · see citing works
Hoyos, L. R., Visser, J. A., McLuskey, A., Chazenbalk, G. D., Grogan, T., & Dumesic, D. A. (2020) · Human Reproduction · doi:10.1093/humrep/deaa199 · Cited by 26 · see citing works
Self-citationCarbone, L., Davis, B. A., Fei, S. S., White, A. E., Nevonen, K. A., Takahashi, D. L., Vinson, A., True, C. A., Roberts, C. T., & Varlamov, O. (2019) · Scientific Reports · doi:10.1038/s41598-019-55291-8 · Cited by 26 · see citing works
Polycystic ovary syndrome: Is it androgen or estrogen receptor?
Walters, K. A. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.01.003 · Cited by 26 · see citing works
Mu, L., Zhao, Y., Li, R., Lai, Y.-C., & Qiao, J. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.08.007 · Cited by 25 · see citing works
Tharayil, S. P., & Shukla, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136233 · Cited by 28 · see citing works
Li, L., Scotti, A., Fang, J., Li, Y., Xiong, T., He, W., Qin, Y., Liew, C. W., Khayyat, N., Zhu, W., et al. (2019) · European Journal of Radiology · doi:10.1016/j.ejrad.2019.108777 · Cited by 23 · see citing works
de Medeiros, S. F., de Medeiros, M. A. S., dos Santos, N. V., Barbosa, B. B., & Yamamoto, M. M. W. (2018) · International Journal of Inflammation · doi:10.1155/2018/9591509 · Cited by 23 · see citing works
Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works
Zhang, Y., Cai, M., Dilimulati, D., Lin, Z., Sun, H., Cui, R., Fei, H., Gao, X., Zeng, Q., Shao, X., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.782808 · Cited by 22 · see citing works
Cannarella, R., Condorelli, R. A., Dall’Oglio, F., Vignera, S. L., Mongioì, L. M., Micali, G., & Calogero, A. E. (2020) · International Journal of Endocrinology · doi:10.1155/2020/1942126 · Cited by 22 · see citing works
Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome
Mansour, A., Noori, M., Hakemi, M. S., Haghgooyan, Z., Mohajeri‐Tehrani, M. R., Mirahmad, M., & Sajjadi‐Jazi, S. M. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01733-y · Cited by 21 · see citing works
Chełchowska, M., Jurczewska, J., Gajewska, J., Mazur, J., Szostak-Węgierek, D. E., Rudnicka, E., & Ambroszkiewicz, J. (2023) · Antioxidants · doi:10.3390/antiox12030730 · Cited by 21 · see citing works
Begum, R. F., & Mohan, S. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04710-8 · Cited by 21 · see citing works
Bishop, C. V., Takahashi, D. L., Mishler, E., Slayden, O. D., Roberts, C. T., Hennebold, J. D., & True, C. A. (2020) · Human Reproduction · doi:10.1093/humrep/deaa321 · Cited by 20 · see citing works
Neuronal androgen receptor: molecular gateway to polycystic ovary syndrome
Abbott, D. H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703436114 · Cited by 20 · see citing works
Self-citationZhang, D., Gao, J., Liu, X., Qin, H., & Wu, X. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00316-1 · Cited by 23 · see citing works
Endocrine and metabolic effects of GLP-1 receptor agonists on women with PCOS, a narrative review
Monney, M., Mavromati, M., Leboulleux, S., & Gariani, K. (2025) · Endocrine Connections · doi:10.1530/ec-24-0529 · Cited by 20 · see citing works
Dumesic, D. A., Winnett, C., Lu, G., Grogan, T., Abbott, D. H., Naik, R., & Chazenbalk, G. D. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.09.324 · Cited by 20 · see citing works
Self-citationPuberty in the Female and Its Disorders
Rosenfield, R. L., Cooke, D. W., & Radovick, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00016-6 · Cited by 22 · see citing works
Interplay between PCOS and microbiome: The road less travelled
Batra, M., Bhatnager, R., Kumar, A., Suneja, P., & Dang, A. S. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13580 · Cited by 19 · see citing works
Predictive Analysis of Polycystic Ovarian Syndrome using CatBoost Algorithm
Rathod, Y., Komare, A., Ajgaonkar, R., Chindarkar, S., Nagare, G. D., Punjabi, N., & Karpate, Y. (2022) · IEEE Region 10 Symposium (TENSYMP) · doi:10.1109/tensymp54529.2022.9864439 · Cited by 19 · see citing works
- Authors
- Dumesic, D. A., Akopians, A. L., Madrigal, V. K., Ramirez, E., Margolis, D. J., Sarma, M. K., Thomas, A. M., Grogan, T. R., Haykal, R., Schooler, T. A., Okeya, B. L., Abbott, D. H., & Chazenbalk, G. D.
- Affiliations
- University of California, Los Angeles (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Dumesic, Daniel A.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2016-11
- Volume
- 101
- Issue
- 11
- Pages
- 4178-4188
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC5095243
- OpenAlex
- W2514157066
- Cited by
- 222
- References
- 59
- Citations by year
- 2026: 20 · 2025: 29 · 2024: 15 · 2023: 20 · 2022: 28 · 2021: 25 · 2020: 24 · 2019: 25 · 2018: 18 · 2017: 17 · 2016: 1
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000124, P51OD011092)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD071836)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- polycystic ovary syndrome, hyperandrogenism, intra-abdominal fat, abdominal fat, subcutaneous adipocytes, adipocyte size, hyperinsulinemia, insulin resistance, beta-cell function, luteinizing hormone, metabolic dysfunction, normal-weight women
- MeSH terms
- Adolescent, Adult, Body Weight, Female, Humans, Polycystic Ovary Syndrome, Prospective Studies, Hyperandrogenism, Intra-Abdominal Fat, Subcutaneous Fat, Abdominal, Adipocytes, White, Young Adult
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